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FI925422L - Indolopyrrolokarbazolderivat - Google Patents

Indolopyrrolokarbazolderivat Download PDF

Info

Publication number
FI925422L
FI925422L FI925422A FI925422A FI925422L FI 925422 L FI925422 L FI 925422L FI 925422 A FI925422 A FI 925422A FI 925422 A FI925422 A FI 925422A FI 925422 L FI925422 L FI 925422L
Authority
FI
Finland
Prior art keywords
indolopyrrolocarbazole derivative
indolopyrrolocarbazole
derivative
Prior art date
Application number
FI925422A
Other languages
English (en)
Other versions
FI106864B (fi
FI925422A0 (fi
Inventor
Katsuhisa Kojiri
Hisao Kondo
Hiroharu Arakawa
Mitsuru Ohkubo
Hiroyuki Suda
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of FI925422A0 publication Critical patent/FI925422A0/fi
Publication of FI925422L publication Critical patent/FI925422L/fi
Application granted granted Critical
Publication of FI106864B publication Critical patent/FI106864B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Silicon Polymers (AREA)
FI925422A 1991-11-29 1992-11-27 Menetelmä terapeuttisesti käyttökelpoisten indolopyrrolokarbatsolijohdannaisten valmistamiseksi FI106864B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP34191691 1991-11-29
JP34191691 1991-11-29
JP6926992 1992-02-18
JP6926992 1992-02-18
JP25730692 1992-09-01
JP25730692 1992-09-01

Publications (3)

Publication Number Publication Date
FI925422A0 FI925422A0 (fi) 1992-11-27
FI925422L true FI925422L (fi) 1993-05-30
FI106864B FI106864B (fi) 2001-04-30

Family

ID=27300000

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925422A FI106864B (fi) 1991-11-29 1992-11-27 Menetelmä terapeuttisesti käyttökelpoisten indolopyrrolokarbatsolijohdannaisten valmistamiseksi

Country Status (27)

Country Link
EP (1) EP0545195B1 (fi)
JP (1) JP2629542B2 (fi)
KR (1) KR100275976B1 (fi)
AT (1) ATE130617T1 (fi)
AU (1) AU650376B2 (fi)
BG (1) BG61036B1 (fi)
CA (1) CA2083534C (fi)
CZ (1) CZ287304B6 (fi)
DE (1) DE69206242T2 (fi)
DK (1) DK0545195T3 (fi)
DZ (1) DZ1634A1 (fi)
ES (1) ES2079774T3 (fi)
FI (1) FI106864B (fi)
GR (1) GR3018527T3 (fi)
HU (3) HU217611B (fi)
IL (1) IL103844A (fi)
MX (1) MX9206847A (fi)
MY (1) MY114655A (fi)
NO (1) NO178929C (fi)
NZ (1) NZ245203A (fi)
PL (1) PL171468B1 (fi)
RO (1) RO113469B1 (fi)
RU (1) RU2117671C1 (fi)
SA (1) SA93130351B1 (fi)
TW (1) TW224469B (fi)
WO (1) WO1993011145A1 (fi)
YU (1) YU48963B (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
CA2190007C (en) * 1994-05-09 2003-04-15 Katsuhisa Kojiri Antitumor indolopyrrolocarbazole derivatives
AU2575395A (en) * 1994-06-13 1996-01-05 Banyu Pharmaceutical Co., Ltd. Gene coding for glycosyltransferase and use thereof
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
HUP9903931A3 (en) * 1996-08-22 2000-09-28 Bristol Myers Squibb Co Wallin Cytotoxic amino sugar and related sugar derivatives of indolopyrrolocarbazoles
GB9811624D0 (en) * 1998-05-29 1998-07-29 Merck Sharp & Dohme Therapeutic use
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6703373B1 (en) 1999-09-10 2004-03-09 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives and antitumor agents
FR2801054B1 (fr) * 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TR200302314T4 (tr) 2000-02-24 2004-01-21 Banyu Pharmaceutical Co., Ltd. İndolopirolokarbazol türevinin hazırlanması için bir işlem, hazırlık işlemindeki ara ürünler ve ara ürünlerin hazırlanmsı için bir işlem.
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6555677B2 (en) 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
JP2004534006A (ja) 2001-03-22 2004-11-11 ブリストル−マイヤーズ　スクイブ　カンパニー インドロピロロカルバゾール化合物のトポイソメラーゼｉ選択的細胞毒シュガー誘導体
US6559299B2 (en) 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
MXPA04009324A (es) * 2002-03-26 2005-01-25 Banyu Pharma Co Ltd Uso de derivado de indolopirrolocarbazol y otro agente anticanceroso en combinacion.
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
CA2496479A1 (en) * 2002-08-23 2004-03-04 Banyu Pharmaceutical Co., Ltd. Process for producing indolopyrrolocarbazole derivative
WO2005010017A1 (ja) * 2003-07-24 2005-02-03 Banyu Pharmaceutical Co., Ltd インドロピロロカルバゾール誘導体及び抗腫瘍剤
CN1852914A (zh) * 2003-09-16 2006-10-25 万有制药株式会社 抗肿瘤性新型吲哚并吡咯并咔唑衍生物
US7169802B2 (en) 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
US7241779B2 (en) 2003-12-23 2007-07-10 Cephalon, Inc. Fused pyrrolocarbazoles
RU2255089C1 (ru) * 2003-12-26 2005-06-27 Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории" Производные гликозидов индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-дионов, обладающие цитотоксической и противоопухолевой активностью
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
MX2011005055A (es) 2008-11-19 2011-05-31 Cephalon Inc Nuevas formas de un compuesto de indazolo [5,4-a]pirrolo[3,4-c]car bazol.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
EP0445736A1 (en) * 1990-03-06 1991-09-11 Bristol-Myers Squibb Company Rebeccamycin analog and pharmaceutical composition containing it
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
MX9201643A (es) * 1991-04-11 1992-10-01 Schering Corp Agentes contra tumores y anti-psoriasicos.

