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FI832092L - 1-aryloxi-2,3,4,5-tetrahydro-3-bensazepiner, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel - Google Patents

1-aryloxi-2,3,4,5-tetrahydro-3-bensazepiner, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel

Info

Publication number
FI832092L
FI832092L FI832092A FI832092A FI832092L FI 832092 L FI832092 L FI 832092L FI 832092 A FI832092 A FI 832092A FI 832092 A FI832092 A FI 832092A FI 832092 L FI832092 L FI 832092L
Authority
FI
Finland
Prior art keywords
sub
dem
tetrahydro
hydrogen
benzazepiner
Prior art date
Application number
FI832092A
Other languages
English (en)
Other versions
FI78473B (fi
FI78473C (fi
FI832092A0 (fi
Inventor
Richard Charles Effland
Joseph Thomas Klein
Larry Davis
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI832092A0 publication Critical patent/FI832092A0/fi
Publication of FI832092L publication Critical patent/FI832092L/fi
Publication of FI78473B publication Critical patent/FI78473B/fi
Application granted granted Critical
Publication of FI78473C publication Critical patent/FI78473C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI832092A 1982-06-14 1983-06-10 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-fenyloxi-2,3,4,5-tetrahydro-3-bensazepinderivat, och vid foerfarandet anvaendbara mellanprodukter. FI78473C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38791682 1982-06-14
US06/387,916 US4988690A (en) 1982-06-14 1982-06-14 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof

Publications (4)

Publication Number Publication Date
FI832092A0 FI832092A0 (fi) 1983-06-10
FI832092L true FI832092L (fi) 1983-12-15
FI78473B FI78473B (fi) 1989-04-28
FI78473C FI78473C (fi) 1989-08-10

Family

ID=23531838

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832092A FI78473C (fi) 1982-06-14 1983-06-10 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-fenyloxi-2,3,4,5-tetrahydro-3-bensazepinderivat, och vid foerfarandet anvaendbara mellanprodukter.

Country Status (17)

Country Link
US (1) US4988690A (fi)
EP (1) EP0096838B1 (fi)
JP (1) JPS595165A (fi)
KR (1) KR900001214B1 (fi)
AT (1) ATE26263T1 (fi)
AU (1) AU570920B2 (fi)
CA (1) CA1214460A (fi)
DE (1) DE3370621D1 (fi)
DK (1) DK270983A (fi)
ES (1) ES523191A0 (fi)
FI (1) FI78473C (fi)
GR (1) GR78291B (fi)
HU (1) HU190902B (fi)
IE (1) IE55404B1 (fi)
IL (1) IL68964A (fi)
PT (1) PT76864B (fi)
ZA (1) ZA834309B (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH27337A (en) * 1987-03-27 1993-06-08 Schering Corp Substituted benzazepines their preparation and pharmaceutical compositions containing them
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
CA1327795C (en) * 1987-08-14 1994-03-15 Jules Freedman Antidepressants which are aryloxy inadanamines
US5202319A (en) * 1991-09-23 1993-04-13 Hoechst-Roussel Pharmaceuticals Inc. Substituted 3-amino-2,3,4,5-tetrahydro-1-aryloxy-3-benzazepines
US5639482A (en) * 1993-11-10 1997-06-17 Crary; Ely J. Composition for control and prevention of diabetic retinopathy
WO2002044144A2 (en) * 2000-11-30 2002-06-06 Advanced Research And Technology Institute, Inc. Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
PL2332921T3 (pl) 2003-06-17 2016-08-31 Arena Pharm Inc Chlorowodorek 8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny
CA2888392A1 (en) * 2003-06-17 2005-03-03 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
EP2149562A1 (en) 2004-12-21 2010-02-03 Arena Pharmaceuticals, Inc. method of preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride hemihydrate
SG158168A1 (en) 2004-12-23 2010-01-29 Arena Pharm Inc 5ht2c receptor modulator compositions and methods of use
EP2518053A1 (en) * 2006-04-03 2012-10-31 Arena Pharmaceuticals, Inc. Process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
US8299241B2 (en) * 2006-12-05 2012-10-30 Arena Pharmaceuticals, Inc. Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
NZ580802A (en) 2007-05-10 2012-09-28 Albany Molecular Res Inc Aryloxy-and heteroaryloxy-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
EP2288585A1 (en) 2008-03-04 2011-03-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
EP2443080A2 (en) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Process for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
MX2013002421A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales no hidroscopicas de agonistas de 5-ht2c.
WO2012030938A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
EP2939677A1 (en) 2010-09-01 2015-11-04 Arena Pharmaceuticals, Inc. Administration of lorcaserin to indviduals with renal impairment
WO2014058441A1 (en) 2012-10-09 2014-04-17 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5233687A (en) * 1975-09-11 1977-03-14 Shionogi & Co Ltd Process for preparation of 1,5-dihydro-2h-1,4-benzodiazepine-2-on deri vatives
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound

Also Published As

Publication number Publication date
KR900001214B1 (ko) 1990-02-28
PT76864B (en) 1986-02-27
JPS595165A (ja) 1984-01-12
IE831384L (en) 1983-12-14
FI78473B (fi) 1989-04-28
EP0096838B1 (en) 1987-04-01
EP0096838A1 (en) 1983-12-28
DK270983A (da) 1983-12-15
JPH0365342B2 (fi) 1991-10-11
PT76864A (en) 1983-07-01
IE55404B1 (en) 1990-09-12
ES8503666A1 (es) 1985-03-01
IL68964A (en) 1988-03-31
IL68964A0 (en) 1983-10-31
DE3370621D1 (en) 1987-05-07
HU190902B (en) 1986-12-28
KR840005103A (ko) 1984-11-03
US4988690A (en) 1991-01-29
FI78473C (fi) 1989-08-10
FI832092A0 (fi) 1983-06-10
ES523191A0 (es) 1985-03-01
DK270983D0 (da) 1983-06-13
AU570920B2 (en) 1988-03-31
CA1214460A (en) 1986-11-25
ATE26263T1 (de) 1987-04-15
ZA834309B (en) 1984-03-28
GR78291B (fi) 1984-09-26
AU1576483A (en) 1983-12-22

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED