FI102388B1 - Process for the preparation of vancomycin - Google Patents
Process for the preparation of vancomycinInfo
- Publication number
- FI102388B1 FI102388B1 FI913586A FI913586A FI102388B1 FI 102388 B1 FI102388 B1 FI 102388B1 FI 913586 A FI913586 A FI 913586A FI 913586 A FI913586 A FI 913586A FI 102388 B1 FI102388 B1 FI 102388B1
- Authority
- FI
- Finland
- Prior art keywords
- pct
- fermentation
- micropolyspora
- ncaim
- sec
- Prior art date
Links
- 108010059993 Vancomycin Proteins 0.000 title abstract 3
- 229960003165 vancomycin Drugs 0.000 title abstract 3
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 238000000855 fermentation Methods 0.000 abstract 3
- 230000004151 fermentation Effects 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 241000187654 Nocardia Species 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- 235000010755 mineral Nutrition 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 abstract 2
- 229920002472 Starch Polymers 0.000 abstract 1
- 238000010564 aerobic fermentation Methods 0.000 abstract 1
- 229940126575 aminoglycoside Drugs 0.000 abstract 1
- 229960004494 calcium gluconate Drugs 0.000 abstract 1
- 239000004227 calcium gluconate Substances 0.000 abstract 1
- 235000013927 calcium gluconate Nutrition 0.000 abstract 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 abstract 1
- 235000013312 flour Nutrition 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000001223 reverse osmosis Methods 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/867—Micromonospora
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
PCT No. PCT/HU90/00079 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed Nov. 27, 1990 PCT Pub. No. WO91/08300 PCT Pub. Date Jun. 13, 1991.The invention relates to a process for preparation of the vancomycin antibiotic in a microbiological way by aerobic fermentation, by using a strain belonging to the Micropolyspora species in a culture-medium containing assimilable carbon and nitrogen sources as well as mineral salts. According to the invention as microorganisms the aminoglycoside-resistant NCAIM 001092 and NCAIM 001093 mutants of the strain belonging to the Micropolyspora orientalis species are used. Nitrates are suitable mineral salts in the fermentation. Soy flour, glycerol, calcium gluconate, starch are useful carbon sources. The fermentation is carried out preferably at a temperature of 29 DEG -30 DEG C. The vancomycin antibiotic produced in the fermentation is separated by using reverse osmosis and ultrafiltration following ion-exchange chromatography.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU896184A HU205971B (en) | 1989-11-27 | 1989-11-27 | Process for producing vancomycin |
| HU618489 | 1989-11-27 | ||
| HU9000079 | 1990-11-27 | ||
| PCT/HU1990/000079 WO1991008300A1 (en) | 1989-11-27 | 1990-11-27 | Process for the preparation of vancomycin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI913586A0 FI913586A0 (en) | 1991-07-26 |
| FI102388B1 true FI102388B1 (en) | 1998-11-30 |
| FI102388B FI102388B (en) | 1998-11-30 |
Family
ID=10971323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI913586A FI102388B (en) | 1989-11-27 | 1991-07-26 | Method for preparing vancomycin |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5223413A (en) |
| EP (1) | EP0455772B1 (en) |
| JP (1) | JP2577133B2 (en) |
| KR (1) | KR920701462A (en) |
| AT (1) | ATE126539T1 (en) |
| AU (1) | AU647757B2 (en) |
| BR (1) | BR9007082A (en) |
| CA (1) | CA2045483A1 (en) |
| DE (1) | DE69021716T2 (en) |
| DK (1) | DK0455772T3 (en) |
| ES (1) | ES2075903T3 (en) |
| FI (1) | FI102388B (en) |
| GR (1) | GR1000960B (en) |
| HU (1) | HU205971B (en) |
| NO (1) | NO180382C (en) |
| WO (1) | WO1991008300A1 (en) |
| ZA (1) | ZA909528B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI9500039B (en) * | 1995-02-07 | 2002-02-28 | Lek, | Novel combined process for purification of vancomicyn hydrochloride |
| KR100419707B1 (en) * | 1995-12-29 | 2004-06-12 | 씨제이 주식회사 | Purification of Vancomycin by Preparative Reverse Phase High Pressure Liquid Chromatography |
| KR100385152B1 (en) * | 2001-03-14 | 2003-05-23 | 씨제이 주식회사 | Process for the purification of capreomycin |
| TWI233932B (en) | 2001-08-24 | 2005-06-11 | Theravance Inc | Process for purifying glycopeptide phosphonate derivatives |
| KR100554481B1 (en) * | 2004-06-30 | 2006-03-03 | 씨제이 주식회사 | Purification Method of Vancomycin Hydrochloride |
| CN101031582B (en) * | 2004-10-27 | 2012-10-24 | 克利亚制药股份公司 | Purification of glycopeptides |
| EP1798237A1 (en) * | 2005-12-16 | 2007-06-20 | Pharmatex Italia Srl | Process for the purification of macrolide antibiotics |
