ES8702913A1 - Un metodo para preparar pirrolo (1,2-b)-(1,2,5) triazepinas - Google Patents
Un metodo para preparar pirrolo (1,2-b)-(1,2,5) triazepinasInfo
- Publication number
- ES8702913A1 ES8702913A1 ES544746A ES544746A ES8702913A1 ES 8702913 A1 ES8702913 A1 ES 8702913A1 ES 544746 A ES544746 A ES 544746A ES 544746 A ES544746 A ES 544746A ES 8702913 A1 ES8702913 A1 ES 8702913A1
- Authority
- ES
- Spain
- Prior art keywords
- image
- hydrogen
- triazepines
- intermediates
- pyrrolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZWLCNUNYROSUKD-UHFFFAOYSA-N 1h-pyrrolo[1,2-b][1,2,5]triazepine Chemical class N1C=CN=CC2=CC=CN12 ZWLCNUNYROSUKD-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- ATVFZXIQTXCGBI-UHFFFAOYSA-N (1-aminopyrrol-2-yl)-phenylmethanone Chemical class NN1C=CC=C1C(=O)C1=CC=CC=C1 ATVFZXIQTXCGBI-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PIRROLO 1,2,B1,2,5TRIAZEPINAS, DE FORMULA (I). COMPRENDE LA REACCION DE CICLIZACION DE UN COMPUESTO DE FORMULA (II), PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE X, Y Y R PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE TAL COMO METANOL, EN PRESENCIA DE ACIDO ACETICO GLACIAL, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION, BAJO ATMOSFERA DE NITROGENO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANALGESICOS, ANSIOLITICOS Y ANTICONVULSIVOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/627,329 US4517195A (en) | 1984-07-02 | 1984-07-02 | Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8702913A1 true ES8702913A1 (es) | 1987-01-16 |
| ES544746A0 ES544746A0 (es) | 1987-01-16 |
Family
ID=24514226
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544746A Expired ES8702913A1 (es) | 1984-07-02 | 1985-07-01 | Un metodo para preparar pirrolo (1,2-b)-(1,2,5) triazepinas |
| ES552023A Expired ES8703836A1 (es) | 1984-07-02 | 1986-02-14 | Un metodo para preparar derivados de 1-amino-2-benzoilpirrol |
| ES552024A Expired ES8703837A1 (es) | 1984-07-02 | 1986-02-14 | Un metodo para preparar derivados de 1-amino-2-benzoilpirrol |
| ES552022A Expired ES8703422A1 (es) | 1984-07-02 | 1986-02-14 | Un metodo para preparar derivados de 1-amino-2-benzoilpirrol |
| ES557083A Expired ES8707536A1 (es) | 1984-07-02 | 1986-09-26 | Un metodo para preparar pirrolo (1,2-b) (1,2,5) triazepinas |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES552023A Expired ES8703836A1 (es) | 1984-07-02 | 1986-02-14 | Un metodo para preparar derivados de 1-amino-2-benzoilpirrol |
| ES552024A Expired ES8703837A1 (es) | 1984-07-02 | 1986-02-14 | Un metodo para preparar derivados de 1-amino-2-benzoilpirrol |
| ES552022A Expired ES8703422A1 (es) | 1984-07-02 | 1986-02-14 | Un metodo para preparar derivados de 1-amino-2-benzoilpirrol |
| ES557083A Expired ES8707536A1 (es) | 1984-07-02 | 1986-09-26 | Un metodo para preparar pirrolo (1,2-b) (1,2,5) triazepinas |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4517195A (es) |
| EP (1) | EP0167922B1 (es) |
| JP (1) | JPS6118781A (es) |
| KR (1) | KR860001113A (es) |
| AT (1) | ATE51401T1 (es) |
| AU (2) | AU593771B2 (es) |
| CA (1) | CA1251790A (es) |
| DE (1) | DE3576822D1 (es) |
| DK (1) | DK298085A (es) |
| ES (5) | ES8702913A1 (es) |
| GR (1) | GR851599B (es) |
| PT (1) | PT80746B (es) |
| ZA (1) | ZA854946B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4800203A (en) * | 1987-09-24 | 1989-01-24 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrrolo(1,2-b)cinnolines |
