FI47101C - Process for the preparation of therapeutically active alpha- (3-indolyl) -lower aliphatic acids. - Google Patents

Process for the preparation of therapeutically active alpha- (3-indolyl) -lower aliphatic acids.

Info

Publication number: FI47101C
Authority: FI; Finland
Prior art keywords: indolyl; preparation; therapeutically active; lower aliphatic; aliphatic acids
Prior art date: 1963-02-01

Application number

FI257570A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI47101B (en

Inventor

George Gal

Sletzinger

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1963-02-01

Filing date

1970-09-21

Publication date

1973-09-10

1970-09-21 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1973-05-31 Application granted granted Critical

1973-05-31 Publication of FI47101B publication Critical patent/FI47101B/fi

1973-09-10 Publication of FI47101C publication Critical patent/FI47101C/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI257570A 1963-02-01 1970-09-21 Process for the preparation of therapeutically active alpha- (3-indolyl) -lower aliphatic acids. FI47101C (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25564263A	1963-02-01	1963-02-01

Publications (2)

Publication Number	Publication Date
FI47101B FI47101B (en)	1973-05-31
FI47101C true FI47101C (en)	1973-09-10

Family

ID=22969254

Family Applications (9)

Application Number	Title	Priority Date	Filing Date
FI16964A FI46955C (en)	1963-02-01	1964-01-29	Process for the preparation of therapeutically active 1-p-chlorobenzoyl-2-lower alkyl-5-lower alkoxy-3-indolylacetic acid
FI257070A FI47097B (en)	1963-02-01	1970-09-21
FI702570A FI47097C (en)	1963-02-01	1970-09-21	Process for the preparation of therapeutically effective 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetic acid.
FI257470A FI47100C (en)	1963-02-01	1970-09-21	Process for the preparation of therapeutically active 1-p-chlorobenzoyl-2-lower-alkyl-5-lower-alkoxy-3-indolyl-acetic acid.
FI256870A FI47096C (en)	1963-02-01	1970-09-21	Process for the preparation of tert-butyl ester of therapeutically active alpha- (3-indolyl) lower aliphatic acids.
FI257270A FI47099C (en)	1963-02-01	1970-09-21	A process for preparing 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetic acid having anti-inflammatory, antipyretic and analgesic activity.
FI257170A FI47098C (en)	1963-02-01	1970-09-21	Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetaldehyde having an anti-inflammatory, antipyretic and analgesic effect.
FI257570A FI47101C (en)	1963-02-01	1970-09-21	Process for the preparation of therapeutically active alpha- (3-indolyl) -lower aliphatic acids.
FI257370A FI47185C (en)	1963-02-01	1970-09-21	Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-indole-3-ethanol with anti-inflammatory and antipyretic action.

Family Applications Before (7)

Application Number	Title	Priority Date	Filing Date
FI16964A FI46955C (en)	1963-02-01	1964-01-29	Process for the preparation of therapeutically active 1-p-chlorobenzoyl-2-lower alkyl-5-lower alkoxy-3-indolylacetic acid
FI257070A FI47097B (en)	1963-02-01	1970-09-21
FI702570A FI47097C (en)	1963-02-01	1970-09-21	Process for the preparation of therapeutically effective 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetic acid.
FI257470A FI47100C (en)	1963-02-01	1970-09-21	Process for the preparation of therapeutically active 1-p-chlorobenzoyl-2-lower-alkyl-5-lower-alkoxy-3-indolyl-acetic acid.
FI256870A FI47096C (en)	1963-02-01	1970-09-21	Process for the preparation of tert-butyl ester of therapeutically active alpha- (3-indolyl) lower aliphatic acids.
FI257270A FI47099C (en)	1963-02-01	1970-09-21	A process for preparing 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetic acid having anti-inflammatory, antipyretic and analgesic activity.
FI257170A FI47098C (en)	1963-02-01	1970-09-21	Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacetaldehyde having an anti-inflammatory, antipyretic and analgesic effect.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
FI257370A FI47185C (en)	1963-02-01	1970-09-21	Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy-indole-3-ethanol with anti-inflammatory and antipyretic action.

