FI873382L - Nmr-avbildning med hjaelp av paramagnetiska, polyvalenta metallsalter av poly-(syra-alkylen-amino) -alkaner. - Google Patents

Nmr-avbildning med hjaelp av paramagnetiska, polyvalenta metallsalter av poly-(syra-alkylen-amino) -alkaner. Download PDF

Info

Publication number: FI873382L
Authority: FI; Finland
Prior art keywords: polyvalenta; paramagnetiska; metallsalter; avbildning; alkaner
Prior art date: 1986-08-04

Application number

FI873382A

Other languages

English (en)

Other versions

FI88677C (fi

FI873382A0 (fi

FI88677B (fi

Inventor

Karl F Kraft

Steven C Quay

Scott M Rocklage

Dilip Worah

Original Assignee

Salutar Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-04

Filing date

1987-08-04

Publication date

1988-02-05

1987-06-15 Priority claimed from US07/057,709 external-priority patent/US5039512A/en

1987-08-04 Application filed by Salutar Inc filed Critical Salutar Inc

1987-08-04 Publication of FI873382A0 publication Critical patent/FI873382A0/fi

1988-02-05 Publication of FI873382L publication Critical patent/FI873382L/fi

1993-03-15 Application granted granted Critical

1993-03-15 Publication of FI88677B publication Critical patent/FI88677B/fi

1993-06-28 Publication of FI88677C publication Critical patent/FI88677C/fi

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Radiology & Medical Imaging (AREA)
Condensed Matter Physics & Semiconductors (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Signal Processing (AREA)
Biochemistry (AREA)
High Energy & Nuclear Physics (AREA)
Crystallography & Structural Chemistry (AREA)
General Physics & Mathematics (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyamides (AREA)
Soft Magnetic Materials (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Thin Magnetic Films (AREA)
Cosmetics (AREA)

FI873382A 1986-08-04 1987-08-04 Komposition som foerstaerker den magnetiska resonansbilden och som omfattar ett kelatkomplex, som bestaor av en kelaterande foerening och en paramagnetisk jon och kalciumsalt samt anvaendning av kelatkomplexet och kalciumsaltet vid framstaellning av denna komposition foer att.......... FI88677C (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US89313686A	1986-08-04	1986-08-04
US89313686		1986-08-04
US90093086A	1986-08-27	1986-08-27
US90093086		1986-08-27
US07/057,709 US5039512A (en)	1986-08-04	1987-06-15	NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
US5770987		1987-06-15

Publications (4)

Publication Number	Publication Date
FI873382A0 FI873382A0 (fi)	1987-08-04
FI873382L true FI873382L (fi)	1988-02-05
FI88677B FI88677B (fi)	1993-03-15
FI88677C FI88677C (fi)	1993-06-28

Family

ID=27369315

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI873382A FI88677C (fi)	1986-08-04	1987-08-04	Komposition som foerstaerker den magnetiska resonansbilden och som omfattar ett kelatkomplex, som bestaor av en kelaterande foerening och en paramagnetisk jon och kalciumsalt samt anvaendning av kelatkomplexet och kalciumsaltet vid framstaellning av denna komposition foer att..........

Country Status (16)