| US5274116A (en) * | 1992-07-30 | 1993-12-28 | Hoechst-Roussel Pharmaceuticals Inc. | 1-aminoacetamidopyrroles and 1-aminoacetamido-2-(substituted)pyrroles and related compounds |
| GB9307833D0 (en) * | 1993-04-15 | 1993-06-02 | Glaxo Inc | Modulators of cholecystokinin and gastrin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3121081A (en) * | 1961-08-18 | 1964-02-11 | Du Pont | 6-amino-7, 8-dicyanopyrrolo [b]-as-triazines and 7-amino-8, 9-dicyanopyrrolo [b]-[1.2.4]triazepines and their preparation |
| US3116203A (en) * | 1962-03-14 | 1963-12-31 | Hoffmann La Roche | Oleaginous systems |
| GB1433103A (en) * | 1974-03-20 | 1976-04-22 | Lepetit Spa | Pharmacologically active pyrrolodiazepines |
| US4201712A (en) * | 1975-07-16 | 1980-05-06 | Boehringer Ingelheim Gmbh | Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines |
| EP0031115A1 (en) * | 1979-12-21 | 1981-07-01 | Sandoz Ag | New pyrrolobenzotriazepines, their production and pharmaceutical compositions containing them |
| GR76455B (es) * | 1981-06-04 | 1984-08-10 | Lepetit Spa |
-
1984
- 1984-07-02 US US06/627,329 patent/US4517195A/en not_active Expired - Lifetime
-
1985
- 1985-06-25 DE DE8585107860T patent/DE3576822D1/de not_active Expired - Fee Related
- 1985-06-25 EP EP85107860A patent/EP0167922B1/en not_active Expired - Lifetime
- 1985-06-25 AT AT85107860T patent/ATE51401T1/de not_active IP Right Cessation
- 1985-06-28 CA CA000485960A patent/CA1251790A/en not_active Expired
- 1985-06-28 GR GR851599A patent/GR851599B/el unknown
- 1985-07-01 KR KR1019850004703A patent/KR860001113A/ko not_active Ceased
- 1985-07-01 ES ES544746A patent/ES8702913A1/es not_active Expired
- 1985-07-01 PT PT80746A patent/PT80746B/pt not_active IP Right Cessation
- 1985-07-01 JP JP60142673A patent/JPS6118781A/ja active Pending
- 1985-07-01 AU AU44514/85A patent/AU593771B2/en not_active Expired - Fee Related
- 1985-07-01 ZA ZA854946A patent/ZA854946B/xx unknown
- 1985-07-01 DK DK298085A patent/DK298085A/da not_active Application Discontinuation
-
1986
- 1986-02-14 ES ES552023A patent/ES8703836A1/es not_active Expired
- 1986-02-14 ES ES552024A patent/ES8703837A1/es not_active Expired
- 1986-02-14 ES ES552022A patent/ES8703422A1/es not_active Expired
- 1986-09-26 ES ES557083A patent/ES8707536A1/es not_active Expired
-
1989
- 1989-12-22 AU AU47228/89A patent/AU4722889A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE51401T1 (de) | 1990-04-15 |
| DK298085A (da) | 1986-01-03 |
| CA1262904C (es) | 1989-11-14 |
| PT80746B (en) | 1987-02-13 |
| ES544746A0 (es) | 1987-01-16 |
| AU4722889A (en) | 1990-05-17 |
| ES8703837A1 (es) | 1987-03-01 |
| ZA854946B (en) | 1986-02-26 |
| EP0167922A3 (en) | 1987-01-21 |
| GR851599B (es) | 1985-11-25 |
| ES552024A0 (es) | 1987-03-01 |
| ES8703836A1 (es) | 1987-03-01 |
| KR860001113A (ko) | 1986-02-22 |
| CA1251790A (en) | 1989-03-28 |
| JPS6118781A (ja) | 1986-01-27 |
| DE3576822D1 (de) | 1990-05-03 |
| PT80746A (en) | 1985-08-01 |
| ES8703422A1 (es) | 1987-02-16 |
| US4517195A (en) | 1985-05-14 |
| DK298085D0 (da) | 1985-07-01 |
| EP0167922B1 (en) | 1990-03-28 |
| AU593771B2 (en) | 1990-02-22 |
| ES552023A0 (es) | 1987-03-01 |
| AU4451485A (en) | 1986-01-09 |
| ES552022A0 (es) | 1987-02-16 |
| ES557083A0 (es) | 1987-08-01 |
| EP0167922A2 (en) | 1986-01-15 |
| ES8707536A1 (es) | 1987-08-01 |
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