Country Status (11)

Country	Link
AT (1)	AT277992B (en)
BE (1)	BE643268A (en)
BR (1)	BR6456479D0 (en)
CH (16)	CH457435A (en)
DE (16)	DE1695492A1 (en)
DK (11)	DK109562C (en)
FI (9)	FI46955C (en)
FR (1)	FR1559559A (en)
GB (13)	GB1050739A (en)
NL (1)	NL6400813A (en)
SE (12)	SE302463B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU163233B (en) *	1970-07-31	1973-07-28
EP0347776B2 (en) *	1988-06-21	2002-07-10	Vita Zahnfabrik H. Rauter GmbH & Co. KG	Dispersed ceramic material
GB9518994D0 (en) *	1995-09-16	1995-11-15	Agrevo Uk Ltd	Fungicides

0
- GB GB1050728D patent/GB1050728A/en active Active
- GB GB1050734D patent/GB1050734A/en active Active
- GB GB1050736D patent/GB1050736A/en active Active
- GB GB1050732D patent/GB1050732A/en active Active
- GB GB1050735D patent/GB1050735A/en active Active
- GB GB1050740D patent/GB1050740A/en active Active
- GB GB1050733D patent/GB1050733A/en active Active
- GB GB1050731D patent/GB1050731A/en active Active
- GB GB1050737D patent/GB1050737A/en active Active
- GB GB1050730D patent/GB1050730A/en active Active
- GB GB1050729D patent/GB1050729A/en active Active
- GB GB1050738D patent/GB1050738A/en active Active
- GB GB1050739D patent/GB1050739A/en active Active
1964
- 1964-01-14 DE DE19641695492 patent/DE1695492A1/en active Pending
- 1964-01-24 DE DE19641695485 patent/DE1695485A1/en active Pending
- 1964-01-24 DE DE19641770116 patent/DE1770116A1/en active Pending
- 1964-01-24 DE DE19641793561 patent/DE1793561A1/en active Pending
- 1964-01-24 DE DE19641770132 patent/DE1770132A1/en active Pending
- 1964-01-24 DE DE19641695490 patent/DE1695490A1/en active Pending
- 1964-01-24 DE DE19641695493 patent/DE1695493A1/en active Pending
- 1964-01-24 DE DE19641695487 patent/DE1695487A1/en active Pending
- 1964-01-24 DE DE19641770802 patent/DE1770802A1/en active Pending
- 1964-01-24 DE DE19641470059D patent/DE1470059B1/en active Pending
- 1964-01-24 DE DE19641695486 patent/DE1695486A1/en active Pending
- 1964-01-24 DE DE19641695488 patent/DE1695488A1/en active Pending
- 1964-01-24 DE DE19641695484 patent/DE1695484A1/en active Pending
- 1964-01-24 DE DE19641695489 patent/DE1695489A1/en active Pending
- 1964-01-24 DE DE19641770134 patent/DE1770134A1/en active Pending
- 1964-01-24 DE DE19641695491 patent/DE1695491A1/en active Pending
- 1964-01-28 AT AT01821/67A patent/AT277992B/en not_active IP Right Cessation
- 1964-01-28 BR BR15647964A patent/BR6456479D0/en unknown
- 1964-01-29 FI FI16964A patent/FI46955C/en active
- 1964-01-31 SE SE89267A patent/SE302463B/xx unknown
- 1964-01-31 DK DK598265A patent/DK109562C/en active
- 1964-01-31 CH CH236068A patent/CH457435A/en unknown
- 1964-01-31 DK DK598765A patent/DK109334C/en active
- 1964-01-31 CH CH236268A patent/CH557815A/en not_active IP Right Cessation
- 1964-01-31 CH CH1674768A patent/CH466290A/en unknown
- 1964-01-31 CH CH444166A patent/CH466285A/en unknown
- 1964-01-31 SE SE123764A patent/SE307948B/xx unknown
- 1964-01-31 CH CH1674468A patent/CH466288A/en unknown
- 1964-01-31 CH CH236368A patent/CH457436A/en unknown
- 1964-01-31 SE SE88967A patent/SE317975B/xx unknown
- 1964-01-31 DK DK48964A patent/DK112238B/en unknown
- 1964-01-31 NL NL6400813A patent/NL6400813A/xx unknown
- 1964-01-31 FR FR1559559D patent/FR1559559A/fr not_active Expired
- 1964-01-31 CH CH236568A patent/CH464203A/en unknown
- 1964-01-31 CH CH236668A patent/CH457437A/en unknown
- 1964-01-31 CH CH235868A patent/CH457434A/en unknown
- 1964-01-31 CH CH1674568A patent/CH466289A/en unknown
- 1964-01-31 CH CH236468A patent/CH466283A/en unknown
- 1964-01-31 CH CH236168A patent/CH464202A/en unknown
- 1964-01-31 CH CH490368A patent/CH466287A/en unknown
- 1964-01-31 DK DK598565A patent/DK109514C/en active
- 1964-01-31 BE BE643268D patent/BE643268A/xx unknown
- 1964-01-31 CH CH419468A patent/CH466284A/en unknown
- 1964-01-31 CH CH490268A patent/CH466286A/en unknown
1965
- 1965-11-22 DK DK598365A patent/DK113501B/en unknown
- 1965-11-22 DK DK598965A patent/DK112314B/en unknown
- 1965-11-22 DK DK598465A patent/DK111751B/en unknown
- 1965-11-22 DK DK598665A patent/DK112239B/en unknown
- 1965-11-22 DK DK598865A patent/DK112313B/en unknown
1966
- 1966-02-23 DK DK93366A patent/DK112447B/en unknown
- 1966-02-23 DK DK93266A patent/DK112446B/en unknown
1967
- 1967-01-20 SE SE896/67A patent/SE320666B/xx unknown
- 1967-01-20 SE SE88867A patent/SE302132B/en unknown
- 1967-01-20 SE SE894/67A patent/SE320367B/xx unknown
- 1967-01-20 SE SE891/67A patent/SE304995B/xx unknown
- 1967-01-20 SE SE89367A patent/SE302133B/en unknown
- 1967-01-20 SE SE895/67A patent/SE320069B/xx unknown
- 1967-01-20 SE SE88667A patent/SE302130B/en unknown
- 1967-01-20 SE SE890/67A patent/SE307133B/xx unknown
- 1967-01-31 SE SE88767A patent/SE302131B/xx unknown
- 1967-02-23 CH CH115364A patent/CH489495A/en not_active IP Right Cessation
1970
- 1970-09-21 FI FI257070A patent/FI47097B/fi active
- 1970-09-21 FI FI702570A patent/FI47097C/en active
- 1970-09-21 FI FI257470A patent/FI47100C/en active
- 1970-09-21 FI FI256870A patent/FI47096C/en active
- 1970-09-21 FI FI257270A patent/FI47099C/en active
- 1970-09-21 FI FI257170A patent/FI47098C/en active
- 1970-09-21 FI FI257570A patent/FI47101C/en active
- 1970-09-21 FI FI257370A patent/FI47185C/en active

