FI881708L - Nitrogen-containing cyclic ligands, method for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes - Google Patents

Nitrogen-containing cyclic ligands, method for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes Download PDF

Info

Publication number: FI881708L
Authority: FI; Finland
Prior art keywords: preparation; complexes; nitrogen; diagnostic compositions; compositions containing
Prior art date: 1987-04-14

Application number

FI881708A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI93830B (en

FI881708A0 (en

FI93830C (en

Inventor

Michel Schaefer

Didier Doucet

Bruno Bonnemain

Dominique Meyer

Original Assignee

Guerbet Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-14

Filing date

1988-04-13

Publication date

1988-10-15

1988-04-13 Application filed by Guerbet Sa filed Critical Guerbet Sa

1988-04-13 Publication of FI881708A0 publication Critical patent/FI881708A0/en

1988-10-15 Publication of FI881708L publication Critical patent/FI881708L/en

1995-02-28 Publication of FI93830B publication Critical patent/FI93830B/en

1995-06-12 Application granted granted Critical

1995-06-12 Publication of FI93830C publication Critical patent/FI93830C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Optics & Photonics (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Paints Or Removers (AREA)

FI881708A 1987-04-14 1988-04-13 Nitrogen-containing cyclic ligands, processes for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes FI93830C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8705288		1987-04-14
FR8705288A FR2614020B1 (en)	1987-04-14	1987-04-14	NOVEL NITROGEN CYCLIC LIGANDS, METAL COMPLEXES FORMED BY SUCH LIGANDS, DIAGNOSTIC COMPOSITIONS CONTAINING THESE COMPLEXES AND PROCESS FOR PREPARING LIGANDS.

Publications (4)

Publication Number	Publication Date
FI881708A0 FI881708A0 (en)	1988-04-13
FI881708L true FI881708L (en)	1988-10-15
FI93830B FI93830B (en)	1995-02-28
FI93830C FI93830C (en)	1995-06-12

Family

ID=9350106

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI881708A FI93830C (en)	1987-04-14	1988-04-13	Nitrogen-containing cyclic ligands, processes for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes

Country Status (22)

Country	Link
EP (1)	EP0287465B1 (en)
JP (1)	JP2675058B2 (en)
KR (1)	KR880012572A (en)
CN (1)	CN1022411C (en)
AT (1)	ATE85052T1 (en)
AU (1)	AU606146B2 (en)
DD (1)	DD293113A5 (en)
DE (1)	DE3877799T2 (en)
DK (1)	DK170946B1 (en)
ES (1)	ES2053779T3 (en)
FI (1)	FI93830C (en)
FR (1)	FR2614020B1 (en)
GR (1)	GR3007495T3 (en)
HR (1)	HRP920514A2 (en)
HU (1)	HU198501B (en)
IE (1)	IE62582B1 (en)
IL (1)	IL86059A (en)
NO (1)	NO176839C (en)
PT (1)	PT87216B (en)
SI (1)	SI8810742A (en)
YU (1)	YU46691B (en)
ZA (1)	ZA882552B (en)

Families Citing this family (37)