Country	Link
EP (2)	EP0258616B1 (fi)
JP (1)	JP2667666B2 (fi)
AT (1)	ATE138809T1 (fi)
AU (1)	AU608759B2 (fi)
CA (1)	CA1321346C (fi)
DE (2)	DE3777727D1 (fi)
DK (1)	DK167797B1 (fi)
ES (2)	ES2087938T3 (fi)
FI (1)	FI88677C (fi)
GR (1)	GR3004576T3 (fi)
HK (1)	HK96597A (fi)
IE (1)	IE64108B1 (fi)
IL (2)	IL83377A0 (fi)
NO (1)	NO173767C (fi)
NZ (1)	NZ221288A (fi)
SG (1)	SG78250A1 (fi)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5064633A (en) *	1984-06-04	1991-11-12	The Dow Chemical Company	Macrocyclic aminophosphonic acid complexes, their formulations and use
US5250285A (en) *	1985-05-08	1993-10-05	The General Hospital Corporation	Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) *	1985-05-08	1995-06-06	The General Hospital Corporation	Hydroxy-aryl metal chelates for diagnostic NMR imaging
ATE130518T1 (de) *	1987-06-30	1995-12-15	Mallinckrodt Inc	Verfahren zur erhöhung der sicherheit von metall- ligandchelaten als röntgenstrahlen- kontrastmittel.
GB8813144D0 (en) *	1988-06-03	1988-07-06	Nycomed As	Compositions
GB8900732D0 (en) *	1989-01-13	1989-03-08	Nycomed As	Agents
GB8900719D0 (en) *	1989-01-13	1989-03-08	Nycomed As	Compounds
GB8916781D0 (en) *	1989-07-21	1989-09-06	Nycomed As	Compositions
US5087440A (en) *	1989-07-31	1992-02-11	Salutar, Inc.	Heterocyclic derivatives of DTPA used for magnetic resonance imaging
FR2654344B1 (fr) *	1989-11-16	1994-09-23	Cis Bio Int	Complexe paramagnetique de gadolinium, son procede de preparation et son utilisation pour le diagnostic par irm.
US5516503A (en) *	1989-11-16	1996-05-14	Guerbet S.A.	Diagnostic composition comprising a binuclear complex, its method of preparation and its use in magnetic resonance imaging
US5236695A (en) *	1989-11-27	1993-08-17	Concat, Ltd.	MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
ES2091251T3 (es) *	1989-11-27	1996-11-01	Concat Ltd	Perfeccionamiento de la imagen en la mri del hueso y del tejido emparentado utilizando complejos de cationes paramagneticos y ligandos polifosfonato.
DE4011684A1 (de) *	1990-04-06	1991-10-10	Schering Ag	Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5843399A (en) *	1990-04-06	1998-12-01	Schering Aktiengesellschaft	DTPA monoamides for MRI
US5562894A (en) *	1991-08-09	1996-10-08	Regents Of The University Of California	Amino-acyl-type and catecholamine-type contrast agents for MRI
IT1252145B (it) *	1991-11-29	1995-06-05	Bracco Ind Chimica Spa	Metodo e formulazioni adatte a migliorare lo studio degli organi cavi nell'uomo
DE4302287A1 (de) *	1993-01-25	1994-07-28	Schering Ag	Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
US5409689A (en) *	1993-08-13	1995-04-25	Concat, Ltd.	MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
US5476644A (en) *	1994-04-13	1995-12-19	Sterling Winthrop Inc.	Cyclic triamine chelating agents
US5582814A (en) *	1994-04-15	1996-12-10	Metasyn, Inc.	1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5639746A (en) *	1994-12-29	1997-06-17	The Procter & Gamble Company	Hydroxamic acid-containing inhibitors of matrix metalloproteases
TW319763B (fi)	1995-02-01	1997-11-11	Epix Medical Inc
DE69635460T2 (de) *	1995-06-26	2006-08-10	Chelator Llc, Concord	Methode zur Hemmung des Wachstums von Bakterien oder Pilzen mit einem Komplexbildner
IT1297035B1 (it)	1997-12-30	1999-08-03	Bracco Spa	Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US5980863A (en) *	1998-11-02	1999-11-09	Eagle Vision Pharmaceutical Corporation	Manganese compositions and methods for MRI
AU5871000A (en)	1999-06-11	2001-01-02	Paul G. Abrams	High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en)	1999-07-11	2006-08-22	Neorx Corporation	Skeletal-targeted radiation to treat bone-associated pathologies
JP2004536034A (ja)	2001-01-08	2004-12-02	ネオルクスコーポレイション	治療的および診断的化合物、組成物および方法
JP2007062462A (ja) *	2005-08-30	2007-03-15	Nifco Inc	多用途収容装置
US8378134B2 (en)	2009-09-30	2013-02-19	General Electric Company	Hydroxylated contrast enhancement agents
NO331773B1 (no)	2009-12-18	2012-03-26	Ge Healthcare As	Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
CA2909919C (fr)	2013-04-26	2022-07-12	Guerbet	Formulation de produit de contraste et son procede de preparation associe
GB201610738D0 (en)	2016-06-20	2016-08-03	Ge Healthcare As	Chelate compounds
BR112019012757A2 (pt)	2016-12-21	2019-11-26	Ge Healthcare As	composto, composição farmacêutica, e, método.
CN111712477B (zh)	2017-12-20	2024-02-02	通用电气公司	阴离子螯合物化合物
GB201919073D0 (en)	2019-12-20	2020-02-05	Ge Healthcare As	Novel manufacturing process

