FI862711A7 - Foerfarande foer utvinning av fraon mikrobvaerdar haerstammande heterologa proteiner innehaollande, refraktiva kroppar. - Google Patents
Foerfarande foer utvinning av fraon mikrobvaerdar haerstammande heterologa proteiner innehaollande, refraktiva kroppar. Download PDFInfo
- Publication number
- FI862711A7 FI862711A7 FI862711A FI862711A FI862711A7 FI 862711 A7 FI862711 A7 FI 862711A7 FI 862711 A FI862711 A FI 862711A FI 862711 A FI862711 A FI 862711A FI 862711 A7 FI862711 A7 FI 862711A7
- Authority
- FI
- Finland
- Prior art keywords
- refraktiva
- mikrobvaerdar
- heterologa
- haerstammande
- kroppar
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fats And Perfumes (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74995185A | 1985-06-26 | 1985-06-26 | |
| US06/843,997 US4748234A (en) | 1985-06-26 | 1986-03-25 | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI862711A0 FI862711A0 (fi) | 1986-06-25 |
| FI862711A7 true FI862711A7 (fi) | 1986-12-27 |
Family
ID=27115201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI862711A FI862711A7 (fi) | 1985-06-26 | 1986-06-25 | Foerfarande foer utvinning av fraon mikrobvaerdar haerstammande heterologa proteiner innehaollande, refraktiva kroppar. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4748234A (fi) |
| EP (1) | EP0206828B1 (fi) |
| JP (1) | JPH0636752B2 (fi) |
| AT (1) | ATE72817T1 (fi) |
| AU (1) | AU591910B2 (fi) |
| CA (1) | CA1329308C (fi) |
| DE (1) | DE3683961D1 (fi) |
| DK (1) | DK304886A (fi) |
| FI (1) | FI862711A7 (fi) |
| MX (1) | MX171171B (fi) |
| NO (1) | NO861932L (fi) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4992271A (en) * | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
| US5523215A (en) * | 1985-03-28 | 1996-06-04 | Chiron Corporation | Enhanced purification and expression of insoluble recombinant proteins |
| US5248769A (en) * | 1985-06-26 | 1993-09-28 | Cetus Oncology Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
| DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
| US4689401A (en) * | 1986-03-06 | 1987-08-25 | Cetus Corporation | Method of recovering microbially produced recombinant ricin toxin a chain |
| US4886889A (en) * | 1986-05-16 | 1989-12-12 | Henkel Corporation | Process for recovery of an amino acid from aqueous mixtures thereof |
| US5179199A (en) * | 1986-10-20 | 1993-01-12 | Genzyme Corporation | Protein purification |
| US4894330A (en) * | 1986-12-23 | 1990-01-16 | Cetus Corporation | Purification of recombinant beta-interferon incorporating RP-HPLC |
| US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
| CA1339757C (en) | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Production of purified biologically active, bacterially produced recombinant human csf-1 |
| CA1305285C (en) * | 1987-04-21 | 1992-07-14 | Malcolm Roy Brandon | Production of proteins in active forms |
| WO1988008428A1 (en) * | 1987-04-28 | 1988-11-03 | Amgen Inc. | Method for purifying granulocyte/macrophage colony stimulating factor |
| US5162507A (en) * | 1987-05-11 | 1992-11-10 | Cetus Corporation | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
| AU622860B2 (en) * | 1987-05-11 | 1992-04-30 | Novartis Vaccines And Diagnostics, Inc. | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
| US4961969A (en) * | 1987-05-11 | 1990-10-09 | Cetus Corporation | Process for recovering microbially produced interferon-β |
