FI893500L - Vampyrfladdermussaliv plasminogenaktivatorer. - Google Patents

Vampyrfladdermussaliv plasminogenaktivatorer. Download PDF

Info

Publication number: FI893500L
Authority: FI; Finland
Prior art keywords: vampyrfladdermussaliv; activatorer; plasminogen; vampyrfladdermussaliv plasminogen; plasminogen activatorer
Prior art date: 1988-07-20

Application number

FI893500A

Other languages

English (en)

Other versions

FI100403B (fi

FI893500A0 (fi

Inventor

Le Thi Doung

Paul A Friedman

Stephen J Gardell

John J Jacobs

Richard A F Dixon

George E Mark

Bruce L Daugherty

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-20

Filing date

1989-07-19

Publication date

1990-01-21

1989-07-19 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1989-07-19 Publication of FI893500A0 publication Critical patent/FI893500A0/fi

1990-01-21 Publication of FI893500L publication Critical patent/FI893500L/fi

1995-08-15 Priority to FI953849A priority Critical patent/FI100406B/fi

1997-11-28 Application granted granted Critical

1997-11-28 Publication of FI100403B publication Critical patent/FI100403B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

FI893500A 1988-07-20 1989-07-19 Menetelmä glykosyloitujen tai glykosyloimattomien vampyyrilepakon sylj en plasminogeeniaktivaattoreiden valmistamiseksi FI100403B (fi)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
FI953849A FI100406B (fi)	1988-07-20	1995-08-15	Menetelmä vampyyrilepakon syljen plasminogeeniaktivaattoreiden valmist amiseksi

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US22169788A	1988-07-20	1988-07-20
US22169788		1988-07-20
US37722189A	1989-07-13	1989-07-13
US37722189		1989-07-13

Publications (3)

Publication Number	Publication Date
FI893500A0 FI893500A0 (fi)	1989-07-19
FI893500L true FI893500L (fi)	1990-01-21
FI100403B FI100403B (fi)	1997-11-28

Family

ID=26916041

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI893500A FI100403B (fi)	1988-07-20	1989-07-19	Menetelmä glykosyloitujen tai glykosyloimattomien vampyyrilepakon sylj en plasminogeeniaktivaattoreiden valmistamiseksi

Country Status (17)

