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ES8900272A1 - Pyridazo-(1,2-A)(1,2)-diazepine-1-carboxylic acid derivs. - Google Patents

Pyridazo-(1,2-A)(1,2)-diazepine-1-carboxylic acid derivs.

Info

Publication number
ES8900272A1
ES8900272A1 ES557864A ES557864A ES8900272A1 ES 8900272 A1 ES8900272 A1 ES 8900272A1 ES 557864 A ES557864 A ES 557864A ES 557864 A ES557864 A ES 557864A ES 8900272 A1 ES8900272 A1 ES 8900272A1
Authority
ES
Spain
Prior art keywords
pyridazo
formula
diazepine
carboxylic acid
acid derivs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557864A
Other languages
Spanish (es)
Other versions
ES557864A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB08516606A external-priority patent/GB2160857B/en
Priority claimed from GB868609591A external-priority patent/GB8609591D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8900272A1 publication Critical patent/ES8900272A1/en
Publication of ES557864A0 publication Critical patent/ES557864A0/en
Expired legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PREPARACION DE DERIVADOS DE PIRIDAZO [1,2-A][1,2] DIACEPINA DE FORMULA I, DONDE R1, R2, R3, R4, R5, R6 Y X TIENEN EL SIGNIFICADO DESCRITO EN LA MEMORIA, SE REALIZA DESESTERIFICANDO EL COMPUESTO CORRESPONDIENTE DE FORMULA I, PERO DONDE R1 PUEDE REPRESENTAR ALCOXILO O ARALCOXILO Y R2 REPRESENTA ALQUILO O ARALQUILO, MEDIANTE TRATAMIENTO CON BROMURO DE TRIMETILSILILO A UNA TEMPERATURA CERCANA A LA AMBIENTE. LOS COMPUESTOS ASI OBTENIDOS INHIBEN EL ENZIMA QUE CONVIERTE ANGIOTENSINA I EN ANGIOTENSINA II (ACE), Y SIN, POR ELLO, UTILES COMO AGENTES ANTIHIPERTENSIVOS. *FORMULA*THE PREPARATION OF DERIVATIVES OF PYRIDAZO [1,2-A] [1,2] DIACEPINE OF FORMULA I, WHERE R1, R2, R3, R4, R5, R6 AND X HAVE THE MEANING DESCRIBED IN THE MEMORY, IT IS CARRIED OUT BY DESTERIFYING THE CORRESPONDING COMPOUND OF FORMULA I, BUT WHERE R1 CAN REPRESENT ALCOXYL OR ARALCOXYL AND R2 REPRESENTS ALKYL OR ARALKYL, THROUGH TREATMENT WITH TRIMETHYLSILYL BROMIDE AT A TEMPERATURE CLOSE TO ROOM. THE COMPOUNDS SO OBTAINED INHIBIT THE ENZYME THAT CONVERTS ANGIOTENSIN I INTO ANGIOTENSIN II (ACE), AND WITHOUT, THEREFORE, USEFUL AS ANTIHYPERTENSIVE AGENTS. *FORMULA*

ES557864A 1985-07-01 1989-01-02 Pyridazo-(1,2-A)(1,2)-diazepine-1-carboxylic acid derivs. Expired ES8900272A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB08516606A GB2160857B (en) 1984-06-29 1985-07-01 Explosive compositions
GB868609591A GB8609591D0 (en) 1985-07-01 1986-04-18 Pyridazodiazepine derivatives

Publications (2)

Publication Number Publication Date
ES8900272A1 true ES8900272A1 (en) 1989-10-16
ES557864A0 ES557864A0 (en) 1989-10-16

Family

ID=26289447

Family Applications (3)

Application Number Title Priority Date Filing Date
ES557863A Expired ES8900271A1 (en) 1985-07-01 1989-01-02 Pyridazo-(1,2-A)(1,2)-diazepine-1-carboxylic acid derivs.
ES557862A Expired ES9000008A1 (en) 1985-07-01 1989-01-02 A PROCEDURE FOR OBTAINING DERIVATIVES OF PIRIDAZO (1,2-A) (1,2) DIACEPINE
ES557864A Expired ES8900272A1 (en) 1985-07-01 1989-01-02 Pyridazo-(1,2-A)(1,2)-diazepine-1-carboxylic acid derivs.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES557863A Expired ES8900271A1 (en) 1985-07-01 1989-01-02 Pyridazo-(1,2-A)(1,2)-diazepine-1-carboxylic acid derivs.
ES557862A Expired ES9000008A1 (en) 1985-07-01 1989-01-02 A PROCEDURE FOR OBTAINING DERIVATIVES OF PIRIDAZO (1,2-A) (1,2) DIACEPINE

Country Status (1)

Country Link
ES (3) ES8900271A1 (en)

Also Published As

Publication number Publication date
ES557862A0 (en) 1989-11-01
ES9000008A1 (en) 1989-11-01
ES557864A0 (en) 1989-10-16
ES557863A0 (en) 1989-10-16
ES8900271A1 (en) 1989-10-16

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