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ES8700250A1 - 1,3-Dioxan-5-ylalkenoic acids. - Google Patents

1,3-Dioxan-5-ylalkenoic acids.

Info

Publication number
ES8700250A1
ES8700250A1 ES528576A ES528576A ES8700250A1 ES 8700250 A1 ES8700250 A1 ES 8700250A1 ES 528576 A ES528576 A ES 528576A ES 528576 A ES528576 A ES 528576A ES 8700250 A1 ES8700250 A1 ES 8700250A1
Authority
ES
Spain
Prior art keywords
formula
dioxan
hydrogen
ylalkenoic
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528576A
Other languages
Spanish (es)
Other versions
ES528576A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES8700250A1 publication Critical patent/ES8700250A1/en
Publication of ES528576A0 publication Critical patent/ES528576A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DEL ACIDO 4-FENIL-1,3-DIOXAN-CIS-5-ILALQUENOICO DE FORMULA (I), EN EL QUE RA, RB Y EL ANILLO BENCENICO B SE PUEDEN ELEGIR DE UNA SERIE DE 25 COMBINACIONES DISTINTAS. COMPRENDE LA REACCION DE UN DERIVADO ERITRO-DIOL DE FORMULA (II) EN EL QUE UNO DE LOS RADICALES QA Y QB ES HIDROGENO Y EL OTRO TAMBIEN HIDROGENO, ALCANOSULFONILO, AERONOSULFONILO O UN GRUPO DE FORMULA -CRR.OH CON UN COMPUESTO CARBONILO DE FORMULA RARB.CO O UN ACETAL, SEMIACETAL O HIDRATO DEL MISMO EN PRESENCIA DE UN CATALIZADOR ACIDO. APLICABLE EN LA PREVENCION O TRATAMIENTO DE ENFERMEDADES ISQUEMICAS DEL CORAZON, CEREBROVASCULARES Y VASCULARES.PROCEDURE TO PREPARE FORMULA (I) 4-PHENYL-1,3-DIOXAN-CIS-5-ILALKENOIC ACID DERIVATIVES, IN WHICH RA, RB AND THE BENZENIC RING B CAN BE CHOSEN FROM A SERIES OF 25 DIFFERENT COMBINATIONS. IT INCLUDES THE REACTION OF AN ERYTHRO-DIOL DERIVATIVE OF FORMULA (II) IN WHICH ONE OF THE QA AND QB RADICALS IS HYDROGEN AND THE OTHER IS ALSO HYDROGEN, ALCANOSULPHONIL, AERONOSULFONYL OR A GROUP OF FORMULA-CRUIT FORMULA COMPOUND. RARB.CO OR AN ACETAL, SEMIACETAL OR HYDRATE OF THE SAME IN THE PRESENCE OF AN ACID CATALYST. APPLICABLE IN THE PREVENTION OR TREATMENT OF ISCHEMIC DISEASES OF THE HEART, CEREBROVASCULAR AND VASCULAR.

ES528576A 1982-05-12 1983-12-30 1,3-Dioxan-5-ylalkenoic acids. Expired ES8700250A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8213702 1982-05-12

Publications (2)

Publication Number Publication Date
ES8700250A1 true ES8700250A1 (en) 1986-10-16
ES528576A0 ES528576A0 (en) 1986-10-16

Family

ID=10530304

Family Applications (4)

Application Number Title Priority Date Filing Date
ES522331A Granted ES522331A0 (en) 1982-05-12 1983-05-12 A DERIVATIVE OF ACID 4-PHENYL-1,3-DIOXAN-CIS-5-ILALQUENOIC.
ES528576A Expired ES8700250A1 (en) 1982-05-12 1983-12-30 1,3-Dioxan-5-ylalkenoic acids.
ES528577A Expired ES8608507A1 (en) 1982-05-12 1983-12-30 PROCEDURE FOR PREPARING 4-PHENYL-1,3-DIOXAN-CIS-5-ILALKENOIC ACIDS
ES528575A Expired ES8700249A1 (en) 1982-05-12 1983-12-30 PROCEDURE FOR PREPARING DERIVATIVES OF 4-PHENYL-1,3-DIOXAN-CIS-5-ILALQUENOIC ACID

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES522331A Granted ES522331A0 (en) 1982-05-12 1983-05-12 A DERIVATIVE OF ACID 4-PHENYL-1,3-DIOXAN-CIS-5-ILALQUENOIC.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES528577A Expired ES8608507A1 (en) 1982-05-12 1983-12-30 PROCEDURE FOR PREPARING 4-PHENYL-1,3-DIOXAN-CIS-5-ILALKENOIC ACIDS
ES528575A Expired ES8700249A1 (en) 1982-05-12 1983-12-30 PROCEDURE FOR PREPARING DERIVATIVES OF 4-PHENYL-1,3-DIOXAN-CIS-5-ILALQUENOIC ACID

