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ES8707541A1 - Un procedimiento para la preparacion de derivados de cefalosporina - Google Patents

Un procedimiento para la preparacion de derivados de cefalosporina

Info

Publication number
ES8707541A1
ES8707541A1 ES556786A ES556786A ES8707541A1 ES 8707541 A1 ES8707541 A1 ES 8707541A1 ES 556786 A ES556786 A ES 556786A ES 556786 A ES556786 A ES 556786A ES 8707541 A1 ES8707541 A1 ES 8707541A1
Authority
ES
Spain
Prior art keywords
group
general formula
hydrogen atom
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556786A
Other languages
English (en)
Other versions
ES556786A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP60171838A external-priority patent/JPH06102668B2/ja
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of ES8707541A1 publication Critical patent/ES8707541A1/es
Publication of ES556786A0 publication Critical patent/ES556786A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CEFALOSPORINA, DE FORMULA GENERAL (I), Y SUS SALES, ESTERES Y SOLVATOS FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN ACILAR UN COMPUESTO DE FORMULA GENERAL (II) O UNA SAL O UN COMPUESTO SILILICO DEL MISMO, CON UN DERIVADO REACTIVO DE UN ACIDO CARBOXILICO, DE FORMULA GENERAL (III), SEGUIDO DE LA ELIMINACION DE LOS GRUPOS PROTECTORES, Y SIENDO R1 UN GRUPO ALQUILO INFERIOR; R2, R3 Y R4 REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE HIDROGENO O UN GRUPO HIDROXILO, METOXI O ACETOXI; R5 ES UN ATOMO DE HIDROGENO O UN GRUPO PROTECTOR DEL AMINO; R6 ES UN ATOMO DE HIDROGENO O UN GRUPO PROTECTOR DEL CARBOXILO; R7 ES UN GRUPO ALQUILO INFERIOR; Y R8, R9 Y R10 REPRESENTAN CADA UNO DE ELLOS HIDROGENO. DE APLICACION COMO ANTIBIOTICOS.
ES556786A 1984-11-12 1986-06-25 Un procedimiento para la preparacion de derivados de cefalosporina Expired ES8707541A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23679684 1984-11-12
JP60171838A JPH06102668B2 (ja) 1985-08-06 1985-08-06 新規セフアロスポリン誘導体

Publications (2)

Publication Number Publication Date
ES8707541A1 true ES8707541A1 (es) 1987-08-01
ES556786A0 ES556786A0 (es) 1987-08-01

Family

ID=26494422

Family Applications (2)

Application Number Title Priority Date Filing Date
ES548774A Expired ES8705453A1 (es) 1984-11-12 1985-11-11 Un procedimiento para la preparacion de derivados de cefalosporina.
ES556786A Expired ES8707541A1 (es) 1984-11-12 1986-06-25 Un procedimiento para la preparacion de derivados de cefalosporina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES548774A Expired ES8705453A1 (es) 1984-11-12 1985-11-11 Un procedimiento para la preparacion de derivados de cefalosporina.

Country Status (7)

Country Link
US (1) US4742053A (es)
EP (1) EP0182210B1 (es)
KR (1) KR930005588B1 (es)
CN (1) CN1008738B (es)
CA (1) CA1276140C (es)
DE (1) DE3581891D1 (es)
ES (2) ES8705453A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA877987B (en) * 1986-11-12 1988-08-31 Ici Pharma Antibiotic compounds
ATE113050T1 (de) * 1986-11-21 1994-11-15 Ici Pharma Cephalosporine, verfahren zu ihrer herstellung und pharmazeutische präparate.
DE3854684T2 (de) * 1987-07-23 1996-03-28 Zeneca Pharma Sa Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate.
EP0300665B1 (en) * 1987-07-23 1995-12-20 ZENECA Pharma S.A. Cephalosporin compounds, process for their preparation and their pharmaceutical compositions
US5232918A (en) * 1987-07-23 1993-08-03 Imperial Chemical Industries Plc Cephalosporin derivatives
GB8816519D0 (en) * 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5273973A (en) * 1988-10-24 1993-12-28 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl esters
NO903360L (no) * 1989-08-11 1991-02-12 Ici Pharma Antibiotiske forbindelser.
WO1991016327A1 (en) * 1990-04-18 1991-10-31 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactams
US5126336A (en) * 1990-08-23 1992-06-30 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
US5194433A (en) * 1990-11-13 1993-03-16 Bristol-Myers Squibb Company Antibiotic c-3 catechol-substituted cephalosporin compounds, compositions and method of use thereof
EP0544166A3 (en) * 1991-11-26 1993-11-03 Hoffmann La Roche Cephalosporinderivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4457929A (en) * 1982-03-29 1984-07-03 Bristol-Myers Company 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins

Also Published As

Publication number Publication date
CN85109545A (zh) 1986-07-23
ES548774A0 (es) 1987-05-01
KR930005588B1 (ko) 1993-06-23
EP0182210B1 (en) 1991-02-27
DE3581891D1 (de) 1991-04-04
EP0182210A2 (en) 1986-05-28
KR860004067A (ko) 1986-06-16
ES8705453A1 (es) 1987-05-01
ES556786A0 (es) 1987-08-01
CA1276140C (en) 1990-11-13
US4742053A (en) 1988-05-03
CN1008738B (zh) 1990-07-11
EP0182210A3 (en) 1987-08-12

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