FI813971A7 - Uusia pyrimidinoneja, niiden valmistus ja niiden käyttö lääkeaineina. - Google Patents

Uusia pyrimidinoneja, niiden valmistus ja niiden käyttö lääkeaineina. Download PDF

Info

Publication number: FI813971A7
Authority: FI; Finland
Prior art keywords: pyrimidinones; pharmaceuticals; preparation; new; new pyrimidinones
Prior art date: 1980-12-12

Application number

FI813971A

Other languages

English (en)

Swedish (sv)

Other versions

FI813971L (fi

Inventor

Rudolf Kadatz

Joachim Heider

Christian Lillie

Wolfgang Eberlein

Volkhard Austel

Original Assignee

Dr Karl Thomae Ges Mit

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-12-12

Filing date

1981-12-10

Publication date

1982-06-13

1980-12-12 Priority claimed from DE19803046871 external-priority patent/DE3046871A1/de

1981-04-16 Priority claimed from DE19813115447 external-priority patent/DE3115447A1/de

1981-12-10 Application filed by Dr Karl Thomae Ges Mit filed Critical Dr Karl Thomae Ges Mit

1982-06-13 Publication of FI813971A7 publication Critical patent/FI813971A7/fi

1982-06-13 Publication of FI813971L publication Critical patent/FI813971L/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

FI813971A 1980-12-12 1981-12-10 Nya pyrimidoner deras framstaellning och deras anvaendning saosom laekemedel FI813971L (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19803046871 DE3046871A1 (de)	1980-12-12	1980-12-12	Neue chinazolinone, ihre herstellung und ihre verwendung als arzneimittel
DE19813115447 DE3115447A1 (de)	1981-04-16	1981-04-16	Neue pyrimidinone, ihre herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number	Publication Date
FI813971A7 true FI813971A7 (fi)	1982-06-13
FI813971L FI813971L (fi)	1982-06-13

Family

ID=25789685

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI813971A FI813971L (fi)	1980-12-12	1981-12-10	Nya pyrimidoner deras framstaellning och deras anvaendning saosom laekemedel

Country Status (22)

