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FI885303L - Proteolytiska fragment och syntetiska peptider, vilka hindrar bindning av von willebrand-faktorn till membranglykoproteinet ib i blodplaettar. - Google Patents

Proteolytiska fragment och syntetiska peptider, vilka hindrar bindning av von willebrand-faktorn till membranglykoproteinet ib i blodplaettar. Download PDF

Info

Publication number
FI885303L
FI885303L FI885303A FI885303A FI885303L FI 885303 L FI885303 L FI 885303L FI 885303 A FI885303 A FI 885303A FI 885303 A FI885303 A FI 885303A FI 885303 L FI885303 L FI 885303L
Authority
FI
Finland
Prior art keywords
membranglykoproteinet
hindrar
faktorn
blodplaettar
peptider
Prior art date
Application number
FI885303A
Other languages
English (en)
Other versions
FI885303A0 (fi
FI885303A7 (fi
Inventor
Theodore S Zimmerman
Zaverio M Ruggeri
Richard A Houghten
Vicente Vincete
Hiroshi Mohri
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of FI885303A0 publication Critical patent/FI885303A0/fi
Publication of FI885303L publication Critical patent/FI885303L/fi
Publication of FI885303A7 publication Critical patent/FI885303A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI885303A 1987-11-17 1988-11-16 Proteolyyttisiä fragmenttejä ja synteettisiä peptidejä, jotka estävät von Willebrandt-tekijän sitoutumisen verihiutaleiden membraaniglykopro teiiniin Ib FI885303A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12145487A 1987-11-17 1987-11-17

Publications (3)

Publication Number Publication Date
FI885303A0 FI885303A0 (fi) 1988-11-16
FI885303L true FI885303L (fi) 1989-05-18
FI885303A7 FI885303A7 (fi) 1989-05-18

Family

ID=22396842

Family Applications (1)

Application Number Title Priority Date Filing Date
FI885303A FI885303A7 (fi) 1987-11-17 1988-11-16 Proteolyyttisiä fragmenttejä ja synteettisiä peptidejä, jotka estävät von Willebrandt-tekijän sitoutumisen verihiutaleiden membraaniglykopro teiiniin Ib

Country Status (9)

Country Link
EP (1) EP0317278A3 (fi)
JP (1) JPH01221394A (fi)
KR (1) KR890008169A (fi)
AU (1) AU626813B2 (fi)
DK (1) DK639988A (fi)
FI (1) FI885303A7 (fi)
IL (1) IL88308A0 (fi)
NO (1) NO885108L (fi)
NZ (1) NZ226964A (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340727A (en) * 1987-11-17 1994-08-23 The Scripps Research Institute GPIbα fragments and recombinant DNA expression vectors
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
WO1991006632A1 (en) * 1989-10-20 1991-05-16 New England Medical Center Hospitals, Inc. Inhibition of padgem-mediated cell binding
US6008193A (en) * 1990-03-02 1999-12-28 Bio-Technology General Corp. Methods of using human von Willebrand factor GPIb binding domain polypeptides
US5849536A (en) * 1990-03-02 1998-12-15 Bio-Technology General Corp. Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5298239A (en) * 1991-10-07 1994-03-29 The Research Foundation Of State University Of New York Mutations rendering platelet glycoprotein IB α less reactive
US5317097A (en) * 1991-10-07 1994-05-31 The Research Foundation Of State University Of New York Mutations in the gene encoding the α chain on platelet glycoprotein IB
US5427939A (en) * 1992-01-06 1995-06-27 The Scripps Research Institute Expression vectors encoding alloantigens of glycoprotein Ibα
AU3734793A (en) * 1992-02-26 1993-09-13 Scripps Research Institute, The Mutant gpibalpha fragments and recombinant expression thereof
AR035779A1 (es) 2001-02-06 2004-07-14 Genetics Inst Llc Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos
WO2004111089A2 (en) * 2003-06-11 2004-12-23 WYETH A Corporaton of the State of Delaware Platelet glycoprotein ib alpha variant fusion polypeptides and methods of use thereof
CN101389356B (zh) 2006-01-06 2012-09-05 武冈真司 药物输送物质
DE102007031708A1 (de) 2007-07-06 2009-01-08 Dade Behring Marburg Gmbh Bestimmung der von Willebrand Faktor-Aktivität in Abwesenheit von Ristocetin

Also Published As

Publication number Publication date
DK639988D0 (da) 1988-11-16
AU2560588A (en) 1989-05-18
EP0317278A3 (en) 1989-11-23
NO885108L (no) 1989-05-18
FI885303A0 (fi) 1988-11-16
AU626813B2 (en) 1992-08-13
NO885108D0 (no) 1988-11-16
JPH01221394A (ja) 1989-09-04
IL88308A0 (en) 1989-06-30
EP0317278A2 (en) 1989-05-24
DK639988A (da) 1989-05-18
FI885303A7 (fi) 1989-05-18
KR890008169A (ko) 1989-07-10
NZ226964A (en) 1991-08-27

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Owner name: SCRIPPS CLINIC AND RESEARCH FOUNDATION