Country	Link
US (1)	US5830849A (fi)
EP (1)	EP0352119B1 (fi)
JP (1)	JP2713467B2 (fi)
KR (1)	KR0138997B1 (fi)
AT (1)	ATE126269T1 (fi)
AU (1)	AU621389B2 (fi)
CA (1)	CA1341090C (fi)
DE (1)	DE68923741T2 (fi)
DK (1)	DK176140B1 (fi)
ES (1)	ES2076965T3 (fi)
FI (1)	FI100403B (fi)
GR (1)	GR3017587T3 (fi)
IE (1)	IE69054B1 (fi)
IL (1)	IL91059A (fi)
NO (2)	NO302954B1 (fi)
NZ (1)	NZ230017A (fi)
PT (1)	PT91236B (fi)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01500322A (ja) *	1986-03-28	1989-02-09	クリエイティブ　バイオモレクレス，インコーポレーテッド	組織プラスミノーゲンアクテイベーター類縁蛋白質
AU642404B2 (en) *	1989-02-13	1993-10-21	Schering Aktiengesellschaft Berlin Und Bergkamen	Novel thrombolytic
US6008019A (en) *	1989-02-13	1999-12-28	Schering Aktiengesellschaft	Plasminogen activator from saliva of the vampire bat
DE3943241A1 (de) *	1989-12-22	1991-06-27	Schering Ag	Thrombolytisch wirkendes kombinationspraeparat
EP0455424A3 (en) *	1990-05-02	1992-04-29	Merck & Co. Inc.	Mammalian inducible promoter cascade system
DK0580685T3 (da) *	1991-04-16	1996-03-04	Boehringer Mannheim Gmbh	Farmaceutisk emballageenhed indeholdende plasminogenaktivatorer til flerfoldig bolusindgift
US5910481A (en) *	1995-11-13	1999-06-08	Immuno Ag	Hybrid proteins with modified activity
US5945432A (en) *	1995-12-22	1999-08-31	The University Of Vermont And State Agricultural College	Thrombolytic agents and thienopyridine derivatives in acute stroke
US5731186A (en) *	1996-02-05	1998-03-24	Schering Aktiengesellschaft	Method for the production of rDSPA α1
DE10153601A1 (de)	2001-11-02	2003-05-22	Paion Gmbh	DSPA zur Behandlung von Schlaganfall
US20060135425A1 (en) *	2003-05-02	2006-06-22	Paion Deutschland Gmbh	Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
AU2003227721A1 (en) *	2003-05-02	2004-11-23	Paion Gmbh	Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
JP2006525270A (ja) *	2003-05-02	2006-11-09	パイオンドイチュラントゲーエムベーハー	脳梗塞の処置のための非神経毒性プラスミノーゲン活性剤の静脈内注射
DE10342518A1 (de) *	2003-09-12	2005-05-12	Paion Gmbh	Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
TWI482628B (zh) *	2007-10-18	2015-05-01	Lundbeck & Co As H	新穎之血栓溶解病患次群
EP2289542A1 (en)	2009-08-31	2011-03-02	PAION Deutschland GmbH	Treatment of neurological or neurodegenerative disorders
EP2289541A1 (en)	2009-08-31	2011-03-02	PAION Deutschland GmbH	Treatment of neurological or neurodegenerative disorders
WO2018141909A1 (en)	2017-02-03	2018-08-09	Acticor Biotech	Inhibition of platelet aggregation using anti-human gpvi antibodies
ES3048619T3 (en)	2017-05-16	2025-12-11	Inst Nat Sante Rech Med	Methods and pharmaceutical compositions for the treatment of acute ischemic stroke
US12123000B2 (en)	2018-06-15	2024-10-22	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Use of PI3KC2B inhibitors for the preservation of vascular endothelial cell barrier integrity
KR102902791B1 (ko) *	2019-02-05	2025-12-22	다이노 노벨 아시아 퍼시픽 피티와이 리미티드	상 안정화 질산암모늄 프릴, 및 관련된 생성물 및 방법
WO2021148439A1 (en)	2020-01-21	2021-07-29	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for stimulating cerebrovascular function
US20240207190A1 (en)	2020-06-09	2024-06-27	INSERM (Institut National de la Santé et de la Recherche Médicale)	Fucoidan-functionalized polysaccharide particles with t-pa for targeted thrombolytic therapy
WO2023156683A1 (en)	2022-02-21	2023-08-24	Acticor Biotech	Treatment of cardiovascular diseases using anti-human gpvi antibodies
EP4556492A1 (en)	2023-11-14	2025-05-21	Acticor Biotech	Treatment of cardiovascular diseases using anti-human gpvi antibodies in subpopulations of subjects

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4766075A (en) *	1982-07-14	1988-08-23	Genentech, Inc.	Human tissue plasminogen activator
US5010002A (en) *	1983-01-19	1991-04-23	Genentech, Inc.	Human t-PA production using vectors coding DHFR protein
WO1987005934A1 (en) *	1986-03-28	1987-10-08	Roberto Crea	Protein analogues of tissue plasminogen activator
AU605364B2 (en) *	1987-10-09	1991-01-10	Monsanto Company	Modified tissue plasminogen activator
AU642404B2 (en) *	1989-02-13	1993-10-21	Schering Aktiengesellschaft Berlin Und Bergkamen	Novel thrombolytic