Also Published As

Publication number Publication date
BG97970A (bg) 1994-04-29
HUT65699A (en) 1994-07-28
YU102692A (sh) 1996-02-19
EP0545195A1 (en) 1993-06-09
WO1993011145A1 (en) 1993-06-10
NO924593L (no) 1993-06-01
HU211254A9 (en) 1995-11-28
TW224469B (fi) 1994-06-01
RO113469B1 (ro) 1998-07-30
KR100275976B1 (ko) 2001-02-01
CA2083534A1 (en) 1993-05-30
AU650376B2 (en) 1994-06-16
IL103844A0 (en) 1993-04-04
DE69206242D1 (de) 1996-01-04
JP2629542B2 (ja) 1997-07-09
IL103844A (en) 1997-09-30
DK0545195T3 (da) 1995-12-18
NO924593D0 (no) 1992-11-27
PL171468B1 (pl) 1997-05-30
CZ350892A3 (en) 1993-10-13
PL304729A1 (en) 1995-01-09
DE69206242T2 (de) 1996-03-28
YU48963B (sh) 2003-01-31
GR3018527T3 (en) 1996-03-31
NO178929B (no) 1996-03-25
MX9206847A (es) 1993-06-30
KR930010039A (ko) 1993-06-21
ES2079774T3 (es) 1996-01-16
NO178929C (no) 1996-07-03
DZ1634A1 (fr) 2002-02-17
CZ287304B6 (cs) 2000-10-11
NZ245203A (en) 1997-07-27
CA2083534C (en) 2003-01-28
JPH06128283A (ja) 1994-05-10
HU217611B (hu) 2000-03-28
EP0545195B1 (en) 1995-11-22
RU2117671C1 (ru) 1998-08-20
SA93130351B1 (ar) 2005-10-16
MY114655A (en) 2002-12-31
FI106864B (fi) 2001-04-30
FI925422A0 (fi) 1992-11-27
HU9203754D0 (en) 1993-03-29
ATE130617T1 (de) 1995-12-15
AU2963792A (en) 1993-06-03
BG61036B1 (bg) 1996-09-30

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