FI114097B - Trisyklisiä 5,6-dihydro-9H-pyratsolo[3,4-c]-1,2,4-triatsolo[4,3-alfa]pyridiinejä - Google Patents

Trisyklisiä 5,6-dihydro-9H-pyratsolo[3,4-c]-1,2,4-triatsolo[4,3-alfa]pyridiinejä Download PDF

Info

Publication number: FI114097B
Authority: FI; Finland
Prior art keywords: pyrazolo; triazolo; pyridine; ethyl; cyclopentyl
Prior art date: 1995-06-06

Application number

FI974434A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI974434A0 (fi

FI974434L (fi

Inventor

Kelvin Cooper

Allen Jacob Duplantier

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-06

Filing date

1997-12-05

Publication date

2004-08-13

1997-12-05 Application filed by Pfizer filed Critical Pfizer

1997-12-05 Publication of FI974434A0 publication Critical patent/FI974434A0/fi

1997-12-05 Publication of FI974434L publication Critical patent/FI974434L/fi

2004-08-13 Application granted granted Critical

2004-08-13 Publication of FI114097B publication Critical patent/FI114097B/fi

Links

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101710111837 Cyclic phosphodiesterase Proteins 0.000 title 1
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125000000217 alkyl group Chemical group 0.000 claims abstract description 22
150000003839 salts Chemical class 0.000 claims abstract description 11
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IEEJXQNVBDRVOQ-UHFFFAOYSA-N 3,4,6,11,12-pentazatricyclo[7.3.0.02,6]dodeca-1,3,7,9,11-pentaene Chemical class C1=CC2=CN=NC2=C2N=NCN21 IEEJXQNVBDRVOQ-UHFFFAOYSA-N 0.000 claims abstract 2
150000001875 compounds Chemical class 0.000 claims description 60
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 38
-1 pyridine compound Chemical class 0.000 claims description 31
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108090001050 Phosphoric Diester Hydrolases Proteins 0.000 claims description 23
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 21
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
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230000002401 inhibitory effect Effects 0.000 claims description 5
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ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
241000124008 Mammalia Species 0.000 claims description 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
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125000002541 furyl group Chemical group 0.000 claims description 2
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150000002367 halogens Chemical class 0.000 claims description 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
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125000004076 pyridyl group Chemical group 0.000 claims description 2
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206010040070 Septic Shock Diseases 0.000 claims 2
AYSYSOQSKKDJJY-UHFFFAOYSA-N [1,2,4]triazolo[4,3-a]pyridine Chemical compound C1=CC=CN2C=NN=C21 AYSYSOQSKKDJJY-UHFFFAOYSA-N 0.000 claims 2
230000036303 septic shock Effects 0.000 claims 2
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125000002252 acyl group Chemical group 0.000 abstract description 2
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract description 2
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238000002360 preparation method Methods 0.000 description 22
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239000000203 mixture Substances 0.000 description 17
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Classifications

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- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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FI974434A 1995-06-06 1997-12-05 Trisyklisiä 5,6-dihydro-9H-pyratsolo[3,4-c]-1,2,4-triatsolo[4,3-alfa]pyridiinejä FI114097B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
IB9500429		1995-06-06
CA002223624A CA2223624C (en)	1995-06-06	1995-06-06	Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines
CA2223624		1995-06-06
PCT/IB1995/000429 WO1996039408A1 (en)	1995-06-06	1995-06-06	TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-α]PYRIDINES
HU9601541A HUP9601541A3 (en)	1995-06-06	1996-06-05	Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolol[4,3-a]-pyridines and pharmaceutical compositions containing them
HU9601541		1996-06-05

Publications (3)

Publication Number	Publication Date
FI974434A0 FI974434A0 (fi)	1997-12-05
FI974434L FI974434L (fi)	1997-12-05
FI114097B true FI114097B (fi)	2004-08-13

Family

ID=89994031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI974434A FI114097B (fi)	1995-06-06	1997-12-05	Trisyklisiä 5,6-dihydro-9H-pyratsolo[3,4-c]-1,2,4-triatsolo[4,3-alfa]pyridiinejä

Country Status (43)

