FI885820A7 - Tricykliska foereningar. - Google Patents

Tricykliska foereningar.

Info

Publication number: FI885820A7
Authority: FI; Finland
Prior art keywords: foereningar; tricycle; tricycle foereningar
Prior art date: 1987-12-18

Application number

FI885820A

Other languages

English (en)

Other versions

FI88799B (fi

FI88799C (fi

FI885820A0 (fi

Inventor

Armin Walser

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-18

Filing date

1988-12-16

Publication date

1989-06-19

1988-12-16 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1988-12-16 Publication of FI885820A0 publication Critical patent/FI885820A0/fi

1989-06-19 Publication of FI885820A7 publication Critical patent/FI885820A7/fi

1993-03-31 Publication of FI88799B publication Critical patent/FI88799B/fi

1993-07-12 Application granted granted Critical

1993-07-12 Publication of FI88799C publication Critical patent/FI88799C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

FI885820A 1987-12-18 1988-12-16 Foerfarande foer framstaellnings av nya terapeutiskt aktiva 4-fenyl-tieno/3,2-f/- och -benso/1,2,4/triazolo/4,3-a//1,4/diazepinderivat och mellanprodukter vilka aer anvaendbara i foerfarandet FI88799C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US13472687A	1987-12-18	1987-12-18
US13472687		1987-12-18
US22794888A	1988-08-03	1988-08-03
US22794888		1988-08-03

Publications (4)

Publication Number	Publication Date
FI885820A0 FI885820A0 (fi)	1988-12-16
FI885820A7 true FI885820A7 (fi)	1989-06-19
FI88799B FI88799B (fi)	1993-03-31
FI88799C FI88799C (fi)	1993-07-12

Family

ID=26832617

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI885820A FI88799C (fi)	1987-12-18	1988-12-16	Foerfarande foer framstaellnings av nya terapeutiskt aktiva 4-fenyl-tieno/3,2-f/- och -benso/1,2,4/triazolo/4,3-a//1,4/diazepinderivat och mellanprodukter vilka aer anvaendbara i foerfarandet

Country Status (21)

