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FI861328A7 - NEW 1,2-BENZIOXAZOL-3-YL- OCH 1,2-BENZISOTHIAZOLE-3-YL DERIVATIVES. - Google Patents

NEW 1,2-BENZIOXAZOL-3-YL- OCH 1,2-BENZISOTHIAZOLE-3-YL DERIVATIVES.

Info

Publication number
FI861328A7
FI861328A7 FI861328A FI861328A FI861328A7 FI 861328 A7 FI861328 A7 FI 861328A7 FI 861328 A FI861328 A FI 861328A FI 861328 A FI861328 A FI 861328A FI 861328 A7 FI861328 A7 FI 861328A7
Authority
FI
Finland
Prior art keywords
alkyl
hydrogen
halogen
amino
groups
Prior art date
Application number
FI861328A
Other languages
Finnish (fi)
Other versions
FI81800B (en
FI81800C (en
FI861328A0 (en
Inventor
Ludo Edmond Josephine Kennis
Jan Vandenberk
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24880589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI861328(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to FI893001A priority Critical patent/FI893001A0/en
Publication of FI861328A0 publication Critical patent/FI861328A0/en
Publication of FI861328A7 publication Critical patent/FI861328A7/en
Publication of FI81800B publication Critical patent/FI81800B/en
Application granted granted Critical
Publication of FI81800C publication Critical patent/FI81800C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

The invention relates to a process for preparing novel 1, 2-benzisoxazol-3-yl- and 1,2-benzisotiaxol -3-yl derivatives of the formula (I), in which R is hydrogen or C1-6-alkyl, each of the groups R1 and R2 is independently hydrogen, halogen or hydroxyl or C1-6-alkyl; x is O or S; Alk is C1-4-alkanediyl; Q is a group of the formula (a), in which Y1 and Y2 are each independently O or S; R3 is hydrogen, halogen or C1-6-alkyl, C1-6-alkoxy, trifluoromethyl, nitro, cyano, hydroxyl, (C1-10- alkylcarbonyl)oxy, amino, mono- or di(C1-6-alkyl) amino, (C1-10-alkylcarbonyl)amino, phenylmethoxy or azide; R4 is hydrogen or halogen or a group of the formula (b) in which R5 is hydrogen of C1-6-alkyl; Z is -S-, -CH2-or CR6- CR7-, where each of the groups R6 and R7 is independently hydrogen or C1-6-alkyl; and A is a bivalent group -CH2-CH2-CH2- or -CR8-CR9- and each of the groups R8 and R9 is independently hydrogen, halogen, amino or alkyl; and their pharmaceutically acceptable acid addition salts. The compounds possess excellent antipsychotic properties and can be used when treating various disorders in which the release of scrotonin is of predominant importance. <IMAGE>
FI861328A 1985-03-27 1986-03-26 Process for the preparation of novel therapeutically useful 1,2-benzis oxazol-3-yl-1-piperidinylalkylpyridopyrimidinone and thiazolopyrimidine derivatives FI81800C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI893001A FI893001A0 (en) 1985-03-27 1986-03-26 FOR EXAMINATION OF FRAMSTAELLNING AV NYA, THERAPEUTIC ANVAENDBARA 1,2-BENZISOXAZOLE-3-YL-OCH 1,2-BENZISOTIAZOLE-3-YLDERIVAT.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71706785A 1985-03-27 1985-03-27
US71706785 1985-03-27

Publications (4)

Publication Number Publication Date
FI861328A0 FI861328A0 (en) 1986-03-26
FI861328A7 true FI861328A7 (en) 1986-09-28
FI81800B FI81800B (en) 1990-08-31
FI81800C FI81800C (en) 1990-12-10

Family

ID=24880589

Family Applications (1)

Application Number Title Priority Date Filing Date
FI861328A FI81800C (en) 1985-03-27 1986-03-26 Process for the preparation of novel therapeutically useful 1,2-benzis oxazol-3-yl-1-piperidinylalkylpyridopyrimidinone and thiazolopyrimidine derivatives

Country Status (13)

Country Link
KR (1) KR910000165B1 (en)
AT (1) ATE79379T1 (en)
DE (1) DE3686341T2 (en)
ES (1) ES8705881A1 (en)
FI (1) FI81800C (en)
GR (1) GR860800B (en)
HU (1) HU195793B (en)
IL (1) IL78250A (en)
NO (2) NO162765C (en)
NZ (1) NZ215462A (en)
PH (1) PH24016A (en)
PT (1) PT82254B (en)
ZA (1) ZA862279B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2050069B1 (en) * 1992-07-10 1994-12-16 Vita Invest Sa PROCEDURE FOR OBTAINING 3- (2- (4- (6-FLUORO-1,2-BENZISOXAZOL-3-IL) PIPERIDINO) ETIL) -2-METHYL-6,7,8,9-TETRAHIDRO-4H-PIRIDO (1,2-A) PIRIMIDIN-4-ONA.
ES2085234B1 (en) * 1994-02-24 1997-01-16 Vita Invest Sa ACTIVE AGENT ON THE CENTRAL NERVOUS SYSTEM, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone

Also Published As

Publication number Publication date
ES553419A0 (en) 1987-05-16
NO162765B (en) 1989-11-06
FI81800B (en) 1990-08-31
FI81800C (en) 1990-12-10
FI861328A0 (en) 1986-03-26
KR910000165B1 (en) 1991-01-21
HUT42461A (en) 1987-07-28
DE3686341D1 (en) 1992-09-17
GR860800B (en) 1986-07-21
ZA862279B (en) 1987-11-25
PT82254A (en) 1986-04-01
HU195793B (en) 1988-07-28
KR860007247A (en) 1986-10-10
IL78250A (en) 1991-05-12
ATE79379T1 (en) 1992-08-15
PH24016A (en) 1990-02-09
NZ215462A (en) 1988-09-29
PT82254B (en) 1988-04-21
NO162765C (en) 1990-02-14
NO1994021I1 (en) 1994-11-03
ES8705881A1 (en) 1987-05-16
DE3686341T2 (en) 1993-01-14
IL78250A0 (en) 1986-07-31
NO861230L (en) 1986-09-29

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Legal Events

Date Code Title Description
ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L34

Extension date: 20071208

FG Patent granted

Owner name: JANSSEN PHARMACEUTICA N.V.

MA Patent expired