Country	Link
US (1)	US6004974A (is)
EP (1)	EP0837860B1 (is)
JP (1)	JP3107827B2 (is)
KR (2)	KR100191972B1 (is)
CN (1)	CN1061044C (is)
AP (1)	AP609A (is)
AR (1)	AR002745A1 (is)
AT (1)	ATE214700T1 (is)
AU (1)	AU694871B2 (is)
BG (1)	BG62568B1 (is)
BR (1)	BR9602627A (is)
CA (1)	CA2223624C (is)
CO (1)	CO4700460A1 (is)
CZ (1)	CZ287251B6 (is)
DE (1)	DE69525978T2 (is)
DK (1)	DK0837860T3 (is)
DZ (1)	DZ2044A1 (is)
ES (1)	ES2172583T3 (is)
FI (1)	FI114097B (is)
HR (1)	HRP960268B1 (is)
HU (1)	HUP9601541A3 (is)
IL (1)	IL118485A (is)
IS (1)	IS1913B (is)
LV (1)	LV11620B (is)
MA (1)	MA23893A1 (is)
MX (1)	MX9709897A (is)
MY (1)	MY116527A (is)
NO (1)	NO306256B1 (is)
NZ (1)	NZ286734A (is)
OA (1)	OA10458A (is)
PL (1)	PL184195B1 (is)
PT (1)	PT837860E (is)
RO (1)	RO115881B1 (is)
RU (1)	RU2161158C2 (is)
SA (1)	SA96170065B1 (is)
SG (1)	SG54341A1 (is)
SI (1)	SI9600186A (is)
SK (1)	SK282167B6 (is)
TN (1)	TNSN96083A1 (is)
TR (1)	TR199600482A1 (is)
TW (1)	TW460469B (is)
WO (1)	WO1996039408A1 (is)
YU (1)	YU49346B (is)

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FR2792938B1 (fr) *	1999-04-28	2001-07-06	Warner Lambert Co	NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
EP1380585B1 (en) *	1999-04-30	2004-11-10	Pfizer Products Inc.	Pyrazolopyridinone as intermediate
US6326495B2 (en) *	1999-04-30	2001-12-04	Pfizer Inc.	Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
AU777012B2 (en)	1999-08-21	2004-09-30	Takeda Gmbh	Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
US6555572B2 (en)	2000-03-16	2003-04-29	Inflazyme Pharmaceuticals Ltd.	Benzylated PDE4 inhibitors
MXPA03010791A (es) *	2001-05-25	2004-03-02	Boehringer Ingelheim Pharma	Combinacion de inhibidor de pde4 y tiotropio a sus derivados para tratamiento de enfermedades obstructivas de vias respiratorias y de otras enfermedades inflamatorias.
PA8546001A1 (es) *	2001-05-25	2003-12-30	Pfizer	Un inhibidor de pde4 y un agente anticolinergico en combinacion para tratar enfermedades obstructivas de vias respiratorias
GB0122031D0 (en) *	2001-09-12	2001-10-31	Pfizer Ltd	Use of pde4 inhibitors in a dry powder inhaler
GB0129395D0 (en) *	2001-12-07	2002-01-30	Pfizer Ltd	Pharmaceutical combination
US20050107420A1 (en) *	2002-05-23	2005-05-19	Boehringe Ingelheim Pharma Gmbh & Co. Kg	Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases
JP2006522151A (ja)	2003-04-01	2006-09-28	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	不妊症におけるホスホジエステラーゼ阻害剤
WO2006075748A1 (ja) *	2005-01-17	2006-07-20	Santen Pharmaceutical Co., Ltd.	アレルギー性結膜疾患治療剤
WO2006135627A2 (en) *	2005-06-10	2006-12-21	Merck & Co., Inc.	Inhibitors of akt activity
WO2007045979A1 (en)	2005-10-19	2007-04-26	Ranbaxy Laboratories Limited	Pharmaceutical compositions of muscarinic receptor antagonists
ES2378281T3 (es)	2006-07-05	2012-04-10	Nycomed Gmbh	Combinación de atorvastatina con un inhibidor de fosfodiesterasa 4 para el tratamiento de neumopatías inflamatorias
EP2350084B1 (en) *	2008-10-17	2015-06-24	Boehringer Ingelheim International GmbH	Tetra-aza-heterocycles as phosphatidylinositol-3-kinases (pi3-kinases) inhibitor
JP5730896B2 (ja) *	2009-12-04	2015-06-10	ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ	トリシクロピラゾール誘導体
WO2013084182A1 (en)	2011-12-08	2013-06-13	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent

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US3697532A (en) *	1970-08-12	1972-10-10	Squibb & Sons Inc	5-methyldipyrazolo {8 3,4-b;3{40 ,4{40 -d{9 {0 pyridin-3(2h)-ones
SU1048746A1 (ru) *	1982-01-29	1987-12-30	Институт физико-органической химии и углехимии АН УССР	Гидробромид 8-адамантил-1,з-диметилимидазо 4,5-с имидазо 1,2-а пиридин-2-она,обладающий спазмолитическим действием
FR2579208B1 (fr) *	1985-03-22	1987-05-07	Sanofi Sa	Nouveaux derives de le 5-h pyrido (3', 4' : 4,5) pyrrolo (3,2-c) pyridine, leur procede de preparation et leur activite antitumorale
US4940715A (en) *	1988-05-17	1990-07-10	Kissei Pharmaceutical Co., Ltd.	5H-pyrazolo[4,3-A] quinolizin-5-one compounds exhibiting therapeutic activities
CA2030056C (en) *	1989-11-17	1995-10-17	Karl D. Hargrave	5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
BR9406946A (pt) *	1993-07-06	1996-08-06	Pfizer	Tetra-hidro-pirazolpiridinas bicíclicas
CA2143143A1 (en) *	1994-03-08	1995-09-09	Toshihiko Tanaka	3-phenylpyrrolidine derivatives

