[go: up one dir, main page]

FI871536A0 - Framstaellning i stor skala av en plasminogenaktivator ur maenniskans normala tjocktarmsceller. - Google Patents

Framstaellning i stor skala av en plasminogenaktivator ur maenniskans normala tjocktarmsceller.

Info

Publication number
FI871536A0
FI871536A0 FI871536A FI871536A FI871536A0 FI 871536 A0 FI871536 A0 FI 871536A0 FI 871536 A FI871536 A FI 871536A FI 871536 A FI871536 A FI 871536A FI 871536 A0 FI871536 A0 FI 871536A0
Authority
FI
Finland
Prior art keywords
tjocktarmsceller
maenniskans
plasminogenaktivator
normala
framstaellning
Prior art date
Application number
FI871536A
Other languages
English (en)
Other versions
FI871536L (fi
FI871536A7 (fi
Inventor
Daniel Thomas Connolly
Joseph Feder
Nicholaos Konstantinos Harakas
Jon Peter Schaumann
Arthur John Wittwer
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of FI871536A0 publication Critical patent/FI871536A0/fi
Publication of FI871536L publication Critical patent/FI871536L/fi
Publication of FI871536A7 publication Critical patent/FI871536A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FI871536A 1986-04-09 1987-04-08 Plasminogeeniaktivaattorin laajamittainentuottaminen ihmisen normaaleista paksusuolisoluista. FI871536A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/849,933 US5132214A (en) 1986-04-09 1986-04-09 Large scale production of plasminogen activator from normal human colon cells

Publications (3)

Publication Number Publication Date
FI871536A0 true FI871536A0 (fi) 1987-04-08
FI871536L FI871536L (fi) 1987-10-10
FI871536A7 FI871536A7 (fi) 1987-10-10

Family

ID=25306874

Family Applications (1)

Application Number Title Priority Date Filing Date
FI871536A FI871536A7 (fi) 1986-04-09 1987-04-08 Plasminogeeniaktivaattorin laajamittainentuottaminen ihmisen normaaleista paksusuolisoluista.

Country Status (13)

Country Link
US (1) US5132214A (fi)
EP (1) EP0241448A3 (fi)
JP (1) JPS6322187A (fi)
KR (1) KR900002345B1 (fi)
AU (1) AU590918B2 (fi)
CA (1) CA1282726C (fi)
DK (1) DK178487A (fi)
ES (1) ES2002685A4 (fi)
FI (1) FI871536A7 (fi)
NO (1) NO168055C (fi)
NZ (1) NZ219920A (fi)
PT (1) PT84637B (fi)
ZA (1) ZA872530B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
AU2921289A (en) * 1987-12-09 1989-07-19 Invitron Corporation Human cell life extension
US4957863A (en) * 1988-01-26 1990-09-18 Monsanto Company Method of increasing yield of t-PA in cell culture
US5089409A (en) * 1989-09-28 1992-02-18 Monsanto Company Method of increasing specific activity of t-pa
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
AU2007292253A1 (en) * 2006-09-08 2008-03-13 Wyeth Arginine wash in protein purification using affinity chromatography

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904480A (en) * 1972-10-24 1975-09-09 Lilly Co Eli Enhanced production of plasminogen activator
US4190708A (en) * 1978-05-24 1980-02-26 Monsanto Company Production of urokinase
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
US4335215A (en) * 1980-08-27 1982-06-15 Monsanto Company Method of growing anchorage-dependent cells
GR79202B (fi) * 1982-05-05 1984-10-22 Genentech Inc
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
IE56716B1 (en) * 1983-01-19 1991-11-20 Genentech Inc Method for producing human tpa and expression vectors therefor
JPS59187779A (ja) * 1983-04-08 1984-10-24 Wakamoto Pharmaceut Co Ltd ウロキナ−ゼ精製用吸着体
US4550080A (en) * 1984-06-05 1985-10-29 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
US4661453A (en) * 1984-06-19 1987-04-28 American Biogenetic Sciences, Inc. Production of tissue plasminogen activator factor
US4751084A (en) * 1986-02-26 1988-06-14 Monsanto Company Tissue plasminogen activator from normal human colon cells