| US4931543A (en) * | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
| EP0377023B1 (en) * | 1988-05-31 | 1995-02-15 | Cetus Oncology Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
| CA1340586C (en) * | 1988-09-23 | 1999-06-08 | Cetus Corporation | Process for recovering microbially produced interferon-beta |
| CA2005311C (en) * | 1988-12-13 | 2006-05-30 | Edward A. Hoover | Prototype felv isolates for use in disease models and vaccines |
| US5530100A (en) * | 1990-05-07 | 1996-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Methods for purification of recombinantly produced proteins |
| US5830452A (en) * | 1990-11-20 | 1998-11-03 | Chiron Corporation | Method for enhancing the anti-tumor therapeutic index of interleukin-2 |
| FR2684878B1 (fr) * | 1991-12-12 | 1994-02-11 | Roussel Uclaf | Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation. |
| US20030171292A1 (en) * | 1992-06-01 | 2003-09-11 | Creasey Abla A. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
| US6063764A (en) * | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
| EP0672144A1 (en) * | 1992-10-20 | 1995-09-20 | Chiron Corporation | Interleukin-6 receptor antagonists |
| US5437986A (en) * | 1994-06-22 | 1995-08-01 | Schering Corporation | Extraction of heterologous insoluble proteins from bacteria |
| US6214221B1 (en) * | 1999-02-22 | 2001-04-10 | Henry B. Kopf | Method and apparatus for purification of biological substances |
| CA2361545C (en) | 1999-02-22 | 2009-01-27 | Henry Kopf | Purification of biological substances |
| EP1935431A3 (en) | 2000-05-15 | 2008-08-13 | Health Research, Inc. | Cancer treatments by using a combination of an antibody against her2 and interleukin-2 |
| CA2444480C (en) * | 2001-02-23 | 2014-05-27 | Lucia Irene Gonzalez-Villasenor | Methods and compositions for production of recombinant peptides |
| AU2002303168B2 (en) | 2001-03-29 | 2005-10-06 | Schering Corporation | Aryl oxime-piperazines useful as ccr5 antagonists |
| AU2002365131B2 (en) * | 2001-10-15 | 2007-03-01 | Novartis Vaccines And Diagnostics, Inc. | Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (TFPI) |
| EP1608629A1 (en) | 2003-03-24 | 2005-12-28 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| EP1682178B8 (en) | 2003-11-04 | 2010-09-01 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for cancers expressing the cd40 antigen |
| WO2005084303A2 (en) * | 2004-03-01 | 2005-09-15 | Enzon Pharmaceuticals, Inc. | Interferon-beta polymer conjugates |
| US20080286279A1 (en) * | 2004-03-17 | 2008-11-20 | Chiron Corporation | Treatment of Severe Community-Acquired Pneumonia by Administration of Tissue Factor Pathway Inhibitor (Tfpi) |
| ES2318916B1 (es) * | 2005-02-07 | 2010-03-22 | Chiron Corporation | Procedimiento para preparar aldesleukina para uso farmaceutico. |
| DE102005005542A1 (de) * | 2005-02-07 | 2006-08-10 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Herstellung von Aldesleukin für die pharmazeutische Verwendung |
| KR20080056220A (ko) | 2005-10-19 | 2008-06-20 | 에프. 호프만-라 로슈 아게 | 페닐-아세트아마이드 nnrt 저해제 |
| RU2304586C1 (ru) * | 2006-03-27 | 2007-08-20 | Михаил Николаевич Смирнов | Препарат интерлейкина-2 и способ его получения |
| ES2360893T3 (es) | 2006-08-16 | 2011-06-10 | F. Hoffmann-La Roche Ag | Inhibidores no nucleósidos de la transcriptasa inversa. |