1995
- 1995-06-06 CA CA002223624A patent/CA2223624C/en not_active Expired - Fee Related
- 1995-06-06 AT AT95918707T patent/ATE214700T1/de not_active IP Right Cessation
- 1995-06-06 DK DK95918707T patent/DK0837860T3/da active
- 1995-06-06 SK SK718-96A patent/SK282167B6/sk unknown
- 1995-06-06 PT PT95918707T patent/PT837860E/pt unknown
- 1995-06-06 MX MX9709897A patent/MX9709897A/es unknown
- 1995-06-06 US US08/973,590 patent/US6004974A/en not_active Expired - Fee Related
- 1995-06-06 WO PCT/IB1995/000429 patent/WO1996039408A1/en not_active Ceased
- 1995-06-06 DE DE69525978T patent/DE69525978T2/de not_active Expired - Fee Related
- 1995-06-06 EP EP95918707A patent/EP0837860B1/en not_active Expired - Lifetime
- 1995-06-06 ES ES95918707T patent/ES2172583T3/es not_active Expired - Lifetime
- 1995-06-06 JP JP08511176A patent/JP3107827B2/ja not_active Expired - Fee Related
1996
- 1996-05-02 TW TW085105271A patent/TW460469B/zh not_active IP Right Cessation
- 1996-05-06 AP APAP/P/1996/000806A patent/AP609A/en active
- 1996-05-20 AR ARP960102626A patent/AR002745A1/es unknown
- 1996-05-27 PL PL96314459A patent/PL184195B1/pl not_active IP Right Cessation
- 1996-05-30 IL IL11848596A patent/IL118485A/xx not_active IP Right Cessation
- 1996-06-03 IS IS4350A patent/IS1913B/is unknown
- 1996-06-04 BR BR9602627A patent/BR9602627A/pt active Search and Examination
- 1996-06-04 LV LVP-96-174A patent/LV11620B/en unknown
- 1996-06-04 SA SA96170065A patent/SA96170065B1/ar unknown
- 1996-06-05 MY MYPI96002201A patent/MY116527A/en unknown
- 1996-06-05 AU AU54773/96A patent/AU694871B2/en not_active Ceased
- 1996-06-05 YU YU34696A patent/YU49346B/sh unknown
- 1996-06-05 RU RU96111027/04A patent/RU2161158C2/ru not_active IP Right Cessation
- 1996-06-05 MA MA24263A patent/MA23893A1/fr unknown
- 1996-06-05 HU HU9601541A patent/HUP9601541A3/hu unknown
- 1996-06-05 DZ DZ960088A patent/DZ2044A1/fr active
- 1996-06-05 CZ CZ19961626A patent/CZ287251B6/cs not_active IP Right Cessation
- 1996-06-05 TN TNTNSN96083A patent/TNSN96083A1/fr unknown
- 1996-06-05 NO NO962320A patent/NO306256B1/no unknown
- 1996-06-05 NZ NZ286734A patent/NZ286734A/en unknown
- 1996-06-05 KR KR1019960020169A patent/KR100191972B1/ko not_active Expired - Fee Related
- 1996-06-05 SG SG1996009983A patent/SG54341A1/en unknown
- 1996-06-05 BG BG100640A patent/BG62568B1/bg unknown
- 1996-06-06 SI SI9600186A patent/SI9600186A/sl not_active IP Right Cessation
- 1996-06-06 HR HR960268A patent/HRP960268B1/xx not_active IP Right Cessation
- 1996-06-06 TR TR96/00482A patent/TR199600482A1/xx unknown
- 1996-06-06 OA OA60834A patent/OA10458A/en unknown
- 1996-06-06 CN CN96107630A patent/CN1061044C/zh not_active Expired - Fee Related
- 1996-06-06 RO RO96-01157A patent/RO115881B1/ro unknown
- 1996-06-06 CO CO96029521A patent/CO4700460A1/es unknown
1997
- 1997-12-05 FI FI974434A patent/FI114097B/fi active
1998
- 1998-10-24 KR KR1019980044720A patent/KR100225719B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1996039408A1 (en)	1996-12-12
DK0837860T3 (da)	2002-05-27
SI9600186A (en)	1997-04-30
BR9602627A (pt)	1998-09-01
CZ287251B6 (en)	2000-10-11
HUP9601541A2 (en)	1997-02-28
BG100640A (bg)	1997-03-31
AR002745A1 (es)	1998-04-29
KR100191972B1 (ko)	1999-06-15
SK71896A3 (en)	1997-05-07
PL184195B1 (pl)	2002-09-30
CZ162696A3 (en)	1997-01-15
DE69525978D1 (de)	2002-04-25
TW460469B (en)	2001-10-21
CA2223624C (en)	2001-02-20
RU2161158C2 (ru)	2000-12-27
SG54341A1 (en)	1998-11-16
AP9600806A0 (en)	1996-07-31
HU9601541D0 (en)	1996-07-29
ES2172583T3 (es)	2002-10-01
TR199600482A1 (tr)	1997-03-21
DZ2044A1 (fr)	2002-07-21
TNSN96083A1 (fr)	2005-03-15
IL118485A (en)	2000-02-17
HRP960268A2 (en)	1997-08-31
NZ286734A (en)	1998-02-26
BG62568B1 (bg)	2000-02-29
AP609A (en)	1997-09-03
PL314459A1 (en)	1996-12-09
PT837860E (pt)	2002-07-31
SA96170065B1 (ar)	2005-12-21
FI974434A0 (fi)	1997-12-05
NO962320L (no)	1996-12-09
JPH10510242A (ja)	1998-10-06
EP0837860B1 (en)	2002-03-20
IS4350A (is)	1996-12-07
RO115881B1 (ro)	2000-07-28
MA23893A1 (fr)	1996-12-31
CN1142499A (zh)	1997-02-12
CA2223624A1 (en)	1996-12-12
SK282167B6 (sk)	2001-11-06
JP3107827B2 (ja)	2000-11-13
LV11620B (en)	1997-04-20
MX9709897A (es)	1998-03-31
KR100225719B1 (en)	1999-10-15
IS1913B (is)	2004-02-03
LV11620A (lv)	1996-12-20
CN1061044C (zh)	2001-01-24
YU34696A (sh)	1999-07-28
YU49346B (sh)	2005-07-19
OA10458A (en)	2002-03-27
ATE214700T1 (de)	2002-04-15
FI974434L (fi)	1997-12-05
KR970003440A (ko)	1997-01-28
HUP9601541A3 (en)	1997-05-28
EP0837860A1 (en)	1998-04-29
AU5477396A (en)	1996-12-19
NO306256B1 (no)	1999-10-11
NO962320D0 (no)	1996-06-05
HRP960268B1 (en)	2002-12-31
DE69525978T2 (de)	2002-12-19
US6004974A (en)	1999-12-21
IL118485A0 (en)	1996-09-12
MY116527A (en)	2004-02-28
CO4700460A1 (es)	1998-12-29
AU694871B2 (en)	1998-07-30

