ES8801813A1 - Procedimiento para preparar 2,4-difenil-1,3-dioxanos - Google Patents
Procedimiento para preparar 2,4-difenil-1,3-dioxanosInfo
- Publication number
- ES8801813A1 ES8801813A1 ES557600A ES557600A ES8801813A1 ES 8801813 A1 ES8801813 A1 ES 8801813A1 ES 557600 A ES557600 A ES 557600A ES 557600 A ES557600 A ES 557600A ES 8801813 A1 ES8801813 A1 ES 8801813A1
- Authority
- ES
- Spain
- Prior art keywords
- dioxanes
- diphenyl
- preparing
- procedure
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Medicinal Preparation (AREA)
- Liquid Crystal Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR 2,4-DIFENIL-1,3-DIOXANOS. EL COMPUESTO MENCIONADO DE FORMULA (I), DONDE X ES FLUOR O: CLORO, BROMO, TRIFLUORMETILO, CIANO, METOXI Y NITRO, UNO DE LOS RADICALES Y Y Z ES HIDROGENO O FLUOR Y EL OTRO ES HIDROGENO Y LOS GRUPOS EN LAS POSICIONES 2,4 Y 5 DEL ANILLO DIOXANO TIENEN ESTEREOQUIMICA CIS-RELATIVA; SE FORMA HACIENDO REACCIONAR, EN UNA PRIMERA ETAPA UN HALURO DE (3-CARBOXIPROPIL)-FOSFONIO CON UNA BASE FUERTE COMO EL HNA, Y DESPUES EN UNA SEGUNDA, EL RESULTANTE (R1) PFCH(CH2)CO2-MB DONDE R1 ES ALQUILO Y MB UN CATION; CON UN ALDEHIDO DE FORMULA (III), EN UN DISOLVENTE COMO EL BENCENO, ETER, DIMETILSULFOXIDO O MEZCLA, A UNA TEMPERATURA ENTRE C80JC Y 40JC, EMPLEANDOSE OPCIONALMENTE, UN MATERIAL DE PARTIDA OPTICAMENTE ACTIVO. APLICABLES COMO ANTAGONISTAS DEL TROMBOXANO A2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858511890A GB8511890D0 (en) | 1985-05-10 | 1985-05-10 | Benzene derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8801813A1 true ES8801813A1 (es) | 1988-02-16 |
| ES557600A0 ES557600A0 (es) | 1988-02-16 |
Family
ID=10578944
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554826A Expired ES8708221A1 (es) | 1985-05-10 | 1986-05-09 | Procedimiento para preparar 2-4,-difenil-1,3-dioxanos. |
| ES557599A Expired ES8801812A1 (es) | 1985-05-10 | 1987-06-16 | Procedimiento para preparar 2,4-difenil-1,3-dioxanos |
| ES557601A Expired ES8800193A1 (es) | 1985-05-10 | 1987-06-16 | Procedimiento para preparar 2,4-difenil-1,3-dioxanos |
| ES557600A Expired ES8801813A1 (es) | 1985-05-10 | 1987-06-16 | Procedimiento para preparar 2,4-difenil-1,3-dioxanos |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES554826A Expired ES8708221A1 (es) | 1985-05-10 | 1986-05-09 | Procedimiento para preparar 2-4,-difenil-1,3-dioxanos. |
| ES557599A Expired ES8801812A1 (es) | 1985-05-10 | 1987-06-16 | Procedimiento para preparar 2,4-difenil-1,3-dioxanos |
| ES557601A Expired ES8800193A1 (es) | 1985-05-10 | 1987-06-16 | Procedimiento para preparar 2,4-difenil-1,3-dioxanos |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US4775685A (es) |
| EP (1) | EP0201354B1 (es) |
| JP (1) | JPS6212772A (es) |
| KR (1) | KR860009003A (es) |
| AT (1) | ATE56716T1 (es) |
| AU (1) | AU583375B2 (es) |
| CA (1) | CA1284330C (es) |
| DD (1) | DD251749A5 (es) |
| DE (1) | DE3674240D1 (es) |
| DK (1) | DK164164C (es) |
| ES (4) | ES8708221A1 (es) |
| FI (1) | FI84602C (es) |
| GB (2) | GB8511890D0 (es) |
| GR (1) | GR861210B (es) |
| HU (1) | HU198467B (es) |
| IL (1) | IL78776A (es) |
| NO (1) | NO169840C (es) |
| NZ (1) | NZ216112A (es) |
| PH (1) | PH23667A (es) |
| PT (1) | PT82546B (es) |
| ZA (1) | ZA863096B (es) |
