ES8609306A1 - Gastric secretion inhibiting benzimidazole deriv. prepn. - Google Patents
Gastric secretion inhibiting benzimidazole deriv. prepn.Info
- Publication number
- ES8609306A1 ES8609306A1 ES548297A ES548297A ES8609306A1 ES 8609306 A1 ES8609306 A1 ES 8609306A1 ES 548297 A ES548297 A ES 548297A ES 548297 A ES548297 A ES 548297A ES 8609306 A1 ES8609306 A1 ES 8609306A1
- Authority
- ES
- Spain
- Prior art keywords
- prepn
- deriv
- benzimidazole
- gastric secretion
- secretion inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 230000002496 gastric effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 abstract 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
- 230000001035 methylating effect Effects 0.000 abstract 1
- BSCHIACBONPEOB-UHFFFAOYSA-N oxolane;hydrate Chemical compound O.C1CCOC1 BSCHIACBONPEOB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Method comprises methylating hydroxy-deriv. (II) with dimethyl sulphate or methyl iodide at 0-50 deg.C in a water-tetrahydrofuran mixt. (b) distilling water under vacuum to remove the solvent (c) extracting with ethyl acetate or methylene chloride to give 5-trifluoromethyl -2- (4-methoxy-3-methyl-2 pyridylmethyl) thio)-(1H) -benzimidazole) (I) and (d) purifying with acetonitrile.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES548297A ES8609306A1 (en) | 1985-10-29 | 1985-10-29 | Gastric secretion inhibiting benzimidazole deriv. prepn. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES548297A ES8609306A1 (en) | 1985-10-29 | 1985-10-29 | Gastric secretion inhibiting benzimidazole deriv. prepn. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8609306A1 true ES8609306A1 (en) | 1986-04-01 |
| ES548297A0 ES548297A0 (en) | 1986-04-01 |
Family
ID=8490047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES548297A Expired ES8609306A1 (en) | 1985-10-29 | 1985-10-29 | Gastric secretion inhibiting benzimidazole deriv. prepn. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8609306A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2047451A1 (en) * | 1992-07-10 | 1994-02-16 | Vita Invest Sa | Stable pharmaceutical compsn prepn - by coating gastrointestinal drug with soluble insulating layer and enteric outer layer |
-
1985
- 1985-10-29 ES ES548297A patent/ES8609306A1/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2047451A1 (en) * | 1992-07-10 | 1994-02-16 | Vita Invest Sa | Stable pharmaceutical compsn prepn - by coating gastrointestinal drug with soluble insulating layer and enteric outer layer |
Also Published As
| Publication number | Publication date |
|---|---|
| ES548297A0 (en) | 1986-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 20051219 |