| GB0814830D0 (en) * | 2008-08-13 | 2008-09-17 | Univ Cardiff | Antimicrobial agent and method for the production thereof |
| KR101101663B1 (en) * | 2009-01-13 | 2011-12-30 | (주) 제노텍 | Purification method of vancomycin |
| CN104610434B (en) * | 2013-11-01 | 2019-06-07 | 浙江医药股份有限公司新昌制药厂 | A kind of isolation and purification method of vancomycin hydrochloride |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3067099A (en) | 1955-09-16 | 1962-12-04 | Lilly Co Eli | Vancomycin and method for its preparation |
| US4400753A (en) | 1981-06-19 | 1983-08-23 | International Business Machines Corporation | Universal magnetic recording disk cartridge |
| JPS58194689A (en) * | 1982-05-08 | 1983-11-12 | Mitsui Eng & Shipbuild Co Ltd | Manufacture of propeller for ship |
| US4549925A (en) * | 1982-11-22 | 1985-10-29 | King Instrument Corporation | Splicer plunger assembly |
| US4558009A (en) * | 1982-12-20 | 1985-12-10 | Eli Lilly And Company | Process for producing antibiotic A-51568 by fermentation and microorganism |
| IL70441A (en) * | 1982-12-20 | 1986-11-30 | Lilly Co Eli | Antibiotic a 51568 factors a and b and process for production thereof |
| US4667024A (en) | 1983-07-13 | 1987-05-19 | Smithkline Beckman Corporation | Process for the preparation of purified vancomycin class antibiotics |
| US4558008A (en) * | 1983-12-13 | 1985-12-10 | Eli Lilly And Company | Process for production of A-51568B antibiotic |
| US4548924A (en) * | 1984-04-16 | 1985-10-22 | Eli Lilly And Company | Antibiotics M43B and M43C, pharmaceutical composition and method of use |
| US4548925A (en) * | 1984-04-16 | 1985-10-22 | Eli Lilly And Company | Antibiotic M43A, pharmaceutical composition and method of use |
| JPH0662674B2 (en) * | 1985-01-11 | 1994-08-17 | 三共株式会社 | Antibiotics chloropolysporin B or C |
| JPS61214694A (en) * | 1985-03-18 | 1986-09-24 | インタ−ナショナル ビジネス マシ−ンズ コ−ポレ−ション | Switching unit for data transmission |
| GB8600952D0 (en) * | 1986-01-16 | 1986-02-19 | Glaxo Group Ltd | Antibiotic production |
| US4946941A (en) * | 1986-01-24 | 1990-08-07 | Shionogi & Co., Ltd. | Novel glycopeptide antibiotics |
| GB8608798D0 (en) * | 1986-04-11 | 1986-05-14 | Lepetit Spa | Recovery of glycopeptide antibiotics from aqueous solutions |
| EG18377A (en) * | 1986-09-19 | 1993-04-30 | Lilly Co Eli | Process for preparing glycopeptide antibiotics |
| US4845194A (en) * | 1987-02-27 | 1989-07-04 | Eli Lilly And Company | Glycopeptide recovery process |
-
1989
- 1989-11-15 JP JP2500264A patent/JP2577133B2/en not_active Expired - Lifetime
- 1989-11-27 HU HU896184A patent/HU205971B/en not_active IP Right Cessation
-
1990
- 1990-11-27 US US07/768,444 patent/US5223413A/en not_active Expired - Fee Related
- 1990-11-27 DK DK90917220.7T patent/DK0455772T3/en active
- 1990-11-27 WO PCT/HU1990/000079 patent/WO1991008300A1/en not_active Ceased
- 1990-11-27 ZA ZA909528A patent/ZA909528B/en unknown
- 1990-11-27 ES ES90917220T patent/ES2075903T3/en not_active Expired - Lifetime
- 1990-11-27 CA CA002045483A patent/CA2045483A1/en not_active Abandoned
- 1990-11-27 DE DE69021716T patent/DE69021716T2/en not_active Expired - Fee Related
- 1990-11-27 GR GR900100826A patent/GR1000960B/en unknown
- 1990-11-27 AT AT90917220T patent/ATE126539T1/en not_active IP Right Cessation
- 1990-11-27 BR BR909007082A patent/BR9007082A/en not_active Application Discontinuation
- 1990-11-27 AU AU67549/90A patent/AU647757B2/en not_active Ceased
- 1990-11-27 EP EP90917220A patent/EP0455772B1/en not_active Expired - Lifetime
-
1991
- 1991-07-19 NO NO912832A patent/NO180382C/en unknown
- 1991-07-26 FI FI913586A patent/FI102388B/en active
- 1991-07-27 KR KR1019910700801A patent/KR920701462A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69021716T2 (en) | 1996-02-22 |
| NO180382C (en) | 1997-04-09 |
| HU896184D0 (en) | 1990-02-28 |
| DK0455772T3 (en) | 1995-09-18 |
| DE69021716D1 (en) | 1995-09-21 |
| WO1991008300A1 (en) | 1991-06-13 |
| ZA909528B (en) | 1991-10-30 |
| EP0455772A1 (en) | 1991-11-13 |
| KR920701462A (en) | 1992-08-11 |
| ATE126539T1 (en) | 1995-09-15 |
| CA2045483A1 (en) | 1991-05-28 |
| AU647757B2 (en) | 1994-03-31 |
| FI102388B (en) | 1998-11-30 |
| GR1000960B (en) | 1993-03-16 |
| HUT55837A (en) | 1991-06-28 |
| BR9007082A (en) | 1991-12-24 |
| JPH05501358A (en) | 1993-03-18 |
| US5223413A (en) | 1993-06-29 |
| AU6754990A (en) | 1991-06-26 |
| NO912832D0 (en) | 1991-07-19 |
| GR900100826A (en) | 1992-04-17 |
| EP0455772B1 (en) | 1995-08-16 |
| FI913586A0 (en) | 1991-07-26 |
| JP2577133B2 (en) | 1997-01-29 |
| ES2075903T3 (en) | 1995-10-16 |
| NO912832L (en) | 1991-09-24 |
| HU205971B (en) | 1992-07-28 |
| NO180382B (en) | 1996-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK |