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ES8800273A1 - IMPROVEMENTS IN THE MANUFACTURE OF CONJUGATES OF PROTEIN CARRIERS OF IMMUNOGENIC ANTIGENS FOR MALARIA VACCINES - Google Patents

IMPROVEMENTS IN THE MANUFACTURE OF CONJUGATES OF PROTEIN CARRIERS OF IMMUNOGENIC ANTIGENS FOR MALARIA VACCINES

Info

Publication number
ES8800273A1
ES8800273A1 ES553425A ES553425A ES8800273A1 ES 8800273 A1 ES8800273 A1 ES 8800273A1 ES 553425 A ES553425 A ES 553425A ES 553425 A ES553425 A ES 553425A ES 8800273 A1 ES8800273 A1 ES 8800273A1
Authority
ES
Spain
Prior art keywords
manufacture
conjugates
immunogenic peptide
immunogenic
protein carriers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553425A
Other languages
Spanish (es)
Other versions
ES553425A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
Original Assignee
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York University NYU filed Critical New York University NYU
Publication of ES8800273A1 publication Critical patent/ES8800273A1/en
Publication of ES553425A0 publication Critical patent/ES553425A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

MODIFICACIONES EN LA FABRICACION DE CONJUGADOS DE PROTEINAS PORTADORAS DE ANTIGENOS INMUNOGENICOS. COMPRENDE. A) SINTETIZAR QUIMICAMENTE UN PEPTIDO INMUNOGENICO; Y B) ACOPLAR EL PEPTIDO INMUNOGENICO A UN PORTADOR DE PROTEINA ADECUADO, EN PRESENCIA DE UN CATALIZADOR SELECCIONADO ENTRE GRUTARALDEHIDO Y BISDIAZOBENCINA. EL PEPTIDO INMUNOGENICO CONSISTE EN LA REPETICION TANDEM DE LA SECUENCIA AMINOACIDO ASN-ALC-ASN-PRO Y LA PROTEINA PORTADORA CONTIEN TOXOIDE DE DIFTERIA, TOXOIDE DE TETANOS Y COPOLIMEROS TANDEM, SINTETICOS DE AMINOACIDOS QUE TIENEN LISINA Y ARGINA. SE UTILIZAN PARA TRATAR LA MALARIA.MODIFICATIONS IN THE MANUFACTURE OF IMMUNOGENIC ANTIGEN CARRIER PROTEIN CONJUGATES. UNDERSTANDS. A) CHEMICALLY SYNTHESIZE AN IMMUNOGENIC PEPTIDE; AND B) COUPLING THE IMMUNOGENIC PEPTIDE TO A SUITABLE PROTEIN CARRIER, IN THE PRESENCE OF A CATALYST SELECTED BETWEEN GRUTARALDEHYDE AND BISDIAZOBENZINE. THE IMMUNOGENIC PEPTIDE CONSISTS OF THE TANDEM REPEAT OF THE AMINO ACID SEQUENCE ASN-ALC-ASN-PRO AND THE CARRIER PROTEIN CONTAINS DIPHTHERIA TOXOID, TETANUS TOXOID AND TANDEM COPOLYMERS, SYNTHETIC AMINO ACIDS CONTAINING LYSINE AND ARGINE. THEY ARE USED TO TREAT MALARIA.

ES553425A 1985-03-28 1986-03-26 IMPROVEMENTS IN THE MANUFACTURE OF CONJUGATES OF PROTEIN CARRIERS OF IMMUNOGENIC ANTIGENS FOR MALARIA VACCINES Expired ES8800273A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71696085A 1985-03-28 1985-03-28

Publications (2)

Publication Number Publication Date
ES8800273A1 true ES8800273A1 (en) 1987-11-01
ES553425A0 ES553425A0 (en) 1987-11-01

Family

ID=24880143

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553425A Expired ES8800273A1 (en) 1985-03-28 1986-03-26 IMPROVEMENTS IN THE MANUFACTURE OF CONJUGATES OF PROTEIN CARRIERS OF IMMUNOGENIC ANTIGENS FOR MALARIA VACCINES