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US5064633A (en) *	1984-06-04	1991-11-12	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes, their formulations and use
US5059412A (en) *	1984-06-04	1991-10-22	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5316757A (en) *	1984-10-18	1994-05-31	Board Of Regents, The University Of Texas System	Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5362476A (en) *	1984-10-18	1994-11-08	Board Of Regents, The University Of Texas System	Alkyl phosphonate polyazamacrocyclic cheates for MRI
FR2637895B1 (en) *	1988-10-14	1992-11-06	Guerbet Sa	NOVEL NITROGEN CYCLIC LIGANDS, METAL COMPLEXES FORMED BY THESE LIGANDS, DIAGNOSTIC COMPOSITIONS CONTAINING THESE COMPLEXES AND PROCESS FOR THE PREPARATION OF LIGANDS
FI900218A7 (en) *	1987-07-16	1990-01-15	Nycomed As	Aminopolycarboxylic acids and their derivatives
AU617338B2 (en) *	1987-07-16	1991-11-28	Nycomed As	Aminopolycarboxylic acids and derivatives thereof
US5531978A (en) *	1987-07-16	1996-07-02	Nycomed Imaging As	Aminopolycarboxylic acids and derivatives thereof
GB8719042D0 (en)	1987-08-12	1987-09-16	Parker D	Conjugate compounds
RU2059642C1 (en) *	1987-12-24	1996-05-10	Бракко Индустрия Кимика С.п.А	Gadolinium chelates and a method of their synthesis
GB8801646D0 (en) *	1988-01-26	1988-02-24	Nycomed As	Chemical compounds
US5446145A (en) *	1990-01-19	1995-08-29	Nycomed Salutar, Inc.	Polychelant compounds
GB8923843D0 (en) *	1989-10-23	1989-12-13	Salutar Inc	Compounds
SG49726A1 (en) *	1989-10-23	1998-06-15	Nycomed Salutar Inc	Compounds
US5021409A (en) *	1989-12-21	1991-06-04	Johnson Matthey Plc	Antiviral cyclic polyamines
NZ236267A (en) *	1989-12-22	1992-12-23	Squibb & Sons Inc	10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane
AU625529B2 (en) *	1989-12-22	1992-07-16	E.R. Squibb & Sons, Inc.	10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
US5679810A (en) *	1990-01-19	1997-10-21	Salutar, Inc.	Linear oligomeric polychelant compounds
WO1992017215A1 (en)	1990-03-28	1992-10-15	Nycomed Salutar, Inc.	Contrast media
GB9024208D0 (en) *	1990-11-07	1990-12-19	Salutar Inc	Compounds
DE4035760A1 (en) *	1990-11-08	1992-05-14	Schering Ag	MONO-N-SUBSTITUTED 1,4,7,10-TETRAAZACYCLODODECAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
CA2072934C (en) *	1991-07-19	2007-08-28	Karl William Aston	Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
JP3155552B2 (en) *	1991-07-19	2001-04-09	モンサントカンパニー	Manganese complexes of nitrogen-containing macrocyclic ligands as effective catalysts for the asymmetric change of superoxide
AU5019193A (en) *	1992-08-19	1994-03-15	Mallinckrodt Medical, Inc.	Ligands for ga-68 pet heart applications
US6204259B1 (en)	1993-01-14	2001-03-20	Monsanto Company	Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
AU679140B2 (en) *	1993-11-26	1997-06-19	Dow Chemical Company, The	Process for preparing polyazamacrocycles
CA2188530A1 (en) *	1994-04-22	1995-11-02	John Charles Alexander	Diagnostic image analysis with metal complexes
JPH11514971A (en) *	1995-08-17	1999-12-21	モンサントカンパニー	Diagnostic imaging method using metal complex of nitrogen-containing macrocyclic ligand
WO1997006830A1 (en)	1995-08-17	1997-02-27	Monsanto Company	Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
AU5871000A (en)	1999-06-11	2001-01-02	Paul G. Abrams	High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en)	1999-07-11	2006-08-22	Neorx Corporation	Skeletal-targeted radiation to treat bone-associated pathologies
CA2434302A1 (en)	2001-01-08	2002-08-15	Neorx Corporation	Therapeutic and diagnostic compounds, compositions, and methods
FR2830253B1 (en) *	2001-09-28	2005-02-04	Air Liquide	NOVEL PROCESS FOR THE PREPARATION OF C-FUNCTIONALIZED NITROGEN MACROCYCLES AND NOVEL INTERMEDIATES OBTAINED
FR2968999B1 (en)	2010-12-20	2013-01-04	Guerbet Sa	CHELATE NANOEMULSION FOR MRI
CN107847617B (en)	2015-03-10	2021-08-31	爱默蕾大学	Metal tricarbonyl complexes containing substituted iminodiacetic acid ligands and their use as radioisotope tracers
WO2017011517A1 (en)	2015-07-16	2017-01-19	Emory University	Bis-amines, compositions, and uses related to cxcr4 inhibition
CN106588925B (en) *	2016-12-05	2018-03-30	天津羲泽润科技有限公司	It is a kind of to prepare the luxuriant method of the pyridine ring of 1,4,7,10 4 azepine 2,6