Country	Link
EP (1)	EP0320992B1 (fi)
JP (1)	JPH0725762B2 (fi)
KR (1)	KR890009932A (fi)
CN (1)	CN1031057C (fi)
AT (1)	ATE109148T1 (fi)
AU (1)	AU612441B2 (fi)
CA (1)	CA1327570C (fi)
CS (1)	CS833288A2 (fi)
DE (1)	DE3850866T2 (fi)
DK (1)	DK704088A (fi)
ES (1)	ES2056889T3 (fi)
FI (1)	FI88799C (fi)
HU (1)	HU204273B (fi)
IE (1)	IE63762B1 (fi)
IL (1)	IL88688A0 (fi)
MC (1)	MC1999A1 (fi)
NO (1)	NO167920C (fi)
NZ (1)	NZ227341A (fi)
PT (1)	PT89250B (fi)
RU (1)	RU2094436C1 (fi)
YU (1)	YU46991B (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH30676A (en) *	1986-07-22	1997-09-16	Boehringer Ingelhein Kg	Hetrazepine compounds which have useful pharmaceutical utility
JP2959598B2 (ja) *	1990-10-12	1999-10-06	吉富製薬株式会社	光学活性なチエノトリアゾロジアゼピン化合物
US5130315A (en) *	1991-01-10	1992-07-14	Raymond R. Wittekind	1-piperazinyl-2-butenes and -2-butynes
EP0661284A1 (en) *	1992-09-18	1995-07-05	Yoshitomi Pharmaceutical Industries, Ltd.	Thienodiazepine compound and medicinal use thereof
US5302590A (en) *	1992-12-18	1994-04-12	Hoffmann-La Roche Inc.	Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
DE19839566C2 (de) *	1998-08-31	2002-01-17	Fumapharm Ag Muri	Verwendung von Fumarsäurederivaten in der Transplantationsmedizin
KR100865410B1 (ko) *	2002-03-28	2008-10-24	위시스 테크놀로지 파운데이션, 인크.	진정 및 운동실조 효과가 감소된 항불안제
EP1925614A1 (en) *	2002-03-28	2008-05-28	Wisys Technology Foundation, Inc.	Anxiolytic agents with reduced sedative and ataxic effects
WO2006004945A1 (en) *	2004-06-30	2006-01-12	Wisys Technology Foundation, Inc.	Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects
AU2005287407B2 (en) *	2004-07-27	2011-11-17	Gilead Sciences, Inc.	Imidazo(4,5-d)pyrimidines, their uses and methods of preparation
ATE463245T1 (de) *	2004-09-09	2010-04-15	Merck Sharp & Dohme	Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten
CN101076527B (zh) *	2004-09-13	2011-11-30	默沙东公司	三环酰苯胺螺乙内酰脲cgrp受体拮抗剂
BRPI0518152A (pt) *	2004-10-13	2008-11-04	Hoffmann La Roche	pirazolbenzodiazepinas dissubstituìdas úteis como inibidores para cdk2 e angiogênese e para o tratamento de cánceres de mama, cólon, pulmão e próstata
US9085582B2 (en) *	2010-06-22	2015-07-21	Glaxosmithkline Llc	Benzotriazolodiazepine compounds inhibitors of bromodomains
US9249161B2 (en)	2010-12-02	2016-02-02	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
AR084070A1 (es)	2010-12-02	2013-04-17	Constellation Pharmaceuticals Inc	Inhibidores del bromodominio y usos de los mismos
US9422292B2 (en)	2011-05-04	2016-08-23	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
UA110640C2 (uk)	2011-05-05	2016-01-25	Янссен Фармацевтика Нв	ПРОТИГРИБКОВІ 5,6-ДИГІДРО-4Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ ТА 6Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ, ЯКІ ЗАМІЩЕНІ ГЕТЕРОЦИКЛІЧНИМИ ПОХІДНИМИ
WO2012174487A2 (en)	2011-06-17	2012-12-20	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
US9624244B2 (en)	2012-06-06	2017-04-18	Constellation Pharmaceuticals, Inc.	Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh)	2012-06-06	2017-10-21	星宿藥物公司	溴域抑制劑及其用途
US9662324B2 (en) *	2013-05-01	2017-05-30	Academia Sinica	Methods and compositions for treating β-thalassemia and sickle cell disease
CN103694253A (zh) *	2013-11-04	2014-04-02	湖南华腾制药有限公司	一种噻吩并三唑并[4,3-a][1,4]二氮杂卓类化合物的制备方法
CA2952830C (en)	2014-06-20	2022-11-01	Constellation Pharmaceuticals, Inc.	Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide
CN109906220A (zh) *	2016-11-01	2019-06-18	豪夫迈·罗氏有限公司	用于治疗cns相关疾病的1,3-二氢-1,4-苯并二氮杂*-2-硫酮化合物
MX2023005678A (es) *	2020-11-16	2023-05-26	Boehringer Ingelheim Int	Derivados de ciclopentatiofen carboxamida como antagonistas del receptor del factor de activacion de plaquetas.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3435973A1 (de) *	1984-10-01	1986-04-10	Boehringer Ingelheim KG, 6507 Ingelheim	Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3778559D1 (de) *	1986-01-21	1992-06-04	Boehringer Ingelheim Kg	Thieno-1,4-diazepine.
DE3610848A1 (de) *	1986-04-01	1987-10-15	Boehringer Ingelheim Kg	Neue 1,4-diazepine
DE3878833T2 (de) *	1987-05-28	1993-06-09	Yoshitomi Pharmaceutical	Thieno(triazolo)diazepinverbindungen, und medizinische verwendung derselben.

1988
- 1988-12-06 MC MC882021A patent/MC1999A1/fr unknown
- 1988-12-15 NZ NZ227341A patent/NZ227341A/en unknown
- 1988-12-15 IL IL88688A patent/IL88688A0/xx unknown
- 1988-12-15 CS CS888332A patent/CS833288A2/cs unknown
- 1988-12-15 CA CA000585981A patent/CA1327570C/en not_active Expired - Fee Related
- 1988-12-16 YU YU228088A patent/YU46991B/sh unknown
- 1988-12-16 AT AT88121165T patent/ATE109148T1/de not_active IP Right Cessation
- 1988-12-16 IE IE375888A patent/IE63762B1/en not_active IP Right Cessation
- 1988-12-16 HU HU886449A patent/HU204273B/hu not_active IP Right Cessation
- 1988-12-16 ES ES88121165T patent/ES2056889T3/es not_active Expired - Lifetime
- 1988-12-16 DE DE3850866T patent/DE3850866T2/de not_active Expired - Fee Related
- 1988-12-16 AU AU26989/88A patent/AU612441B2/en not_active Ceased
- 1988-12-16 JP JP63316555A patent/JPH0725762B2/ja not_active Expired - Lifetime
- 1988-12-16 EP EP88121165A patent/EP0320992B1/en not_active Expired - Lifetime
- 1988-12-16 NO NO885597A patent/NO167920C/no unknown
- 1988-12-16 PT PT89250A patent/PT89250B/pt not_active IP Right Cessation
- 1988-12-16 FI FI885820A patent/FI88799C/fi not_active IP Right Cessation
- 1988-12-16 DK DK704088A patent/DK704088A/da not_active Application Discontinuation
- 1988-12-17 CN CN88108697A patent/CN1031057C/zh not_active Expired - Fee Related
- 1988-12-17 KR KR1019880016887A patent/KR890009932A/ko not_active Ceased
1992
- 1992-01-31 RU SU925010684A patent/RU2094436C1/ru active

