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FI884652L - Menetelmä t-PA-kaltaisten proteiinien tuotannon tehostamiseksi - Google Patents

Menetelmä t-PA-kaltaisten proteiinien tuotannon tehostamiseksi Download PDF

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Publication number
FI884652L
FI884652L FI884652A FI884652A FI884652L FI 884652 L FI884652 L FI 884652L FI 884652 A FI884652 A FI 884652A FI 884652 A FI884652 A FI 884652A FI 884652 L FI884652 L FI 884652L
Authority
FI
Finland
Prior art keywords
proteins
enhancing
production
Prior art date
Application number
FI884652A
Other languages
English (en)
Swedish (sv)
Other versions
FI94963B (fi
FI94963C (fi
FI884652A0 (fi
Inventor
Andrea Stecher-Schilling
Rolf-Guenter Werner
William Werz
Hans Zaehner
Axel Zeeck
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873734632 external-priority patent/DE3734632A1/de
Priority claimed from DE19873738649 external-priority patent/DE3738649A1/de
Priority claimed from DE19883801562 external-priority patent/DE3801562A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI884652A0 publication Critical patent/FI884652A0/fi
Publication of FI884652L publication Critical patent/FI884652L/fi
Publication of FI94963B publication Critical patent/FI94963B/fi
Application granted granted Critical
Publication of FI94963C publication Critical patent/FI94963C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6456Plasminogen activators
    • C12N9/6459Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21069Protein C activated (3.4.21.69)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/36Lipids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI884652A 1987-10-13 1988-10-11 Menetelmä t-PA-kaltaisten proteiinien tuotannon tehostamiseksi FI94963C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19873734632 DE3734632A1 (de) 1987-10-13 1987-10-13 Verfahren zur herstellung von t-pa
DE3734632 1987-10-13
DE19873738649 DE3738649A1 (de) 1987-11-13 1987-11-13 Verfahren zur herstellung von proteinen
DE3738649 1987-11-13
DE19883801562 DE3801562A1 (de) 1988-01-20 1988-01-20 Verfahren zur herstellung von proteinen
DE3801562 1988-01-20

Publications (4)

Publication Number Publication Date
FI884652A0 FI884652A0 (fi) 1988-10-11
FI884652L true FI884652L (fi) 1989-04-14
FI94963B FI94963B (fi) 1995-08-15
FI94963C FI94963C (fi) 1995-11-27

Family

ID=27196629

Family Applications (1)

Application Number Title Priority Date Filing Date
FI884652A FI94963C (fi) 1987-10-13 1988-10-11 Menetelmä t-PA-kaltaisten proteiinien tuotannon tehostamiseksi

Country Status (16)

Country Link
EP (1) EP0315782B1 (fi)
JP (1) JP2688222B2 (fi)
KR (1) KR890006671A (fi)
AT (1) ATE112308T1 (fi)
AU (1) AU614999B2 (fi)
CA (1) CA1341400C (fi)
DE (1) DE3851685D1 (fi)
DK (1) DK175411B1 (fi)
ES (1) ES2064336T3 (fi)
FI (1) FI94963C (fi)
HU (1) HU205381B (fi)
IE (1) IE65986B1 (fi)
IL (1) IL88001A (fi)
NO (1) NO174778C (fi)
NZ (1) NZ226521A (fi)
PT (1) PT88751B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2085744A1 (en) * 1991-04-18 1992-10-19 Shingou Sakurai Interleukin-6 compositions, and a production process thereof
DE4113750A1 (de) 1991-04-26 1992-10-29 Boehringer Mannheim Gmbh Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen
ATE312195T1 (de) * 1997-04-03 2005-12-15 Mitsubishi Pharma Corp Verfahren zur herstellung von fremden proteinen
AU2002354363A1 (en) * 2001-12-04 2003-06-17 Mitsubishi Pharma Corporation Method of activating protein
WO2004056872A1 (ja) * 2002-12-20 2004-07-08 Mitsubishi Pharma Corporation タンパク質のチオール基を保護する方法
DK2154244T3 (en) * 2007-04-26 2017-06-12 Chugai Pharmaceutical Co Ltd CELL CULTIVATION PROCEDURE WHEN AN ACID-ENRICHED MEDIUM IS USED

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0163751B1 (en) * 1984-06-05 1989-09-20 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
GB8606386D0 (en) * 1986-03-14 1986-04-23 Celltech Ltd Production of protein

Also Published As

Publication number Publication date
NO884549D0 (no) 1988-10-12
EP0315782A2 (de) 1989-05-17
PT88751A (pt) 1989-07-31
ES2064336T3 (es) 1995-02-01
AU614999B2 (en) 1991-09-19
NO174778B (no) 1994-03-28
AU2373388A (en) 1989-05-11
KR890006671A (ko) 1989-06-15
HU205381B (en) 1992-04-28
EP0315782A3 (en) 1989-09-20
DK567888D0 (da) 1988-10-12
ATE112308T1 (de) 1994-10-15
NZ226521A (en) 1991-04-26
FI94963B (fi) 1995-08-15
DK175411B1 (da) 2004-09-27
CA1341400C (en) 2002-11-19
FI94963C (fi) 1995-11-27
PT88751B (pt) 1995-03-01
IL88001A (en) 1996-01-19
IL88001A0 (en) 1989-06-30
FI884652A0 (fi) 1988-10-11
NO884549L (no) 1989-04-14
EP0315782B1 (de) 1994-09-28
DE3851685D1 (de) 1994-11-03
JPH01231887A (ja) 1989-09-18
IE883079L (en) 1989-04-13
NO174778C (no) 1994-07-06
DK567888A (da) 1989-04-14
JP2688222B2 (ja) 1997-12-08
HUT48306A (en) 1989-05-29
IE65986B1 (en) 1995-11-29

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Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: DR. KARL THOMAE GESELLSCHAFT MIT

MA Patent expired