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FI890186A7 - Förfarande för framställning av 1-hydroxialkyl-5-nitroimidazoler - Google Patents

Förfarande för framställning av 1-hydroxialkyl-5-nitroimidazoler Download PDF

Info

Publication number
FI890186A7
FI890186A7 FI890186A FI890186A FI890186A7 FI 890186 A7 FI890186 A7 FI 890186A7 FI 890186 A FI890186 A FI 890186A FI 890186 A FI890186 A FI 890186A FI 890186 A7 FI890186 A7 FI 890186A7
Authority
FI
Finland
Prior art keywords
nitroimidazoles
hydroxyalkyl
preparation
Prior art date
Application number
FI890186A
Other languages
English (en)
Finnish (fi)
Other versions
FI890186A0 (fi
FI890186L (fi
Inventor
Viviane Massonneau
Albert Buforn
Bernadette Mandard-Cazin
Michel Mulhauser
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Publication of FI890186A0 publication Critical patent/FI890186A0/fi
Publication of FI890186A7 publication Critical patent/FI890186A7/sv
Publication of FI890186L publication Critical patent/FI890186L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Resins (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Detergent Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Luminescent Compositions (AREA)
  • Catalysts (AREA)
FI890186A 1988-01-15 1989-01-13 Foerfarande foer framstaellning av 1-hydroxialkyl-5-nitroimidazoler. FI890186L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8800415A FR2625998B1 (fr) 1988-01-15 1988-01-15 Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles

Publications (3)

Publication Number Publication Date
FI890186A0 FI890186A0 (fi) 1989-01-13
FI890186A7 true FI890186A7 (sv) 1989-07-16
FI890186L FI890186L (fi) 1989-07-16

Family

ID=9362336

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890186A FI890186L (fi) 1988-01-15 1989-01-13 Foerfarande foer framstaellning av 1-hydroxialkyl-5-nitroimidazoler.

Country Status (22)

Country Link
US (1) US4925952A (sv)
EP (1) EP0324691B1 (sv)
JP (1) JPH01216976A (sv)
KR (1) KR890011855A (sv)
CN (1) CN1023318C (sv)
AT (1) ATE70831T1 (sv)
AU (1) AU608933B2 (sv)
CA (1) CA1310326C (sv)
DE (1) DE68900582D1 (sv)
DK (1) DK14889A (sv)
ES (1) ES2028444T3 (sv)
FI (1) FI890186L (sv)
FR (1) FR2625998B1 (sv)
GR (1) GR3003445T3 (sv)
HU (1) HU200447B (sv)
IL (1) IL88944A0 (sv)
MX (1) MX169604B (sv)
NO (1) NO172798C (sv)
PT (1) PT89443B (sv)
SU (1) SU1657060A3 (sv)
YU (1) YU46997B (sv)
ZA (1) ZA89307B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0325512B1 (fr) * 1988-01-15 1993-01-20 Rhone-Poulenc Sante Procédé de préparation d'alkyl-1 nitro-5 imidazoles
FR2625999B1 (fr) * 1988-01-15 1990-06-08 Rhone Poulenc Sante Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles
FR2659326A1 (fr) * 1990-03-12 1991-09-13 Rhone Poulenc Sante Procede de preparation d'hydroxyalkyl-1 nitro-5 imidazoles.
UA80839C2 (en) * 2002-10-15 2007-11-12 1-substituted 4-nitroimidazole compound and process for producing the same
CN102321028B (zh) * 2011-06-30 2013-12-25 湖北省宏源药业有限公司 一种合成2-甲基-5-硝基咪唑-1-乙醇的方法
RU2531616C1 (ru) * 2013-03-29 2014-10-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский государственный университет" (ТГУ) Способ получения метронидазола
WO2015198107A1 (en) * 2014-06-24 2015-12-30 Kiany Fard Taghi Synthesis of metronidazole
KR20170052626A (ko) 2014-09-05 2017-05-12 심바이오믹스 세러퓨틱스 엘엘씨 세균질증 치료에 사용하기 위한 세크니다졸
US11253501B2 (en) 2015-06-01 2022-02-22 Lupin Inc. Secnidazole formulations and use in treating bacterial vaginosis
CN110749682A (zh) * 2019-10-24 2020-02-04 湖北省宏源药业科技股份有限公司 一种2-甲基-5-硝基咪唑含量检测方法
US12280037B2 (en) 2020-09-22 2025-04-22 Evofem Biosciences, Inc. Method and pharmaceutical composition for treating or preventing trichomoniasis and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3178446A (en) * 1961-07-27 1965-04-13 Luso Farmaco Inst Oxyethylation of imidazole compounds
FR3270M (fr) * 1963-10-10 1965-04-26 Rhone Poulenc Sa Nouveaux dérivés de l'imidazole et compositions les contenant.
FR1427627A (fr) * 1963-10-10 1966-02-11 Rhone Poulenc Sa Nouveaux dérivés de l'imidazole et leur préparation
US3743653A (en) * 1970-12-28 1973-07-03 Merck & Co Inc Hydroxyethylation with ethylene sulfate
DE3400531A1 (de) * 1984-01-10 1985-07-18 Basf Ag, 6700 Ludwigshafen Verfahren zur gewinnung von hochreinem 1(2-hydroxiethyl)-2-methyl-5-nitroimidazol
EP0325512B1 (fr) * 1988-01-15 1993-01-20 Rhone-Poulenc Sante Procédé de préparation d'alkyl-1 nitro-5 imidazoles
FR2625999B1 (fr) * 1988-01-15 1990-06-08 Rhone Poulenc Sante Procede de preparation d'hydroxyalkyl-1 methyl-2 nitro-5 imidazoles

Also Published As

Publication number Publication date
KR890011855A (ko) 1989-08-22
PT89443A (pt) 1990-02-08
NO172798C (no) 1993-09-08
ZA89307B (en) 1989-10-25
CN1035288A (zh) 1989-09-06
DE68900582D1 (de) 1992-02-06
DK14889A (da) 1989-07-16
US4925952A (en) 1990-05-15
CN1023318C (zh) 1993-12-29
AU2845289A (en) 1989-07-20
GR3003445T3 (en) 1993-02-17
NO172798B (no) 1993-06-01
PT89443B (pt) 1993-09-30
YU7289A (en) 1990-12-31
YU46997B (sh) 1994-11-15
HUT49586A (en) 1989-10-30
FI890186A0 (fi) 1989-01-13
CA1310326C (fr) 1992-11-17
EP0324691A1 (fr) 1989-07-19
EP0324691B1 (fr) 1991-12-27
MX169604B (es) 1993-07-14
SU1657060A3 (ru) 1991-06-15
JPH01216976A (ja) 1989-08-30
DK14889D0 (da) 1989-01-13
FR2625998B1 (fr) 1990-06-08
ES2028444T3 (es) 1992-07-01
FR2625998A1 (fr) 1989-07-21
ATE70831T1 (de) 1992-01-15
AU608933B2 (en) 1991-04-18
NO890157D0 (no) 1989-01-13
FI890186L (fi) 1989-07-16
IL88944A0 (en) 1989-08-15
NO890157L (no) 1989-07-17
HU200447B (en) 1990-06-28

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FD Application lapsed

Owner name: RHONE-POULENC SANTE