Country	Link
US (1)	US4379788A (fi)
EP (1)	EP0054132B1 (fi)
AR (1)	AR227567A1 (fi)
AU (1)	AU543568B2 (fi)
CA (1)	CA1217767A (fi)
CS (1)	CS227024B2 (fi)
DD (1)	DD208151A5 (fi)
DE (1)	DE3166627D1 (fi)
DK (1)	DK525481A (fi)
ES (2)	ES8207156A1 (fi)
FI (1)	FI813971L (fi)
GB (1)	GB2090249B (fi)
GR (1)	GR76952B (fi)
HU (1)	HU187384B (fi)
IL (1)	IL64504A (fi)
MY (1)	MY8700562A (fi)
NO (1)	NO814239L (fi)
NZ (1)	NZ199254A (fi)
PH (1)	PH18930A (fi)
PL (1)	PL135330B1 (fi)
PT (1)	PT74116B (fi)
SU (1)	SU1056900A3 (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4460589A (en) *	1980-10-03	1984-07-17	The Upjohn Company	Process for treating hypertension
US4379778A (en) *	1980-10-10	1983-04-12	Air Products And Chemicals, Inc.	Hydrogen peroxide synthesis
DE3428476A1 (de) *	1984-08-02	1986-02-13	Basf Ag, 6700 Ludwigshafen	4h-pyrido(2,3-d)(1,3)oxazin-4-on-derivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
DE3631294A1 (de) *	1986-09-13	1988-03-24	Thomae Gmbh Dr K	Neue synergistische kombination bestehend aus einem phosphodiesterase-hemmer und einem thromboxan-a(pfeil abwaerts)2(pfeil abwaerts)-antagonisten und deren verwendung bzw. herstellung
US5037980A (en) *	1988-04-18	1991-08-06	American Cyanamid Company	Phenyl imidazo[1,2-a]pyrimidines
GB8928346D0 (en) *	1989-12-15	1990-02-21	Smith Kline French Lab	Chemical compounds
GB9126260D0 (en) *	1991-12-11	1992-02-12	Pfizer Ltd	Therapeutic agents
GB9404485D0 (en) *	1994-03-09	1994-04-20	Cancer Res Campaign Tech	Benzamide analogues
CA2309332C (en)	1997-11-12	2002-12-03	Bayer Aktiengesellschaft	2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
WO2000029389A1 (en) *	1998-11-18	2000-05-25	Elena Alexandrovna Izaxon	6-(3-carboxymethylphenyl)-aminouracyl having a biological activity
US20040102324A1 (en)	2002-02-28	2004-05-27	Annis Gary David	Heterocyclic diamide invertebrate pest control agents
US6642244B2 (en)	2001-03-16	2003-11-04	Bristol-Myers Squibb Co.	Pyrazolopyridopyrimidine inhibitors of cGMP phosphodiesterase
CN1518447A (zh) *	2001-04-23	2004-08-04	��Ǵ�ѧר��	作为抗血管生成剂的新的苯邻二甲酰亚胺模拟物的合成和评估
WO2002089808A1 (de) *	2001-05-09	2002-11-14	Bayer Healthcare Ag	Neue verwendung von 2-phenyl-substituierten imidazotriazinonen
DE10232113A1 (de) *	2002-07-16	2004-01-29	Bayer Ag	Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
CA2549641A1 (en) *	2003-12-19	2005-07-21	Merck & Co., Inc.	Mitotic kinesin inhibitors
SE0401342D0 (sv) *	2004-05-25	2004-05-25	Astrazeneca Ab	Therapeutic compounds
SE0401345D0 (sv) *	2004-05-25	2004-05-25	Astrazeneca Ab	Therapeutic compounds: Pyridine as scaffold
JPWO2005115993A1 (ja) *	2004-05-31	2008-03-27	萬有製薬株式会社	キナゾリン誘導体
DE102005001989A1 (de) *	2005-01-15	2006-07-20	Bayer Healthcare Ag	Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009240A1 (de) *	2005-03-01	2006-09-07	Bayer Healthcare Ag	Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
DE102005009241A1 (de) *	2005-03-01	2006-09-07	Bayer Healthcare Ag	Arzneiformen mit kontrollierter Bioverfügbarkeit
RU2435588C2 (ru) *	2005-09-29	2011-12-10	Байер Шеринг Фарма Акциенгезельшафт	Ингибиторы фдэ и их комбинации для лечения урологических расстройств
KR101129868B1 (ko) *	2006-10-04	2012-04-12	화이자 프로덕츠 인코포레이티드	칼슘 수용체 길항제로서의 피리도［4,3-ｄ］피리미딘-4(3Ｈ)-온 유도체
CA2689638A1 (en) *	2007-06-13	2008-12-18	Bayer Schering Pharma Aktiengesellschaft	Pde inhibitors for the treatment of hearing impairment
CN101531638B (zh) *	2008-03-13	2011-12-28	中国科学院广州生物医药与健康研究院	用作雌激素相关受体调节剂的化合物及其应用
WO2009139834A1 (en) *	2008-05-13	2009-11-19	Poniard Pharmaceuticals, Inc.	Bioactive compounds for treatment of cancer and neurodegenerative diseases
CN101628913B (zh)	2008-07-18	2013-01-23	中国科学院广州生物医药与健康研究院	用作雌激素相关受体调节剂的化合物及其应用
SG11201502120XA (en) *	2012-09-26	2015-04-29	Merck Patent Gmbh	Quinazolinone derivatives as parp inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3265697A (en) *	1964-09-04	1966-08-09	Shulton Inc	2-p-dialkylaminoalkoxyphenyl-2, 3-dihydro-4 (1h)-quinazolinones and their derivatives
DE1939109A1 (de) *	1968-08-31	1970-03-05	Troponwerke Dinklage & Co	2-Methyl-3-[2-(2-diaethylaminoaethoxy)-phenyl]-chinazolinon-(4) und Verfahren zu seiner Herstellung
US3862191A (en) *	1972-09-27	1975-01-21	Pfizer	Pyrido{8 2,3-d{9 pyrimidin-4(3H)-one