| RU2469032C2 (ru) | 2006-12-13 | 2012-12-10 | Ф.Хоффманн-Ля Рош Аг | Производные 2-(пиперидин-4-ил)-4-фенокси- или фениламинопиримидина в качестве ненуклеозидных ингибиторов обратной транскриптазы |
| AU2008257771B2 (en) | 2007-05-30 | 2015-02-19 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| US8399260B2 (en) | 2007-08-08 | 2013-03-19 | School Juridical Person Kitasato Institute | Method for concentration of low-molecular-weight proteins and peptides in body fluid sample |
| JP5411160B2 (ja) | 2007-12-21 | 2014-02-12 | エフ.ホフマン−ラ ロシュ アーゲー | 複素環式抗ウイルス性化合物 |
| WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| US9273336B2 (en) | 2011-02-21 | 2016-03-01 | E. I. Du Pont De Nemours And Company | Recombinant host cells having an increase in buoyant density |
| KR102220006B1 (ko) | 2011-03-11 | 2021-02-24 | 아시스땅스 퍼블리끄-오삐또 드 빠리 | 자가면역 - 관련 또는 염증성 장애를 치료하기 위한 저용량 il2 의 용도 |
| AU2014247991B2 (en) * | 2013-04-05 | 2019-05-09 | Qiagen Sciences, Llc | Kits and methods for isolating protein from biological and environmental samples |
| US10183061B2 (en) | 2013-06-25 | 2019-01-22 | Icm (Institut Du Cerveau Et De La Moelle Epiniere) | Boosting Treg cells for treating Alzheimer disease and related disorders |
| CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
| EP2918285A1 (en) | 2014-03-11 | 2015-09-16 | Université Pierre et Marie Curie (Paris 6) | Interleukin-2 for treating food allergy |
| CN106659757B (zh) | 2014-04-24 | 2022-01-28 | 利兰斯坦福初级大学董事会 | 白介素2的超级激动剂、部分激动剂和拮抗剂 |
| JP6941561B2 (ja) | 2014-10-09 | 2021-09-29 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 免疫障害を処置するための複数の可変il−2用量レジメン |
| EP3344643B1 (en) | 2015-09-04 | 2025-07-02 | Qiagen Sciences LLC | Methods for co-isolation of nucleic acids and proteins |
| AU2016341241B9 (en) | 2015-10-22 | 2021-11-18 | Iltoo Pharma | Pharmaceutical compositions of IL-2 |
| WO2018218119A1 (en) * | 2017-05-25 | 2018-11-29 | The Board Of Trustees Of The Leland Stanford Junior University | Combination of low dose il-2 and an inhibitor of treg il-2r desensitization to treat autoimmune and allergic inflammatory diseases |
| AU2018287317B2 (en) | 2017-06-19 | 2024-06-20 | Medicenna Therapeutics Inc. | Uses and methods for IL-2 superagonists, agonists, and fusions thereof |
| KR102777151B1 (ko) | 2017-11-21 | 2025-03-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 인터루킨-2의 부분 효능제 |
| WO2019158764A1 (en) | 2018-02-16 | 2019-08-22 | Iltoo Pharma | Use of interleukin 2 for treating sjögren's syndrome |
| CN112313344A (zh) | 2018-04-24 | 2021-02-02 | 凯杰科技有限公司 | 从复杂样品中分离核酸并去除抑制剂 |
| WO2020007937A1 (en) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| MX2022008771A (es) | 2020-01-14 | 2022-10-07 | Synthekine Inc | Metodos y composiciones de muteinas de il2 sesgadas. |
| JP2023516774A (ja) | 2020-03-06 | 2023-04-20 | サントル、オスピタリエ、ユニヴェルシテール、ド、ニーム | 筋萎縮性側索硬化症の治療のための低用量ヒトインターロイキン-2 |
| WO2024121173A1 (en) | 2022-12-05 | 2024-06-13 | Centre Hospitalier Universitaire De Nimes | Low dose human interleukin-2 for the treatment of amyotrophic lateral sclerosis in a subgroup of patients |
| WO2025032158A1 (en) | 2023-08-08 | 2025-02-13 | Institut National de la Santé et de la Recherche Médicale | Method to treat tauopathies |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3975344A (en) * | 1974-10-02 | 1976-08-17 | G. D. Searle & Co. | Interferon purification |
| US4426323A (en) * | 1980-01-10 | 1984-01-17 | Ionics, Incorporated | Selected recovery of proteins from fermentation broths |