Also Published As

Publication number	Publication date
GB1050737A (en)
FI47185B (en)	1973-07-02
DK112447B (en)	1968-12-16
DE1695488A1 (en)	1970-09-17
FI46955B (en)	1973-05-02
CH557815A (en)	1975-01-15
GB1050740A (en)
DE1770802A1 (en)	1972-02-17
FI47096B (en)	1973-05-31
FR1559559A (en)	1969-03-14
DE1793561A1 (en)	1972-01-20
GB1050730A (en)
FI47100C (en)	1973-09-10
GB1050729A (en)
GB1050736A (en)
DK112239B (en)	1968-11-25
DK112313B (en)	1968-12-02
FI47098B (en)	1973-05-31
DE1695489A1 (en)	1970-08-13
DE1695493A1 (en)	1971-04-01
DE1695484A1 (en)	1971-04-15
CH457434A (en)	1968-06-15
SE304995B (en)	1968-10-14
SE317975B (en)	1969-12-01
SE302132B (en)	1968-07-08
DK112238B (en)	1968-11-25
BR6456479D0 (en)	1973-09-20
CH466285A (en)	1968-12-15
SE320367B (en)	1970-02-09
DK113501B (en)	1969-03-31
FI47096C (en)	1973-09-10
FI47185C (en)	1973-10-10
DE1695492A1 (en)	1971-04-01
DE1695487A1 (en)	1970-10-01
DE1770132A1 (en)	1971-09-30
CH466287A (en)	1968-12-15
DK109514C (en)	1968-05-06
DE1770116A1 (en)	1971-10-14
SE302133B (en)	1968-07-08
DE1470059B1 (en)	1970-01-29
DE1695491A1 (en)	1971-04-15
CH466284A (en)	1968-12-15
GB1050738A (en)
SE307133B (en)	1968-12-23
GB1050731A (en)
DE1770134A1 (en)	1971-09-30
SE320069B (en)	1970-02-02
DK111751B (en)	1968-10-07
SE307948B (en)	1969-01-27
SE302463B (en)	1968-07-22
DE1695485A1 (en)	1971-04-15
FI47099C (en)	1973-09-10
GB1050733A (en)
FI47100B (en)	1973-05-31
FI47099B (en)	1973-05-31
DE1695490A1 (en)	1971-04-15
DK112446B (en)	1968-12-16
CH457435A (en)	1968-06-15
FI47097B (en)	1973-05-31
CH466286A (en)	1968-12-15
CH466283A (en)	1968-12-15
NL6400813A (en)	1964-08-03
CH466290A (en)	1968-12-15
GB1050735A (en)
BE643268A (en)	1964-07-31
DK109334C (en)	1968-04-16
CH466289A (en)	1968-12-15
GB1050739A (en)
DK112314B (en)	1968-12-02
FI47098C (en)	1973-09-10
CH489495A (en)	1970-04-30
AT277992B (en)	1970-01-12
GB1050734A (en)
CH464202A (en)	1968-10-31
FI47097C (en)	1973-09-10
SE320666B (en)	1970-02-16
SE302131B (en)	1968-07-08
FI47101B (en)	1973-05-31
CH457436A (en)	1968-06-15
CH466288A (en)	1968-12-15
DE1695486A1 (en)	1971-04-15
SE302130B (en)	1968-07-08
DK109562C (en)	1968-05-13
GB1050728A (en)
CH457437A (en)	1968-06-15
CH464203A (en)	1968-10-31
GB1050732A (en)
FI46955C (en)	1973-08-10

