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ES8800952A1 - Un procedimiento para la preparacion de derivados de carbapenem. - Google Patents

Un procedimiento para la preparacion de derivados de carbapenem.

Info

Publication number
ES8800952A1
ES8800952A1 ES554474A ES554474A ES8800952A1 ES 8800952 A1 ES8800952 A1 ES 8800952A1 ES 554474 A ES554474 A ES 554474A ES 554474 A ES554474 A ES 554474A ES 8800952 A1 ES8800952 A1 ES 8800952A1
Authority
ES
Spain
Prior art keywords
formula
preparation
pharmaceutical compositions
compositions containing
carbapenem derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554474A
Other languages
English (en)
Other versions
ES554474A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8800952A1 publication Critical patent/ES8800952A1/es
Publication of ES554474A0 publication Critical patent/ES554474A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBAPENEM, DE FORMULA (I), Y DE SUS SALES Y ESTERES FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN MERCAPTANO DE FORMULA (III), EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, A UNA TEMPERATURA COMPRENDIDA ENTRE C20JC Y LA AMBIENTE, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LAS QUE X, Y, R8 Y R9 PUEDEN SER VARIOS TIPOS DE RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIBACTERIANOS.
ES554474A 1985-04-27 1986-04-28 Un procedimiento para la preparacion de derivados de carbapenem. Expired ES8800952A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9198885 1985-04-27

Publications (2)

Publication Number Publication Date
ES8800952A1 true ES8800952A1 (es) 1987-12-01
ES554474A0 ES554474A0 (es) 1987-12-01

Family

ID=14041841

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554474A Expired ES8800952A1 (es) 1985-04-27 1986-04-28 Un procedimiento para la preparacion de derivados de carbapenem.

Country Status (17)

Country Link
US (1) US4771046A (es)
EP (1) EP0202048B1 (es)
JP (1) JPH0710868B2 (es)
KR (1) KR920010076B1 (es)
AT (1) ATE69053T1 (es)
AU (1) AU583113B2 (es)
CA (1) CA1305709C (es)
DE (1) DE3682225D1 (es)
DK (1) DK189686A (es)
ES (1) ES8800952A1 (es)
FI (1) FI81577C (es)
HU (1) HU194882B (es)
IE (1) IE58892B1 (es)
NO (1) NO163452C (es)
NZ (1) NZ215957A (es)
PH (1) PH22555A (es)
ZA (1) ZA863109B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0759581B2 (ja) * 1986-09-05 1995-06-28 日本レダリ−株式会社 （１ｒ）−１−メチルカルバペネム−３−カルボン酸誘導体
JPS6425780A (en) * 1987-04-28 1989-01-27 Sankyo Co 1-methylcarbapenem derivative
IE910606A1 (en) * 1990-02-23 1991-08-28 Sankyo Co Carbapenem derivatives having antibiotic activity, their¹preparation and their use
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
AU691971B2 (en) 1994-09-16 1998-05-28 Banyu Pharmaceutical Co., Ltd. Novel carbapenem derivative
CA2199855A1 (en) * 1994-09-16 1996-03-21 Ryosuke Ushijima Novel carbapenem derivative
US5932048A (en) * 1995-04-06 1999-08-03 Komatsu Electronic Metals Co., Ltd. Method of fabricating direct-bonded semiconductor wafers
CA2534001C (en) * 2005-01-28 2013-12-03 Ed Vaes Multi piece curved moldings

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
EP0060612A1 (en) * 1981-02-04 1982-09-22 Beecham Group Plc Process for the preparation of azabicyclo(3.2.0)-hept-2-ene derivatives
ES8404184A1 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
JPS60178888A (ja) * 1984-02-22 1985-09-12 Sankyo Co Ltd ペネムまたはカルバペネム誘導体およびその製法

Also Published As

Publication number Publication date
FI81577C (fi) 1990-11-12
DE3682225D1 (de) 1991-12-05
AU583113B2 (en) 1989-04-20
EP0202048B1 (en) 1991-10-30
EP0202048A1 (en) 1986-11-20
IE861106L (en) 1986-10-27
FI861763A0 (fi) 1986-04-25
DK189686D0 (da) 1986-04-24
AU5671086A (en) 1986-10-30
DK189686A (da) 1986-10-28
IE58892B1 (en) 1993-12-01
KR860008178A (ko) 1986-11-12
PH22555A (en) 1988-10-17
ZA863109B (en) 1986-12-30
ATE69053T1 (de) 1991-11-15
JPH0710868B2 (ja) 1995-02-08
HUT40661A (en) 1987-01-28
KR920010076B1 (ko) 1992-11-13
FI861763A7 (fi) 1986-10-28
ES554474A0 (es) 1987-12-01
NO861630L (no) 1986-10-28
CA1305709C (en) 1992-07-28
US4771046A (en) 1988-09-13
FI81577B (fi) 1990-07-31
NZ215957A (en) 1988-04-29
JPS6230781A (ja) 1987-02-09
NO163452C (no) 1990-05-30
NO163452B (no) 1990-02-19
HU194882B (en) 1988-03-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001