ES8702877A1 - Benzoic acid derivatives and process for their preparation - Google Patents
Benzoic acid derivatives and process for their preparationInfo
- Publication number
- ES8702877A1 ES8702877A1 ES548360A ES548360A ES8702877A1 ES 8702877 A1 ES8702877 A1 ES 8702877A1 ES 548360 A ES548360 A ES 548360A ES 548360 A ES548360 A ES 548360A ES 8702877 A1 ES8702877 A1 ES 8702877A1
- Authority
- ES
- Spain
- Prior art keywords
- benzoic acid
- acid derivatives
- preparation
- asthmatic
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001558 benzoic acid derivatives Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000001088 anti-asthma Effects 0.000 abstract 2
- 239000000924 antiasthmatic agent Substances 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Benzoic acid derivatives represented by general formula (I) (wherein R<1> represents lower alkyl, R<2> represents optionally protected carboxy, and X represents halogen) or salts thereof, particularly those wherein R<2> represents a carboxy group protected by a group represented by formula (II) (wherein n represents an integer of 2 to 4, R<3> and R<4> may be the same or different and each represents hydrogen or alkyl or, when taken together with the adjacent nitrogen atom, R<3> and R<4> may form a heterocyclic group) or salts thereof, have excellent anti-asthmatic and anti-inflammatory effects, thus being utilized as anti-asthmatic and anti-inflammatory agents for mammals.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1984/000520 WO1986002636A1 (en) | 1984-10-30 | 1984-10-30 | Benzoic acid derivatives and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES548360A0 ES548360A0 (en) | 1987-01-16 |
| ES8702877A1 true ES8702877A1 (en) | 1987-01-16 |
Family
ID=13818454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES548360A Expired ES8702877A1 (en) | 1984-10-30 | 1985-10-30 | Benzoic acid derivatives and process for their preparation |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS61267539A (en) |
| KR (1) | KR870003047A (en) |
| AU (1) | AU4900085A (en) |
| ES (1) | ES8702877A1 (en) |
| SU (1) | SU1454247A3 (en) |
| WO (1) | WO1986002636A1 (en) |
| ZA (1) | ZA858341B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683242A (en) * | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
-
1984
- 1984-10-30 WO PCT/JP1984/000520 patent/WO1986002636A1/en not_active Ceased
-
1985
- 1985-09-25 JP JP60213578A patent/JPS61267539A/en active Pending
- 1985-10-23 AU AU49000/85A patent/AU4900085A/en not_active Abandoned
- 1985-10-30 KR KR1019850008050A patent/KR870003047A/en not_active Abandoned
- 1985-10-30 ES ES548360A patent/ES8702877A1/en not_active Expired
- 1985-10-30 SU SU853969758A patent/SU1454247A3/en active
- 1985-10-30 ZA ZA858341A patent/ZA858341B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES548360A0 (en) | 1987-01-16 |
| SU1454247A3 (en) | 1989-01-23 |
| WO1986002636A1 (en) | 1986-05-09 |
| ZA858341B (en) | 1987-06-24 |
| KR870003047A (en) | 1987-04-14 |
| AU4900085A (en) | 1986-05-08 |
| JPS61267539A (en) | 1986-11-27 |
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