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ES8609272A1 - Un procedimiento para preparar derivados de hidantoina - Google Patents

Un procedimiento para preparar derivados de hidantoina

Info

Publication number
ES8609272A1
ES8609272A1 ES541029A ES541029A ES8609272A1 ES 8609272 A1 ES8609272 A1 ES 8609272A1 ES 541029 A ES541029 A ES 541029A ES 541029 A ES541029 A ES 541029A ES 8609272 A1 ES8609272 A1 ES 8609272A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
compositions containing
hydantoin derivatives
hydrogen
hydantoin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541029A
Other languages
English (en)
Other versions
ES541029A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Zoki Pharmaceutical Co Ltd
Original Assignee
Nippon Zoki Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59045278A external-priority patent/JPH062748B2/ja
Priority claimed from JP59241439A external-priority patent/JPH0686436B2/ja
Application filed by Nippon Zoki Pharmaceutical Co Ltd filed Critical Nippon Zoki Pharmaceutical Co Ltd
Publication of ES541029A0 publication Critical patent/ES541029A0/es
Publication of ES8609272A1 publication Critical patent/ES8609272A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE HICLANTOINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X REPRESENTA HIDROGENO O GRUPO OR4; Y R1, R2, R3 Y R4 PUEDEN SER HIDROGENO, ALQUILO O CICLOALQUILO. COMPRENDE LA REACCION DE CONDENSACION CON CIERRE DE ANILLO DE UN COMPUESTO DE FORMULA (II), CON UN COMPUESTO DE FORMULA (III), EN LAS QUE R5, R6 Y R7 PUEDEN SER HIDROGENO, ALQUILO O ARALQUILO Y R1 Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN AGUA O EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y LA DE REFLUJO DE LA MEZCLA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA DIABETES.
ES541029A 1984-03-08 1985-03-07 Un procedimiento para preparar derivados de hidantoina Expired ES8609272A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59045278A JPH062748B2 (ja) 1984-03-08 1984-03-08 新規ヒダントイン誘導体及び該化合物を有効成分として含有する医薬組成物
JP59241439A JPH0686436B2 (ja) 1984-11-15 1984-11-15 新規ヒダントイン誘導体及び該化合物を含有する医薬組成物

Publications (2)

Publication Number Publication Date
ES541029A0 ES541029A0 (es) 1986-07-16
ES8609272A1 true ES8609272A1 (es) 1986-07-16

Family

ID=26385246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541029A Expired ES8609272A1 (es) 1984-03-08 1985-03-07 Un procedimiento para preparar derivados de hidantoina

Country Status (6)

Country Link
US (1) US4647574A (es)
EP (1) EP0160618B1 (es)
KR (1) KR930001835B1 (es)
AU (1) AU578068B2 (es)
DE (1) DE3583765D1 (es)
ES (1) ES8609272A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2678499B2 (ja) * 1989-08-09 1997-11-17 日本臓器製薬 株式会社 尿毒症毒素低下剤
US5912261A (en) * 1994-12-20 1999-06-15 Nippon Zoki Pharmaceutical Co., Ltd. Carboxyalkyl heterocyclic derivatives
US5681843A (en) * 1994-12-20 1997-10-28 Nippon Zoki Pharmaceutical Co., Ltd. Parabanic acid derivatives
US6197806B1 (en) 1995-12-20 2001-03-06 Nippon Zoki Pharmaceutical Co., Ltd. Eliminating agent for activated oxygen and free radicals
JPH10182460A (ja) * 1996-12-27 1998-07-07 Nippon Zoki Pharmaceut Co Ltd ３−デオキシグルコソン生成阻害剤
KR19980076014A (ko) * 1997-04-04 1998-11-16 성재갑 용액상 및 고체상 반응을 이용한 하이덴토인 유도체의 합성방법
AU754989B2 (en) * 1998-11-16 2002-11-28 Nippon Zoki Pharmaceutical Co., Ltd. A therapeutic agent for intractable vasculitis
DE19934231B4 (de) * 1999-07-21 2004-02-19 Bayer Ag Verfahren zur Herstellung von 1-substituierten 5-Hydroxy-imidazolin-2,4-dionen und 1-substituierten 5-Alkoxy-imidazolin-2,4-dionen
JP4711523B2 (ja) 2001-02-13 2011-06-29 日本臓器製薬株式会社 低アルブミン血症改善剤
TWI353979B (en) * 2002-04-10 2011-12-11 Nippon Zoki Pharmaceutical Co Novel crystal form of 5-hydroxy-1-methylhydantoin
US20060241162A1 (en) * 2005-04-20 2006-10-26 Kaoru Okamoto Optically active (R)-hydantoin derivative
US20060241163A1 (en) * 2005-04-20 2006-10-26 Kaoru Okamoto Optically active (S)-hydantoin derivative
EP2571354B1 (en) 2010-05-20 2020-07-08 University of Iowa Research Foundation Ursolic acid for inhibiting muscle atrophy
US11090313B2 (en) 2010-05-20 2021-08-17 University Of Iowa Research Foundation Methods for inhibiting muscle atrophy
CA2838275C (en) 2011-06-06 2021-08-10 University Of Iowa Research Foundation Methods for inhibiting muscle atrophy
CN117100744B (zh) * 2023-10-11 2024-04-02 吉林大学 1-mh在制备减肥、降血脂、治疗脂肪肝和糖尿病的药物中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2553055A (en) * 1946-11-07 1951-05-15 Dow Chemical Co Synthesis of 5-(sec.-butyl) hydantion
NL292187A (es) * 1962-05-02
US3395153A (en) * 1964-12-16 1968-07-30 United States Borax Chem 3, 5-dialkylhydantoins
CH523279A (de) * 1968-11-11 1972-05-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Diglycidylverbindungen von N-heterocyclischen Verbindungen und deren Verwendung
US3696198A (en) * 1970-04-02 1972-10-03 Frederick J Mccarty Treatment of anoxia with 3,5-dialkyl hydantoins
US3847933A (en) * 1970-12-09 1974-11-12 Exxon Research Engineering Co Acid catalyzed alkylation of hydantoin
NL158172B (nl) * 1972-09-18 1978-10-16 Farmaceutici Italia Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats.
IE46672B1 (en) * 1977-03-18 1983-08-24 Kanegafuchi Chemical Ind Process for preparing 5-(4-hydroxyphenyl)hydantoin
GB1600880A (en) * 1978-05-23 1981-10-21 Lilly Industries Ltd Pharmaceutical compositions comprising hydantoin derivatives
US4198423A (en) * 1979-03-20 1980-04-15 Basf Aktiengesellschaft 1,3-Bis-(trihalomethylsulfenyl)-imidazoline-2,4-diones

Also Published As

Publication number Publication date
ES541029A0 (es) 1986-07-16
US4647574A (en) 1987-03-03
EP0160618A1 (en) 1985-11-06
KR930001835B1 (ko) 1993-03-15
AU578068B2 (en) 1988-10-13
DE3583765D1 (de) 1991-09-19
AU3917285A (en) 1985-09-12
EP0160618B1 (en) 1991-08-14
KR850006187A (ko) 1985-10-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970701