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ES8708207A1 - Procedimiento para la preparacion de metil ester de -l-aspartil-l-fenilalanina o su hidrocloruro - Google Patents

Procedimiento para la preparacion de metil ester de -l-aspartil-l-fenilalanina o su hidrocloruro

Info

Publication number
ES8708207A1
ES8708207A1 ES553331A ES553331A ES8708207A1 ES 8708207 A1 ES8708207 A1 ES 8708207A1 ES 553331 A ES553331 A ES 553331A ES 553331 A ES553331 A ES 553331A ES 8708207 A1 ES8708207 A1 ES 8708207A1
Authority
ES
Spain
Prior art keywords
aspartil
hydrochloride
procedure
methyl ester
phenylalanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553331A
Other languages
English (en)
Other versions
ES553331A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP60066097A external-priority patent/JPS61225196A/ja
Priority claimed from JP60066665A external-priority patent/JPH0751596B2/ja
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Publication of ES8708207A1 publication Critical patent/ES8708207A1/es
Publication of ES553331A0 publication Critical patent/ES553331A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/801—Peptide sweetners

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE METILESTER DE ALFA-L-ASPARTIL-L-FENILALAMINA Y DE SU HIDROCLORURO. COMPRENDE LA REACCION DE ACIDO 5-BENCIL-3,6-DIOXO-2-PIPEERAZINA ACETICO CON ACIDO CLORHIDRICO AL 3-33 POR CIENTO, EN PRESENCIA DE METANOL, O EL ESTER METILICO DE DICHO ACIDO, EN PRESENCIA O AUSENCIA DE METANOL; SEGUIDA DE LA SEPARACION DEL CLORURO O METILESTER DE ALFA-L-ASPARTIL-L-FENILAMINA FORMADO Y NEUTRALIZACION CON UN ALCALI. ESTE COMPUESTO TIENE APLICACIONES COMO AGENTE EDULCORANTE DIETETICO. E
ES553331A 1985-03-29 1986-03-24 Procedimiento para la preparacion de metil ester de -l-aspartil-l-fenilalanina o su hidrocloruro Expired ES8708207A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP60066097A JPS61225196A (ja) 1985-03-29 1985-03-29 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製造法
JP60066665A JPH0751596B2 (ja) 1985-04-01 1985-04-01 α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製造方法

Publications (2)

Publication Number Publication Date
ES8708207A1 true ES8708207A1 (es) 1987-10-16
ES553331A0 ES553331A0 (es) 1987-10-16

Family

ID=26407276

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553331A Expired ES8708207A1 (es) 1985-03-29 1986-03-24 Procedimiento para la preparacion de metil ester de -l-aspartil-l-fenilalanina o su hidrocloruro

Country Status (8)

Country Link
US (1) US4780561A (es)
EP (1) EP0196866A3 (es)
KR (1) KR890005039B1 (es)
AU (1) AU586669B2 (es)
BR (1) BR8601385A (es)
CA (1) CA1286845C (es)
ES (1) ES8708207A1 (es)
MX (1) MX162176A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3780585T2 (de) * 1986-12-05 1993-03-18 Mitsui Toatsu Chemicals Herstellung von alpha-l-aspartyl-l-phenylalanin-methylester oder deren hydrohalide.
US4897507A (en) * 1987-07-22 1990-01-30 Ajinomoto Co., Inc. Method for producing α-L-aspartyl-L-phenylalanine derivatives
US5144073A (en) * 1988-08-31 1992-09-01 Hubbs John C Process for preparation of dipeptides
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids
AU628257B2 (en) * 1990-03-15 1992-09-10 Nutrasweet Company, The Process for manufacturing aspartame from a diketopiperazine and novel intermediates and derivatives therefor
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
JPH05194587A (ja) * 1992-01-14 1993-08-03 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの精製法
CN105315327A (zh) * 2014-08-04 2016-02-10 南京集美新型材料研发有限公司 2-（5-苄基-3,6-二酮哌嗪-2-基）乙酸和2-（5-苄基-3,6-二酮哌嗪-2-基）乙酸甲酯转化的方法
CN105315328A (zh) * 2014-08-04 2016-02-10 南京集美新型材料研发有限公司 N-α-L-天冬氨酞-L-苯丙1-氨酸甲酯中去除杂质的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS461370Y1 (es) * 1966-05-25 1971-01-19
JPS5113737A (en) * 1974-07-23 1976-02-03 Ajinomoto Kk Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
US4088649A (en) * 1975-07-02 1978-05-09 Firmenich S.A. Process for preparing a diketo-piperazine
MX4704E (es) * 1976-12-27 1982-08-04 Monsanto Co Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina
US4173562A (en) * 1976-12-27 1979-11-06 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
GB8300810D0 (en) * 1983-01-13 1983-02-16 Erba Farmitalia Aspartame synthesis
JPS59219258A (ja) * 1983-05-28 1984-12-10 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法
US4618695A (en) * 1983-06-02 1986-10-21 Ajinomoto Co., Inc. Method of preparing methyl ester and its hydrochloride
JPH0613550B2 (ja) * 1983-06-03 1994-02-23 味の素株式会社 α―Ｌ―アスパルチル―Ｌ―フェニルアラニン―低級アルキルエステルの製造法
JPS59227849A (ja) * 1983-06-08 1984-12-21 Ajinomoto Co Inc Ｌ―α―アスパルチル―Ｌ―フェニルアラニンメチルエステル束状晶の晶析分離法
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法

Also Published As

Publication number Publication date
EP0196866A3 (en) 1988-03-23
US4780561A (en) 1988-10-25
EP0196866A2 (en) 1986-10-08
ES553331A0 (es) 1987-10-16
CA1286845C (en) 1991-07-23
BR8601385A (pt) 1986-12-02
MX162176A (es) 1991-04-05
AU5493186A (en) 1986-10-02
KR890005039B1 (ko) 1989-12-08
AU586669B2 (en) 1989-07-20
KR860007284A (ko) 1986-10-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303