ES8707549A1 - Substituted peptide compounds - Google Patents
Substituted peptide compoundsInfo
- Publication number
- ES8707549A1 ES8707549A1 ES539083A ES539083A ES8707549A1 ES 8707549 A1 ES8707549 A1 ES 8707549A1 ES 539083 A ES539083 A ES 539083A ES 539083 A ES539083 A ES 539083A ES 8707549 A1 ES8707549 A1 ES 8707549A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- peptide compounds
- substituted peptide
- amicetone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR COMPUESTOS PEPTIDICOS SUSTITUIDOS. COMPRENDE: A) OBTENER LA AMICETONA DE FORMULA (II) POR CONVERSION DE LA CARBOXIALQUILAMINA DE FORMULA (VI), EN SU CLORURO DE ACIDO Y REACCION POSTERIOR CON UNA OXAZOLONA PARA DAR UN COMPUESTO DE FORMULA (VII) Y SEPARAR EL GRUPO PROTECTOR R40 POR HIDROGENACION. SIENDO: R, H, ALQUILO INFERIOR Y OTROS; R2 ES UN COMPUESTO DE FORMULA (V) Y OTROS; R3 ES H, ALCOHILO INFERIOR Y OTROS; R40 ES UN GRUPO PROTECTOR; Y B) HACER REACCIONAR UNA AMICETONA DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: HALO, EL, BR; R1, R6 Y R7 IGUAL QUE R; R14 ES H, ALQUILO INFERIOR DE C 1 A4, Y OTROS; X ES UN GRUPO PROTECTOR DE ESTER; M ES 0 A 4; Y P, 1 A 3. SE UTILIZAN PARA REDUCIR LA HIPERTENSION RELACIONADA CON LAS ANGIOTENSINAS.PROCEDURE FOR PREPARING SUBSTITUTED PEPTIDE COMPOUNDS. IT INCLUDES: A) OBTAIN AMICETONE FROM FORMULA (II) BY CONVERSION OF THE CARBOXIALKYLAMINE FROM FORMULA (VI), INTO ITS ACID CHLORIDE AND SUBSEQUENT REACTION WITH AN OXAZOLONE TO GIVE A COMPOUND OF FORMULA (VII) AND SEPARATE THE R40 BY GROUP HYDROGENATION. BEING: R, H, LOWER RENT AND OTHERS; R2 IS A COMPOUND OF FORMULA (V) AND OTHERS; R3 IS H, LOWER ALCOHYL, AND OTHERS; R40 IS A PROTECTIVE GROUP; AND B) REACTING AN AMICETONE OF FORMULA (II) WITH A COMPOUND OF FORMULA (III) TO OBTAIN A COMPOUND OF FORMULA (I) AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS. BEING: HALO, EL, BR; R1, R6 AND R7 SAME AS R; R14 IS H, LOWER ALKYL OF C 1 A4, AND OTHERS; X IS A PROTECTIVE GROUP OF ESTHER; M IS 0 TO 4; AND P, 1 TO 3. ARE USED TO REDUCE ANGIOTENSIN-RELATED HYPERTENSION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39965082A | 1982-07-19 | 1982-07-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8707549A1 true ES8707549A1 (en) | 1986-04-01 |
| ES539083A0 ES539083A0 (en) | 1986-04-01 |
Family
ID=23580391
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES83524200A Expired ES8504675A1 (en) | 1982-07-19 | 1983-07-18 | Substituted peptide compounds |
| ES539084A Expired ES8707550A1 (en) | 1982-07-19 | 1984-12-27 | Substituted peptide compounds |
| ES539083A Expired ES8707549A1 (en) | 1982-07-19 | 1984-12-27 | Substituted peptide compounds |
| ES539082A Expired ES8707548A1 (en) | 1982-07-19 | 1984-12-27 | A PROCEDURE FOR PREPARING REPLACED PEPTIDE COMPOUNDS |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES83524200A Expired ES8504675A1 (en) | 1982-07-19 | 1983-07-18 | Substituted peptide compounds |
| ES539084A Expired ES8707550A1 (en) | 1982-07-19 | 1984-12-27 | Substituted peptide compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES539082A Expired ES8707548A1 (en) | 1982-07-19 | 1984-12-27 | A PROCEDURE FOR PREPARING REPLACED PEPTIDE COMPOUNDS |
Country Status (21)
| Country | Link |
|---|---|
| JP (3) | JPS5951246A (en) |
| KR (1) | KR840005709A (en) |
| AU (1) | AU1643283A (en) |
| BE (1) | BE897327A (en) |
| CA (1) | CA1244006A (en) |
| CH (1) | CH659475A5 (en) |
| DE (1) | DE3325850A1 (en) |
| DK (1) | DK330683A (en) |
| ES (4) | ES8504675A1 (en) |
| FI (1) | FI832620L (en) |
| FR (3) | FR2530238B1 (en) |
| GB (1) | GB2123834B (en) |
| GR (1) | GR79602B (en) |
| HU (1) | HU187090B (en) |
| IE (1) | IE55818B1 (en) |
| IL (1) | IL69136A0 (en) |
| IT (1) | IT1163800B (en) |
| NL (1) | NL8302562A (en) |
| PT (1) | PT77045B (en) |
| SE (1) | SE8304031L (en) |
| ZA (1) | ZA834980B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55159749A (en) * | 1979-05-31 | 1980-12-12 | Takeda Chem Ind Ltd | Preparation of dried fish flesh |