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3818061A (en) *	1971-11-09	1974-06-18	Merck Sharp & Dohme	Transparent nmr shift reagents
US4647447A (en) *	1981-07-24	1987-03-03	Schering Aktiengesellschaft	Diagnostic media
DE3129906C3 (de) *	1981-07-24	1996-12-19	Schering Ag	Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
NL194579C (nl) *	1983-01-21	2002-08-05	Schering Ag	Diagnostisch middel.
DE3324235A1 (de) *	1983-07-01	1985-01-10	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue komplexbildner, komplexe und komplexsalze
FR2550449B1 (fr) *	1983-08-12	1986-01-31	Commissariat Energie Atomique	Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire
CA1242643A (en) *	1983-08-12	1988-10-04	Eric T. Fossel	Nmr imaging utilizing chemical shift reagents
US4749560A (en) *	1984-08-13	1988-06-07	Research Corporation	Metal organo phosphorous compounds for NMR analysis
US4687659A (en) *	1984-11-13	1987-08-18	Salutar, Inc.	Diamide-DTPA-paramagnetic contrast agents for MR imaging
US4639365A (en) *	1984-10-18	1987-01-27	The Board Of Regents, The University Of Texas System	Gadolinium chelates as NMR contrast agents
GB8518300D0 (en) *	1985-07-19	1985-08-29	Amersham Int Plc	Contrast agent
ATE130518T1 (de) *	1987-06-30	1995-12-15	Mallinckrodt Inc	Verfahren zur erhöhung der sicherheit von metall- ligandchelaten als röntgenstrahlen- kontrastmittel.

1987
- 1987-07-16 AU AU75735/87A patent/AU608759B2/en not_active Expired
- 1987-07-22 CA CA000542735A patent/CA1321346C/en not_active Expired - Lifetime
- 1987-07-25 ES ES91116072T patent/ES2087938T3/es not_active Expired - Lifetime
- 1987-07-25 DE DE8787110801T patent/DE3777727D1/de not_active Expired - Lifetime
- 1987-07-25 EP EP87110801A patent/EP0258616B1/en not_active Expired - Lifetime
- 1987-07-25 SG SG1996004804A patent/SG78250A1/en unknown
- 1987-07-25 AT AT91116072T patent/ATE138809T1/de not_active IP Right Cessation
- 1987-07-25 ES ES198787110801T patent/ES2030023T3/es not_active Expired - Lifetime
- 1987-07-25 EP EP91116072A patent/EP0463644B1/en not_active Expired - Lifetime
- 1987-07-25 DE DE3751829T patent/DE3751829T2/de not_active Expired - Lifetime
- 1987-07-30 IL IL83377A patent/IL83377A0/xx not_active IP Right Cessation
- 1987-07-31 JP JP62190530A patent/JP2667666B2/ja not_active Expired - Lifetime
- 1987-07-31 DK DK401087A patent/DK167797B1/da not_active IP Right Cessation
- 1987-07-31 NZ NZ221288A patent/NZ221288A/xx unknown
- 1987-07-31 IE IE207687A patent/IE64108B1/en not_active IP Right Cessation
- 1987-08-03 NO NO873237A patent/NO173767C/no not_active IP Right Cessation
- 1987-08-04 FI FI873382A patent/FI88677C/fi not_active IP Right Cessation
1992
- 1992-03-12 IL IL10121092A patent/IL101210A/en not_active IP Right Cessation
- 1992-05-12 GR GR920400924T patent/GR3004576T3/el unknown
1997
- 1997-06-26 HK HK96597A patent/HK96597A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO173767B (no)	1993-10-25
FI88677C (fi)	1993-06-28
ES2087938T3 (es)	1996-08-01
AU7573587A (en)	1988-02-11
NO873237L (no)	1988-02-05
JP2667666B2 (ja)	1997-10-27
GR3004576T3 (fi)	1993-04-28
IL101210A (en)	1996-10-31
JPS63119446A (ja)	1988-05-24
EP0463644A3 (en)	1992-11-19
AU608759B2 (en)	1991-04-18
FI873382A0 (fi)	1987-08-04
DE3751829D1 (de)	1996-07-11
IE872076L (en)	1988-02-04
NO873237D0 (no)	1987-08-03
IE64108B1 (en)	1995-07-12
NO173767C (no)	1994-02-02
ES2030023T3 (es)	1992-10-16
DE3751829T2 (de)	1996-10-31
EP0258616A1 (en)	1988-03-09
DE3777727D1 (de)	1992-04-30
DK401087A (da)	1988-02-05
CA1321346C (en)	1993-08-17
EP0463644B1 (en)	1996-06-05
SG78250A1 (en)	2001-02-20
ATE138809T1 (de)	1996-06-15
IL83377A0 (en)	1987-12-31
DK401087D0 (da)	1987-07-31
HK96597A (en)	1997-08-08
EP0463644A2 (en)	1992-01-02
DK167797B1 (da)	1993-12-20
FI88677B (fi)	1993-03-15
NZ221288A (en)	1990-10-26
EP0258616B1 (en)	1992-03-25