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO149961C (en) *	1981-06-01	1984-07-25	Borregaard Ind	PROCEDURE FOR THE PREPARATION OF N- (2-HYDROXYethyl) DERIVATIVES OF MACROCYCLIC POLYAMINES, CONTAINING MULTIPLE 1.4 NITROGEN ATOMS IN THE RING
NL194579C (en) *	1983-01-21	2002-08-05	Schering Ag	Diagnostic.
DE3316703A1 (en) *	1983-05-04	1984-11-08	Schering AG, 1000 Berlin und 4709 Bergkamen	ORAL CONTRAST AGENT FOR MRI MRI AND THE PRODUCTION THEREOF
JPS60202869A (en) *	1984-03-26	1985-10-14	Ajinomoto Co Inc	Macrocyclic polyamine derivative and its use
US4639365A (en) *	1984-10-18	1987-01-27	The Board Of Regents, The University Of Texas System	Gadolinium chelates as NMR contrast agents
EP0232751B1 (en) *	1986-01-23	1991-09-11	E.R. Squibb & Sons, Inc.	1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
GB8603537D0 (en) *	1986-02-13	1986-03-19	Parker D	Conjugate compound
DE3625417C2 (en) *	1986-07-28	1998-10-08	Schering Ag	Tetraazacyclododecane derivatives
GB8719041D0 (en) *	1987-08-12	1987-09-16	Parker D	Conjugate compounds
GB8719042D0 (en) *	1987-08-12	1987-09-16	Parker D	Conjugate compounds

1987
- 1987-04-14 FR FR8705288A patent/FR2614020B1/en not_active Expired
1988
- 1988-04-12 ZA ZA882552A patent/ZA882552B/en unknown
- 1988-04-12 NO NO881567A patent/NO176839C/en unknown
- 1988-04-12 DD DD88314659A patent/DD293113A5/en not_active IP Right Cessation
- 1988-04-12 PT PT87216A patent/PT87216B/en not_active IP Right Cessation
- 1988-04-13 JP JP63089189A patent/JP2675058B2/en not_active Expired - Lifetime
- 1988-04-13 SI SI8810742A patent/SI8810742A/en unknown
- 1988-04-13 DE DE8888400895T patent/DE3877799T2/en not_active Expired - Fee Related
- 1988-04-13 AT AT88400895T patent/ATE85052T1/en not_active IP Right Cessation
- 1988-04-13 HU HU881897A patent/HU198501B/en not_active IP Right Cessation
- 1988-04-13 ES ES88400895T patent/ES2053779T3/en not_active Expired - Lifetime
- 1988-04-13 FI FI881708A patent/FI93830C/en not_active IP Right Cessation
- 1988-04-13 IE IE111488A patent/IE62582B1/en not_active IP Right Cessation
- 1988-04-13 KR KR1019880004187A patent/KR880012572A/en not_active Ceased
- 1988-04-13 IL IL86059A patent/IL86059A/en not_active IP Right Cessation
- 1988-04-13 YU YU74288A patent/YU46691B/en unknown
- 1988-04-13 EP EP88400895A patent/EP0287465B1/en not_active Expired - Lifetime
- 1988-04-13 DK DK202788A patent/DK170946B1/en not_active IP Right Cessation
- 1988-04-14 CN CN88102139A patent/CN1022411C/en not_active Expired - Fee Related
- 1988-04-14 AU AU14611/88A patent/AU606146B2/en not_active Ceased
1992
- 1992-09-26 HR HRP920514AA patent/HRP920514A2/en not_active Application Discontinuation
1993
- 1993-03-30 GR GR930400681T patent/GR3007495T3/el unknown

