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FI20055253L - Analytical techniques for liquid chromatography/mass spectrometry - Google Patents

Analytical techniques for liquid chromatography/mass spectrometry Download PDF

Info

Publication number
FI20055253L
FI20055253L FI20055253A FI20055253A FI20055253L FI 20055253 L FI20055253 L FI 20055253L FI 20055253 A FI20055253 A FI 20055253A FI 20055253 A FI20055253 A FI 20055253A FI 20055253 L FI20055253 L FI 20055253L
Authority
FI
Finland
Prior art keywords
spectrum
liquid chromatography
mass spectrometry
peak
mass
Prior art date
Application number
FI20055253A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI20055253A7 (en
FI20055253A0 (en
Inventor
Matej Oresic
Mikko Katajamaa
Original Assignee
Valtion Teknillinen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valtion Teknillinen filed Critical Valtion Teknillinen
Priority to FI20055253A priority Critical patent/FI20055253L/en
Publication of FI20055253A0 publication Critical patent/FI20055253A0/en
Priority to PCT/FI2006/050208 priority patent/WO2006125863A1/en
Publication of FI20055253A7 publication Critical patent/FI20055253A7/en
Publication of FI20055253L publication Critical patent/FI20055253L/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8631—Peaks

Landscapes

  • Engineering & Computer Science (AREA)
  • Library & Information Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method for analyzing liquid chromatography/mass spectrometry [="CL/MS"] data comprises: preparing (1-2) a plurality of sample runs; processing (1-4) each of the prepared sample runs in an LC/MS spectrometer to obtain a spectrum in respect of each processed sample run; internally representing (1-10) each spectrum as a layout of mass/charge versus retention time; performing a first peak detection (1-12) to detect peaks of each spectrum; visualizing peaks of each spectrum, wherein the visualizing step comprises: mapping (1-22) each peak to be visualized to a coordinate system in which a first coordinate indicates mass/charge ratio and a second coordinate indicates retention time; and assigning (1-24) a specific visual attribute to each peak to be visualized.
FI20055253A 2005-05-26 2005-05-26 Analytical techniques for liquid chromatography/mass spectrometry FI20055253L (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI20055253A FI20055253L (en) 2005-05-26 2005-05-26 Analytical techniques for liquid chromatography/mass spectrometry
PCT/FI2006/050208 WO2006125863A1 (en) 2005-05-26 2006-05-24 Analysis techniques for liquid chromatography/mass spectrometry

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20055253A FI20055253L (en) 2005-05-26 2005-05-26 Analytical techniques for liquid chromatography/mass spectrometry

Publications (3)

Publication Number Publication Date
FI20055253A0 FI20055253A0 (en) 2005-05-26
FI20055253A7 FI20055253A7 (en) 2006-11-27
FI20055253L true FI20055253L (en) 2006-11-27

Family

ID=34630188

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20055253A FI20055253L (en) 2005-05-26 2005-05-26 Analytical techniques for liquid chromatography/mass spectrometry

Country Status (2)

Country Link
FI (1) FI20055253L (en)
WO (1) WO2006125863A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6152301B2 (en) * 2013-06-03 2017-06-21 国立医薬品食品衛生研究所長 Quantitation method and program
JP6213208B2 (en) * 2013-12-17 2017-10-18 株式会社島津製作所 Data output method and data output apparatus for printing apparatus
CN109507347B (en) * 2017-09-14 2021-01-29 湖南中烟工业有限责任公司 Chromatographic peak selection method
GB2598770B (en) * 2020-09-11 2024-01-17 Thermo Fisher Scient Bremen Gmbh Method of control of a spectrometer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5119315A (en) * 1989-04-28 1992-06-02 Amoco Corporation Method of correlating a record of sample data with a record of reference data
US5175430A (en) * 1991-05-17 1992-12-29 Meridian Instruments, Inc. Time-compressed chromatography in mass spectrometry
US5885841A (en) * 1996-09-11 1999-03-23 Eli Lilly And Company System and methods for qualitatively and quantitatively comparing complex admixtures using single ion chromatograms derived from spectroscopic analysis of such admixtures
US5905192A (en) * 1997-07-23 1999-05-18 Hewlett-Packard Company Method for identification of chromatographic peaks
US6835927B2 (en) * 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
US6989100B2 (en) * 2002-05-09 2006-01-24 Ppd Biomarker Discovery Sciences, Llc Methods for time-alignment of liquid chromatography-mass spectrometry data
US20040096982A1 (en) * 2002-11-19 2004-05-20 International Business Machines Corporation Methods and apparatus for analysis of mass spectra
US6906320B2 (en) * 2003-04-02 2005-06-14 Merck & Co., Inc. Mass spectrometry data analysis techniques
DE602004009091T2 (en) * 2004-12-15 2008-01-10 Agilent Technologies Inc., Santa Clara Calibration of peak pattern

Also Published As

Publication number Publication date
FI20055253A7 (en) 2006-11-27
FI20055253A0 (en) 2005-05-26
WO2006125863A1 (en) 2006-11-30

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