FI852856A7 - Prostaglandiinianalogeja ja niiden valmistusmenetelmä. - Google Patents
Prostaglandiinianalogeja ja niiden valmistusmenetelmä. Download PDFInfo
- Publication number
- FI852856A7 FI852856A7 FI852856A FI852856A FI852856A7 FI 852856 A7 FI852856 A7 FI 852856A7 FI 852856 A FI852856 A FI 852856A FI 852856 A FI852856 A FI 852856A FI 852856 A7 FI852856 A7 FI 852856A7
- Authority
- FI
- Finland
- Prior art keywords
- preparing
- prostaglandin analogues
- prostaglandin
- analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Emergency Protection Circuit Devices (AREA)
- Materials For Medical Uses (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59151369A JPS6130554A (ja) | 1984-07-23 | 1984-07-23 | プロスタグランジン類似化合物のある特定の立体配置を有する異性体及びそれらを有効成分として含有する治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI852856A0 FI852856A0 (fi) | 1985-07-22 |
| FI852856A7 true FI852856A7 (fi) | 1986-01-24 |
| FI852856L FI852856L (fi) | 1986-01-24 |
Family
ID=15517042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI852856A FI852856L (fi) | 1984-07-23 | 1985-07-22 | Prostaglandinanaloger och foerfaranden foer framstaellning av dessa. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4935446A (fi) |
| EP (1) | EP0196380B1 (fi) |
| JP (1) | JPS6130554A (fi) |
| KR (1) | KR860001119A (fi) |
| AT (1) | ATE67484T1 (fi) |
| AU (1) | AU596947B2 (fi) |
| CA (1) | CA1264320A (fi) |
| DE (1) | DE3584158D1 (fi) |
| DK (1) | DK333385A (fi) |
| ES (3) | ES8609232A1 (fi) |
| FI (1) | FI852856L (fi) |
| GR (1) | GR851812B (fi) |
| HU (1) | HU199781B (fi) |
| NO (1) | NO852916L (fi) |
| PT (1) | PT80848B (fi) |
| YU (3) | YU45985B (fi) |
| ZA (1) | ZA855533B (fi) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2192395B (en) * | 1986-07-08 | 1990-11-14 | Kotobuki Seiyaku Co Ltd | Carbacyclin derivatives |
| US5218139A (en) * | 1990-12-27 | 1993-06-08 | G. D. Searle & Co. | Method for inhibiting IgE production |
| US5148032A (en) * | 1991-06-28 | 1992-09-15 | Siemens Medical Laboratories, Inc. | Radiation emitting device with moveable aperture plate |
| US5235816A (en) * | 1991-10-10 | 1993-08-17 | Praxair Technology, Inc. | Cryogenic rectification system for producing high purity oxygen |
| AR053710A1 (es) * | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| LT1976828T (lt) | 2005-12-29 | 2017-04-25 | Celtaxsys, Inc. | Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai |
| CL2007002953A1 (es) * | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | Compuestos derivados de espiro-oxindol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del dolor, cancer, prurito, hiperplasia prostatica benigna, hipercolesterolemia. |
| AR063280A1 (es) | 2006-10-12 | 2009-01-21 | Xenon Pharmaceuticals Inc | Uso de compuestos de espiro-oxindol como agentes terapeuticos |
| CA2741029A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| CA2741024A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| NZ599334A (en) | 2009-10-14 | 2014-03-28 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
| US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| RU2596488C2 (ru) | 2010-02-26 | 2016-09-10 | Ксенон Фармасьютикалз Инк. | Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов |
| EA201491854A1 (ru) | 2012-04-12 | 2015-03-31 | Ксенон Фармасьютикалз Инк. | Асимметрический синтез соединений спирооксиндола, полезных в качестве терапевтических средств |
| BR112015022226A2 (pt) | 2013-03-14 | 2017-07-18 | Celtaxsys Inc | inibidores de leucotrieno a4 hidrolase |
| US9682033B2 (en) | 2015-02-05 | 2017-06-20 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| WO2017218920A1 (en) | 2016-06-16 | 2017-12-21 | Teva Pharmaceuticals International Gmbh | Asymmetric synthesis of funapide |
| US10385007B2 (en) | 2016-12-09 | 2019-08-20 | Celtaxsys, Inc. | Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase |
| EP3551608A1 (en) | 2016-12-09 | 2019-10-16 | Celtaxsys Inc. | Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase |
| WO2018107153A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4180675A (en) * | 1975-07-17 | 1979-12-25 | Warner-Lambert Company | 15-Cycloalkyl-prostaglandin derivatives |
| US4087620A (en) * | 1975-07-17 | 1978-05-02 | Ono Pharmaceutical Company | 15-Cycloalkyl-prostaglandin derivatives |
| JPS53103464A (en) * | 1977-02-21 | 1978-09-08 | Ono Pharmaceut Co Ltd | Prostaglandin x analogues and process for their preparation |
