FI87887B - Foerfarande foer framstaellning av fasta farmaceutiska preparat - Google Patents
Foerfarande foer framstaellning av fasta farmaceutiska preparat Download PDFInfo
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- FI87887B FI87887B FI871539A FI871539A FI87887B FI 87887 B FI87887 B FI 87887B FI 871539 A FI871539 A FI 871539A FI 871539 A FI871539 A FI 871539A FI 87887 B FI87887 B FI 87887B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 239000000825 pharmaceutical preparation Substances 0.000 title description 2
- 229920000642 polymer Polymers 0.000 claims abstract description 38
- 238000000034 method Methods 0.000 claims abstract description 24
- 239000011230 binding agent Substances 0.000 claims abstract description 16
- 239000007787 solid Substances 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000001301 oxygen Substances 0.000 claims abstract description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 3
- -1 gramisidine Chemical compound 0.000 claims description 25
- 239000004480 active ingredient Substances 0.000 claims description 24
- 239000013543 active substance Substances 0.000 claims description 22
- 239000006104 solid solution Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 11
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 7
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 6
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- 239000003999 initiator Substances 0.000 claims description 6
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- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 5
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims description 4
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- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims description 3
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- JWYVGKFDLWWQJX-UHFFFAOYSA-N 1-ethenylazepan-2-one Chemical compound C=CN1CCCCCC1=O JWYVGKFDLWWQJX-UHFFFAOYSA-N 0.000 claims description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
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- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 2
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- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- 229960002036 phenytoin Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229960002508 pindolol Drugs 0.000 description 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
- 229960001289 prazosin Drugs 0.000 description 1
- 229960001989 prenylamine Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960002393 primidone Drugs 0.000 description 1
- DQMZLTXERSFNPB-UHFFFAOYSA-N primidone Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NCNC1=O DQMZLTXERSFNPB-UHFFFAOYSA-N 0.000 description 1
- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 1
- 229960003912 probucol Drugs 0.000 description 1
- JWHAUXFOSRPERK-UHFFFAOYSA-N propafenone Chemical compound CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 JWHAUXFOSRPERK-UHFFFAOYSA-N 0.000 description 1
- 229960000203 propafenone Drugs 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- 229960004986 pyritinol Drugs 0.000 description 1
- SIXLXDIJGIWWFU-UHFFFAOYSA-N pyritinol Chemical compound OCC1=C(O)C(C)=NC=C1CSSCC1=CN=C(C)C(O)=C1CO SIXLXDIJGIWWFU-UHFFFAOYSA-N 0.000 description 1
- 229960001404 quinidine Drugs 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 150000003330 sebacic acids Chemical class 0.000 description 1
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229960004245 silymarin Drugs 0.000 description 1
- 235000017700 silymarin Nutrition 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 229960002370 sotalol Drugs 0.000 description 1
- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960000654 sulfafurazole Drugs 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- 229960004940 sulpiride Drugs 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000007885 tablet disintegrant Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 150000003899 tartaric acid esters Chemical class 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 229960002784 thioridazine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 229960001312 tiaprofenic acid Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229960004380 tramadol Drugs 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229960002726 vincamine Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
- B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
- B29K2105/0035—Medical or pharmaceutical agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Surgical Instruments (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Steroid Compounds (AREA)
Claims (9)
1. Förfarande för framställning av fasta farmaceu-tiska former genom blandning av ätminstone ett farmaceu- 5 tiskt verksamt medel med ätminstone ett smältbart farma-kologiskt fördragbart bindemedel och eventuellt ytterli-gare galeniska hjälpmedel och genom formsprutning eller extrudering samt formgivning vid en temperatur i omrädet 50-180 °C, kännetecknat därav, att man som 10 smältbart bindemedel använder ett lösningsmedelfritt N- vinylpyrrolidon-polymerisat, vars vattenhalt är högst 3,5 vikt-% och vilket innehäller ätminstone 20 vikt-% N-vi-nylpyrrolidon-2-(NVP) i en polymeriserad form, varvid samtliga eventuellt polymeriserade sammonomerer innehäl-15 ler kväve och/eller syre, och att ätminstone dä, när blandningens förglasningstemperatur är över 130 °C, använder man ett NVP-polymerisät, som erhällits genom att polymerisera i ett organiskt lösningsmedel eller med en organisk peroxid som initiator i en vattenlösning, och 20 att blandningen inte innehäller termoplaster som är svär-lösliga i magsaft.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man använder ett polymert bindemedel, som innehäller ätminstone 60 vikt-% NVP-polyme- 25 risat.
