[go: up one dir, main page]

FI915003A0 - Inhibitorer av endotel cellvaext och angiogenesis som innehaoller oligosakkarider. - Google Patents

Inhibitorer av endotel cellvaext och angiogenesis som innehaoller oligosakkarider.

Info

Publication number
FI915003A0
FI915003A0 FI915003A FI915003A FI915003A0 FI 915003 A0 FI915003 A0 FI 915003A0 FI 915003 A FI915003 A FI 915003A FI 915003 A FI915003 A FI 915003A FI 915003 A0 FI915003 A0 FI 915003A0
Authority
FI
Finland
Prior art keywords
oligosakkarider
endotel
cellvaext
angiogenesis
och
Prior art date
Application number
FI915003A
Other languages
English (en)
Other versions
FI915003A7 (fi
Inventor
Karin Helena Louise Bergendahl
Rolf Arne Johansson
Jan Christer Mattsson
Carl Magnus Erik Svahn
Moses Judah Folkman
Judith Sudhalter
Amore Patricia D
Original Assignee
Kabi Pharmacia Ab
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab, Harvard College filed Critical Kabi Pharmacia Ab
Publication of FI915003A0 publication Critical patent/FI915003A0/fi
Publication of FI915003A7 publication Critical patent/FI915003A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FI915003A 1989-04-24 1990-04-24 Endoteelisolukasvun ja angiogeneesin inhibiittorit, jotka sisältävät o ligosakkarideja FI915003A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34206589A 1989-04-24 1989-04-24
PCT/EP1990/000654 WO1990012580A1 (en) 1989-04-24 1990-04-24 Oligosaccharide-containing inhibitors of endothelial cell growth and angiogenesis

Publications (2)

Publication Number Publication Date
FI915003A0 true FI915003A0 (fi) 1991-10-23
FI915003A7 FI915003A7 (fi) 1991-10-23

Family

ID=23340174

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915003A FI915003A7 (fi) 1989-04-24 1990-04-24 Endoteelisolukasvun ja angiogeneesin inhibiittorit, jotka sisältävät o ligosakkarideja

Country Status (7)

Country Link
EP (1) EP0394971A1 (fi)
AU (1) AU5445290A (fi)
CA (1) CA2053883A1 (fi)
FI (1) FI915003A7 (fi)
HU (1) HUT59828A (fi)
PT (1) PT93847A (fi)
WO (1) WO1990012580A1 (fi)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
MX9201801A (es) * 1991-04-16 1992-10-30 Seikagaku Kogyo Co Ltd Oligosacarido que tiene afinidad para el factor de desarrollo del fibroplasto y procedimiento para producirlo.
CZ232593A3 (en) * 1991-05-02 1994-07-13 Yeda Res & Dev Pharmaceutical preparation for preventing and/or therapy of pathological states
GB9206291D0 (en) * 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
US6750207B1 (en) 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
WO1994020520A1 (en) * 1993-03-10 1994-09-15 Magainin Pharmaceuticals Inc. Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants
CA2176934A1 (en) * 1993-11-17 1995-05-26 Ramnath Sasisekharan Method for inhibiting angiogenesis using heparinase
DE69535565T2 (de) 1994-07-01 2008-05-08 Seikagaku Corp. Verwendung von desulfatiertem Heparin
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
EP0910382B1 (en) * 1996-04-26 2003-06-11 Magainin Pharmaceuticals Inc. Squalamine in combination with other anti-cancer agents for treating tumors
US5801012A (en) 1996-09-17 1998-09-01 Northwestern University Methods and compositions for generating angiostatin
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
WO1999004801A1 (en) * 1997-07-28 1999-02-04 Rijks Universiteit Leiden Use of sulfated glycosaminoglycans for treating of retinopathy
DE19747195A1 (de) * 1997-10-24 1999-04-29 Knoll Ag Verwendung von Glykosaminoglykanen zur Herstellung von pharmazeutischen Zubereitungen zur Behandlung von mit Diabetes assoziierten Augenkrankheiten
CA2341412A1 (en) 1998-08-27 2000-03-09 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase i and ii
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
JP4824170B2 (ja) 1999-04-23 2011-11-30 マサチューセッツ インスティテュート オブ テクノロジー ポリマーを表記するためのシステムおよび方法
CA2402160C (en) 2000-03-08 2012-02-14 Massachusetts Institute Of Technology Heparinase iii and uses thereof
JP2003531148A (ja) 2000-04-12 2003-10-21 ジェネーラ・コーポレーション 保護されていない７−α−ヒドロキシ基を有する中間体を使用する、７−α−ヒドロキシ３−アミノ置換ステロイドの調製のためのプロセス
DE10028204A1 (de) * 2000-06-09 2002-01-03 Aventis Pharma Gmbh Verfahren zur Auffindung von medizinisch wertvollen Wirkstoffen
EP1319183B1 (en) 2000-09-12 2009-03-25 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
AU2002224408B2 (en) 2000-10-18 2007-08-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
PT2343077E (pt) 2001-09-12 2013-08-29 Sigma Tau Res Switzerland Sa Derivados de glicosaminoglicanos totalmente n-dessulfatados como inibidores da heparanase, capazes de atividade antiangiogénica e desprovidos de efeito anticoagulante
US7285536B2 (en) 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
ITMI20021372A1 (it) 2002-06-21 2003-12-22 Derivati Organici Lab Processo per la depolimerizzazione fisica dei glicosamminogliacani e prodotti da esso ottenuti
FR2866650B1 (fr) * 2004-02-24 2006-04-28 Aventis Pharma Sa Oligosaccharides, procede de preparation, utilisation et compositions pharmaceutiques les renfermant
JP2008526258A (ja) * 2005-01-12 2008-07-24 マサチューセッツ・インスティテュート・オブ・テクノロジー 細胞外幹細胞環境を調節することに関する方法および組成物
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US20090035787A1 (en) * 2007-07-23 2009-02-05 The University Of North Carolina At Chapel Hill Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues
WO2012088416A2 (en) 2010-12-23 2012-06-28 The University Of North Carolina At Chapel Hill Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
ES2924830T3 (es) 2013-06-17 2022-10-11 Univ North Carolina Chapel Hill Moléculas de heparina reversibles
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
WO2018107200A1 (en) 2016-12-13 2018-06-21 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
JP7330893B2 (ja) 2017-03-10 2023-08-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法
WO2019010216A1 (en) 2017-07-03 2019-01-10 The University Of North Carolina At Chapel Hill ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES
EP3691653B1 (en) 2017-11-03 2025-03-12 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
JP7538724B2 (ja) 2018-06-20 2024-08-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 細胞保護の方法と組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
FR2597484B1 (fr) * 1986-04-17 1988-12-23 Sanofi Sa Glycosaminoglycanes de type heparine ou heparane-sulfate dotes d'une activite sur la division et la differentiation cellulaires, leur preparation et leurs applications therapeutiques.

