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ES8702403A1 - Un procedimiento para la preparacion de nuevas n-((4-piperidinil)alquil)oxazol y tiazolaminas condensadas biciclicas sustituidas - Google Patents

Un procedimiento para la preparacion de nuevas n-((4-piperidinil)alquil)oxazol y tiazolaminas condensadas biciclicas sustituidas

Info

Publication number
ES8702403A1
ES8702403A1 ES553936A ES553936A ES8702403A1 ES 8702403 A1 ES8702403 A1 ES 8702403A1 ES 553936 A ES553936 A ES 553936A ES 553936 A ES553936 A ES 553936A ES 8702403 A1 ES8702403 A1 ES 8702403A1
Authority
ES
Spain
Prior art keywords
alkyl
condensed
new
piperidinyl
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553936A
Other languages
English (en)
Other versions
ES553936A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of ES553936A0 publication Critical patent/ES553936A0/es
Publication of ES8702403A1 publication Critical patent/ES8702403A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVAS N-(4-PIPERIDINIL)ALQUILOXAZOL Y TIAZOLAMINAS CONDENSADAS BICICLICAS SUSTITUIDAS. CONSISTE EN SOMETER A REACCION DE N-ALQUILACION UNA PIPERIDINA DE FORMULA (II) CON UN REACTIVO DE FORMULA L-W, PARA OBTENER NUEVAS N-(4-PIPERIDINIL)ALQUIL;OXAZOL Y TIAZOLAMINAS CONDENSADAS BICICLICAS SUSTITUIDAS DE FORMULA (I), DONDE -A1FA2-A3FA4- ES UN RADICAL DIVALENTE DE FORMULA -CHFCH-CHBCH-, NFCH-CHFCH- Y OTRAS; Z ES -O- O -S-; R1 ES UN MIEMBRO SELECCIONADO DEL GRUPO FORMADO POR H, ALQUILO C 1 A 6, ALQUIL C 1 A 6 CARBONILO Y OTROS; Q ES ALCANODIILO C 1 A 4; R ES UN MIEMBRO SELECCIONADO DEL GRUPO FORMADO POR H, ALQUILO C 1 A 6, HIDROXI Y ALQUILOXI C 1 A 6; Y L ES UN MIEMBRO SELECCIONADO DEL GRUPO FORMADO POR RADICALES DE FORMULAS (III) O (IV). TIENE UTILIDAD PARA EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON ESTEROQUINESIA ALTERADA.
ES553936A 1985-04-15 1986-04-11 Un procedimiento para la preparacion de nuevas n-((4-piperidinil)alquil)oxazol y tiazolaminas condensadas biciclicas sustituidas Expired ES8702403A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72340085A 1985-04-15 1985-04-15

Publications (2)

Publication Number Publication Date
ES553936A0 ES553936A0 (es) 1987-01-01
ES8702403A1 true ES8702403A1 (es) 1987-01-01

Family

ID=24906098

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553936A Expired ES8702403A1 (es) 1985-04-15 1986-04-11 Un procedimiento para la preparacion de nuevas n-((4-piperidinil)alquil)oxazol y tiazolaminas condensadas biciclicas sustituidas

Country Status (21)