1981
- 1981-10-21 DE DE8181108623T patent/DE3166627D1/de not_active Expired
- 1981-10-21 EP EP81108623A patent/EP0054132B1/de not_active Expired
- 1981-11-18 SU SU813354550A patent/SU1056900A3/ru active
- 1981-11-26 DK DK525481A patent/DK525481A/da not_active Application Discontinuation
- 1981-12-04 US US06/327,348 patent/US4379788A/en not_active Expired - Fee Related
- 1981-12-07 DD DD81235494A patent/DD208151A5/de unknown
- 1981-12-07 ES ES507761A patent/ES8207156A1/es not_active Expired
- 1981-12-10 GR GR66768A patent/GR76952B/el unknown
- 1981-12-10 FI FI813971A patent/FI813971L/fi not_active Application Discontinuation
- 1981-12-10 CS CS819180A patent/CS227024B2/cs unknown
- 1981-12-10 IL IL64504A patent/IL64504A/xx unknown
- 1981-12-10 PL PL1981234175A patent/PL135330B1/pl unknown
- 1981-12-11 PT PT74116A patent/PT74116B/pt unknown
- 1981-12-11 NO NO814239A patent/NO814239L/no unknown
- 1981-12-11 AU AU78473/81A patent/AU543568B2/en not_active Ceased
- 1981-12-11 CA CA000392067A patent/CA1217767A/en not_active Expired
- 1981-12-11 HU HU813747A patent/HU187384B/hu unknown
- 1981-12-11 NZ NZ199254A patent/NZ199254A/en unknown
- 1981-12-11 GB GB8137458A patent/GB2090249B/en not_active Expired
- 1981-12-11 AR AR287776A patent/AR227567A1/es active
- 1981-12-11 PH PH26759A patent/PH18930A/en unknown
1982
- 1982-04-30 ES ES82511835A patent/ES8304096A1/es not_active Expired
1987
- 1987-12-30 MY MY562/87A patent/MY8700562A/xx unknown

Also Published As

Publication number	Publication date
IL64504A0 (en)	1982-03-31
ES507761A0 (es)	1982-09-01
DD208151A5 (de)	1984-03-28
GB2090249A (en)	1982-07-07
EP0054132B1 (de)	1984-10-10
US4379788A (en)	1983-04-12
MY8700562A (en)	1987-12-31
CA1217767A (en)	1987-02-10
AU543568B2 (en)	1985-04-26
NZ199254A (en)	1985-02-28
HU187384B (en)	1985-12-28
AR227567A1 (es)	1982-11-15
GB2090249B (en)	1984-08-22
GR76952B (fi)	1984-09-04
PL135330B1 (en)	1985-10-31
ES8207156A1 (es)	1982-09-01
PL234175A1 (fi)	1982-08-16
CS227024B2 (en)	1984-04-16
DE3166627D1 (en)	1984-11-15
PT74116A (de)	1982-01-01
NO814239L (no)	1982-06-14
DK525481A (da)	1982-06-13
IL64504A (en)	1985-02-28
FI813971L (fi)	1982-06-13
EP0054132A1 (de)	1982-06-23
ES511835A0 (es)	1983-02-16
PH18930A (en)	1985-11-11
ES8304096A1 (es)	1983-02-16
SU1056900A3 (ru)	1983-11-23
PT74116B (de)	1983-12-19
AU7847381A (en)	1982-06-17