| IE53517B1 (en) * | 1981-06-17 | 1988-12-07 | Celltech Ltd | Process for the production of a polypeptide |
| US4450103A (en) * | 1982-03-01 | 1984-05-22 | Cetus Corporation | Process for recovering human IFN-β from a transformed microorganism |
| US4462940A (en) * | 1982-09-23 | 1984-07-31 | Cetus Corporation | Process for the recovery of human β-interferon-like polypeptides |
| US4992271A (en) * | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
| US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| GR79124B (fi) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
| US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4464295A (en) * | 1983-08-17 | 1984-08-07 | The United States Of America As Represented By The Secretary Of Agriculture | Simple and rapid method for extraction of proteins from bacteria |
| JPS60115528A (ja) * | 1983-11-28 | 1985-06-22 | Takeda Chem Ind Ltd | ヒトインタ―ロイキン―2蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物 |
| CA1340853C (en) * | 1983-12-23 | 1999-12-21 | Hsiang-Fu Kung | Purification of recombinant interleukin-2 |
| US4569790A (en) * | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
| GB8414354D0 (en) * | 1984-06-05 | 1984-07-11 | Biogen Nv | Purifying protein |
| CA1267615A (en) * | 1984-08-27 | 1990-04-10 | Dan Hadary | Method for recovering purified growth hormones from genetically engineered microorganisms |
| US4659568A (en) * | 1985-02-27 | 1987-04-21 | American Cyanamid Company | Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom |
| DE3515336C2 (de) * | 1985-04-27 | 1994-01-20 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Reinigung von â-Interferon |
| US4675387A (en) * | 1985-07-26 | 1987-06-23 | E. I. Du Pont De Nemours And Company | Method for extracting protein with organic acid |
| US4656255A (en) * | 1985-09-09 | 1987-04-07 | International Minerals & Chemical Corp. | Protein recovery |
-
1986
- 1986-03-25 US US06/843,997 patent/US4748234A/en not_active Expired - Lifetime
- 1986-04-18 CA CA000507016A patent/CA1329308C/en not_active Expired - Lifetime
- 1986-05-15 NO NO861932A patent/NO861932L/no unknown
- 1986-06-25 DE DE8686304946T patent/DE3683961D1/de not_active Expired - Lifetime
- 1986-06-25 AT AT86304946T patent/ATE72817T1/de not_active IP Right Cessation
- 1986-06-25 AU AU59242/86A patent/AU591910B2/en not_active Ceased
- 1986-06-25 EP EP86304946A patent/EP0206828B1/en not_active Expired
- 1986-06-25 FI FI862711A patent/FI862711A7/fi not_active IP Right Cessation
- 1986-06-26 JP JP61148320A patent/JPH0636752B2/ja not_active Expired - Lifetime
- 1986-06-26 DK DK304886A patent/DK304886A/da not_active Application Discontinuation
- 1986-06-26 MX MX002944A patent/MX171171B/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE72817T1 (de) | 1992-03-15 |
| NO861932L (no) | 1986-12-29 |
| AU591910B2 (en) | 1989-12-21 |
| EP0206828B1 (en) | 1992-02-26 |
| JPH0636752B2 (ja) | 1994-05-18 |
| JPS6265695A (ja) | 1987-03-24 |
| MX171171B (es) | 1993-10-06 |
| AU5924286A (en) | 1987-01-08 |
| US4748234A (en) | 1988-05-31 |
| EP0206828A3 (en) | 1988-09-21 |
| CA1329308C (en) | 1994-05-03 |
| EP0206828A2 (en) | 1986-12-30 |
| DE3683961D1 (de) | 1992-04-02 |
| DK304886D0 (da) | 1986-06-26 |
| FI862711A0 (fi) | 1986-06-25 |
| DK304886A (da) | 1986-12-27 |
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