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ES8707502A1 - Procedimiento para la preparacion de -aminocarbonil-1-ben- cil-3,4-dihidro-isoquinoleinas - Google Patents

Procedimiento para la preparacion de -aminocarbonil-1-ben- cil-3,4-dihidro-isoquinoleinas

Info

Publication number
ES8707502A1
ES8707502A1 ES501245A ES501245A ES8707502A1 ES 8707502 A1 ES8707502 A1 ES 8707502A1 ES 501245 A ES501245 A ES 501245A ES 501245 A ES501245 A ES 501245A ES 8707502 A1 ES8707502 A1 ES 8707502A1
Authority
ES
Spain
Prior art keywords
dihydro
procedure
preparation
solvent
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501245A
Other languages
English (en)
Other versions
ES501245A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES501245A0 publication Critical patent/ES501245A0/es
Publication of ES8707502A1 publication Critical patent/ES8707502A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65C—LABELLING OR TAGGING MACHINES, APPARATUS, OR PROCESSES
    • B65C2210/00—Details of manually controlled or manually operable label dispensers
    • B65C2210/0037—Printing equipment
    • B65C2210/004—Printing equipment using printing heads
    • B65C2210/0045—Printing equipment using printing heads mechanically actuated, e.g. by a hand lever

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE A-AMINOCARBONIL-1-BENCIL-3,4-DIHIDRO-ISOQUINOLEINAS, DE FORMULA GENERAL (I), EN LA QUE R1, R2 Y R3 SIGNIFICAN HIDROGENO O GRUPOS HIDROXI, METOXI O METILENDIOXI; Y X SIGNIFICA GRUPOS DIALCOHILAMINO CON 1 A 3 ATOMOS DE CARBONO O RADICALES HETEROCICLICOS, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SOMETER A UNA REACCION DE CICLIZACION UNA DIAMIDA DE ACIDO FENILAMALONICO DE FORMULA GENERAL (II), EN PRESENCIA DE UN AGENTE DE CONDENSACION, PREFERIBLEMENTE EN EXCESO, Y EN PRESENCIA O AUSENCIA DE UN DISOLVENTE, PARA FORMAR LA 3,4-DIHIDRO-ISOQUINOLEINA CORRESPONDIENTE. DICHA REACCION GENERALMENTE SE LLEVA A EFECTO CALENTANDO A TEMPERATURA MODERADA EL DISOLVENTE. DE APLICACION EN MEDICINA PARA MEJORAR LA CIRCULACION SANGUINEA TISULAR Y EL ABASTECIMIENTO DE OXIGENO A LOS TEJIDOS.
ES501245A 1980-04-11 1981-04-10 Procedimiento para la preparacion de -aminocarbonil-1-ben- cil-3,4-dihidro-isoquinoleinas Expired ES8707502A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803013906 DE3013906A1 (de) 1980-04-11 1980-04-11 Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung

Publications (2)

Publication Number Publication Date
ES501245A0 ES501245A0 (es) 1986-04-16
ES8707502A1 true ES8707502A1 (es) 1986-04-16

Family

ID=6099734

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501245A Expired ES8707502A1 (es) 1980-04-11 1981-04-10 Procedimiento para la preparacion de -aminocarbonil-1-ben- cil-3,4-dihidro-isoquinoleinas

Country Status (17)

Country Link
US (1) US4322418A (es)
EP (1) EP0037934A3 (es)
JP (1) JPS56158765A (es)
AU (1) AU6938481A (es)
DE (1) DE3013906A1 (es)
DK (1) DK164281A (es)
ES (1) ES8707502A1 (es)
FI (1) FI811123L (es)
GB (1) GB2074159A (es)
GR (1) GR74904B (es)
HU (1) HU183394B (es)
IL (1) IL62621A0 (es)
NO (1) NO811245L (es)
NZ (1) NZ196788A (es)
PT (1) PT72832B (es)
YU (1) YU94181A (es)
ZA (1) ZA812391B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3143876A1 (de) * 1981-11-05 1983-05-11 Boehringer Ingelheim KG, 6507 Ingelheim Neue1-furyl-3,4-dihydroisochinoline diese enthaltende arzneimittel sowie verfahren zu deren herstellung und deren verwendung
DE3621413A1 (de) * 1986-06-26 1988-01-07 Boehringer Ingelheim Kg Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung
IL86131A0 (en) * 1987-04-24 1988-11-15 Boehringer Ingelheim Kg Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion
DE9017900U1 (de) 1990-12-22 1993-01-28 Boehringer Ingelheim Kg, 55218 Ingelheim 3,4-Dihydro-1-benzyl-6,7-dimethoxy-α- [di-2-(2,3,4-trimethoxyphenyl)ethyl] aminocarbonyl-isochinolin
CA2138788A1 (en) * 1992-06-22 1994-01-06 Dietrich Arndts Ring-closed dihydropyridines and their use in the preparation of pharmaceutical compositions
US5674878A (en) * 1992-06-22 1997-10-07 Boehringer Ingelheim Kg Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparations
CN1056832C (zh) * 1992-06-22 2000-09-27 贝林格尔·英格海姆公司 稠合二氢吡啶衍生物及其制法和含有其的药物组合物
ATE198328T1 (de) * 1992-09-28 2001-01-15 Hoechst Ag Antiarrhythmische und cardioprotektive substituierte 1(2h)-isochinoline, verfahren zu deren herstellung, diese enthaltende arzneimittel und ihre anwendung für die herstellung eines arzneimittels zur behandlung von herzinsuffizienzen
AU688833B2 (en) 1993-12-21 1998-03-19 Boehringer Ingelheim International Gmbh Anellated dihydropyridines and their use in the production of pharmaceutical preparations
DE4343683A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
CA2679985A1 (en) * 2007-03-15 2008-09-18 F. Hoffmann-La Roche Ag Malonamides as orexin antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2769810A (en) * 1955-08-15 1956-11-06 Shionogi & Co Process for preparing hydroxy-n-methylmorphinan
US3207759A (en) * 1962-08-01 1965-09-21 Hoffmann La Roche Isoquinoline acetamides and acetonitriles
JPS5242886A (en) * 1975-10-02 1977-04-04 Takeda Chem Ind Ltd Preparation of esoquinoline compounds

Also Published As

Publication number Publication date
DK164281A (da) 1981-10-12
US4322418A (en) 1982-03-30
JPS56158765A (en) 1981-12-07
FI811123A7 (fi) 1981-10-12
NZ196788A (en) 1983-05-10
YU94181A (en) 1983-04-30
NO811245L (no) 1981-10-12
GR74904B (es) 1984-07-12
PT72832A (de) 1981-05-01
PT72832B (de) 1983-01-10
DE3013906A1 (de) 1981-10-15
FI811123L (fi) 1981-10-12
IL62621A0 (en) 1981-06-29
AU6938481A (en) 1981-10-29
GB2074159A (en) 1981-10-28
EP0037934A3 (de) 1982-05-12
HU183394B (en) 1984-04-28
ZA812391B (en) 1982-12-29
ES501245A0 (es) 1986-04-16
EP0037934A2 (de) 1981-10-21

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