FI884879A0 - Terapeutiskt anvaendbara heterocykliska foereningar. - Google Patents
Terapeutiskt anvaendbara heterocykliska foereningar.Info
- Publication number
- FI884879A0 FI884879A0 FI884879A FI884879A FI884879A0 FI 884879 A0 FI884879 A0 FI 884879A0 FI 884879 A FI884879 A FI 884879A FI 884879 A FI884879 A FI 884879A FI 884879 A0 FI884879 A0 FI 884879A0
- Authority
- FI
- Finland
- Prior art keywords
- aryl
- alkyl
- group
- benzyl
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878724912A GB8724912D0 (en) | 1987-10-23 | 1987-10-23 | Indole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI884879A0 true FI884879A0 (fi) | 1988-10-21 |
| FI884879A7 FI884879A7 (fi) | 1989-04-24 |
Family
ID=10625806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI884879A FI884879A7 (fi) | 1987-10-23 | 1988-10-21 | Terapeutiskt anvaendbara heterocykliska foereningar. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0313397B1 (fi) |
| JP (1) | JP2501631B2 (fi) |
| CN (1) | CN1035113A (fi) |
| AT (1) | ATE90089T1 (fi) |
| AU (1) | AU604165B2 (fi) |
| DD (1) | DD283140A5 (fi) |
| DE (1) | DE3881472T2 (fi) |
| DK (1) | DK586588A (fi) |
| ES (1) | ES2054825T3 (fi) |
| FI (1) | FI884879A7 (fi) |
| GB (1) | GB8724912D0 (fi) |
| HU (1) | HU202230B (fi) |
| IL (1) | IL88122A0 (fi) |
| MC (1) | MC1983A1 (fi) |
| NZ (1) | NZ226671A (fi) |
| PL (1) | PL158305B1 (fi) |
| PT (1) | PT88829B (fi) |
| ZA (1) | ZA887900B (fi) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
| IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| PT97888B (pt) | 1990-06-07 | 1998-12-31 | Zeneca Ltd | Processo para a preparacao de compostos heterociclicos derivados de indol e de composicoes farmaceuticas que os contem |
| EP0494774A1 (en) * | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Indazole-substituted fivemembered heteroaromatic compounds |
| US5317103A (en) * | 1991-01-15 | 1994-05-31 | Merck Sharp & Dohme Limited | Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists |
| SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| TW263508B (fi) * | 1991-02-12 | 1995-11-21 | Pfizer | |
| GB9104136D0 (en) * | 1991-02-27 | 1991-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| WO1993011106A1 (en) * | 1991-11-25 | 1993-06-10 | Pfizer, Inc. | Indole derivatives |
| CA2083891A1 (en) * | 1991-12-03 | 1993-06-04 | Angus Murray Macleod | Heterocyclic compounds, compositions containing them and their use in therapy |
| US5409941A (en) * | 1992-02-03 | 1995-04-25 | Pfizer Inc. | 5-heteroyl indole derivatives |
| TW288010B (fi) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| EP0630374B1 (en) * | 1992-03-13 | 2001-09-05 | MERCK SHARP & DOHME LTD. | Imidazole, triazole and tetrazole derivatives |
| GB9207396D0 (en) * | 1992-04-03 | 1992-05-13 | Merck Sharp & Dohme | Therapeutic agents |
| US6380233B1 (en) | 1992-04-07 | 2002-04-30 | Pfizer Inc | Indole derivatives as 5-HT1 agonists |
| RU2101283C1 (ru) | 1992-04-07 | 1998-01-10 | Пфайзер Инк. | Производные индола или их фармацевтически приемлемые соли |
| DK0635015T3 (da) * | 1992-04-10 | 1997-03-17 | Pfizer | Acylaminoindolderivater som 5-Htl agonister |
| GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
| GB9208463D0 (en) * | 1992-04-16 | 1992-06-03 | Merck Sharp & Dohme | Therapeutic agents |
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| WO1993025547A1 (en) * | 1992-06-05 | 1993-12-23 | Merck Sharp & Dohme Limited | The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy |
| GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
| WO1994002477A1 (en) * | 1992-07-24 | 1994-02-03 | Merck Sharp & Dohme Limited | Imidazole, triazole and tetrazole derivatives |
| IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
| TW251284B (fi) * | 1992-11-02 | 1995-07-11 | Pfizer | |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| LT3594B (en) | 1993-07-29 | 1995-12-27 | Merck Sharp & Dohme | Imidazole,triazole and tetrazole derivatives |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| GB9401436D0 (en) * | 1994-01-26 | 1994-03-23 | Wellcome Found | Therapeutic heterocyclic compounds |
| GB9407447D0 (en) * | 1994-04-14 | 1994-06-08 | Glaxo Group Ltd | Chemical compounds |