Publication	Publication Date	Title
FI813971A7 (fi)	1982-06-13	Uusia pyrimidinoneja, niiden valmistus ja niiden käyttö lääkeaineina.
FI830378A7 (fi)	1983-08-07	Pyratsolioksatsiinit, -tiatsiinit, - kinoliinit, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeainlääkeaineina.
FI853626A7 (fi)	1986-03-23	Isoksatsolikarboksyylihappojohdannaiset, niiden valmistus ja käyttö.
FI822542A7 (fi)	1983-01-21	Virusvastainen menetelmä, koostumus ja tuote.
FI831457A7 (fi)	1983-10-31	1-sulfo-2-atsetidinon-johdannaiset, niiden valmistus ja käyttö.
FI831234A7 (fi)	1983-10-27	Uudet välituotteet, niiden valmistusmenetelmä ja niiden käyttö.
TR21476A (tr)	1984-07-04	Herbisidler olarak kullanilmaya elverisli n-fenilpirazol tuerevleri
FI830984A7 (fi)	1983-09-25	Uusi DNA ja sen käyttö.
FI845117A7 (fi)	1985-06-29	Uudet 2-fenyyli-imidatsolit, niiden valmistaminen ja näitä yhdisteitä sisältävät lääkeaineet.
FI830163A7 (fi)	1983-07-24	Fenyylietyleeni-johdannaisia, niiden valmistus ja käyttö lääkeaineina.
FI813934A7 (fi)	1982-06-11	Uusia fenyylialkyyliamiineja, niiden valmistus ja niiden käyttö lääkeaineina.
FI800770A7 (fi)	1981-01-01	Uudet indolijohdokset, niiden valmistaminen ja niiden käyttö lääkeaineina.
FI832575A7 (fi)	1984-01-20	Uusia 6,16- dimetyylikortikoideja, niiden valmistus ja käyttö.
FI803356A7 (fi)	1981-05-03	Uudet atsepinoindolit, niiden valmistus ja niitä sisältävät farmaseuttiset yhdisteet.
FI833075A7 (fi)	1984-03-02	2-nitro-1,1-eteenidiamiineja, menetelmiä niiden valmistamiseksi sekä niiden käyttö lääkeaineina.
FI823022A7 (fi)	1983-03-04	Amino-organoaminosilaanit, niiden valmistusmenetelmä ja niiden käyttö.
FI852657A7 (fi)	1986-01-06	Heterosyklisiä farmaseuttisia yhdisteitä, valmistus ja käyttö.
FI821824A7 (fi)	1982-11-23	Uusia karbasykliinejä, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä.
FI813289A7 (fi)	1982-04-24	Fosfonohydroksiasetonitriili, menetelmä sen valmistamiseksi ja sen käyttö välituotteena lääkeaineiden valmistuvalmistuksessa.
FI852647A7 (fi)	1986-01-05	3-aminokarbonyylimetoksi-5 -fenyylipyratsoliyhdisteet ja niiden valmistusmenetelmä sekä näitä yhdisteitä sisältävät lääkeaineet.
FI822616A0 (fi)	1982-07-26	Markerat, immunologiskt aktivt medel
NL7902863A (nl)	1979-10-15	7alpha-methoxycefalosporine verbindingen, hun gebruik en bereiding.
FI800350A7 (fi)	1981-01-01	Dehydropeptidejä, menetelmiä niiden valmistamiseksi sekä niiden käyttö lääkeaineina.
FI853621A7 (fi)	1986-03-23	Vinyylitetrasolyylifenyyli-johdannaisia, niiden valmistus ja käyttö.
FI792416A7 (fi)	1981-01-01	1-bentsoyyli-3-pyridinyyli-karbamideja, niiden käyttö, valmistus ja seoksia.

Legal Events

Date	Code	Title	Description
2004-08-31	FD	Application lapsed	Owner name: DR. KARL THOMAE GESELLSCHAFT MIT