ES8609248A1 - N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory - Google Patents
N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatoryInfo
- Publication number
- ES8609248A1 ES8609248A1 ES542813A ES542813A ES8609248A1 ES 8609248 A1 ES8609248 A1 ES 8609248A1 ES 542813 A ES542813 A ES 542813A ES 542813 A ES542813 A ES 542813A ES 8609248 A1 ES8609248 A1 ES 8609248A1
- Authority
- ES
- Spain
- Prior art keywords
- carboxamide
- formula
- andantiinflammatory
- oxyindole
- disubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000202 analgesic effect Effects 0.000 title 1
- UYINJAQCJCYCGO-UHFFFAOYSA-N 2-oxo-3h-indole-1-carboxamide Chemical compound C1=CC=C2N(C(=O)N)C(=O)CC2=C1 UYINJAQCJCYCGO-UHFFFAOYSA-N 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDURE FOR OBTAINING 2-OXINDOL-1-CARBOXAMIDE. IT CONSISTS IN REACTIONING A COMPOUND OF FORMULA (II) WITH AN ISOCYANATE OF FORMULA R1-NFCFO, IN EQUIMOLAR RELATIONSHIP, AT A TEMPERATURE OF 50 TO 150ºC, IN AN ORGANIC INERT SOLVENT, AROMATIC OROTIC, OTHER AND AROMATIC -OXINDOL-1-CARBOXAMIDE OF FORMULA (I) OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS. BEING: R1, ALKYL FROM C 1 TO 6, CYCLOALKYL FROM C 3 TO 7 AND OTHERS; R2, C 1 TO 6 ALKYL, BENCIL AND OTHERS; X, H, F, CL AND OTHERS; AND, H, RENT OF C 1 TO 4 AND OTHERS; Y X E Y, TOGETHER, 4,5-METHYLENDIOXI, 5,6-ETHYLENDIOXI AND OTHERS. THEY ARE USED IN PHARMACOLOGY AS ANTI-INFLAMMATORIES AND ANALGESICS IN MAMIFE (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60735684A | 1984-05-04 | 1984-05-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8609248A1 true ES8609248A1 (en) | 1986-07-16 |
| ES542813A0 ES542813A0 (en) | 1986-07-16 |
Family
ID=24431933
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542813A Expired ES8609248A1 (en) | 1984-05-04 | 1985-05-03 | N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory |
| ES551275A Expired ES8707182A1 (en) | 1984-05-04 | 1986-01-27 | N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551275A Expired ES8707182A1 (en) | 1984-05-04 | 1986-01-27 | N,3-disubstituted 2-oxyindole-1-carboxamide as analgesic andantiinflammatory |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS60243068A (en) |
| KR (1) | KR870000497B1 (en) |
| AR (1) | AR241159A1 (en) |
| BG (2) | BG60208B2 (en) |
| CS (1) | CS252828B2 (en) |
| DD (1) | DD232916A5 (en) |
| EG (1) | EG17193A (en) |
| ES (2) | ES8609248A1 (en) |
| FI (1) | FI80016C (en) |
| HU (1) | HU196057B (en) |
| IE (1) | IE851103L (en) |
| IN (1) | IN161509B (en) |
| MA (1) | MA20424A1 (en) |
| MW (1) | MW1685A1 (en) |
| MX (1) | MX5839A (en) |
| NO (1) | NO163132C (en) |
| OA (1) | OA08098A (en) |
| PL (2) | PL145416B1 (en) |
| PT (1) | PT80375B (en) |
| RO (2) | RO94455B (en) |
| RU (1) | RU2017729C1 (en) |
| SU (1) | SU1468413A3 (en) |
| YU (1) | YU44998B (en) |
| ZA (1) | ZA853324B (en) |
| ZW (1) | ZW7885A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| IL95880A (en) * | 1989-10-13 | 1995-12-31 | Pfizer | Use of 3-substituted-2-oxindole derivatives for the preparation of a pharmaceutical preparation for inhibiting interleukin-1 biosynthesis |
-
1985
- 1985-04-08 IN IN288/DEL/85A patent/IN161509B/en unknown
- 1985-04-30 PT PT80375A patent/PT80375B/en unknown
- 1985-04-30 YU YU730/85A patent/YU44998B/en unknown
- 1985-05-02 DD DD85275898A patent/DD232916A5/en not_active IP Right Cessation
- 1985-05-02 EG EG275/85A patent/EG17193A/en active
- 1985-05-02 JP JP60095275A patent/JPS60243068A/en active Granted
- 1985-05-02 AR AR300259A patent/AR241159A1/en active
- 1985-05-02 IE IE851103A patent/IE851103L/en unknown
- 1985-05-03 NO NO851774A patent/NO163132C/en not_active IP Right Cessation
- 1985-05-03 FI FI851756A patent/FI80016C/en not_active IP Right Cessation
- 1985-05-03 MA MA20648A patent/MA20424A1/en unknown
- 1985-05-03 ES ES542813A patent/ES8609248A1/en not_active Expired
- 1985-05-03 BG BG070071A patent/BG60208B2/en unknown
- 1985-05-03 OA OA58583A patent/OA08098A/en unknown
- 1985-05-03 ZW ZW78/85A patent/ZW7885A1/en unknown
- 1985-05-03 RO RO123678A patent/RO94455B/en unknown
- 1985-05-03 PL PL1985253203A patent/PL145416B1/en unknown
- 1985-05-03 KR KR1019850003013A patent/KR870000497B1/en not_active Expired
- 1985-05-03 ZA ZA853324A patent/ZA853324B/en unknown
- 1985-05-03 PL PL1985257892A patent/PL147508B1/en unknown
- 1985-05-03 RO RO118604A patent/RO91141B/en unknown
- 1985-05-03 MX MX583985A patent/MX5839A/en unknown
- 1985-05-03 MW MW16/85A patent/MW1685A1/en unknown
- 1985-05-04 RU SU853891002A patent/RU2017729C1/en active
- 1985-05-04 CS CS853202A patent/CS252828B2/en not_active IP Right Cessation
- 1985-05-31 HU HU851693A patent/HU196057B/en unknown
-
1986
- 1986-01-27 ES ES551275A patent/ES8707182A1/en not_active Expired
- 1986-05-12 SU SU864027453A patent/SU1468413A3/en active
-
1992
- 1992-07-08 BG BG096583A patent/BG60207B2/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050418 |