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ES8801310A1 - Pharmaceutically active dipeptide derivatives. - Google Patents

Pharmaceutically active dipeptide derivatives.

Info

Publication number
ES8801310A1
ES8801310A1 ES553610A ES553610A ES8801310A1 ES 8801310 A1 ES8801310 A1 ES 8801310A1 ES 553610 A ES553610 A ES 553610A ES 553610 A ES553610 A ES 553610A ES 8801310 A1 ES8801310 A1 ES 8801310A1
Authority
ES
Spain
Prior art keywords
alkyl
group
pharmaceutically active
dipeptide derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553610A
Other languages
Spanish (es)
Other versions
ES553610A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES553610A0 publication Critical patent/ES553610A0/en
Publication of ES8801310A1 publication Critical patent/ES8801310A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ALANIL-PROLINA. CONSISTENTE EN COPULAR EN EL ORDEN DESEADO EL RESTO ARILO, LA CADENA LATERAL DE AMINO (HIDROXI) ALCOZXI, Y LOS AMINOACIDOS QUE FORMAN JUNTOS LOS COMPUESTOS DE FORMULA (I), PARA OBTENER DICHO COMPUESTO, Y TRANSFORMARLO EN UNA SAL FISIOLOGICAMENTE ACEPTABLE. SIENDO: Q Y Q1 A Q9, H O ALQUILO DE C 1 A 4; A, GRUPO -(CO)K-(NQ9)M-(CH2)N-; K Y M, AMBOS 0 O 1; N, 1, 2, 3, 4, 5 O 6; B, ALQUILO DE C 1 A 6, E Y Z, DERIVADOS DE CARBOXILO; D, H O ALQUILO DE C 1 A 6; (X), ANILLO BENCEMICO Y OTROS; -NY, ANILLO PIRROLIDINILO Y OTROS; R, GRUPO DE FORMULA (IV); R5 Y R6, GRUPO -NHQ7. SE USA EN EL TRATAMIENTO Y LA PROFILAXIS DE LA HIPERTENSION.PROCEDURE TO PREPARE ALANIL-PROLINE DERIVATIVES. CONSISTENT OF COPULATING IN THE DESIRED ORDER THE REST OF ARYL, THE SIDE CHAIN OF AMINO (HYDROXY) ALCOZXI, AND THE AMINO ACIDS THAT TOGETHER FORMULA (I) COMPOUNDS, TO OBTAIN SAID COMPOUND, AND TRANSFORM IT INTO AN ACCEPTABLE SALT. BEING: Q AND Q1 TO Q9, H OR ALKYL FROM C 1 TO 4; A, GROUP - (CO) K- (NQ9) M- (CH2) N-; K AND M, BOTH 0 OR 1; N, 1, 2, 3, 4, 5 O 6; B, ALKYL OF C 1 TO 6, E AND Z, CARBOXYL DERIVATIVES; D, H OR C 1 TO 6 ALKYL; (X), BENZEMIC RING AND OTHERS; -NY, PYRROLIDINYL RING AND OTHERS; R, FORMULA GROUP (IV); R5 AND R6, GROUP -NHQ7. IT IS USED IN THE TREATMENT AND PROPHYLAXIS OF HYPERTENSION.

ES553610A 1984-09-01 1986-04-01 Pharmaceutically active dipeptide derivatives. Expired ES8801310A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848422165A GB8422165D0 (en) 1984-09-01 1984-09-01 Compounds

Publications (2)

Publication Number Publication Date
ES553610A0 ES553610A0 (en) 1988-01-01
ES8801310A1 true ES8801310A1 (en) 1988-01-01

Family

ID=10566163

Family Applications (6)

Application Number Title Priority Date Filing Date
ES546595A Expired ES8703418A1 (en) 1984-09-01 1985-08-30 Pharmaceutically active dipeptide derivatives.
ES553614A Expired ES8801672A1 (en) 1984-09-01 1986-04-01 A PROCEDURE FOR PREPARING ALANYL-PROLIN DERIVATIVES.
ES553610A Expired ES8801310A1 (en) 1984-09-01 1986-04-01 Pharmaceutically active dipeptide derivatives.
ES553611A Expired ES8801311A1 (en) 1984-09-01 1986-04-01 A PROCEDURE FOR PREPARING ALAMIL-PROLIN DERIVATIVES.
ES553613A Expired ES8801313A1 (en) 1984-09-01 1986-04-01 Pharmaceutically active dipeptide derivatives.
ES553612A Expired ES8801312A1 (en) 1984-09-01 1986-04-01 A PROCEDURE FOR PREPARING ALANYL-PROLIN DERIVATIVES.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES546595A Expired ES8703418A1 (en) 1984-09-01 1985-08-30 Pharmaceutically active dipeptide derivatives.
ES553614A Expired ES8801672A1 (en) 1984-09-01 1986-04-01 A PROCEDURE FOR PREPARING ALANYL-PROLIN DERIVATIVES.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES553611A Expired ES8801311A1 (en) 1984-09-01 1986-04-01 A PROCEDURE FOR PREPARING ALAMIL-PROLIN DERIVATIVES.
ES553613A Expired ES8801313A1 (en) 1984-09-01 1986-04-01 Pharmaceutically active dipeptide derivatives.
ES553612A Expired ES8801312A1 (en) 1984-09-01 1986-04-01 A PROCEDURE FOR PREPARING ALANYL-PROLIN DERIVATIVES.

