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FI896279A0 - Nya insulinderivat, foerfarande foer deras framstaellning, deras anvaendning och dessa innehaollande preparat. - Google Patents

Nya insulinderivat, foerfarande foer deras framstaellning, deras anvaendning och dessa innehaollande preparat.

Info

Publication number
FI896279A0
FI896279A0 FI896279A FI896279A FI896279A0 FI 896279 A0 FI896279 A0 FI 896279A0 FI 896279 A FI896279 A FI 896279A FI 896279 A FI896279 A FI 896279A FI 896279 A0 FI896279 A0 FI 896279A0
Authority
FI
Finland
Prior art keywords
deras
basic
insulinderivat
preparat
foerfarande foer
Prior art date
Application number
FI896279A
Other languages
English (en)
Other versions
FI102843B1 (fi
FI102843B (fi
Inventor
Laszlo Vertesy
Karl Geisen
Guenther Johannes Riess
Klaus Sauber
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI896279A0 publication Critical patent/FI896279A0/fi
Application granted granted Critical
Publication of FI102843B1 publication Critical patent/FI102843B1/fi
Publication of FI102843B publication Critical patent/FI102843B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
FI896279A 1988-12-29 1989-12-27 Menetelmä oleellisesti puhdistettujen insuliinijohdannaisten valmistam iseksi FI102843B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3844211 1988-12-29
DE3844211A DE3844211A1 (de) 1988-12-29 1988-12-29 Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Publications (3)

Publication Number Publication Date
FI896279A0 true FI896279A0 (fi) 1989-12-27
FI102843B1 FI102843B1 (fi) 1999-02-26
FI102843B FI102843B (fi) 1999-02-26

Family

ID=6370457

Family Applications (1)

Application Number Title Priority Date Filing Date
FI896279A FI102843B (fi) 1988-12-29 1989-12-27 Menetelmä oleellisesti puhdistettujen insuliinijohdannaisten valmistam iseksi

Country Status (20)

Country Link
US (1) US5506202A (fi)
EP (1) EP0376156B1 (fi)
JP (1) JP3129722B2 (fi)
KR (1) KR900009698A (fi)
AT (1) ATE136038T1 (fi)
AU (1) AU623963B2 (fi)
CA (1) CA2006818C (fi)
DE (2) DE3844211A1 (fi)
DK (1) DK173178B1 (fi)
ES (1) ES2085271T3 (fi)
FI (1) FI102843B (fi)
GR (1) GR3019560T3 (fi)
HU (1) HU205172B (fi)
IE (1) IE73672B1 (fi)
IL (1) IL92905A (fi)
NO (1) NO180379C (fi)
NZ (1) NZ231944A (fi)
PH (1) PH27425A (fi)
PT (1) PT92757B (fi)
ZA (1) ZA899946B (fi)

Families Citing this family (44)

