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ES8802030A1 - Procedimiento para preparar dihidropiridinas. - Google Patents

Procedimiento para preparar dihidropiridinas.

Info

Publication number
ES8802030A1
ES8802030A1 ES551847A ES551847A ES8802030A1 ES 8802030 A1 ES8802030 A1 ES 8802030A1 ES 551847 A ES551847 A ES 551847A ES 551847 A ES551847 A ES 551847A ES 8802030 A1 ES8802030 A1 ES 8802030A1
Authority
ES
Spain
Prior art keywords
general formula
procedure
alkyl
carbon atoms
dihydropyridines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551847A
Other languages
English (en)
Other versions
ES551847A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES8802030A1 publication Critical patent/ES8802030A1/es
Publication of ES551847A0 publication Critical patent/ES551847A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DIHIDROPIRIDINAS, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UNA AMINA DE FORMULA GENERAL (II), EN LA QUE A ES UN ANILLO BENCENICO QUE LLEVA UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE HALOGENO, CIANO, NITRO O ALQUILO; R1 Y R2 REPRESENTAN CADA UNO DE ELLOS ALQUILO O ALCOXIALQUILO; R3 ES ALQUILO DE HASTA 6 ATOMOS DE CARBONO; AR ES FENILENO O NAFTILO; X ES OXIGENO O NH; Q ES 1, 2, 3 O 4; E Y ES ALQUILENO DE CADENA RECTA O RAMIFICADA DE 1 A 12 ATOMOS DE CARBONO, CON UN EPOXIDO DE FORMULA GENERAL (III). DE APLICACION EN MEDICINA POR SUS PROPIEDADES ANTIHIPERTENSIVAS.
ES551847A 1985-02-11 1986-02-11 Procedimiento para preparar dihidropiridinas. Expired ES8802030A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858503428A GB8503428D0 (en) 1985-02-11 1985-02-11 Nitrogen-containing compounds

Publications (2)

Publication Number Publication Date
ES8802030A1 true ES8802030A1 (es) 1988-03-16
ES551847A0 ES551847A0 (es) 1988-03-16

Family

ID=10574273

Family Applications (1)

Application Number Title Priority Date Filing Date
ES551847A Expired ES8802030A1 (es) 1985-02-11 1986-02-11 Procedimiento para preparar dihidropiridinas.

Country Status (13)

Country Link
EP (1) EP0194752A1 (es)
JP (1) JPS61233667A (es)
AU (1) AU5326386A (es)
DK (1) DK65686A (es)
ES (1) ES8802030A1 (es)
FI (1) FI860618A7 (es)
GB (1) GB8503428D0 (es)
GR (1) GR860366B (es)
HU (1) HUT40412A (es)
IL (1) IL77799A0 (es)
NO (1) NO860462L (es)
PT (1) PT82010B (es)
ZA (1) ZA86814B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254682A1 (de) * 1986-07-22 1988-01-27 Ciba-Geigy Ag Neue Phenoxyaliphatylphenylenoxyalkylester und -amide
US5468746A (en) * 1988-07-29 1995-11-21 Zambon Group S.P.A. Compounds active on the cardiovascular system
IT1229118B (it) * 1988-07-29 1991-07-22 Simes Composti attivi sul sistema cardiovascolare che presentano sia la struttura dei beta-bloccanti sia una porzione calcio-antagonista
EP0352863A3 (en) * 1988-07-29 1990-08-22 ZAMBON GROUP S.p.A. 1,4-dihydropyridine dicarboxylic acid derivatives
FR2700541B1 (fr) * 1993-01-21 1995-03-03 Adir Nouveaux composés de 1,4-dihydropyridine, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2753946A1 (de) * 1977-12-03 1979-06-13 Bayer Ag 1-n-aryl-1,4-dihydropyridine und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
IL77799A0 (en) 1986-08-31
FI860618A0 (fi) 1986-02-11
PT82010A (en) 1986-03-01
EP0194752A1 (en) 1986-09-17
FI860618A7 (fi) 1986-08-12
NO860462L (no) 1986-08-12
GR860366B (en) 1986-06-03
PT82010B (en) 1987-12-16
HUT40412A (en) 1986-12-28
GB8503428D0 (en) 1985-03-13
JPS61233667A (ja) 1986-10-17
ES551847A0 (es) 1988-03-16
DK65686A (da) 1986-08-12
ZA86814B (en) 1986-11-26
DK65686D0 (da) 1986-02-11
AU5326386A (en) 1986-08-14

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