[go: up one dir, main page]

ES8800897A1 - Un procedimiento para preparar el compuesto 3(s)-3-amino-2-oxo-4,4-dimetil-1-azetidinilsulfato - Google Patents

Un procedimiento para preparar el compuesto 3(s)-3-amino-2-oxo-4,4-dimetil-1-azetidinilsulfato

Info

Publication number
ES8800897A1
ES8800897A1 ES557056A ES557056A ES8800897A1 ES 8800897 A1 ES8800897 A1 ES 8800897A1 ES 557056 A ES557056 A ES 557056A ES 557056 A ES557056 A ES 557056A ES 8800897 A1 ES8800897 A1 ES 8800897A1
Authority
ES
Spain
Prior art keywords
amino
oxo
procedure
azetidinilsulfato
dimetil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557056A
Other languages
English (en)
Other versions
ES557056A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES557056A0 publication Critical patent/ES557056A0/es
Publication of ES8800897A1 publication Critical patent/ES8800897A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/18—Salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS (3S)-3-AMINO-2-OXO-4,4-DIMETIL-1-AZETIDINILSULFATO, DE FORMULA GENERAL (I), Y SUS SALES BASICAS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SULFONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE A ES UN GRUPO PROTECTOR DE AMINO QUE ES POSTERIORMENTE ELIMINADO. LA REACCION DE SULFONACION SE LLEVA A CABO PREFERENTEMENTE MEDIANTE EL EMPLEO, COMO AGENTE DE SULFONACION, UN COMPLEJO DE PIRIDINA-TIOXIDO DE AZUFRE DE PIRIDINA COMO DISOLVENTE. DE APLICACION COMO MEDICAMENTO PARA COMBATIR INFECCIONES POR BACTERIAS GRAM-NEGATIVAS EN ESPECIES MAMIFERAS, TALES COMO ANIMALES DOMESTICOS Y SERES HUMANOS.
ES557056A 1985-01-28 1986-09-09 Un procedimiento para preparar el compuesto 3(s)-3-amino-2-oxo-4,4-dimetil-1-azetidinilsulfato Expired ES8800897A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/695,775 US4638061A (en) 1985-01-28 1985-01-28 [3S(Z)]-2-[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy] acetic acid and intermediate

Publications (2)

Publication Number Publication Date
ES557056A0 ES557056A0 (es) 1987-12-01
ES8800897A1 true ES8800897A1 (es) 1987-12-01

Family

ID=24794413

Family Applications (3)

Application Number Title Priority Date Filing Date
ES551252A Expired ES8706112A1 (es) 1985-01-28 1986-01-27 Un procedimiento para preparar derivados de 4 4-dialquil- -2-azetidinomas
ES557057A Expired ES8801917A1 (es) 1985-01-28 1986-09-09 Un procedimiento para preparar el compuesto acido (3s(z))7-2-(1-(2-amino-4-tiazolil)-2-(2,2-dimetil-4-oxo-1(sulfooxi)-3-azetidinil)amino)-2-oxoetiliden)amino)oxi)acetico
ES557056A Expired ES8800897A1 (es) 1985-01-28 1986-09-09 Un procedimiento para preparar el compuesto 3(s)-3-amino-2-oxo-4,4-dimetil-1-azetidinilsulfato

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES551252A Expired ES8706112A1 (es) 1985-01-28 1986-01-27 Un procedimiento para preparar derivados de 4 4-dialquil- -2-azetidinomas
ES557057A Expired ES8801917A1 (es) 1985-01-28 1986-09-09 Un procedimiento para preparar el compuesto acido (3s(z))7-2-(1-(2-amino-4-tiazolil)-2-(2,2-dimetil-4-oxo-1(sulfooxi)-3-azetidinil)amino)-2-oxoetiliden)amino)oxi)acetico

Country Status (35)