Country Link
EP (1) EP0199400B1 (es)
JP (1) JPH08824B2 (es)
KR (1) KR930005004B1 (es)
CN (1) CN1019393B (es)
AT (1) ATE56972T1 (es)
AU (1) AU582642B2 (es)
CA (1) CA1271474A (es)
DE (1) DE3674448D1 (es)
DK (1) DK165183C (es)
ES (1) ES8702403A1 (es)
FI (1) FI82047C (es)
GR (1) GR861014B (es)
HU (1) HU196393B (es)
IE (1) IE59040B1 (es)
IL (1) IL78487A (es)
NO (1) NO163818C (es)
NZ (1) NZ215700A (es)
PH (1) PH26181A (es)
PT (1) PT82368B (es)
SU (1) SU1524809A3 (es)
ZA (1) ZA862776B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120843A (en) * 1987-04-27 1992-06-09 Upjohn Pharmaceutically active amines
IL90337A0 (en) * 1988-05-24 1989-12-15 Pfizer Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
JP2679745B2 (ja) * 1989-06-29 1997-11-19 明治製菓株式会社 アゾール誘導体及びそれらを有効成分とする抗潰瘍剤
US5089637A (en) * 1990-03-21 1992-02-18 Pfizer Inc. Process and intermediates for 2r-benzyl-chroman-6-carbaldehyde
KR100190299B1 (ko) * 1990-07-19 1999-06-01 디르크 반테 신규한 옥사졸릴 유도체
FR2672888B1 (fr) * 1991-02-14 1994-02-04 Fabre Medicament Pierre Nouvelles urees et thiourees, leur preparation et leur application en therapeutique.
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol
DE4120322A1 (de) * 1991-06-20 1992-12-24 Bayer Ag Aminomethyl-substituierte 2,3-dihydropyrano(2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
WO1994020476A1 (fr) * 1993-03-02 1994-09-15 Fujisawa Pharmaceutical Co., Ltd. Nouveau compose heterocyclique
TW282469B (es) * 1993-06-11 1996-08-01 Janssen Pharmaceutica Nv
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
FR2753970B1 (fr) * 1996-10-01 1998-10-30 Synthelabo Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
JP2000224822A (ja) 1998-06-29 2000-08-11 Mitsubishi Electric Corp 電動パワーステアリング装置用モータ
KR100526487B1 (ko) * 2000-06-21 2005-11-08 에프. 호프만-라 로슈 아게 벤조티아졸 유도체
FR2821356A1 (fr) * 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
DK1753760T3 (da) 2004-05-24 2008-04-14 Hoffmann La Roche 4-hydroxy-4-methyl-piperidin-1-carboxylsyre-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amid
CN101056857B (zh) 2004-11-05 2010-12-01 弗·哈夫曼-拉罗切有限公司 异烟酸衍生物的制备方法
DE602006012815D1 (de) 2005-03-23 2010-04-22 Hoffmann La Roche Acetylenylpyrazolopyrimidinderivate als mglur2-antagonsten
JP5048675B2 (ja) 2005-09-27 2012-10-17 エフ．ホフマン−ラ ロシュ アーゲー ｍＧｌｕＲ２アンタゴニストとしてのオキサジアゾリルピラゾロ−ピリミジン類

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035369A (en) * 1975-10-08 1977-07-12 Janssen Pharmaceutica N.V. 1-Benzazolylalkyl-4-substituted-piperidines
DE2545645C2 (de) * 1975-10-11 1983-04-14 Bayer Ag, 5090 Leverkusen Thiazolinylamino-piperidin-Derivate
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
CA1260474A (en) * 1984-12-03 1989-09-26 Raymond A. Stokbroekx Benzoxazol- and benzothiazolamine derivatives

Also Published As

Publication number Publication date
PT82368B (pt) 1988-05-27
DK169486A (da) 1986-10-16
DE3674448D1 (de) 1990-10-31
IE59040B1 (en) 1993-12-15
HUT40633A (en) 1987-01-28
DK165183B (da) 1992-10-19
KR930005004B1 (ko) 1993-06-11
NO163818B (no) 1990-04-17
EP0199400A2 (en) 1986-10-29
IE860967L (en) 1986-10-15
AU5613586A (en) 1986-10-23
DK169486D0 (da) 1986-04-14
CA1271474A (en) 1990-07-10
ES553936A0 (es) 1987-01-01
FI861562A0 (fi) 1986-04-14
ZA862776B (en) 1987-11-25
HU196393B (en) 1988-11-28
PH26181A (en) 1992-03-18
ATE56972T1 (de) 1990-10-15
PT82368A (en) 1986-05-01
NO861442L (no) 1986-10-16
FI861562A7 (fi) 1986-10-16
NO163818C (no) 1990-07-25
FI82047C (fi) 1991-01-10
IL78487A (en) 1989-12-15
GR861014B (en) 1986-08-07
NZ215700A (en) 1988-07-28
JPS62129282A (ja) 1987-06-11
CN1019393B (zh) 1992-12-09
FI82047B (fi) 1990-09-28
JPH08824B2 (ja) 1996-01-10
EP0199400B1 (en) 1990-09-26
SU1524809A3 (ru) 1989-11-23
IL78487A0 (en) 1986-08-31
KR860008173A (ko) 1986-11-12
EP0199400A3 (en) 1987-08-19
CN86102349A (zh) 1986-11-19
AU582642B2 (en) 1989-04-06
DK165183C (da) 1993-03-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041022