| US4178367A (en) * | 1977-02-21 | 1979-12-11 | Ono Pharmaceutical Co. Ltd. | Prostaglandin I2 analogues |
| JPS53127441A (en) * | 1977-04-11 | 1978-11-07 | Ono Pharmaceut Co Ltd | Prostaglandin-like compounds and their preparation |
| GB1588196A (en) * | 1977-06-14 | 1981-04-15 | Ono Pharmaceutical Co | Prostaglandin analogues |
| JPS6022710B2 (ja) * | 1977-09-16 | 1985-06-03 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| JPS54125653A (en) * | 1978-03-18 | 1979-09-29 | Ono Pharmaceut Co Ltd | Prostaglandin i2 analog, its preparation, and drug composition comprising it as active constituent |
| JPS54130543A (en) * | 1978-03-31 | 1979-10-09 | Ono Pharmaceut Co Ltd | Prostagladin i2 analog, and its preparation |
| IT1113341B (it) * | 1978-03-31 | 1986-01-20 | Ono Pharmaceutical Co | Analoghi della 6,9-metano-pgi2 |
| US4220795A (en) * | 1978-08-14 | 1980-09-02 | Miles Laboratories, Inc. | Cyclobutyl substituted derivatives of prostaglandin analogs |
| DE2902809A1 (de) * | 1979-01-25 | 1980-08-07 | Hoechst Ag | Neue analoga von prostacyclin |
| DE3006865A1 (de) * | 1980-02-23 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Hetero-imino-prostacycline |
| JPS58164512A (ja) * | 1982-03-25 | 1983-09-29 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤 |
| JPS591463A (ja) * | 1982-06-28 | 1984-01-06 | Ono Pharmaceut Co Ltd | 新規なプロスタグランジンd類似化合物 |
| JPS5944340A (ja) * | 1982-09-08 | 1984-03-12 | Sankyo Co Ltd | メタノプロスタサイクリン誘導体の光学活性結晶性アミン塩およびその製法 |
| JPS59163365A (ja) * | 1983-03-08 | 1984-09-14 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物 |
-
1984
- 1984-07-23 JP JP59151369A patent/JPS6130554A/ja active Pending
-
1985
- 1985-07-22 FI FI852856A patent/FI852856L/fi not_active Application Discontinuation
- 1985-07-22 CA CA000487203A patent/CA1264320A/en not_active Expired - Lifetime
- 1985-07-22 YU YU120185A patent/YU45985B/sh unknown
- 1985-07-22 ES ES545457A patent/ES8609232A1/es not_active Expired
- 1985-07-22 NO NO852916A patent/NO852916L/no unknown
- 1985-07-22 EP EP85305202A patent/EP0196380B1/en not_active Expired - Lifetime
- 1985-07-22 ZA ZA855533A patent/ZA855533B/xx unknown
- 1985-07-22 KR KR1019850005225A patent/KR860001119A/ko not_active Ceased
- 1985-07-22 DK DK333385A patent/DK333385A/da unknown
- 1985-07-22 PT PT80848A patent/PT80848B/pt not_active IP Right Cessation
- 1985-07-22 GR GR851812A patent/GR851812B/el unknown
- 1985-07-22 AT AT85305202T patent/ATE67484T1/de not_active IP Right Cessation
- 1985-07-22 DE DE8585305202T patent/DE3584158D1/de not_active Expired - Lifetime
- 1985-07-22 HU HU852791A patent/HU199781B/hu unknown
- 1985-07-22 AU AU45232/85A patent/AU596947B2/en not_active Ceased
-
1986
- 1986-02-28 ES ES552554A patent/ES8705385A1/es not_active Expired
- 1986-02-28 ES ES552553A patent/ES8705384A1/es not_active Expired
-
1987
- 1987-07-30 YU YU143287A patent/YU46219B/sh unknown
- 1987-07-30 YU YU143387A patent/YU46220B/sh unknown
-
1989
- 1989-03-30 US US07/331,011 patent/US4935446A/en not_active Expired - Fee Related
-
1990
- 1990-05-25 US US07/528,865 patent/US5109021A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4935446A (en) | 1990-06-19 |
| YU143387A (en) | 1988-04-30 |
| AU596947B2 (en) | 1990-05-24 |
| FI852856A0 (fi) | 1985-07-22 |
| HU199781B (en) | 1990-03-28 |
| PT80848A (en) | 1985-08-01 |
| GR851812B (fi) | 1985-11-26 |
| EP0196380A3 (en) | 1987-07-01 |
| KR860001119A (ko) | 1986-02-22 |
| US5109021A (en) | 1992-04-28 |
| ES8609232A1 (es) | 1986-09-01 |
| ES552553A0 (es) | 1987-05-01 |
| DK333385D0 (da) | 1985-07-22 |
| DK333385A (da) | 1986-01-24 |
| FI852856L (fi) | 1986-01-24 |
| YU45985B (sh) | 1992-12-21 |
| ATE67484T1 (de) | 1991-10-15 |
| PT80848B (pt) | 1987-11-30 |
| ES552554A0 (es) | 1987-05-01 |
| YU46220B (sh) | 1993-05-28 |
| HUT39157A (en) | 1986-08-28 |
| YU143287A (en) | 1988-04-30 |
| ES8705384A1 (es) | 1987-05-01 |
| YU120185A (en) | 1988-04-30 |
| CA1264320A (en) | 1990-01-09 |
| ZA855533B (en) | 1986-03-26 |
| JPS6130554A (ja) | 1986-02-12 |
| YU46219B (sh) | 1993-05-28 |
| EP0196380A2 (en) | 1986-10-08 |
| ES8705385A1 (es) | 1987-05-01 |
| AU4523285A (en) | 1986-01-30 |
| EP0196380B1 (en) | 1991-09-18 |
| NO852916L (no) | 1986-01-24 |
| ES545457A0 (es) | 1986-09-01 |
| DE3584158D1 (de) | 1991-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |
Owner name: ONO PHARMACEUTICAL CO LTD |