Also Published As

Publication number	Publication date
NO176839C (en)	1995-06-14
GR3007495T3 (en)	1993-07-30
PT87216A (en)	1988-05-01
CN88102139A (en)	1988-10-26
DK202788D0 (en)	1988-04-13
HU198501B (en)	1989-10-30
NO176839B (en)	1995-02-27
YU46691B (en)	1994-04-05
IL86059A (en)	1993-01-14
DK202788A (en)	1988-10-15
HRP920514A2 (en)	1994-04-30
IE62582B1 (en)	1995-02-08
JPH01211573A (en)	1989-08-24
ZA882552B (en)	1988-09-27
DE3877799T2 (en)	1993-07-22
NO881567L (en)	1988-10-17
PT87216B (en)	1992-07-31
FI93830B (en)	1995-02-28
EP0287465A1 (en)	1988-10-19
EP0287465B1 (en)	1993-01-27
SI8810742A (en)	1996-08-31
NO881567D0 (en)	1988-04-12
ES2053779T3 (en)	1994-08-01
JP2675058B2 (en)	1997-11-12
DK170946B1 (en)	1996-03-25
FI881708A0 (en)	1988-04-13
AU606146B2 (en)	1991-01-31
DD293113A5 (en)	1991-08-22
HUT47075A (en)	1989-01-30
KR880012572A (en)	1988-11-28
FI93830C (en)	1995-06-12
ATE85052T1 (en)	1993-02-15
AU1461188A (en)	1988-10-20
FR2614020B1 (en)	1989-07-28
IL86059A0 (en)	1988-09-30
FR2614020A1 (en)	1988-10-21
YU74288A (en)	1990-04-30
CN1022411C (en)	1993-10-13
IE881114L (en)	1988-10-14
DE3877799D1 (en)	1993-03-11

Publication	Publication Date	Title
FI881708L (en)	1988-10-15	Nitrogen-containing cyclic ligands, method for their preparation and their use for the preparation of metal complexes and diagnostic compositions containing these complexes
IE842979L (en)	1985-05-22	Desulfatohirudins
DE3883080D1 (en)	1993-09-16	ALLOY POWDER MIXTURE FOR THE TREATMENT OF ALLOYS.
IT8748642A0 (en)	1987-11-27	TRICYCLIC KETONES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
IL62082A (en)	1986-08-31	Beta-lactam derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
FI842560A7 (en)	1984-12-28	Method for purifying and preparing human cancer death factor.
PH22821A (en)	1989-01-19	Phenyl butenamide, pharmaceutical composition containing said compound and method of use thereof
FI812810A7 (en)	1982-03-13	Ammoniomethyl compounds, methods for their preparation, pharmaceutical preparations containing these compounds and the use of the latter.
ZA777532B (en)	1978-10-25	1,4-dihydropyridine compounds,process for preparation thereof and pharmaceutical composition of the same
DE3776983D1 (en)	1992-04-09	ASHTRAY POWDER AND METHOD FOR THE PRODUCTION THEREOF.
DE3886088D1 (en)	1994-01-20	Chelates of dipyridoxyl phosphate with radioactive metals.
FI841161A7 (en)	1984-09-24	Compound and composition for therapeutic or diagnostic use and therapeutic method of treatment.
ZA772413B (en)	1978-03-29	Magnesium-containing complexes,method for their preparation,and compositions containing the same
DE3483330D1 (en)	1990-11-08	AGENT FOR TREATMENT OF THE DENTAL ROOTS.
PH23447A (en)	1989-08-07	B-actam compounds,pharmaceutical compositions containing the same and method of use thereof
DE3883608D1 (en)	1993-10-07	Process for the preparation of maltose powder.
NO844037L (en)	1986-04-10	DENTAL TREATMENT PREPARATION CONTAINING FLUORIDIONS.
DE68921582D1 (en)	1995-04-27	Process for the preparation of functional isothiocyanato metal complexes.
JPS5328133A (en)	1978-03-16	Novel compound having lipidddepleting activity in blood*process for preparation thereof and pharmaceutical composition containing these
FI895285A7 (en)	1990-05-31	Antimicrobial compounds, method for their preparation, compositions containing them and their use
JPS6480287A (en)	1989-03-27	Novel compound, method for manufacture of the same and drug composition containing the same
FI874686A7 (en)	1988-04-25	Polyfluoro compounds and their preparation method.
FI853854A7 (en)	1986-04-10	Iodotriaminobenzene compounds, a process for their preparation and their use as X-ray contrast agents.
FI852341A7 (en)	1985-06-12	Method for preparing medical cosmetic compositions.
PH14398A (en)	1981-06-25	Pharmaceutical compounds,compositions containing same and method of use

Legal Events

Date	Code	Title	Description
1995-02-01	BB	Publication of examined application
1997-11-14	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: GUERBET S.A.