Country Link
US (1) US4638061A (es)
JP (2) JPH0780840B2 (es)
KR (1) KR900000675B1 (es)
CN (1) CN1014894B (es)
AR (1) AR242024A1 (es)
AT (1) AT389511B (es)
AU (1) AU588017B2 (es)
BE (1) BE904121A (es)
CA (2) CA1283924C (es)
CH (3) CH670824A5 (es)
CS (1) CS253740B2 (es)
DD (3) DD241600A5 (es)
DE (1) DE3602347A1 (es)
DK (1) DK39486A (es)
EG (1) EG17682A (es)
ES (3) ES8706112A1 (es)
FI (1) FI85022C (es)
FR (1) FR2576596B1 (es)
GB (2) GB2170201B (es)
GR (1) GR860239B (es)
HU (1) HU196367B (es)
IE (2) IE930750L (es)
IL (1) IL77661A (es)
IT (1) IT1190604B (es)
LU (1) LU86262A1 (es)
NL (1) NL8600136A (es)
NO (1) NO170014C (es)
NZ (1) NZ214836A (es)
PH (3) PH22425A (es)
PL (3) PL262318A1 (es)
PT (1) PT81914B (es)
RO (1) RO93483B (es)
SE (3) SE467824B (es)
YU (2) YU45760B (es)
ZA (1) ZA86302B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751220A (en) * 1986-12-19 1988-06-14 E. R. Squibb & Sons, Inc. Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy]acetic acid
EP0336667A3 (en) * 1988-04-04 1991-04-10 E.R. Squibb & Sons, Inc. [3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]-amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate
US5143913A (en) * 1988-04-04 1992-09-01 E. R. Squibb & Sons, Inc. [3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate
US4973747A (en) * 1989-08-15 1990-11-27 E. R. Squibb & Sons, Inc. Process for preparing 3-hydroxy 2-keto acids
DK2484680T3 (da) * 2005-12-07 2013-09-08 Basilea Pharmaceutica Ag Nyttige kombinationer af monolactam-antibiotika med beta-lactamase-inhibitorer
WO2017180794A1 (en) 2016-04-13 2017-10-19 Skyline Antiinfectives, Inc. Deuterated o-sulfated beta-lactam hydroxamic acids and deuterated n-sulfated beta-lactams

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337197A (en) * 1980-10-31 1982-06-29 E. R. Squibb & Sons, Inc. O-sulfated β-lactam hydroxamic acids and intermediates
JPS58113174A (ja) * 1981-12-26 1983-07-05 Toyama Chem Co Ltd 新規なアゼチジン誘導体またはその塩類を含有する抗菌剤
JPS58194856A (ja) * 1982-05-10 1983-11-12 Yamanouchi Pharmaceut Co Ltd 新規２−アゼチジノン誘導体
JPS58206589A (ja) * 1982-05-26 1983-12-01 Yamanouchi Pharmaceut Co Ltd ２−アゼチジノン誘導体
US4565654A (en) * 1983-03-28 1986-01-21 University Of Notre Dame Du Lac N-Acyloxy monocyclic β-lactams

Also Published As

Publication number Publication date
GB8800425D0 (en) 1988-02-10
CN86100736A (zh) 1986-10-22
AR242024A1 (es) 1993-02-26
SE9002338L (sv) 1990-07-03
HU196367B (en) 1988-11-28
LU86262A1 (fr) 1986-08-04
DK39486A (da) 1986-07-29
GB2198133B (en) 1989-01-11
IE59629B1 (en) 1994-03-09
RO93483A (ro) 1987-12-31
CA1279322C (en) 1991-01-22
CA1283924C (en) 1991-05-07
AU588017B2 (en) 1989-09-07
DK39486D0 (da) 1986-01-27
SE9002337D0 (sv) 1990-07-03
SE9002337L (sv) 1990-07-03
PL262317A1 (en) 1987-09-07
RO93483B (ro) 1988-01-01
AU5246086A (en) 1986-07-31
DD248584A5 (de) 1987-08-12
CH670824A5 (es) 1989-07-14
DE3602347A1 (de) 1986-07-31
ZA86302B (en) 1986-08-27
KR860005812A (ko) 1986-08-13
SE467824B (sv) 1992-09-21
DD248592A5 (de) 1987-08-12
ES557057A0 (es) 1988-03-01
JPS61176563A (ja) 1986-08-08
NO170014C (no) 1992-09-02
PH22425A (en) 1988-09-12
PH23084A (en) 1989-04-10
JPH0853404A (ja) 1996-02-27
US4638061A (en) 1987-01-20
YU45760B (sh) 1992-07-20
NL8600136A (nl) 1986-08-18
PL149156B1 (en) 1990-01-31
PT81914A (en) 1986-02-01
BE904121A (fr) 1986-05-15
ES8706112A1 (es) 1987-06-01
NZ214836A (en) 1988-10-28
NO860273L (no) 1986-07-29
FI85022B (fi) 1991-11-15
IT1190604B (it) 1988-02-16
EG17682A (en) 1990-10-30
FR2576596A1 (fr) 1986-08-01
FI85022C (fi) 1992-02-25
PT81914B (pt) 1987-11-30
SE468896B (sv) 1993-04-05
PH23093A (en) 1989-04-10
CH667872A5 (fr) 1988-11-15
CS253740B2 (en) 1987-12-17
YU5886A (en) 1988-02-29
GB2170201B (en) 1989-01-11
FI860247A0 (fi) 1986-01-20
IL77661A (en) 1989-06-30
NO170014B (no) 1992-05-25
IE930750L (en) 1986-07-28
AT389511B (de) 1989-12-27
PL257668A1 (en) 1987-03-09
ES557056A0 (es) 1987-12-01
SE8600355D0 (sv) 1986-01-27
IE860205L (en) 1986-07-28
GB2198133A (en) 1988-06-08
FR2576596B1 (fr) 1989-12-15
IT8619206A0 (it) 1986-01-28
FI860247L (fi) 1986-07-29
ES8801917A1 (es) 1988-03-01
SE8600355L (sv) 1986-07-29
PL262318A1 (en) 1987-09-07
YU167087A (en) 1988-04-30
CH670825A5 (es) 1989-07-14
KR900000675B1 (ko) 1990-02-02
GB2170201A (en) 1986-07-30
GR860239B (en) 1986-05-28
SE502442C2 (sv) 1995-10-16
CN1014894B (zh) 1991-11-27
JPH0780840B2 (ja) 1995-08-30
DD241600A5 (de) 1986-12-17
ES551252A0 (es) 1987-06-01
SE9002338D0 (sv) 1990-07-03
ATA20386A (de) 1989-05-15
HUT40407A (en) 1986-12-28