Country Status (9)

Country Link
EP (1) EP0216901A4 (en)
JP (1) JPS62502340A (en)
AU (1) AU5695686A (en)
ES (1) ES8800273A1 (en)
IE (1) IE860846L (en)
IL (1) IL78292A0 (en)
PT (1) PT82282B (en)
WO (1) WO1986005790A1 (en)
ZA (1) ZA862376B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA855232B (en) * 1984-07-23 1986-02-26 Univ New York Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein
IT1187710B (en) * 1985-07-25 1987-12-23 Eniricerche Spa USEFUL PEPTIDAL COMPOSITION FOR THE PREPARATION OF MALARIA VACCINES AND DIAGNOSTIC KITS FOR THE DETERMINATION OF MALARIC DISEASES
IT1196501B (en) * 1986-07-16 1988-11-16 Eniricerche Spa POLYPEPTIDE USEFUL FOR THE PREPARATION OF MALARIA VACCINES AND DIAGNOSTIC KITS FOR THE DETERMINATION OF MALARIC DISEASES
US5225530A (en) * 1986-07-16 1993-07-06 Eniricerche S.P.A. Polypeptide useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of malarial affections
EP0289110A3 (en) * 1987-02-02 1990-01-24 Swiss Serum and Vaccine Institute Berne Conjugate malaria vaccine
IT1223301B (en) * 1987-09-11 1990-09-19 Eniricerche Spa IMMUNOLOGICALLY ACTIVE SEQUENTIAL POLYPEPTIDES
IT1233419B (en) * 1987-12-11 1992-03-31 Eniricerche Spa IMMUNOLOGICALLY ACTIVE SYNTHETIC PEPTIDES USEFUL FOR THE PREPARATION OF AN ANIMALARY VACCINE
IT8820888A0 (en) * 1988-06-08 1988-06-08 Eniricerche Spa IMMUNOLOGICALLY ACTIVE SYNTHETIC PEPTIDES FOR THE PREPARATION OF ANTIMALARIA VACCINES.
IT1226728B (en) * 1988-08-05 1991-02-05 Eniricerche Spa IMMUNOLOGICALLY ACTIVE PEPTID CONJUGATE USEFUL AS ANIMALARY VACCINE AND IMMUNIZATION METHOD USING THE SAME
ES2055785T3 (en) * 1989-01-17 1994-09-01 Eniricerche Spa SYNTHETIC PEPTIDES AND THEIR USE AS UNIVERSAL VEHICLES FOR THE PREPARATION OF IMMUNOGENOUS CONJUGATES SUITABLE FOR THE DEVELOPMENT OF SYNTHETIC VACCINES.
IT1237764B (en) * 1989-11-10 1993-06-17 Eniricerche Spa SYNTHETIC PEPTIDES USEFUL AS UNIVERSAL CARRIERS FOR THE PREPARATION OF IMMUNOGENIC CONJUGATES AND THEIR USE FOR THE DEVELOPMENT OF SYNTHETIC VACCINES.
GB9616351D0 (en) * 1996-08-02 1996-09-11 Smithkline Beecham Biolog Vaccine composition
GB9808932D0 (en) 1998-04-27 1998-06-24 Chiron Spa Polyepitope carrier protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5344613A (en) * 1976-09-30 1978-04-21 Eisai Co Ltd Tumor vaccine containing lectin/tumor cell-complex
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4707357A (en) * 1984-06-26 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor
ZA855232B (en) * 1984-07-23 1986-02-26 Univ New York Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein

Also Published As

Publication number Publication date
EP0216901A4 (en) 1989-10-04
ZA862376B (en) 1986-11-26
PT82282B (en) 1988-02-17
ES553425A0 (en) 1987-11-01
AU5695686A (en) 1986-10-23
PT82282A (en) 1986-04-01
IE860846L (en) 1986-09-28
EP0216901A1 (en) 1987-04-08
JPS62502340A (en) 1987-09-10
IL78292A0 (en) 1986-07-31
WO1986005790A1 (en) 1986-10-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519