| US4500518A (en) * | 1984-04-19 | 1985-02-19 | E. R. Squibb & Sons, Inc. | Amino thiol dipeptides |
| IL76345A (en) * | 1984-09-12 | 1988-12-30 | Usv Pharma Corp | Proline derivatives and antihypertensive and anti-glaucoma pharmaceutical preparations containing the same |
| US4629724A (en) * | 1984-12-03 | 1986-12-16 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitors |
| FR2578544A1 (en) * | 1985-03-11 | 1986-09-12 | Usv Pharma Corp | Antihypertension spirocyclic compounds |
| FI89058C (en) * | 1987-02-27 | 1993-08-10 | Yamanouchi Pharma Co Ltd | Process for the Preparation of Remin Inhibitors Using 2- (L-Alayl-L-Histidylamino) -butanol Derivatives |
| US6858565B2 (en) | 2001-05-14 | 2005-02-22 | Oji Paper Co., Ltd. | Thermosensitive recording material and novel color developer compounds |
| EP3414099A1 (en) | 2017-01-10 | 2018-12-19 | Mitsubishi HiTec Paper Europe GmbH | Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3751239A (en) * | 1969-05-29 | 1973-08-07 | Rohm & Haas | Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides |
| JPS5430167A (en) * | 1977-08-11 | 1979-03-06 | Mitsubishi Chem Ind Ltd | 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts |
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| FR2480747A1 (en) * | 1980-04-17 | 1981-10-23 | Roques Bernard | AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION |
| IE51409B1 (en) * | 1980-07-24 | 1986-12-24 | Ici Ltd | Amide derivatives |
| EP0048159A3 (en) * | 1980-09-17 | 1982-05-12 | University Of Miami | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents |
| LU88621I2 (en) * | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
| US4462943A (en) * | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
| EP0054862B1 (en) * | 1980-12-18 | 1985-11-27 | Schering Corporation | Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase |
| US4514391A (en) * | 1983-07-21 | 1985-04-30 | E. R. Squibb & Sons, Inc. | Hydroxy substituted peptide compounds |
-
1983
- 1983-06-30 AU AU16432/83A patent/AU1643283A/en not_active Abandoned
- 1983-06-30 IL IL69136A patent/IL69136A0/en unknown
- 1983-07-07 ZA ZA834980A patent/ZA834980B/en unknown
- 1983-07-08 CA CA000432071A patent/CA1244006A/en not_active Expired
- 1983-07-08 GB GB08318492A patent/GB2123834B/en not_active Expired
- 1983-07-13 FR FR838311764A patent/FR2530238B1/fr not_active Expired
- 1983-07-14 JP JP58129255A patent/JPS5951246A/en active Granted
- 1983-07-15 IE IE1655/83A patent/IE55818B1/en not_active IP Right Cessation
- 1983-07-18 PT PT77045A patent/PT77045B/en unknown
- 1983-07-18 SE SE8304031A patent/SE8304031L/en not_active Application Discontinuation
- 1983-07-18 KR KR1019830003289A patent/KR840005709A/en not_active Withdrawn
- 1983-07-18 DE DE19833325850 patent/DE3325850A1/en not_active Ceased
- 1983-07-18 DK DK330683A patent/DK330683A/en not_active Application Discontinuation
- 1983-07-18 IT IT22114/83A patent/IT1163800B/en active
- 1983-07-18 ES ES83524200A patent/ES8504675A1/en not_active Expired
- 1983-07-18 HU HU832537A patent/HU187090B/en unknown
- 1983-07-18 NL NL8302562A patent/NL8302562A/en not_active Application Discontinuation
- 1983-07-18 GR GR71963A patent/GR79602B/el unknown
- 1983-07-19 BE BE0/211203A patent/BE897327A/en not_active IP Right Cessation
- 1983-07-19 FI FI832620A patent/FI832620L/en not_active Application Discontinuation
- 1983-07-19 CH CH3950/83A patent/CH659475A5/en not_active IP Right Cessation
-
1984
- 1984-01-05 FR FR8400114A patent/FR2540866A1/en active Pending
- 1984-01-05 FR FR8400115A patent/FR2540867B1/en not_active Expired
- 1984-12-27 ES ES539084A patent/ES8707550A1/en not_active Expired
- 1984-12-27 ES ES539083A patent/ES8707549A1/en not_active Expired
- 1984-12-27 ES ES539082A patent/ES8707548A1/en not_active Expired
-
1991
- 1991-09-11 JP JP3231633A patent/JPH0653713B2/en not_active Expired - Lifetime
- 1991-09-11 JP JP3231635A patent/JPH0645582B2/en not_active Expired - Lifetime
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