Country Status (16)

Country Link
EP (1) EP0174162A3 (en)
JP (1) JPS6183198A (en)
KR (1) KR860002501A (en)
AU (1) AU581455B2 (en)
CS (1) CS621585A2 (en)
DD (1) DD236522A5 (en)
DK (1) DK396885A (en)
ES (6) ES8703418A1 (en)
FI (1) FI853336L (en)
GB (1) GB8422165D0 (en)
GR (1) GR852113B (en)
HU (1) HUT39190A (en)
MC (1) MC1695A1 (en)
PL (3) PL265522A1 (en)
PT (1) PT81055B (en)
ZA (1) ZA856672B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0237239A3 (en) * 1986-02-28 1988-08-17 The Wellcome Foundation Limited New compounds
EP0234946A3 (en) * 1986-02-28 1988-08-17 The Wellcome Foundation Limited New compounds
US5036051A (en) * 1987-10-06 1991-07-30 Abbott Laboratories Glaucoma treatment
US4927807A (en) * 1987-10-06 1990-05-22 Abbott Laboratories Glaucoma treatment
US5346887A (en) * 1987-10-06 1994-09-13 Abbott Laboratories Glaucoma treatment
US5025001A (en) * 1988-06-15 1991-06-18 Brigham And Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
US5187183A (en) * 1988-06-15 1993-02-16 Brigham & Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
US5356890A (en) * 1988-06-15 1994-10-18 Brigham And Women's Hospital S-nitroso derivatives of ace inhibitors and the use thereof
US5059589A (en) * 1988-09-08 1991-10-22 Abbott Laboratories Glaucoma treatment
US4916129A (en) * 1989-01-19 1990-04-10 E. I. Du Pont De Nemours And Company Combination β-blocking/angiotensin II blocking antihypertensives
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US9259535B2 (en) 2006-06-22 2016-02-16 Excelsior Medical Corporation Antiseptic cap equipped syringe
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
US10166381B2 (en) 2011-05-23 2019-01-01 Excelsior Medical Corporation Antiseptic cap
CN103796704B (en) 2011-07-12 2016-12-07 博讯瓦勒公司 Device for delivering an antimicrobial agent into a percutaneous catheter
JP6546988B2 (en) 2014-05-02 2019-07-17 エクセルシオール・メディカル・コーポレイションＥｘｃｅｌｓｉｏｒ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ Strip package for preservative cap
ES3040274T3 (en) 2015-05-08 2025-10-29 Icu Medical Inc Medical connectors configured to receive emitters of therapeutic agents
WO2018071717A1 (en) 2016-10-14 2018-04-19 Icu Medical, Inc. Sanitizing caps for medical connectors
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
JP2022513096A (en) 2018-11-21 2022-02-07 アイシーユー・メディカル・インコーポレーテッド Antibacterial device with cap with ring and insert
AU2021396147A1 (en) 2020-12-07 2023-06-29 Icu Medical, Inc. Peritoneal dialysis caps, systems and methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705907A (en) * 1970-02-19 1972-12-12 Sandoz Ltd 4-(2-hydroxy)-3-aminopropoxy)-indole derivatives
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2503155A2 (en) * 1980-10-02 1982-10-08 Science Union & Cie NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
EP0278530A3 (en) * 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Amino acid derivatives, process for their preparation, agents containing them and their use
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
EP0080822A1 (en) * 1981-11-27 1983-06-08 Beecham Group Plc Anti-hypertensive prolinol-based peptides
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
EP0088350B1 (en) * 1982-03-08 1985-02-20 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
AU560285B2 (en) * 1982-07-19 1987-04-02 Imperial Chemical Industries Plc Heterocyclyl carbonyl sulphonamides

Also Published As

Publication number Publication date
DD236522A5 (en) 1986-06-11
EP0174162A3 (en) 1988-07-27
ES553613A0 (en) 1988-01-01
ES553611A0 (en) 1987-12-16
ES8801672A1 (en) 1988-02-16
ES8703418A1 (en) 1987-02-16
ES546595A0 (en) 1987-02-16
KR860002501A (en) 1986-04-26
ES553612A0 (en) 1987-12-16
PL255192A1 (en) 1987-09-21
EP0174162A2 (en) 1986-03-12
PT81055A (en) 1985-09-01
PL265523A1 (en) 1988-02-04
DK396885D0 (en) 1985-08-30
GB8422165D0 (en) 1984-10-03
MC1695A1 (en) 1986-07-18
HUT39190A (en) 1986-08-28
PL265522A1 (en) 1988-05-12
ES553610A0 (en) 1988-01-01
ES553614A0 (en) 1988-02-16
ES8801312A1 (en) 1987-12-16
ZA856672B (en) 1987-05-27
AU4693285A (en) 1986-03-06
JPS6183198A (en) 1986-04-26
PT81055B (en) 1987-07-02
CS621585A2 (en) 1989-08-14
FI853336A0 (en) 1985-08-30
FI853336A7 (en) 1986-03-02
AU581455B2 (en) 1989-02-23
GR852113B (en) 1985-12-24
ES8801311A1 (en) 1987-12-16
FI853336L (en) 1986-03-02
DK396885A (en) 1986-03-02
ES8801313A1 (en) 1988-01-01

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