Also Published As

Publication number	Publication date
AU2698988A (en)	1989-06-29
ATE109148T1 (de)	1994-08-15
JPH0725762B2 (ja)	1995-03-22
DE3850866T2 (de)	1994-12-08
AU612441B2 (en)	1991-07-11
PT89250B (pt)	1993-07-30
DK704088A (da)	1989-06-19
YU228088A (en)	1990-06-30
YU46991B (sh)	1994-11-15
EP0320992A2 (en)	1989-06-21
CA1327570C (en)	1994-03-08
KR890009932A (ko)	1989-08-05
FI88799B (fi)	1993-03-31
HUT50823A (en)	1990-03-28
FI88799C (fi)	1993-07-12
NO885597D0 (no)	1988-12-16
EP0320992A3 (en)	1991-01-09
DK704088D0 (da)	1988-12-16
CN1034722A (zh)	1989-08-16
FI885820A0 (fi)	1988-12-16
IL88688A0 (en)	1989-07-31
JPH01197484A (ja)	1989-08-09
ES2056889T3 (es)	1994-10-16
CS833288A2 (en)	1990-10-12
EP0320992B1 (en)	1994-07-27
NO167920C (no)	1991-12-27
NZ227341A (en)	1992-01-29
CN1031057C (zh)	1996-02-21
MC1999A1 (fr)	1990-01-26
RU2094436C1 (ru)	1997-10-27
NO167920B (no)	1991-09-16
HU204273B (en)	1991-12-30
DE3850866D1 (de)	1994-09-01
NO885597L (no)	1989-06-19
PT89250A (pt)	1989-12-29
IE883758L (en)	1989-06-18
IE63762B1 (en)	1995-06-14

Publication	Publication Date	Title
IT220897Z2 (it)	1993-11-30	Motocicletta.
DE3884830D1 (de)	1993-11-18	Motorrad.
FI874804A0 (fi)	1987-11-02	Bicykliska foereningar.
FI885820A7 (fi)	1989-06-19	Tricykliska foereningar.
DE3875834D1 (de)	1992-12-17	Motorrad.
FI882826A7 (fi)	1988-12-21	Handredskap.
FI871559A0 (fi)	1987-04-09	Isbrytare.
FI872153A0 (fi)	1987-05-15	Vaermegradient-inkubator.
DE3860441D1 (de)	1990-09-13	Rollerbahn.
FI870472A0 (fi)	1987-02-04	Dykarkompass.
FI871240A0 (fi)	1987-03-20	Maolfaergnyanseringsmaskin.
FI871591L (fi)	1988-10-11	Saxkran.
FI871308A0 (fi)	1987-03-25	Teleskopdoerr foer hissar.
NO871944D0 (no)	1987-05-12	Trehjulssykkel.
FI871573A0 (fi)	1987-04-10	Kopplingsdosa.
FI871798A0 (fi)	1987-04-24	Maetarrangemang foer en fiskraekneanordning.
NO864559D0 (no)	1986-11-17	Trehjulssykkel.
BR6702704U (pt)	1989-07-18	Triciclo
KR890012432U (ko)	1989-08-07	세발기
IT8621297V0 (it)	1986-03-21	Monopattino perfezionato.
IT8761956V0 (it)	1987-11-20	B.s. buccola special.
ES1004268Y (es)	1989-08-16	Interruptor-pulsador.
FI870497A0 (fi)	1987-02-06	Cigarrettsslaeckare.
FI872316A0 (fi)	1987-05-26	Skadeavvaerjningspresenning foer farliga aemnen.
FI870855A0 (fi)	1987-02-27	Byggfoerfarande.

Legal Events

Date	Code	Title	Description
1993-03-01	BB	Publication of examined application
1995-07-14	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: F. HOFFMANN-LA ROCHE AG