Also Published As

Publication number Publication date
PT84637A (en) 1987-05-01
AU7130287A (en) 1987-10-15
AU590918B2 (en) 1989-11-23
ZA872530B (en) 1988-01-27
NO168055B (no) 1991-09-30
KR870010182A (ko) 1987-11-30
NZ219920A (en) 1989-08-29
NO871477D0 (no) 1987-04-08
DK178487D0 (da) 1987-04-08
JPS6322187A (ja) 1988-01-29
FI871536L (fi) 1987-10-10
CA1282726C (en) 1991-04-09
NO168055C (no) 1992-01-08
KR900002345B1 (ko) 1990-04-12
ES2002685A4 (es) 1988-10-01
EP0241448A3 (en) 1988-01-07
US5132214A (en) 1992-07-21
EP0241448A2 (en) 1987-10-14
FI871536A7 (fi) 1987-10-10
NO871477L (no) 1987-10-12
DK178487A (da) 1987-10-10
PT84637B (pt) 1989-11-30

Similar Documents

Publication Publication Date Title
FI861880L (fi) Foerfarande foer framstaellning av kolvaetehaltiga vaetskor ur biomassa.
FI870575A7 (fi) Foerfarande foer kontinuerlig avskiljning av vatten ur blandningar av organiska aemnen.
DE3771319D1 (de) Metrologische skala.
FI882740A7 (fi) Foerfarande foer tillvaratagande av betain ur melass.
FI855027A0 (fi) Foerfarande foer framstaellning av dimerisatprodukter ur olefiner.
FI865110L (fi) Tillvaratagande av dimetyleter ur olefiniska c3-c5-floeden i vaetskefas.
FI885435A7 (fi) Foerfarande foer loesgoerande av cellkulturer ur mikrobaerare.
FI873101L (fi) Redskap foer utklaemning av foeremaol ur foerpackningsutrymmen.
FI880260L (fi) Foerfarande foer avskiljande av gasformigt kvicksilver ur gaser.
FI863337A0 (fi) Inhibering av styrenemissioner ur omaettade polyesterhartser.
FI872273L (fi) Foerbaettrat skaerhuvud foer en roterande fanersvarv foer utsvarvning av faner ur traeblock.
FI860854A7 (fi) Anordning foer repning av traodar ur vaevnad.
FI882148A7 (fi) Anordning foer avlindning av materialbanor ur en rulle.
FI863502A0 (fi) Foerfarande foer framstaellning av syntesgas ur fasta braenslen.
FI871536A0 (fi) Framstaellning i stor skala av en plasminogenaktivator ur maenniskans normala tjocktarmsceller.
FI864317A0 (fi) Faongkoppling foer aotervinnande av baervaogen ur en qam-signal.
FI874696A0 (fi) Elektrokemiskt avlaegsnande av hypokloriter ur kloratcelloesningar.
FI870897L (fi) Foerfarande foer avskiljning av fasta aemnen ur dessa rikligt innehaollande uppslamningar.
DE3768834D1 (de) Spannungsregler.
FI872232A0 (fi) Avlaegsnande av klor ur alkalimetallklorid-vattenloesning.
FI861187A0 (fi) Framstaellning av karboxylsyror ur organiska formiatestrar under anvaendning av rodiumkomplexkatalysatorer.
FI853603L (fi) Anordning foer aotervinning av vaerme ur roekgaser.
FI871714A0 (fi) Foerfarande foer utvinning av elementaert svavel ur jaernsulfidmalm.
FI871715L (fi) Foerbaettring av svavelextraktion ur jaernmalm behandlat med oxideringsextraktion.
FI881091L (fi) Foerfarande foer framstaellning av isobutylbensen ur isobutenylcyklohexen.

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: MONSANTO COMPANY