Publication	Publication Date	Title
FI114097B (fi)	2004-08-13	Trisyklisiä 5,6-dihydro-9H-pyratsolo[3,4-c]-1,2,4-triatsolo[4,3-alfa]pyridiinejä
US8138193B2 (en)	2012-03-20	Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
US6303613B1 (en)	2001-10-16	Aminopyrimidine derivatives, processes for their preparation, compositions containing them and their use as pharmaceuticals
AU2007275816A1 (en)	2008-01-24	1-hydroxy naphthyridine compounds as anti-HIV agents
TW201136936A (en)	2011-11-01	Pyrrolopyrazine kinase inhibitors
KR20100114095A (ko)	2010-10-22	피롤로피라진 키나아제 저해제
RU2656853C2 (ru)	2018-06-07	Пирроло[2,3-в]пиразины в качестве ингибиторов syk
US20090036482A1 (en)	2009-02-05	Imidazopyridine-derivatives as inductible no-synthase inhibitors
AU2005273867B2 (en)	2010-12-23	Benzothienopyridines for use as inhibitors of Eg5 kinesin
CA2540230A1 (en)	2005-07-07	Aminopyridine-derivatives as inductible no-synthase inhibitors
AP932A (en)	2001-02-02	Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
WO1998046611A1 (en)	1998-10-22	Compounds
WO2000006576A1 (en)	2000-02-10	Compounds
UA45961C2 (uk)	2002-05-15	ТРИЦИКЛІЧНІ 5,6-ДИГІДРО-9Н-ПІРАЗОЛО[3,4-с]-1,2,4-ТРИАЗОЛО[4,3-а]ПІРИДИНИ, СПОСІБ ІНГІБУВАННЯ ФОСФОДІЕСТЕРАЗИ (PDE) ТИПУ IV, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ
MXPA99009188A (en)	2001-12-04	Compounds