Country Status (32)

Country Link
US (3) US4567197A (en)
EP (1) EP0094239B1 (en)
JP (1) JPS58222081A (en)
KR (1) KR880002001B1 (en)
AR (1) AR240817A1 (en)
AT (1) ATE28329T1 (en)
AU (1) AU562056B2 (en)
CA (4) CA1258464A (en)
CS (2) CS245795B2 (en)
CY (1) CY1453A (en)
DD (2) DD212515A5 (en)
DE (1) DE3372483D1 (en)
DK (1) DK163431C (en)
ES (4) ES522331A0 (en)
FI (1) FI80027C (en)
GB (1) GB8310407D0 (en)
GR (1) GR78138B (en)
HK (1) HK17889A (en)
HU (1) HU198705B (en)
IE (1) IE55114B1 (en)
IL (1) IL68628A0 (en)
KE (1) KE3823A (en)
MW (1) MW1583A1 (en)
NO (1) NO162383B (en)
NZ (1) NZ204202A (en)
PH (1) PH21691A (en)
PL (3) PL140463B1 (en)
PT (1) PT76684B (en)
SG (1) SG57088G (en)
SU (1) SU1277893A3 (en)
ZA (1) ZA833179B (en)
ZW (1) ZW10083A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310407D0 (en) * 1982-05-12 1983-05-25 Ici Plc 1 3 - dioxan -5- ylalkenoic acids
FR2551446B1 (en) * 1983-08-31 1987-03-20 Elf Aquitaine RESIN COMPOSITIONS HAVING IMPROVED IMPACT RESISTANCE CONTAINING A THERMOPLASTIC POLYMER, A SHOCK ADDTIVE OF THE GRAFT COPOLYMER TYPE, AND POSSIBLY OTHER ADDITIVES, AND CORRESPONDING GRAFT COPOLYMER, WITH THE CHARACTER OF SHOCK ADDITIVE
GB8330120D0 (en) * 1983-11-11 1983-12-21 Ici Plc Chemical process
GB8330094D0 (en) * 1983-11-11 1983-12-21 Ici Plc Diphenyl compounds
GB8330097D0 (en) * 1983-11-11 1983-12-21 Ici Plc Cyclic ethers
GB8417314D0 (en) * 1984-07-06 1984-08-08 Ici Plc Carboxylic acid derivatives
GB8511891D0 (en) * 1985-05-10 1985-06-19 Ici Plc Alkenoic acids
GB8511894D0 (en) 1985-05-10 1985-06-19 Ici Plc Phenol derivatives
GB8511890D0 (en) * 1985-05-10 1985-06-19 Ici Plc Benzene derivatives
GB8511892D0 (en) * 1985-05-10 1985-06-19 Ici Plc Fluoralkane derivatives
GB8511897D0 (en) * 1985-05-10 1985-06-19 Ici Plc Carboxylic acids
GR861209B (en) * 1985-05-10 1986-08-29 Ici Plc Process for preparing novel alkene derivatives
HU198706B (en) * 1985-05-10 1989-11-28 Ici Plc Process for producing 1,3-dioxan-ethers and pharmaceutical compositions containing them
GB8511895D0 (en) * 1985-05-10 1985-06-19 Ici Plc Heterocyclic compounds
ES2017633B3 (en) * 1985-11-12 1991-03-01 Ici Plc AMIDO DERIVATIVES.
GB8611174D0 (en) * 1986-05-08 1986-06-18 Ici Plc Amide derivatives
GB8531892D0 (en) * 1985-12-30 1986-02-05 Ici Plc Carboxylic acids
DE3603662A1 (en) * 1986-02-06 1987-08-13 Basf Ag ACETALIZED OR KETALIZED DIHYDROXYALDEHYDE, METHOD FOR THE PRODUCTION THEREOF AND SOLUTIONS CONTAINING THEM
GB8626296D0 (en) * 1986-11-04 1986-12-03 Ici Plc Therapeutic agents
GB8626297D0 (en) * 1986-11-04 1986-12-03 Ici Plc Pharmaceutical compositions
GB8709794D0 (en) * 1987-04-24 1987-05-28 Ici Plc Heterocyclic acids
US5248780A (en) * 1988-02-16 1993-09-28 Imperial Chemical Industries, Plc Pyridyl substituted alkenoic acid derivatives
GB8901201D0 (en) * 1988-02-16 1989-03-15 Ici Plc Pyridine derivatives
EP0346511A1 (en) * 1988-06-15 1989-12-20 Fujisawa Pharmaceutical Co., Ltd. Oxygen-containing hererocyclic compound, processes for their preparation and pharmaceutical compositions comprising them
IE81170B1 (en) * 1988-10-21 2000-05-31 Zeneca Ltd Pyridine derivatives
CN1034120C (en) * 1988-10-21 1997-02-26 曾尼卡有限公司 Process for preparing dioxane alkenoic acid derivatives
GB9021571D0 (en) * 1990-10-04 1990-11-21 Ici Plc Heterocyclic acids
US5925795A (en) * 1996-09-16 1999-07-20 Zeneca Limited Processes for the preparation of aryl-β-diketones, arylpyrimidine ketones and crop protection intermediates
GB0413970D0 (en) * 2004-06-22 2004-07-28 Syngenta Participations Ag Chemical compounds
EP1976509B1 (en) * 2006-01-18 2014-12-17 Evolva SA Ppar modulators
CA2676435C (en) * 2007-01-18 2015-03-24 Evolva Sa Substituted 1,3-dioxanes useful as ppar modulators
BRPI0806686A2 (en) * 2007-01-18 2014-11-04 Evolva Sa COMPOUNDS AND ITS USES, METHODS OF TREATMENT OR PREVENTION, PHARMACEUTICAL COMPOSITIONS AND CRYSTALLINE COMPOUND AND SOLVAT
CA2871545A1 (en) * 2012-05-18 2013-11-21 Sanofi Benzo[1,3]dioxine derivatives and their use as lpar5 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4243592A (en) * 1979-03-12 1981-01-06 The Upjohn Company 9,11-Dideoxy-10-oxa-TXB compounds
GB8310407D0 (en) * 1982-05-12 1983-05-25 Ici Plc 1 3 - dioxan -5- ylalkenoic acids
GB8417314D0 (en) * 1984-07-06 1984-08-08 Ici Plc Carboxylic acid derivatives

