[go: up one dir, main page]

FI811266L - ANTIHYPERTENSIVE LACTAMER - Google Patents

ANTIHYPERTENSIVE LACTAMER

Info

Publication number
FI811266L
FI811266L FI811266A FI811266A FI811266L FI 811266 L FI811266 L FI 811266L FI 811266 A FI811266 A FI 811266A FI 811266 A FI811266 A FI 811266A FI 811266 L FI811266 L FI 811266L
Authority
FI
Finland
Prior art keywords
unsubstituted
carbon atoms
alkyl
antihypertensive
lactamer
Prior art date
Application number
FI811266A
Other languages
Finnish (fi)
Other versions
FI811266A7 (en
Inventor
John Taiyoung Suh
Bruce Earl Williams
Jerry Wallace Skiles
Bernard Loev
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of FI811266A7 publication Critical patent/FI811266A7/en
Publication of FI811266L publication Critical patent/FI811266L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Antihypertensive compounds of the structure <CHEM> wherein n is the integer 1 or 2, R1, R2, R3, R4, R5, when taken separately are independently hydrogen, unsubstituted alkyl containing from 1 to 20 carbon atoms, unsubstituted alkenyl containing from 2 to 20 carbon atoms, unsubstituted alkynyl containing from 2 to 20 carbon atoms, R6 and R7 taken together with the carbon to which R6 is attached and the nitrogen to which R7 is attached form a substituted or unsubstituted heterocyclic ring, the substituents being alkyl, substituted alkyl, alkenyl, hydroxy, amino, nitro, carboxy, carbalkoxy, aryl, heteroaryl, or heterocycloalkyl, and Y is =O, =S, -NR1-, R1 being the same as defined herein.
FI811266A 1980-04-23 1981-04-23 ANTIHYPERTENSIVE LACTAMER FI811266L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/142,945 US4287203A (en) 1980-04-23 1980-04-23 Antihypertensive 1,4-thiazepine-ones, 1,4-thiazonine-ones, and method of use thereof

Publications (2)

Publication Number Publication Date
FI811266A7 FI811266A7 (en) 1981-10-24
FI811266L true FI811266L (en) 1981-10-24

Family

ID=22501906

Family Applications (1)

Application Number Title Priority Date Filing Date
FI811266A FI811266L (en) 1980-04-23 1981-04-23 ANTIHYPERTENSIVE LACTAMER

Country Status (14)

Country Link
US (1) US4287203A (en)
EP (2) EP0040332B1 (en)
JP (1) JPS56167676A (en)
AT (1) ATE22290T1 (en)
AU (1) AU546679B2 (en)
CA (1) CA1192188A (en)
DE (1) DE3175327D1 (en)
DK (1) DK182181A (en)
ES (1) ES8203358A1 (en)
FI (1) FI811266L (en)
IN (1) IN151285B (en)
NO (1) NO811376L (en)
NZ (1) NZ196909A (en)
ZA (1) ZA812673B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
DE3260831D1 (en) * 1981-06-05 1984-10-31 Merck & Co Inc Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives, process for preparing and pharmceutical composition containing the same
FR2525220A1 (en) * 1982-04-15 1983-10-21 Oreal NOVEL SUBSTITUTED THIAMORPHOLINONE DERIVATIVES AND METHODS FOR PREPARING THEM
SU1435151A3 (en) * 1984-04-10 1988-10-30 Санкио Компани Лимитед (Фирма) Method of producing derivatives of perhydrothiazepin or acid-additive pharmaceutically acceptable salts thereof
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071627A (en) * 1976-09-29 1978-01-31 Union Carbide Corporation 2-Oximino-tetrahydro-1,4-thiazin-5-one compounds and pesticidal carbamate derivatives
JPS5576888A (en) * 1978-12-04 1980-06-10 Yoshitomi Pharmaceut Ind Ltd Bicyclic hetero compound and its preparation
US4192945A (en) * 1978-12-07 1980-03-11 E. R. Squibb & Sons, Inc. Process for preparing proline and homoproline derivatives
JPS55100393A (en) * 1979-01-27 1980-07-31 Yoshitomi Pharmaceut Ind Ltd Hetero bicyclic compound and its preparation
EP0017390A3 (en) * 1979-03-23 1981-06-24 American Home Products Corporation Bicyclic oxo-thiolactones, pharmaceutical compositions containing them, processes for their preparation and compounds useful as intermediates for their preparation
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
IL60799A (en) * 1979-08-13 1985-12-31 American Home Prod Derivatives of 2,3-dihydro-1h-indole-2-carboxylic acids
US4251444A (en) * 1980-04-07 1981-02-17 American Home Products Corporation Thiazepino-[4,3-b]-isoquinoline-1,5-dione derivatives and precursors

