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FI20001192L - Substituoituja 2-(2,6-diokso-3-fluoropiperidin-3-yyli)-isoindoleja ja niiden käyttö TNF alfa-tasojen alentamiseksi - Google Patents

Substituoituja 2-(2,6-diokso-3-fluoropiperidin-3-yyli)-isoindoleja ja niiden käyttö TNF alfa-tasojen alentamiseksi Download PDF

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Publication number
FI20001192L
FI20001192L FI20001192A FI20001192A FI20001192L FI 20001192 L FI20001192 L FI 20001192L FI 20001192 A FI20001192 A FI 20001192A FI 20001192 A FI20001192 A FI 20001192A FI 20001192 L FI20001192 L FI 20001192L
Authority
FI
Finland
Prior art keywords
isoindoles
fluoropiperidin
dioxo
substituted
tnf alpha
Prior art date
Application number
FI20001192A
Other languages
English (en)
Swedish (sv)
Other versions
FI20001192A7 (fi
Inventor
George W Muller
Roger Shen-Chu Chen
David I Stirling
Hon-Wah Man
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/976,140 external-priority patent/US5874448A/en
Priority claimed from US09/042,274 external-priority patent/US5955476A/en
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of FI20001192L publication Critical patent/FI20001192L/fi
Publication of FI20001192A7 publication Critical patent/FI20001192A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI20001192A 1997-11-18 2000-05-18 Substituoituja 2-(2,6-diokso-3-fluoropiperidin-3-yyli)-isoindoleja ja niiden käyttö TNF alfa-tasojen alentamiseksi FI20001192A7 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/976,140 US5874448A (en) 1997-11-18 1997-11-18 Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
US09/042,274 US5955476A (en) 1997-11-18 1998-03-13 Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
PCT/US1998/024453 WO1999046258A1 (en) 1998-03-13 1998-11-17 SUBSTITUTED 2-(2,6-DIOXO-3-FLUOROPIPERIDIN-3-YL)-ISOINDOLINES AND THEIR USE TO REDUCE TNFα LEVELS

Publications (2)

Publication Number Publication Date
FI20001192L true FI20001192L (fi) 2000-07-14
FI20001192A7 FI20001192A7 (fi) 2000-07-14

Family

ID=26719049

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20001192A FI20001192A7 (fi) 1997-11-18 2000-05-18 Substituoituja 2-(2,6-diokso-3-fluoropiperidin-3-yyli)-isoindoleja ja niiden käyttö TNF alfa-tasojen alentamiseksi

Country Status (14)

Country Link
EP (3) EP1062214B1 (fi)
AT (2) ATE233753T1 (fi)
AU (1) AU752958B2 (fi)
CY (1) CY1106100T1 (fi)
CZ (1) CZ299808B6 (fi)
DE (2) DE69811962T2 (fi)
DK (1) DK1308444T3 (fi)
ES (2) ES2262753T3 (fi)
FI (1) FI20001192A7 (fi)
HK (1) HK1054381B (fi)
NO (1) NO318737B1 (fi)
PT (1) PT1308444E (fi)
SI (1) SI1308444T1 (fi)
SK (1) SK7382000A3 (fi)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060036124A (ko) * 1998-03-16 2006-04-27 셀진 코포레이션 염증성 사이토카인 억제제용2-(2,6-디옥소피페리딘-3-일)이소인돌린 유도체, 그제조방법 및 그 용도
US20050100529A1 (en) * 2003-11-06 2005-05-12 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014455A1 (en) * 1991-02-14 1992-09-03 The Rockefeller University METHOD FOR CONTROLLING ABNORMAL CONCENTRATION TNF α IN HUMAN TISSUES
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
DE4422237A1 (de) * 1994-06-24 1996-01-04 Gruenenthal Gmbh Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
CA2560523C (en) * 1996-07-24 2011-09-20 Celgene Corporation Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and -1-oxoisoindolines and method of reducing tnf.alpha. levels
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines

Also Published As

Publication number Publication date
EP1062214B1 (en) 2003-03-05
ATE233753T1 (de) 2003-03-15
DE69811962T2 (de) 2003-08-28
DK1308444T3 (da) 2006-09-18
EP1308444A1 (en) 2003-05-07
SK7382000A3 (en) 2000-12-11
DE69834668D1 (de) 2006-06-29
CY1106100T1 (el) 2011-06-08
EP1308444B1 (en) 2006-05-24
FI20001192A7 (fi) 2000-07-14
AU752958B2 (en) 2002-10-03
HK1054381B (en) 2006-10-13
ES2262753T3 (es) 2006-12-01
SI1308444T1 (sl) 2007-04-30
NO318737B1 (no) 2005-05-02
NO20002529D0 (no) 2000-05-16
EP1710242A1 (en) 2006-10-11
EP1062214A1 (en) 2000-12-27
ATE327228T1 (de) 2006-06-15
PT1308444E (pt) 2006-08-31
CZ299808B6 (cs) 2008-12-03
NO20002529L (no) 2000-06-30
DE69834668T2 (de) 2007-01-11
HK1054381A1 (en) 2003-11-28
AU1413899A (en) 1999-09-27
DE69811962D1 (de) 2003-04-10
ES2192342T3 (es) 2003-10-01
CZ20001822A3 (cs) 2000-11-15

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