Also Published As

Publication number Publication date
CS725784A2 (en) 1985-09-17
GB8310407D0 (en) 1983-05-25
EP0094239B1 (en) 1987-07-15
CA1268771C (en) 1990-05-08
SU1277893A3 (en) 1986-12-15
FI80027C (en) 1990-04-10
ZA833179B (en) 1984-04-25
KE3823A (en) 1988-10-21
ES8407038A1 (en) 1984-08-16
US4567197A (en) 1986-01-28
NO831679L (en) 1983-11-14
SG57088G (en) 1989-01-27
HK17889A (en) 1989-03-10
FI80027B (en) 1989-12-29
IL68628A0 (en) 1984-05-31
AU1422383A (en) 1983-11-17
DK163431C (en) 1992-07-20
PL241920A1 (en) 1985-03-26
DE3372483D1 (en) 1987-08-20
PL250099A1 (en) 1985-07-02
US4745198A (en) 1988-05-17
ES8608507A1 (en) 1986-06-16
FI831664L (en) 1983-11-13
IE55114B1 (en) 1990-06-06
CA1268772A (en) 1990-05-08
GR78138B (en) 1984-09-26
CS245795B2 (en) 1986-10-16
PL250098A1 (en) 1985-07-02
AR240817A1 (en) 1991-02-28
AR240817A2 (en) 1991-02-28
ES522331A0 (en) 1984-08-16
MW1583A1 (en) 1985-02-13
DK211883A (en) 1983-11-13
PT76684A (en) 1983-06-01
IE831005L (en) 1983-11-12
NO162383B (en) 1989-09-11
PL140462B1 (en) 1987-04-30
EP0094239A3 (en) 1984-12-12
DK163431B (en) 1992-03-02
KR880002001B1 (en) 1988-10-11
ES528575A0 (en) 1986-10-16
PL140463B1 (en) 1987-04-30
HU198705B (en) 1989-11-28
CS333683A2 (en) 1985-09-17
ZW10083A1 (en) 1984-11-28
CA1258464A (en) 1989-08-15
ES8700249A1 (en) 1986-10-16
DK211883D0 (en) 1983-05-11
ES528576A0 (en) 1986-10-16
JPH0378389B2 (en) 1991-12-13
JPS58222081A (en) 1983-12-23
DD212515A5 (en) 1984-08-15
CY1453A (en) 1989-07-21
CA1268771A (en) 1990-05-08
DD219769A5 (en) 1985-03-13
PH21691A (en) 1988-01-13
CA1269109A (en) 1990-05-15
PL140274B1 (en) 1987-04-30
EP0094239A2 (en) 1983-11-16
FI831664A0 (en) 1983-05-12
US5166377A (en) 1992-11-24
AU562056B2 (en) 1987-05-28
CS245783B2 (en) 1986-10-16
NZ204202A (en) 1986-05-09
ATE28329T1 (en) 1987-08-15
PT76684B (en) 1986-01-14
KR840004739A (en) 1984-10-24
ES528577A0 (en) 1986-06-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401