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FI874463L - Foerfarande foer rening av toxinkonjugat med anvaendning av vaexelverkande hydrofob kromatografi. - Google Patents

Foerfarande foer rening av toxinkonjugat med anvaendning av vaexelverkande hydrofob kromatografi. Download PDF

Info

Publication number
FI874463L
FI874463L FI874463A FI874463A FI874463L FI 874463 L FI874463 L FI 874463L FI 874463 A FI874463 A FI 874463A FI 874463 A FI874463 A FI 874463A FI 874463 L FI874463 L FI 874463L
Authority
FI
Finland
Prior art keywords
vaexelverkande
toxinkonjugat
hydrophob
chromatograph
foerfarande foer
Prior art date
Application number
FI874463A
Other languages
English (en)
Other versions
FI874463A7 (fi
FI874463A0 (fi
Inventor
Robert Ferris
Walter Joseph Laird
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of FI874463A0 publication Critical patent/FI874463A0/fi
Publication of FI874463L publication Critical patent/FI874463L/fi
Publication of FI874463A7 publication Critical patent/FI874463A7/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
    • A61K47/6827—Ricin A

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI874463A 1986-10-10 1987-10-09 Menetelmä toksiinikonjugaattien puhdistamiseksi käyttäen vuorovaikutuksellista hydrofobista kromatografiaa. FI874463A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/917,469 US4771128A (en) 1986-10-10 1986-10-10 Method of purifying toxin conjugates using hydrophobic interaction chromatography

Publications (3)

Publication Number Publication Date
FI874463A0 FI874463A0 (fi) 1987-10-09
FI874463L true FI874463L (fi) 1988-04-11
FI874463A7 FI874463A7 (fi) 1988-04-11

Family

ID=25438836

Family Applications (1)

Application Number Title Priority Date Filing Date
FI874463A FI874463A7 (fi) 1986-10-10 1987-10-09 Menetelmä toksiinikonjugaattien puhdistamiseksi käyttäen vuorovaikutuksellista hydrofobista kromatografiaa.

Country Status (12)

Country Link
US (1) US4771128A (fi)
EP (1) EP0263526B1 (fi)
JP (1) JPS63115900A (fi)
AT (1) ATE74137T1 (fi)
AU (1) AU611397B2 (fi)
CA (1) CA1305415C (fi)
DE (1) DE3777744D1 (fi)
DK (1) DK530587A (fi)
ES (1) ES2031101T3 (fi)
FI (1) FI874463A7 (fi)
GR (1) GR3004145T3 (fi)
NO (1) NO874137L (fi)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962189A (en) * 1985-06-20 1990-10-09 Cetus Corportion Ribotoxin conjugates
GB8725606D0 (en) * 1987-11-02 1987-12-09 Soc D Etudes Prod Chimique Preparation polynucleotides
WO1989011871A1 (en) * 1988-06-01 1989-12-14 Cetus Corporation One-step chromatographic purification of immunotoxin conjugates using a thiophilic matrix
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IL91933A (en) * 1988-10-11 1994-12-29 Univ Southern California Their immuno-bracelet and isophiles which are beneficial in increasing vascular permeability or blood supply to tumor or otherwise damaged tissue
US6750329B1 (en) * 1989-05-05 2004-06-15 Research Development Foundation Antibody delivery system for biological response modifiers
US5101018A (en) * 1989-06-12 1992-03-31 International Minerals & Chemical Corp. Method for recovering recombinant proteins
US5208323A (en) * 1989-08-10 1993-05-04 Universite Laval Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent
US5047511A (en) * 1989-08-28 1991-09-10 Pitman-Moore, Inc. Method for recovering recombinant proteins
US5110912A (en) * 1990-03-02 1992-05-05 Seragen, Inc. Purification of il-2-containing hybrid compounds
NZ237688A (en) * 1990-04-19 1993-01-27 Res Dev Foundation Antibody-cytotoxic immunoconjugate-containing compositions and cancer treatment
US5110913A (en) * 1990-05-25 1992-05-05 Miles Inc. Antibody purification method
US5194594A (en) * 1990-09-07 1993-03-16 Techniclone, Inc. Modified antibodies
GB9108085D0 (en) * 1991-04-16 1991-06-05 Scras Complexes of polyadenylic acid with polyuridylic acid
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification
US5811403A (en) * 1996-09-30 1998-09-22 Vanderbilt University Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
JP2004535202A (ja) * 2001-07-17 2004-11-25 リサーチ　ディベロップメント　ファンデーション アポトーシス促進性蛋白質を含む治療剤
ES2916174T3 (es) 2002-05-02 2022-06-28 Wyeth Holdings Llc Conjugados de transportador derivado de caliqueamicina
AU2003275985A1 (en) * 2002-06-12 2003-12-31 Research Development Foundation Immunotoxin as a therapeutic agent and uses thereof
US7329353B2 (en) * 2004-01-23 2008-02-12 Amgen Inc. LC/MS method of analyzing high molecular weight proteins
EP1855724A2 (en) * 2005-02-01 2007-11-21 Research Development Foundation Blys fusion proteins for targeting blys receptor and methods for treatment of b-cell proliferative disorders
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
WO2010101865A1 (en) 2009-03-02 2010-09-10 Zymo Research Corporation Universal column
JP5699429B2 (ja) * 2009-12-18 2015-04-08 東ソー株式会社 Ｆｃレセプターの精製方法
CN106749665B (zh) 2010-04-21 2021-03-26 辛塔佳有限公司 Cc-1065类似物和双功能接头的缀合物
GB2516178B (en) * 2012-05-21 2018-08-08 Src Inc Methods and systems for the detection of ricin and other ribosome inactivating proteins
LT3092010T (lt) * 2014-01-10 2018-10-25 Synthon Biopharmaceuticals B.V. Metodas, skirtas gryninimui cys-sujungtų antikūno-vaisto konjugatų
PT2948184T (pt) 2014-01-10 2016-07-08 Synthon Biopharmaceuticals Bv Conjugados de anticorpo-fármaco de duocarmicina apresentando uma melhor atividade antitumoral in vivo.
JP6224268B2 (ja) 2014-01-10 2017-11-01 シントン・バイオファーマシューティカルズ・ビー．ブイ．Ｓｙｎｔｈｏｎ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． 子宮内膜癌の治療において使用するためのデュオカルマイシンａｄｃ

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1907014A1 (de) * 1969-02-12 1970-09-03 Haller Dr Wolfgang Verfahren zur Trennung von Blutkomponenten,insbesondere von immunologisch aktiven Globulinen,von anderen Komponenten
US4000098A (en) * 1974-08-16 1976-12-28 Palo Alto Medical Research Foundation Separation of proteins by hydrophobic adsorption
JPS5436201A (en) * 1977-08-25 1979-03-16 Microbial Chem Res Found New oncostatic antibiotic auromomycin and its preparation
FR2437213A1 (fr) * 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
US4315851A (en) * 1978-12-29 1982-02-16 Kureha Kagaku Kogyo Kabushiki Kaisha Pharmaceutical composition having antitumor activity
US4276206A (en) * 1979-01-18 1981-06-30 Scripps Clinic & Research Foundation Immunochemical conjugates: method and composition
JPS5616418A (en) * 1979-07-20 1981-02-17 Teijin Ltd Antitumor protein complex and its preparation
US4355023A (en) * 1980-09-30 1982-10-19 The Massachusetts General Hospital Antibody fragment compositions and process
FR2504010B1 (fr) * 1981-04-15 1985-10-25 Sanofi Sa Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
FR2516794B1 (fr) * 1981-11-20 1985-10-25 Sanofi Sa Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique
US4461833A (en) * 1982-06-23 1984-07-24 University Patents, Inc. Chromatographically purifying proteolytic procoagulant enzyme from animal tissue extract
US4579941A (en) * 1982-08-13 1986-04-01 Mitsuitoatsu Chemicals, Inc. Thermally-denatured deoxyribonucleic acid MD-011 and antitumor agent
US4568488A (en) * 1984-01-11 1986-02-04 Lee Huang Sylvia Reverse immunoaffinity chromatography purification method
DE3426049A1 (de) * 1984-07-14 1986-03-06 Boehringer Ingelheim International GmbH, 6507 Ingelheim Humaner-tumor-nekrose-faktor
CA1286843C (en) * 1985-10-30 1991-07-23 Leo S. Lin Purification method for proteins
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US4689401A (en) * 1986-03-06 1987-08-25 Cetus Corporation Method of recovering microbially produced recombinant ricin toxin a chain
ATE169672T1 (de) * 1986-03-07 1998-08-15 Chiron Corp Rekombinantes ricin-toxin

Also Published As

Publication number Publication date
AU7952787A (en) 1988-04-14
NO874137D0 (no) 1987-10-01
GR3004145T3 (fi) 1993-03-31
AU611397B2 (en) 1991-06-13
ES2031101T3 (es) 1992-12-01
CA1305415C (en) 1992-07-21
DE3777744D1 (de) 1992-04-30
EP0263526A1 (en) 1988-04-13
JPS63115900A (ja) 1988-05-20
EP0263526B1 (en) 1992-03-25
FI874463A7 (fi) 1988-04-11
DK530587A (da) 1988-04-11
NO874137L (no) 1988-04-11
FI874463A0 (fi) 1987-10-09
US4771128A (en) 1988-09-13
DK530587D0 (da) 1987-10-09
ATE74137T1 (de) 1992-04-15

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Owner name: CETUS CORPORATION