Publication	Publication Date	Title
FI48460C (en)	1974-10-10	Process for the preparation of pharmacologically active novel amino-dihalophenylethylamines.
FI52858C (en)	1977-12-12	Process for the preparation of therapeutically active 1- (beta-aryl) ethylimidazole derivatives.
FI52335C (en)	1977-08-10	Process for the preparation of therapeutically active ethylamine derivatives.
FI44619C (en)	1971-12-10	Process for the preparation of novel therapeutically active substituted phenylacetic acids.
FI49512C (en)	1975-07-10	Process for the preparation of novel therapeutically active s-triazinyl-piperazine derivatives.
FI47365C (en)	1973-11-12	Process for the preparation of new therapeutically active indolder t.
FI52857C (en)	1977-12-12	Process for the preparation of therapeutically active amidoximes.
DK119877B (en)	1971-03-08	Analogous process for the preparation of therapeutically active carboxylic acids or pharmaceutically acceptable salts thereof.
FI46516C (en)	1973-04-10	Process for the preparation of an enzyme-containing detergent composition.
FI52076C (en)	1977-06-10	Process for the preparation of novel therapeutically active esters of trans-4-aminomethylcyclohexane-1-carboxylic acid and 4-aminomethylbenzoic acid.
FI45041C (en)	1972-03-10	Process for the preparation of therapeutically useful pyrrole derivatives.
FI49032C (en)	1975-03-10	Process for the preparation of therapeutically active 7-nitro-8-hydroxyquinoline esters.
FI46961C (en)	1973-08-10	Process for the preparation of therapeutically active 5-nitroimidazole bamates
FI47101C (en)	1973-09-10	Process for the preparation of therapeutically active alpha- (3-indolyl) -lower aliphatic acids.
FI47189C (en)	1973-10-10	Process for the preparation of therapeutically active d-lysergic acid-N-phenylpiperazides.
FI45043C (en)	1972-03-10	Process for the preparation of therapeutically active, substituted butynylsuccinimides and glutarimides.
FI48576C (en)	1974-11-11	Process for the preparation of therapeutically active alpha-fluoromalic acid derivatives.
FI45045C (en)	1972-03-10	Process for the preparation of novel therapeutically active 5-nitro-2-furyl-isoxazole derivatives.
FI49417C (en)	1975-06-10	Process for the preparation of pharmacologically active 2,3-dihydro-benz ofuran-2-carboxylic acids.
SE220242C1 (en)	1968-04-30	Process for the preparation of cytostatically active substituted 1-benzyl-2-methylhydrazines
FI50879C (en)	1976-08-10	Process for the preparation of therapeutically active substituted 3-aminoacylamino-thiophenes.
FI45954C (en)	1972-11-10	Process for the preparation of therapeutically active benzenesulfonylcuramides.
FI50875C (en)	1976-08-10	Process for the preparation of therapeutically active dihydro-2-aminoisoquinolines.
FI50243C (en)	1976-01-12	Process for the preparation of therapeutically active N-substituted 3-hydroxy-9-azamorfinan.
FI49162C (en)	1975-04-10	Process for the preparation of therapeutically useful 3-indolyl-aliphatic acid derivatives.