Also Published As

Publication number Publication date
WO1990012580A1 (en) 1990-11-01
AU5445290A (en) 1990-11-16
HUT59828A (en) 1992-07-28
EP0394971A1 (en) 1990-10-31
HU903414D0 (en) 1992-01-28
FI915003A7 (fi) 1991-10-23
PT93847A (pt) 1990-11-20
CA2053883A1 (en) 1990-10-25

Similar Documents

Publication Publication Date Title
FI915003A0 (fi) Inhibitorer av endotel cellvaext och angiogenesis som innehaoller oligosakkarider.
FI921952A0 (fi) Foerfarande foer framstaellning av dialkylenpiperidinofoereningar och enantiomerer daerav anvaendbara som laekemedel.
FI925735L (fi) Polymerer och oligomerer av gallsyraderivat, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
FI895692A0 (fi) Displaysystem som utnyttjar ljusgenomslaepplig skaerm och foerfarande foer framstaellning av detsamma.
FI893105A0 (fi) Tryckkapsel foer spraybehaollare och spraybehaollare som utnyttjar en saodan kapsel.
FI903929A0 (fi) Proteiner som induserar immunologisk effektorcellaktivation och kemattraktion.
FI901575A0 (fi) Foerfarande foer tillfoering av pappersrullar till rullrotationstyckmaskiner och anordning foer genomfoerande av foerfarandet.
FI922454L (fi) Peptider och antikroppar som inhiberar integrinligandbindning.
FI885533L (fi) Polymerkomposition foer anvaendning som belaeggning foer elledningar och foerfarande foer belaeggning av elledningar.
FI923558A0 (fi) Tetrahydroindazol-, tetrahydrocyklo -pentapyrazol- och hexahydrocykloheptapyrazolfoereningar och deras anvaendning som inhibitorer av hmg-coa-reduktas.
FI921833A0 (fi) Anordning foer plastroerframstaellning innehaollande formkokiller som ledat kan oeppnas och staengas.
FI923756A0 (fi) Polyolefinkompositioner som omfattar glycerolmonoestrar av c20-24-fettsyror och daerav framstaellda skumprodukter.
FI923185A0 (fi) Foerfarande och anordning foer framstaellning av fogloesa band- och traodoeglor och deras anvaendning som kapverktyg i band- och traodsaogar.
FI885877L (fi) Fotopolymeriserbar blandning och uppteckningsmaterial som framstaellts av densamma.
FI885152L (fi) Foerfarande foer framstaellning av biologiskt foerstoerbara mikrokapslar som innehaoller vattenloesliga peptider och proteiner och medelst detta foerfarande framstaellda mikrokapslar.
FI900045A0 (fi) Proteasfattiga gram-positiva bakterier och anvaendning daerav som vaerdorganism foer framstaellning av rekombinationsprodukter.
FI913138A0 (fi) Foerfarande foer framstaellning av b -laktamer som innehaoller aminotiazol(iminooxiaettiksyra) aettiksyrasidokedjor och mellanprodukter daerav.
FI915259A7 (fi) Siktanordning foer avlaegsning av kvistar fraon massasuspension som transporterar fibrer och kvistar.
FI915609A0 (fi) Foerfarande och anordning foer styrning av en m-pulsvaexelriktaranordning som bestaor av en mastervaexelriktare och aotminstone en slavvaexelriktare.
FI882899L (fi) Ytteknik som accelererar polering och putsning av metallartiklar i roterande behandlingsutrustning.
FI894653L (fi) Stabila oxapenem-3-karboxylsyror och deras anvaendning som b-laktamasfoerhindrare.
FI914776A0 (fi) Inhibitorer foer bildning av tumoernekrosfaktor, foerfarande foer deras framstaellning och anvaendning daerav.
FI916092A7 (fi) Foerfarande foer limning av korsverkkonstruktioner av plastprofil och limfoerbindning foer korsverkkonstruktioner som framstaellts plastprofil.
FI893707A0 (fi) Foerfarande foer framstaellning av polymerer och deras anvaendning som stabiliseringsaemne foer formaldehyds vattenloesningar.
FI915044L (fi) Korrosionsinhibitorer foer anvaendning i belaeggningskompositioner som innehaoller synergistiska kombinationer av kalciumborater och aminokarboxylater.

Legal Events

Date Code Title Description
FD Application lapsed