FI101700B1 - Menetelmä terapeuttisesti käyttökelpoisen, optisesti aktiivisen 2-amino-N-(2,6-dimetyylifenyyli)-N-[3-(3-pyridyyli)-propyyli]propanamidin happoadditiosuolan valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisen, optisesti aktiivisen 2-amino-N-(2,6-dimetyylifenyyli)-N-[3-(3-pyridyyli)-propyyli]propanamidin happoadditiosuolan valmistamiseksiInfo
- Publication number
- FI101700B1 FI101700B1 FI913774A FI913774A FI101700B1 FI 101700 B1 FI101700 B1 FI 101700B1 FI 913774 A FI913774 A FI 913774A FI 913774 A FI913774 A FI 913774A FI 101700 B1 FI101700 B1 FI 101700B1
- Authority
- FI
- Finland
- Prior art keywords
- acid addition
- optically active
- propanamide
- dimethylphenyl
- pyridyl
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 2
- -1 2,6-dimethylphenyl Chemical group 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000005425 toluyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21120890 | 1990-08-08 | ||
| JP2211208A JP2514855B2 (ja) | 1990-08-08 | 1990-08-08 | 光学活性なアラニンアニリド誘導体の酸付加塩 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI913774A0 FI913774A0 (fi) | 1991-08-08 |
| FI913774L FI913774L (fi) | 1992-02-09 |
| FI101700B FI101700B (fi) | 1998-08-14 |
| FI101700B1 true FI101700B1 (fi) | 1998-08-14 |
Family
ID=16602123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI913774A FI101700B1 (fi) | 1990-08-08 | 1991-08-08 | Menetelmä terapeuttisesti käyttökelpoisen, optisesti aktiivisen 2-amino-N-(2,6-dimetyylifenyyli)-N-[3-(3-pyridyyli)-propyyli]propanamidin happoadditiosuolan valmistamiseksi |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0472325B1 (fi) |
| JP (1) | JP2514855B2 (fi) |
| KR (1) | KR100192531B1 (fi) |
| AT (1) | ATE116296T1 (fi) |
| AU (1) | AU646276B2 (fi) |
| CA (1) | CA2048714A1 (fi) |
| DE (1) | DE69106276T2 (fi) |
| DK (1) | DK143991A (fi) |
| ES (1) | ES2066363T3 (fi) |
| FI (1) | FI101700B1 (fi) |
| HK (1) | HK1003787A1 (fi) |
| HU (1) | HU213210B (fi) |
| NO (1) | NO913004D0 (fi) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9320273D0 (en) * | 1993-04-01 | 1993-11-17 | Fisons Corp | Compound useful in therapy |
| ZA942140B (en) * | 1993-04-01 | 1994-10-03 | Fisons Corp | Salt of (S)-alpha-phenyl-2-pyridineethanamine useful in therapy |
| PE20120249A1 (es) | 2008-12-24 | 2012-04-19 | Astrazeneca Ab | Compuestos etanaminicos |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE786875A (fr) * | 1971-07-28 | 1973-01-29 | Astra Pharma Prod | Amide, methode pour sa preparation et ses compositions therapeutiques |
| US4696930A (en) * | 1985-04-12 | 1987-09-29 | Hoffmann-La Roche Inc. | N-(heteroarylalkyl)acylanilide derivatives as antiarrhythmic agents |
| JPS6452797A (en) * | 1987-01-06 | 1989-02-28 | Takeda Chemical Industries Ltd | Production of crystalline trh-tartrate |
-
1990
- 1990-08-08 JP JP2211208A patent/JP2514855B2/ja not_active Expired - Lifetime
-
1991
- 1991-07-30 AU AU81458/91A patent/AU646276B2/en not_active Ceased
- 1991-08-01 NO NO913004A patent/NO913004D0/no unknown
- 1991-08-07 HU HU912640A patent/HU213210B/hu not_active IP Right Cessation
- 1991-08-07 ES ES91307249T patent/ES2066363T3/es not_active Expired - Lifetime
- 1991-08-07 AT AT91307249T patent/ATE116296T1/de not_active IP Right Cessation
- 1991-08-07 KR KR1019910013652A patent/KR100192531B1/ko not_active Expired - Fee Related
- 1991-08-07 EP EP91307249A patent/EP0472325B1/en not_active Expired - Lifetime
- 1991-08-07 DE DE69106276T patent/DE69106276T2/de not_active Expired - Fee Related
- 1991-08-07 DK DK143991A patent/DK143991A/da not_active Application Discontinuation
- 1991-08-08 FI FI913774A patent/FI101700B1/fi active
- 1991-08-08 CA CA002048714A patent/CA2048714A1/en not_active Abandoned
-
1998
- 1998-04-02 HK HK98102795A patent/HK1003787A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO913004D0 (no) | 1991-08-01 |
| FI913774L (fi) | 1992-02-09 |
| ES2066363T3 (es) | 1995-03-01 |
| DK143991D0 (da) | 1991-08-07 |
| FI101700B (fi) | 1998-08-14 |
| DE69106276D1 (de) | 1995-02-09 |
| HU912640D0 (en) | 1992-01-28 |
| FI913774A0 (fi) | 1991-08-08 |
| DK143991A (da) | 1992-02-09 |
| EP0472325A3 (en) | 1992-03-04 |
| KR920004334A (ko) | 1992-03-27 |
| KR100192531B1 (ko) | 1999-06-15 |
| HK1003787A1 (en) | 1998-11-06 |
| EP0472325A2 (en) | 1992-02-26 |
| HUT58292A (en) | 1992-02-28 |
| HU213210B (en) | 1997-03-28 |
| ATE116296T1 (de) | 1995-01-15 |
| EP0472325B1 (en) | 1994-12-28 |
| JPH0495072A (ja) | 1992-03-27 |
| DE69106276T2 (de) | 1995-05-18 |
| CA2048714A1 (en) | 1992-02-09 |
| AU8145891A (en) | 1992-02-13 |
| AU646276B2 (en) | 1994-02-17 |
| JP2514855B2 (ja) | 1996-07-10 |
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