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat därav, att man använder högst 20 vikt-% av ett mjukningsmedel beräknat pä polymerisatet.
4. Förfarande enligt nägot av patentkraven 1-3, 30 kännetecknat därav, att man använder ett polymert bindemedel, vilket innehäller polyvinylpyrrolidon eller förutom N-polyvinylpyrrolidon innehäller bara vi-nylacetat i en polymeriserad form.
5. Förfarande enligt nägot av patentkraven 1-3, 35 kännetecknat därav, att man använder ett po lymert bindemedel, vars sammonomer är frän följande li 21 87887 grupp: akrylsyra, metakrylsyra, krotonsyra, maleinsyra-(anhydrid), itakonsyra(anhydrid) eller estrar av nämnda syror eller halvestrar av nämnda dikarboxylsyror, vilka bildats med alkoholer med 1-12 kolatomer eller hydroxi-5 etyl- eller hydroxlpropylakrylat eller -metakrylat, ak-rylamid, metakrylamld, N-vlnylkaprolaktam och vinylpro-plonat.
6. Förfarande enligt nägot av patentkraven 1-5, kännetecknat därav, att man använder ett i 10 vatten svärlösligt verksamt medel, vilket löser sig 1 form av en molekyldispersion i en smält polymer utan tlllägg av lösningsmedel eller vatten och blldar en fast lösnlng efter att smältan stelnat.
7. Förfarande enligt patentkravet 6, k ä n n e-15 tecknat därav, att man använder ätminstone ett verksamt medel ur följande grupp: acetaminofen (= parace-namol), acetohexamid, acetyldlgoxln, acetylsallsylsyra, acromysln, anipamil, bensokaln, β-karotin, kloramfenicol, klordiazepoxid, klormadlnoacetat, klorotiazid, kinnari-20 zln, klonazepam, kodein, dexametason, diazepam, dlkuma-rol, digitoxin, digoxin, dlhydroergotamin, drotaverin, flunitrazepam, furosemld, gramicidin, griseofulvin, hexo-barbital, hydroklortiazid, hydrokortion, hydroflumet1-azid, Indometasin, ketoprofen, lonetil, medazepam, mefru-25 sld, metandorstenolon, metylprednisolon, metylsulfadi- azid, (* sulfaperln), nalldlxlnsyra, nlfedipln, nitrazepam, nitrofurantoin, nystatin, estradiol, papaverin, fen-acetin, fenobarbital, fenylbutazon, fenytoin, predniso-lon, reserpin, sprionolakton, streptomysin, sulfadimidin 30 (- sulfametazin), sulafmetizol, sulfametoxazol, sulfamet- oxidiazin (sulfameter), sulfaperln, sulfatiazol, sulfis-oxazol, testosteron, tolazamid, tolbutamid, trimetoprim, tyrotrlein.
8. Förfarande enligt nägot av patentkraven 1-7, 35 kännetecknat därav, att man använder ett NVP- 22 87887 polymerisät, vars K-värde enligt Fikantscher är inom om-rädet 10-50.
9. Förfarande enligt nägot av patentkraven 1-7, kännetecknat därav, att man använder ett NVP-5 polymerisat, vars K-värde enligt Fikantscher är inom om-rädet 12-35. li
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863612212 DE3612212A1 (de) | 1986-04-11 | 1986-04-11 | Verfahren zur herstellung von festen pharmazeutischen formen |
| DE3612212 | 1986-04-11 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI871539A0 FI871539A0 (fi) | 1987-04-08 |
| FI871539L FI871539L (fi) | 1987-10-12 |
| FI87887B true FI87887B (fi) | 1992-11-30 |
| FI87887C FI87887C (sv) | 1993-03-10 |
Family
ID=6298473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI871539A FI87887C (sv) | 1986-04-11 | 1987-04-08 | Förfarande för framställning av fasta farmaceutiska preparat |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4801460A (sv) |
| EP (1) | EP0240904B1 (sv) |
| JP (1) | JPH089551B2 (sv) |
| KR (1) | KR920003575B1 (sv) |
| CN (1) | CN1022666C (sv) |
| AT (1) | ATE77739T1 (sv) |
| AU (1) | AU587897B2 (sv) |
| CA (1) | CA1308353C (sv) |
| CS (1) | CS268177B2 (sv) |
| DE (2) | DE3612212A1 (sv) |
| ES (1) | ES2037020T3 (sv) |
| FI (1) | FI87887C (sv) |
| GR (1) | GR3005866T3 (sv) |
| HU (1) | HU196132B (sv) |
| MD (1) | MD374C2 (sv) |
| NO (1) | NO170570C (sv) |
| PT (1) | PT84661B (sv) |
| SU (1) | SU1731037A3 (sv) |
| UA (1) | UA13038A1 (sv) |
| YU (1) | YU46534B (sv) |
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| CA1334379C (en) * | 1987-11-24 | 1995-02-14 | James William Mcginity | Method for preparing a solid sustained release form of a functionally active composition |
| DE3803482A1 (de) * | 1988-02-05 | 1989-08-17 | Lohmann Therapie Syst Lts | Schwimmfaehiges orales therapeutisches system |
| DE3807895A1 (de) * | 1988-03-10 | 1989-09-21 | Knoll Ag | Erzeugnisse, enthaltend einen calciumantagonisten und einen lipidsenker |
| DE3812567A1 (de) * | 1988-04-15 | 1989-10-26 | Basf Ag | Verfahren zur herstellung pharmazeutischer mischungen |
| DE3830355A1 (de) * | 1988-09-07 | 1990-03-15 | Basf Ag | Verfahren zur herstellung von pharmazeutischen tabletten |
| DE3830353A1 (de) * | 1988-09-07 | 1990-03-15 | Basf Ag | Verfahren zur kontinuierlichen herstellung von festen pharmazeutischen formen |
| PH26730A (en) * | 1988-12-30 | 1992-09-28 | Ciba Geigy Ag | Coated adhesive tablets |
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| WO1991007184A1 (en) * | 1989-11-08 | 1991-05-30 | Gaf Chemicals Corporation | SUBSTANTIALLY ANHYDROUS COMPLEXES OF PVP and H2O¿2? |
| US5008106A (en) * | 1989-12-14 | 1991-04-16 | Gaf Chemicals Corporation | Method for reducing the microbial content of surfaces with a microbiocidal, anhydrous complex of PVP-H2 O2 |
| IE63986B1 (en) * | 1989-12-30 | 1995-06-28 | Akzo Nv | Pharmaceutical preparation for oral administration in fluid form |
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1986
- 1986-04-11 DE DE19863612212 patent/DE3612212A1/de not_active Withdrawn
-
1987
- 1987-03-31 AT AT87104724T patent/ATE77739T1/de not_active IP Right Cessation
- 1987-03-31 EP EP87104724A patent/EP0240904B1/de not_active Expired - Lifetime
- 1987-03-31 DE DE8787104724T patent/DE3780059D1/de not_active Expired - Lifetime
- 1987-03-31 ES ES198787104724T patent/ES2037020T3/es not_active Expired - Lifetime
- 1987-04-03 YU YU59187A patent/YU46534B/sh unknown
- 1987-04-06 US US07/034,938 patent/US4801460A/en not_active Expired - Lifetime
- 1987-04-08 CS CS872532A patent/CS268177B2/cs not_active IP Right Cessation
- 1987-04-08 FI FI871539A patent/FI87887C/sv not_active IP Right Cessation
- 1987-04-09 JP JP62085889A patent/JPH089551B2/ja not_active Expired - Lifetime
- 1987-04-10 UA UA4202334A patent/UA13038A1/uk unknown
- 1987-04-10 HU HU871617A patent/HU196132B/hu not_active IP Right Cessation
- 1987-04-10 PT PT84661A patent/PT84661B/pt not_active IP Right Cessation
- 1987-04-10 SU SU874202334A patent/SU1731037A3/ru active
- 1987-04-10 NO NO871513A patent/NO170570C/no not_active IP Right Cessation
- 1987-04-10 CA CA000534435A patent/CA1308353C/en not_active Expired - Lifetime
- 1987-04-10 AU AU71413/87A patent/AU587897B2/en not_active Ceased
- 1987-04-11 KR KR1019870003527A patent/KR920003575B1/ko not_active Expired
- 1987-04-11 CN CN87103409A patent/CN1022666C/zh not_active Expired - Lifetime
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1992
- 1992-10-01 GR GR920402198T patent/GR3005866T3/el unknown
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1994
- 1994-12-29 MD MD95-0073A patent/MD374C2/ro unknown
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Owner name: BASF AKTIENGESELLSCHAFT |