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ES8707299A1 - Un procedimiento para la preparacion de difficol y su hidroxi derivado. - Google Patents

Un procedimiento para la preparacion de difficol y su hidroxi derivado.

Info

Publication number
ES8707299A1
ES8707299A1 ES551639A ES551639A ES8707299A1 ES 8707299 A1 ES8707299 A1 ES 8707299A1 ES 551639 A ES551639 A ES 551639A ES 551639 A ES551639 A ES 551639A ES 8707299 A1 ES8707299 A1 ES 8707299A1
Authority
ES
Spain
Prior art keywords
difficol
rfh
atcc
strain
prepare
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551639A
Other languages
English (en)
Other versions
ES551639A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8707299A1 publication Critical patent/ES8707299A1/es
Publication of ES551639A0 publication Critical patent/ES551639A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65525—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN HIDROXI DERIVADO DE DIFFICOL. COMPRENDE: A) CULTIVAR UNA CEPA DE BACILLUS SUBTILIS, EN CONDICIONES AEROBIAS EN UN MEDIO NUTRITIVO ACUOSO, ENTRE 20 Y 40JC Y DURANTE 24 A 120 HORAS, PARA OBTENER UN COMPUESTO DE FORMULA (I) (RFH); Y B) TRATAR A (I) (RFH) CON CLORURO MAGNESICO A PH 8,3 A 8,5, PARA PREPARAR UN COMPUESTO DE FORMULA (I) (RFOH). LA CEPA B SUBTILIS SE SELECCIONA ENTRE ATCC 39374 Y ATCC 39329. EL MEDIO NUTRITIVO CONTIENE FUENTES DE CARBONO DE NITROGENO Y SALES MINERALES. SE UTILIZAN COMO ANTIBACERIANOS.
ES551639A 1985-02-04 1986-02-04 Un procedimiento para la preparacion de difficol y su hidroxi derivado. Expired ES8707299A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/697,806 US4609742A (en) 1985-02-04 1985-02-04 Difficol, intermediate in antibiotic preparation

Publications (2)

Publication Number Publication Date
ES8707299A1 true ES8707299A1 (es) 1987-07-16
ES551639A0 ES551639A0 (es) 1987-07-16

Family

ID=24802626

Family Applications (2)

Application Number Title Priority Date Filing Date
ES551639A Expired ES8707299A1 (es) 1985-02-04 1986-02-04 Un procedimiento para la preparacion de difficol y su hidroxi derivado.
ES557509A Expired ES8801947A1 (es) 1985-02-04 1987-04-18 Un procedimiento para la preparacion de difficol y su hidroxi derivado

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557509A Expired ES8801947A1 (es) 1985-02-04 1987-04-18 Un procedimiento para la preparacion de difficol y su hidroxi derivado

Country Status (8)

Country Link
US (1) US4609742A (es)
EP (1) EP0190658B1 (es)
JP (1) JPH0660170B2 (es)
CA (1) CA1253099A (es)
DE (1) DE3670082D1 (es)
DK (1) DK50686A (es)
ES (2) ES8707299A1 (es)
IE (1) IE860279L (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0466365A3 (en) * 1990-07-03 1992-04-15 Merck & Co. Inc. Novel immunosuppressant fermentation products of a microorganism
US5430053A (en) * 1994-04-19 1995-07-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Isolation and structure of dictyostatin 1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2035812A1 (de) * 1970-07-18 1972-02-03 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt Neues Antibiotikum und Verfahren zu seiner Herstellung
US4545991A (en) * 1983-06-13 1985-10-08 Merck & Co., Inc. Difficidin and derivative antibacterials

Also Published As

Publication number Publication date
EP0190658A1 (en) 1986-08-13
ES8801947A1 (es) 1988-03-01
DE3670082D1 (de) 1990-05-10
CA1253099A (en) 1989-04-25
DK50686D0 (da) 1986-02-03
ES557509A0 (es) 1988-03-01
DK50686A (da) 1986-08-05
US4609742A (en) 1986-09-02
JPH0660170B2 (ja) 1994-08-10
IE860279L (en) 1986-08-04
JPS61183280A (ja) 1986-08-15
ES551639A0 (es) 1987-07-16
EP0190658B1 (en) 1990-04-04

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