| ZW (1) | ZW9386A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8511891D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Alkenoic acids |
| HU198706B (en) * | 1985-05-10 | 1989-11-28 | Ici Plc | Process for producing 1,3-dioxan-ethers and pharmaceutical compositions containing them |
| GB8626297D0 (en) * | 1986-11-04 | 1986-12-03 | Ici Plc | Pharmaceutical compositions |
| GB8709794D0 (en) * | 1987-04-24 | 1987-05-28 | Ici Plc | Heterocyclic acids |
| US5248780A (en) * | 1988-02-16 | 1993-09-28 | Imperial Chemical Industries, Plc | Pyridyl substituted alkenoic acid derivatives |
| GB8901201D0 (en) * | 1988-02-16 | 1989-03-15 | Ici Plc | Pyridine derivatives |
| GB8814340D0 (en) * | 1988-06-16 | 1988-07-20 | Ici Plc | Process |
| GB9021571D0 (en) * | 1990-10-04 | 1990-11-21 | Ici Plc | Heterocyclic acids |
| EP1976509B1 (en) * | 2006-01-18 | 2014-12-17 | Evolva SA | Ppar modulators |
| CA2676435C (en) * | 2007-01-18 | 2015-03-24 | Evolva Sa | Substituted 1,3-dioxanes useful as ppar modulators |
| BRPI0806686A2 (pt) * | 2007-01-18 | 2014-11-04 | Evolva Sa | Compostos e seus usos, métodos de tratamento ou prevenção, composições farmacêuticas e composto e solvato cristalinos |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8310407D0 (en) * | 1982-05-12 | 1983-05-25 | Ici Plc | 1 3 - dioxan -5- ylalkenoic acids |
| GB8330120D0 (en) * | 1983-11-11 | 1983-12-21 | Ici Plc | Chemical process |
-
1985
- 1985-05-10 GB GB858511890A patent/GB8511890D0/en active Pending
-
1986
- 1986-04-17 GB GB868609451A patent/GB8609451D0/en active Pending
- 1986-04-23 PH PH33695A patent/PH23667A/en unknown
- 1986-04-24 ZA ZA863096A patent/ZA863096B/xx unknown
- 1986-04-28 ZW ZW93/86A patent/ZW9386A1/xx unknown
- 1986-05-02 AU AU57044/86A patent/AU583375B2/en not_active Ceased
- 1986-05-07 HU HU861875A patent/HU198467B/hu not_active IP Right Cessation
- 1986-05-09 AT AT86303562T patent/ATE56716T1/de not_active IP Right Cessation
- 1986-05-09 US US06/861,329 patent/US4775685A/en not_active Expired - Lifetime
- 1986-05-09 PT PT82546A patent/PT82546B/pt not_active IP Right Cessation
- 1986-05-09 KR KR1019860003597A patent/KR860009003A/ko not_active Ceased
- 1986-05-09 DE DE8686303562T patent/DE3674240D1/de not_active Expired - Lifetime
- 1986-05-09 NO NO861869A patent/NO169840C/no unknown
- 1986-05-09 FI FI861949A patent/FI84602C/fi not_active IP Right Cessation
- 1986-05-09 GR GR861210A patent/GR861210B/el unknown
- 1986-05-09 DK DK216286A patent/DK164164C/da not_active IP Right Cessation
- 1986-05-09 NZ NZ216112A patent/NZ216112A/xx unknown
- 1986-05-09 EP EP86303562A patent/EP0201354B1/en not_active Expired - Lifetime
- 1986-05-09 CA CA000508782A patent/CA1284330C/en not_active Expired - Lifetime
- 1986-05-09 JP JP61105049A patent/JPS6212772A/ja active Pending
- 1986-05-09 ES ES554826A patent/ES8708221A1/es not_active Expired
- 1986-05-09 DD DD86290093A patent/DD251749A5/de not_active IP Right Cessation
- 1986-05-13 IL IL78776A patent/IL78776A/xx not_active IP Right Cessation
-
1987
- 1987-06-16 ES ES557599A patent/ES8801812A1/es not_active Expired
- 1987-06-16 ES ES557601A patent/ES8800193A1/es not_active Expired
- 1987-06-16 ES ES557600A patent/ES8801813A1/es not_active Expired
-
1988
- 1988-07-13 US US07/218,251 patent/US4895962A/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970401 |