Similar Documents

Publication Publication Date Title
DE3267039D1 (en) Stable s-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle
PT95826A (pt) Processo para a preparacao de composicoes farmaceuticas contendo como ingrediente activo acido r-alfa-liponico ou acido s-alfa-liponico
GB2037745B (en) Diphenylbutyl - piperazinecarboxamides
ES2032899T3 (es) Agente cosmetico para aplicacion externa y su uso.
DE68919010D1 (de) Purinverbindungen, Verfahren zu ihrer Herstellung und pharmazeutische Präparate.
DK0430045T3 (da) Ascorbinsyretocopherylphosphatdiestere til hæmning af Maillards reaktion
ES2008865B3 (es) Procedimiento para preparar una composicion antiseptica.
SE7600284L (sv) Terapeutisk insulinberedning.
ES8102804A1 (es) Un metodo para preparar compuestos utiles como precursores de aminoacidos esenciales y semiesenciales
ES2012467B3 (es) Compuesto de embulsion del tipo o/w
ATE77047T1 (de) Sebosuppressive topische zubereitungen.
IT1205958B (it) Derivati di acido chinolincarbossilico e procedimento per la loro preparazione
ES521086A0 (es) Procedimiento para la preparacion de imidazolilfenil-tetrahidropiridazinas.
SE7902742L (sv) Disubstituerade 3-cefem-4-karboxylsyraderivat samt forfarande for framstellning derav
SE8604950L (sv) Demensforbettrande och terapeutiska medel
ES8800897A1 (es) Un procedimiento para preparar el compuesto 3(s)-3-amino-2-oxo-4,4-dimetil-1-azetidinilsulfato
ES8303427A1 (es) "un procedimiento para preparar compuestos de cefem".
FI930261A0 (fi) Polypeptidfoereningar som har vaexthormon frigoerande verkan
SE7411243L (es)
FI803202L (fi) Fosfonohydroxiaettiksyra foerfarande foer dess framstaellning och dess anvaendning saosom laekemedel
SE7902866L (sv) 3-0-(beta-d-glukuronopyranosyl)-sojasapogenol b
EP0009636A3 (en) 3-chloro-6-hydroxy-5-methylbenzoic acid derivative, corresponding pharmaceutical preparations, growth promoting compositions, the use of the compounds in the treatment and prophylaxis of diseases and for promoting growth of certain animals, and their manufacture
SE8503225D0 (sv) Diacyloxi-1,8-acyl-10-antroner, sett for deras framstellning och deras anvendning som lekemedel for djur och menniska samt for kosmetika
SE8701592L (sv) Farmaceutisk komposition som innehaller ett organiskt zinkkomplex samt forfarande for framstellning av den aktiva substansen
ES8400238A1 (es) "un procedimiento para la preparacion de soluciones acuosas de sulfonamidas potenciales".

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102