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FI103178B1 - Process for the preparation of aqueous liposome suspensions containing an active substance - Google Patents

Process for the preparation of aqueous liposome suspensions containing an active substance

Info

Publication number
FI103178B1
FI103178B1 FI916120A FI916120A FI103178B1 FI 103178 B1 FI103178 B1 FI 103178B1 FI 916120 A FI916120 A FI 916120A FI 916120 A FI916120 A FI 916120A FI 103178 B1 FI103178 B1 FI 103178B1
Authority
FI
Finland
Prior art keywords
preparation
suspensions containing
active substance
aqueous phase
liposome
Prior art date
Application number
FI916120A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI103178B (en
FI916120A0 (en
Inventor
Georg Roessling
Andreas Sachse
Hans-Joachim Schroeter
Claudia Sprenger
Cornelia Wawretschek
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6405285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI103178(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of FI916120A0 publication Critical patent/FI916120A0/en
Application granted granted Critical
Publication of FI103178B1 publication Critical patent/FI103178B1/en
Publication of FI103178B publication Critical patent/FI103178B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Described is a process for the preparation of aqueous liposome suspensions containing active substances, the suspensions being prepared from a solution of a liposome-forming substance, or mixture of such substances, in a lower alcohol with a maximum of three carbon atoms and an aqueous phase, the active ingredients being dissolved or suspended in the lipid solution and/or the aqueous phase. The process is characterized in that the aqueous phase is incorporated, by mixing, in the alcoholic solution and the lower alcohol removed by vacuum distillation and, if necessary, the liposome suspension freeze-dried.
FI916120A 1990-04-24 1991-12-23 Process for the preparation of aqueous liposome suspensions containing an active substance FI103178B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4013580A DE4013580A1 (en) 1990-04-24 1990-04-24 METHOD FOR THE PRODUCTION OF ACTIVE AQUEOUS LIPOSOME SUSPENSIONS
PCT/DE1991/000294 WO1991016039A1 (en) 1990-04-24 1991-04-04 Process for the preparation of aqueous liposome suspensions containing active substances

Publications (3)

Publication Number Publication Date
FI916120A0 FI916120A0 (en) 1991-12-23
FI103178B1 true FI103178B1 (en) 1999-05-14
FI103178B FI103178B (en) 1999-05-14

Family

ID=6405285

Family Applications (1)

Application Number Title Priority Date Filing Date
FI916120A FI103178B (en) 1990-04-24 1991-12-23 Process for the preparation of aqueous liposome suspensions containing an active substance

Country Status (15)

Country Link
EP (1) EP0478727B1 (en)
JP (1) JPH04506814A (en)
AT (1) ATE141503T1 (en)
AU (1) AU651969B2 (en)
CA (1) CA2041075A1 (en)
DE (2) DE4013580A1 (en)
DK (1) DK0478727T3 (en)
ES (1) ES2093701T3 (en)
FI (1) FI103178B (en)
HU (1) HU215960B (en)
IE (1) IE911350A1 (en)
NO (1) NO303481B1 (en)
PT (1) PT97468B (en)
WO (1) WO1991016039A1 (en)
ZA (1) ZA913091B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU667672B2 (en) * 1991-06-18 1996-04-04 Imarx Therapeutics, Inc. Novel liposomal drug delivery systems
EP0713387B1 (en) * 1993-08-06 1998-03-04 Opperbas Holding B.V. A method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
WO1995026205A1 (en) * 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes
AU2066897A (en) * 1996-03-27 1997-10-17 Ortho Pharmaceutical Corporation Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
RU2134967C1 (en) * 1997-05-30 1999-08-27 Шестаков Константин Алексеевич Method of preparing microcapsulated preparations containing pyrethroid insecticides
WO2000045791A2 (en) * 1999-02-08 2000-08-10 Alza Corporation Method for controlling liposome size
WO2004002453A1 (en) 2002-06-28 2004-01-08 Protiva Biotherapeutics Ltd. Method and apparatus for producing liposomes
CN103989633A (en) 2005-07-27 2014-08-20 普洛体维生物治疗公司 Systems and methods for manufacturing liposomes
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
EP4182297B1 (en) 2020-07-16 2025-09-03 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
CN118647600A (en) 2021-12-16 2024-09-13 爱康泰生治疗公司 Lipids for lipid nanoparticle formulation
CN114344291B (en) * 2022-02-16 2023-09-29 中南大学湘雅医院 Application of 4-phenyl-1H-pyrrole-3-carboxylic acid in preparation of medicine for treating osteoporosis and liposome

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3416978A1 (en) * 1983-05-12 1984-12-06 Stauffer Chemical Co., Westport, Conn. TRANSFORMATION OF EUKARYOTIC CELLS MEDIATED BY LIPOSOME
JPS607932A (en) * 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd Preparation of liposome
EP0158441B2 (en) * 1984-03-08 2001-04-04 Phares Pharmaceutical Research N.V. Liposome-forming composition
FR2634375B3 (en) * 1988-06-30 1991-07-05 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF DISPERSIBLE COLLOIDAL LIPID AMPHIPHILIC SYSTEMS IN THE FORM OF SUBMICRON LIPOSOMES
JP2554880B2 (en) * 1987-05-07 1996-11-20 ポーラ化成工業株式会社 Skin cosmetics

Also Published As

Publication number Publication date
DE59108097D1 (en) 1996-09-26
AU7593391A (en) 1991-11-07
HU215960B (en) 1999-03-29
JPH04506814A (en) 1992-11-26
HUT62457A (en) 1993-05-28
FI103178B (en) 1999-05-14
EP0478727B1 (en) 1996-08-21
CA2041075A1 (en) 1991-10-25
IE911350A1 (en) 1991-11-06
NO915012L (en) 1991-12-18
WO1991016039A1 (en) 1991-10-31
NO915012D0 (en) 1991-12-18
ZA913091B (en) 1992-12-30
DE4013580A1 (en) 1991-10-31
NO303481B1 (en) 1998-07-20
PT97468B (en) 1999-12-31
FI916120A0 (en) 1991-12-23
EP0478727A1 (en) 1992-04-08
HU9200235D0 (en) 1992-04-28
ATE141503T1 (en) 1996-09-15
PT97468A (en) 1992-01-31
AU651969B2 (en) 1994-08-11
DK0478727T3 (en) 1997-01-20
ES2093701T3 (en) 1997-01-01

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