ES8707179A1 - Metho-carbamol di:hydrogen phosphate prepn. - Google Patents
Metho-carbamol di:hydrogen phosphate prepn.Info
- Publication number
- ES8707179A1 ES8707179A1 ES556557A ES556557A ES8707179A1 ES 8707179 A1 ES8707179 A1 ES 8707179A1 ES 556557 A ES556557 A ES 556557A ES 556557 A ES556557 A ES 556557A ES 8707179 A1 ES8707179 A1 ES 8707179A1
- Authority
- ES
- Spain
- Prior art keywords
- carbamol
- metho
- prepn
- hydrogen phosphate
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GNXFOGHNGIVQEH-UHFFFAOYSA-N 2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate Chemical compound COC1=CC=CC=C1OCC(O)COC(N)=O GNXFOGHNGIVQEH-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002330 methocarbamol Drugs 0.000 title abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 229910019213 POCl3 Inorganic materials 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Metho-carbamol dihydrogen phosphate of formula (I) and its salts, for treatment of muscular spasm are made by (a) reacting metho-carbamol and POCl3 in acetone; (b) removing the solvent in vacuum; (c) ppting. The cpd. of formula (I); and (d) purifying with water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES556557A ES8707179A1 (en) | 1986-06-24 | 1986-06-24 | Metho-carbamol di:hydrogen phosphate prepn. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES556557A ES8707179A1 (en) | 1986-06-24 | 1986-06-24 | Metho-carbamol di:hydrogen phosphate prepn. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES556557A0 ES556557A0 (en) | 1987-07-16 |
| ES8707179A1 true ES8707179A1 (en) | 1987-07-16 |
Family
ID=8491584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES556557A Expired ES8707179A1 (en) | 1986-06-24 | 1986-06-24 | Metho-carbamol di:hydrogen phosphate prepn. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8707179A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101863917A (en) * | 2010-06-17 | 2010-10-20 | 天津市若围药物研究所 | Methocarbamol salt |
| CN103130683A (en) * | 2013-03-22 | 2013-06-05 | 南开大学 | Polymorphism of methocarbamol dihydric phosphate and preparation method thereof |
| CN103193677A (en) * | 2013-03-22 | 2013-07-10 | 南开大学 | Polymorphic form of methocarbamol disodium phosphate and preparation method thereof |
-
1986
- 1986-06-24 ES ES556557A patent/ES8707179A1/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101863917A (en) * | 2010-06-17 | 2010-10-20 | 天津市若围药物研究所 | Methocarbamol salt |
| CN101863917B (en) * | 2010-06-17 | 2013-06-12 | 天津市若围药物研究所 | Methocarbamol salt |
| CN103130683A (en) * | 2013-03-22 | 2013-06-05 | 南开大学 | Polymorphism of methocarbamol dihydric phosphate and preparation method thereof |
| CN103193677A (en) * | 2013-03-22 | 2013-07-10 | 南开大学 | Polymorphic form of methocarbamol disodium phosphate and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ES556557A0 (en) | 1987-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970505 |