Also Published As

Publication number Publication date
DE3175327D1 (en) 1986-10-23
FI811266A7 (en) 1981-10-24
ATE22290T1 (en) 1986-10-15
AU546679B2 (en) 1985-09-12
EP0127196A3 (en) 1985-09-25
JPS56167676A (en) 1981-12-23
EP0040332A1 (en) 1981-11-25
NZ196909A (en) 1986-04-11
NO811376L (en) 1981-10-26
EP0127196A2 (en) 1984-12-05
DK182181A (en) 1981-10-24
EP0040332B1 (en) 1986-09-17
ES502073A0 (en) 1982-04-01
ZA812673B (en) 1982-04-28
CA1192188A (en) 1985-08-20
AU6975881A (en) 1981-10-29
IN151285B (en) 1983-03-19
ES8203358A1 (en) 1982-04-01
US4287203A (en) 1981-09-01

Similar Documents

Publication Publication Date Title
ES470134A1 (en) Cyclohexane derivatives
ES474149A1 (en) Phenylethanolamine derivatives
HUP9802859A2 (en) Acylaminosalicylic acid amides and their uses as pesticides
ES397765A1 (en) 1,5-disubstituted-3-substituted phenyl hydantoins
DE69431576D1 (en) Isoxazole derivatives and their use as herbicides
EP0665208A4 (en)
ES440426A1 (en) Thienothiazines
MX9301045A (en) PROCEDURE FOR PREPARING FIBRINOGEN RECEIVING ANTAGONISTS.
ES8604543A1 (en) Piperazine derivatives with anticholinergic and/or antihistaminic activity
ES8102136A1 (en) 3-Vinyl-cephalosporin derivatives
IN165718B (en)
CO4910142A1 (en) FURANO NITRONA COMPOUNDS
ES2065994T3 (en) SUBSTITUTED BETA-DICETONES.
DK0841327T3 (en) Triazolant antifungal agent
SE8203877L (en) AMINOSULFONYLBENSOESYRADERIVAT
FI811266L (en) ANTIHYPERTENSIVE LACTAMER
MY101728A (en) Fungicides
ATE72435T1 (en) DERIVATIVES OF PHENYL-, PYRROLIDIN-2-YL-SUBSTITUTED 5-RINGED HETEROCYCLENE WITH ANTI-SYCHOTIC ACTIVITY.
PT70740B (en) DERIVATE DES 2-HYDROXY-NAPHTALINS UND IHRE VERWENDUNG ALS KUPPLINGSKOMPONENTE IN DIAZOTYPIEMATERIALEN
MY109714A (en) Process for preparing 8-chloroquinolone derivatives
IE780182L (en) N-9,10-DIHYDROLYSERGYL-m-AMINOBENZOIC ACID AMIDES.
DK165247C (en) 2,3,3,3-2,3,3,3-2,3,3-2,3,4-SUBLITIONATE 2,6 AND PHARMACEUTICALS CONTAINING THESE DERIVATIVES
SE7714407L (en) IMIDAZOLINES AND PROCEDURES FOR THE PREPARATION OF THEM
ES466682A1 (en) Organic compounds
ES2019904B3 (en) 4-AMINOPYRIMIDINE DERIVATIVE

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: USV PHARMACEUTICAL CORPORATION