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DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
NZ245170A (en) * 1991-11-26 1994-07-26 Lilly Co Eli Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
WO1996029344A1 (en) * 1995-03-17 1996-09-26 Novo Nordisk A/S Insulin derivatives
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US6746853B1 (en) 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
HUP0700126A2 (en) * 2001-12-20 2007-06-28 Lilly Co Eli Insulin molecule having protracted time action
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
CA2587985C (en) * 2004-11-24 2016-05-10 Neopro Labs, Llc Peptides for use in treatment in fever or pain
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
TWI376234B (en) * 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
PL373543A1 (pl) * 2005-03-10 2006-09-18 Instytut Biotechnologii i Antybiotyków Kompozycja farmaceutyczna zawierająca biosyntetyczny analog insuliny ludzkiej, oraz jej zastosowanie w terapii cukrzycy
US20060212009A1 (en) * 2005-03-16 2006-09-21 Accisano Nicholas G Iii Drainage catheter hub with rotatable lever handle
US7824367B2 (en) * 2005-08-17 2010-11-02 Merit Medical Systems, Inc. Drainage catheter with locking hub
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
US7557088B2 (en) * 2006-03-28 2009-07-07 Neopro Labs, Llc Methods and compositions for treating conditions
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
ES2542146T3 (es) * 2006-07-31 2015-07-31 Novo Nordisk A/S Insulinas extendidas PEGiladas.
US9233226B2 (en) * 2006-08-22 2016-01-12 Merit Medical Systems, Inc. Drainage catheter with pig-tail straightener
PT2074141T (pt) 2006-09-22 2016-11-10 Novo Nordisk As Análogos de insulina resistentes a proteases
EP2074140B8 (en) * 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
ES2563038T3 (es) 2007-04-30 2016-03-10 Novo Nordisk A/S Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca
CA2683288A1 (en) 2007-05-17 2008-11-27 Neopro Labs, Llc Crystalline and amorphous forms of peptide
KR20100017667A (ko) * 2007-06-01 2010-02-16 노보 노르디스크 에이/에스 안정한 비-수성의 약학 조성물
WO2009012472A2 (en) * 2007-07-18 2009-01-22 Neopro Labs, Llc Methods and compositions for treating conditions
CN101970477B (zh) 2008-03-14 2014-12-31 诺沃-诺迪斯克有限公司 蛋白酶稳定的胰岛素类似物
PL2910570T3 (pl) 2008-03-18 2017-06-30 Novo Nordisk A/S Stabilizowane względem proteaz, acylowane analogi insuliny
WO2009129250A2 (en) * 2008-04-14 2009-10-22 Case Western Reserve University Meal-time insulin analogues of enhanced stability
RU2010147076A (ru) * 2008-04-22 2012-05-27 Кейз Вестерн Ризев Юнивесити (Us) Аналоги инсулина специфичные к изоформам
PL219335B1 (pl) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
KR20120129875A (ko) * 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
RU2012123642A (ru) 2009-12-11 2014-01-20 Кейз Вестерн Ризев Юнивесити Аналоги инсулина, содержащие хлорированные аминокислоты
KR20150002777A (ko) 2012-04-11 2015-01-07 노보 노르디스크 에이/에스 인슐린 제제
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
CN107108716A (zh) 2014-10-06 2017-08-29 卡斯西部储备大学 双相性单链胰岛素类似物
GB2549275B (en) * 2016-04-11 2018-05-09 Tectonic Facades Ltd Construction assembly
EP3535015B1 (en) 2016-11-03 2021-12-15 Merit Medical Systems, Inc. Drainage catheter
CN115154591B (zh) 2016-12-16 2023-04-14 诺和诺德股份有限公司 含胰岛素的药物组合物
WO2024137820A1 (en) * 2022-12-20 2024-06-27 The Board Of Trustees Of The Leland Stanford Junior University Insulin receptor antagonist

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
US4343898A (en) * 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DE3636903A1 (de) * 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
DE3541856A1 (de) * 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3545595A1 (de) * 1985-12-21 1987-06-25 Behringwerke Ag Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
DE3805150A1 (de) * 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser

Also Published As

Publication number Publication date
DK173178B1 (da) 2000-03-06
CA2006818C (en) 2000-05-23
NO180379C (no) 1997-04-09
DK669889A (da) 1990-06-30
IL92905A (en) 1994-10-21
EP0376156A3 (de) 1991-05-02
ATE136038T1 (de) 1996-04-15
NO180379B (no) 1996-12-30
PH27425A (en) 1993-06-21
JPH02225498A (ja) 1990-09-07
CA2006818A1 (en) 1990-06-29
DE58909633D1 (de) 1996-05-02
ZA899946B (en) 1990-09-26
KR900009698A (ko) 1990-07-05
AU4733289A (en) 1990-07-05
FI102843B1 (fi) 1999-02-26
IL92905A0 (en) 1990-09-17
JP3129722B2 (ja) 2001-01-31
NZ231944A (en) 1993-02-25
NO895296L (no) 1990-07-02
PT92757B (pt) 1995-12-29
US5506202A (en) 1996-04-09
HU896781D0 (en) 1990-03-28
GR3019560T3 (en) 1996-07-31
HU205172B (en) 1992-03-30
ES2085271T3 (es) 1996-06-01
AU623963B2 (en) 1992-05-28
FI102843B (fi) 1999-02-26
DE3844211A1 (de) 1990-07-05
EP0376156A2 (de) 1990-07-04
HUT53150A (en) 1990-09-28
IE894200L (en) 1990-06-29
IE73672B1 (en) 1997-07-02
PT92757A (pt) 1990-06-29
NO895296D0 (no) 1989-12-28
EP0376156B1 (de) 1996-03-27
DK669889D0 (da) 1989-12-28

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FI905439A0 (fi) Nya insulinderivat, foerfarande foer deras framstaellning, deras anvaendning och dessa innehaollande farmaceutisk produkt.

Legal Events

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Owner name: HOECHST AKTIENGESELLSCHAFT