| ATE203533T1 (de) * | 1994-06-01 | 2001-08-15 | Astrazeneca Ab | INDOLDERIVATE ALS PRODRUGS VON ß5-HT1-LIKEß REZEPTOR AGONISTEN |
| MX9700693A (es) * | 1994-07-26 | 1997-04-30 | Pfizer | Derivados del 4-indol. |
| JPH10509721A (ja) * | 1994-12-06 | 1998-09-22 | メルク シヤープ エンド ドーム リミテツド | ５ｈｔ１レセプターアゴニストとしてのアゼチジン、ピロリジン及びピペリジン誘導体 |
| GB9516145D0 (en) * | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US6909005B1 (en) | 1995-08-07 | 2005-06-21 | Astrazeneca Uk Limited | One post synthesis of 2-oxazolidinone derivatives |
| GB9516143D0 (en) | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US5998438A (en) * | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| AU4961499A (en) * | 1998-06-26 | 2000-01-17 | Eli Lilly And Company | 5-HT1f agonists |
| AU2003249584B9 (en) | 2002-06-21 | 2008-05-15 | Suven Life Sciences Limited | Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them |
| CA2490254C (en) | 2002-06-21 | 2011-11-01 | Suven Life Sciences Limited | Novel tetracyclic arylsulfonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them |
| PT1567492E (pt) | 2002-11-28 | 2013-07-22 | Suven Life Sciences Ltd | N-arilsulfonil-3-aminoalcoxi-indóis |
| DK1581492T3 (da) | 2002-11-28 | 2008-11-10 | Suven Life Sciences Ltd | N-arylsulfonyl-3-substituerede indoler med serotoninreceptoraffinitet, fremgangsmåde til fremstilling heraf og en farmaceutisk sammensætning indeholdende disse |
| NZ540841A (en) | 2002-12-18 | 2008-08-29 | Suven Life Sciences Ltd | Tetracyclic 3-substituted indoles having serotonin receptor affinity |
| DE102005018191A1 (de) * | 2005-04-19 | 2006-10-26 | Grünenthal GmbH | Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| CN108697637A (zh) | 2016-01-27 | 2018-10-23 | 因斯塔尔科技股份公司 | 用于治疗性处理的口腔粘膜纳米纤维载体 |
| CN112759550A (zh) * | 2019-11-04 | 2021-05-07 | 上海科技大学 | 一种平滑受体拮抗剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0225726B1 (en) | 1985-11-08 | 1991-04-17 | Glaxo Group Limited | Indole derivatives |
| GB8600397D0 (en) | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
-
1987
- 1987-10-23 GB GB878724912A patent/GB8724912D0/en active Pending
-
1988
- 1988-10-21 JP JP63265917A patent/JP2501631B2/ja not_active Expired - Lifetime
- 1988-10-21 DE DE88309943T patent/DE3881472T2/de not_active Expired - Fee Related
- 1988-10-21 AT AT88309943T patent/ATE90089T1/de not_active IP Right Cessation
- 1988-10-21 HU HU885431A patent/HU202230B/hu unknown
- 1988-10-21 PL PL1988275423A patent/PL158305B1/pl unknown
- 1988-10-21 PT PT88829A patent/PT88829B/pt not_active IP Right Cessation
- 1988-10-21 DD DD88320940A patent/DD283140A5/de not_active IP Right Cessation
- 1988-10-21 ES ES88309943T patent/ES2054825T3/es not_active Expired - Lifetime
- 1988-10-21 ZA ZA887900A patent/ZA887900B/xx unknown
- 1988-10-21 NZ NZ226671A patent/NZ226671A/xx unknown
- 1988-10-21 IL IL88122A patent/IL88122A0/xx unknown
- 1988-10-21 EP EP88309943A patent/EP0313397B1/en not_active Expired - Lifetime
- 1988-10-21 FI FI884879A patent/FI884879A7/fi not_active Application Discontinuation
- 1988-10-21 CN CN88108816A patent/CN1035113A/zh active Pending
- 1988-10-21 DK DK586588A patent/DK586588A/da not_active Application Discontinuation
- 1988-10-21 MC MC882012A patent/MC1983A1/fr unknown
- 1988-10-24 AU AU24181/88A patent/AU604165B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN1035113A (zh) | 1989-08-30 |
| AU604165B2 (en) | 1990-12-06 |
| JPH01146882A (ja) | 1989-06-08 |
| DK586588A (da) | 1989-04-24 |
| ATE90089T1 (de) | 1993-06-15 |
| PL275423A1 (en) | 1989-08-07 |
| HUT50163A (en) | 1989-12-28 |
| PL158305B1 (en) | 1992-08-31 |
| EP0313397B1 (en) | 1993-06-02 |
| MC1983A1 (fr) | 1989-11-23 |
| NZ226671A (en) | 1991-09-25 |
| ZA887900B (en) | 1990-06-27 |
| IL88122A0 (en) | 1989-06-30 |
| GB8724912D0 (en) | 1987-11-25 |
| PT88829B (pt) | 1993-01-29 |
| JP2501631B2 (ja) | 1996-05-29 |
| EP0313397A1 (en) | 1989-04-26 |
| DK586588D0 (da) | 1988-10-21 |
| FI884879A7 (fi) | 1989-04-24 |
| DE3881472D1 (de) | 1993-07-08 |
| DD283140A5 (de) | 1990-10-03 |
| HU202230B (en) | 1991-02-28 |
| ES2054825T3 (es) | 1994-08-16 |
| DE3881472T2 (de) | 1993-12-16 |
| AU2418188A (en) | 1989-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn [patent] |
Owner name: THE WELLCOME FOUNDATION LIMITED |