1989
- 1989-07-19 IE IE235489A patent/IE69054B1/en not_active IP Right Cessation
- 1989-07-19 DK DK198903575A patent/DK176140B1/da not_active IP Right Cessation
- 1989-07-19 FI FI893500A patent/FI100403B/fi active IP Right Grant
- 1989-07-20 EP EP89307411A patent/EP0352119B1/en not_active Expired - Lifetime
- 1989-07-20 AT AT89307411T patent/ATE126269T1/de not_active IP Right Cessation
- 1989-07-20 KR KR1019890010264A patent/KR0138997B1/ko not_active Expired - Fee Related
- 1989-07-20 JP JP1188673A patent/JP2713467B2/ja not_active Expired - Lifetime
- 1989-07-20 PT PT91236A patent/PT91236B/pt not_active IP Right Cessation
- 1989-07-20 ES ES89307411T patent/ES2076965T3/es not_active Expired - Lifetime
- 1989-07-20 NO NO892976A patent/NO302954B1/no not_active IP Right Cessation
- 1989-07-20 IL IL9105989A patent/IL91059A/en unknown
- 1989-07-20 CA CA000606185A patent/CA1341090C/en not_active Expired - Lifetime
- 1989-07-20 DE DE68923741T patent/DE68923741T2/de not_active Expired - Lifetime
- 1989-07-20 NZ NZ230017A patent/NZ230017A/en unknown
- 1989-07-25 AU AU38915/89A patent/AU621389B2/en not_active Expired
1995
- 1995-06-06 US US08/467,966 patent/US5830849A/en not_active Expired - Lifetime
- 1995-09-29 GR GR950402700T patent/GR3017587T3/el unknown
1997
- 1997-02-10 NO NO19970603A patent/NO314548B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0352119B1 (en)	1995-08-09
PT91236A (pt)	1990-02-08
IL91059A0 (en)	1990-02-09
AU621389B2 (en)	1992-03-12
NO314548B1 (no)	2003-04-07
DK357589A (da)	1990-01-23
NO970603L (no)	1990-01-22
FI100403B (fi)	1997-11-28
JPH02167075A (ja)	1990-06-27
US5830849A (en)	1998-11-03
JP2713467B2 (ja)	1998-02-16
KR910003094A (ko)	1991-02-26
FI893500A0 (fi)	1989-07-19
NO970603D0 (no)	1997-02-10
IL91059A (en)	1995-06-29
DK357589D0 (da)	1989-07-19
EP0352119A3 (en)	1990-07-04
ATE126269T1 (de)	1995-08-15
ES2076965T3 (es)	1995-11-16
NO302954B1 (no)	1998-05-11
DE68923741T2 (de)	1996-02-15
IE69054B1 (en)	1996-08-07
NO892976D0 (no)	1989-07-20
NO892976L (no)	1990-01-22
NZ230017A (en)	1992-05-26
GR3017587T3 (en)	1995-12-31
EP0352119A2 (en)	1990-01-24
DE68923741D1 (de)	1995-09-14
PT91236B (pt)	1995-03-01
DK176140B1 (da)	2006-09-25
CA1341090C (en)	2000-08-29
AU3891589A (en)	1990-01-25
IE892354L (en)	1990-01-20
KR0138997B1 (ko)	1998-04-30

Publication	Publication Date	Title
FI893539A0 (fi)	1989-07-24	Andningsanordning.
FI894579A7 (fi)	1990-03-30	En moduluppbyggd enhet foer elbatterigrupper.
FI893500L (fi)	1990-01-21	Vampyrfladdermussaliv plasminogenaktivatorer.
FI894714L (fi)	1990-04-08	Fluorsubstituerade benzenderivat.
FI883943L (fi)	1989-03-08	Modifierade plasminogen-aktivatorer.
FI895753A0 (fi)	1989-12-01	Avgasledningssystem foer en komprimerad braenslekraftsmaskin.
DE68922014D1 (de)	1995-05-11	Protease.
DE58902190D1 (de)	1992-10-08	Schaelmaschine.
DE58903566D1 (de)	1993-03-25	Drehkreuz.
FI881992A0 (fi)	1988-04-28	Baerbar aelgskjutbana.
FI80861B (fi)	1990-04-30	Plastdosa.
DE68905146D1 (de)	1993-04-08	Indanderivate.
FI880711A0 (fi)	1988-02-16	Kasettflake.
FI893221L (fi)	1990-01-03	Behandlingsanordning foer runda balar.
NO910149D0 (no)	1991-01-14	Vevs-plasminogen-aktivator-analog.
ES1006845Y (es)	1989-08-16	Bufete-mesa.
ATE82110T1 (de)	1992-11-15	Magensonde.
FI882095L (fi)	1989-11-06	Taong krok faongstredskap.
FI885774A0 (fi)	1988-12-14	Lyftdoerrsmekanism.
FI881671A0 (fi)	1988-04-11	Vibrationbestaendighetsprovanordning foer flaektblad.
FI885011A0 (fi)	1988-11-01	Stenuppsamlare.
FI882446A0 (fi)	1988-05-24	Steriliseringspaose.
FI885246A0 (fi)	1988-11-14	Gaongad kapsyl.
FI880574A0 (fi)	1988-02-09	Maetapparat.
MX9203774A (es)	1992-09-01	Dibenzofurancarboxiamidas.

Legal Events

Date	Code	Title	Description
1994-09-08	GB	Transfer or assigment of application	Owner name: SCHERING AG
2004-08-31	FG	Patent granted	Owner name: SCHERING AG