Publication	Publication Date	Title
FI873382L (fi)	1988-02-05	Nmr-avbildning med hjaelp av paramagnetiska, polyvalenta metallsalter av poly-(syra-alkylen-amino) -alkaner.
FI873498L (fi)	1988-02-14	Med en elastisk taetningsprofil foersedd glasskiva, i synnerhet bilglas.
FI883948L (fi)	1989-03-01	Spolvaetska foer foerstoerning av kroppsfraemmande avlagringar med intensiv, pulserande laserstraolning.
FI883438A0 (fi)	1988-07-20	Smoerjmedelkompositioner, vilka innehaoller transitiometaller foer kontroll av viskositet.
FI875597A7 (fi)	1988-06-23	Tobaksprodukt foer sjaelvframstaellning av en cigarrett, i synnerhet en filtercigarrett.
FI884892A0 (fi)	1988-10-24	Tippbar slaepvagn foer motorfordon, speciellt personbilar.
FI881152A7 (fi)	1988-09-13	Foerfarande foer framstaellning av tiazolderivat, med kolinergisk aktivitet.
FI872594A0 (fi)	1987-06-10	Cementprodukter, vilka innehaoller ytbehandlade oorganiska partiklar.
FI872630L (fi)	1987-12-14	Farmaceutiska kompositioner foer utvaertes bruk, vilka laett penetrerar huden.
FI861110A0 (fi)	1986-03-17	Foerfarande foer framstaellning av en haerdad stenmaterialprodukt, isynnerhet betong.
FI874902A7 (fi)	1987-11-05	Applikator med behaollare foer applicering av harts- och lackaemnen, isynnerhet nagellack.
FI872267L (fi)	1987-11-24	Stabila, vattenhaltiga suspensionskoncentratkompositioner.
FI874329L (fi)	1988-04-11	Foerfarande foer framstaellning av faergloest, lukt- och smakneutralt cassia-froevitamjoel.
FI875355L (fi)	1988-06-12	Foerpackningsbehaollare med oeppningsbar, foerseglingsfoersvagad toppfoerslutning.
FI872815A7 (fi)	1988-01-04	Luckpanel med foerbaettrad taetningsanordning, saerskilt anvaendbar i kontainertransportfartyg.
FI875417A7 (fi)	1988-06-23	Anordning, speciellt foer reglering av en ammoniakkonverter.
FI872598A0 (fi)	1987-06-10	N-1h-tetrazol-5-yl-2-tiofen-, n-1h -tetrazol-5-yl-2-pyrrol- och n-1h-tetrazol-5-yl-2-furankarboxamider.
FI872704L (fi)	1987-12-19	Roderstyranordning, i vilken styrhjulet installerats i bakdelen av stoedkonstruktionen.
FI872660L (fi)	1987-12-21	Foerfarande foer framstaellning av metylenderivat av androst-4-en-3,17-dioner.
FI871014L (fi)	1987-09-12	Anordning foer reglering av en ljudbild, saosom efterklangstiden, i en lokal.
FI874302A7 (fi)	1988-04-04	Diaminplatina(ii)-komplexfoereningar, med en hydroxylerad 2-fenyl-indolring.
FI871432L (fi)	1987-10-04	Foerkopplingsdrossel, speciellt foer gasurladdningslampor.
FI870544L (fi)	1987-08-12	Foerfarande foer framstaellning av o-alkyl-s,s-dialkylfosforditioater.
FI875322L (fi)	1987-12-02	Foerfarande foer framstaellning av 17a--hydroxi-d-homo-1,4-pregnadien-3,20-dion.
FI870924A7 (fi)	1987-09-06	Aromatiska -alkylimino-tetrahydro-6h -1,3-tiazin-6-onderivater.

Legal Events

Date	Code	Title	Description
1993-02-16	BB	Publication of examined application
1993-03-01	BB	Publication of examined application
1996-01-02	BB	Publication of examined application
2004-08-31	MM	Patent lapsed	Owner name: SALUTAR, INC.