ES8608534A1 - Procedimiento para la fabricacion de etoposido. - Google Patents
Procedimiento para la fabricacion de etoposido.Info
- Publication number
- ES8608534A1 ES8608534A1 ES544985A ES544985A ES8608534A1 ES 8608534 A1 ES8608534 A1 ES 8608534A1 ES 544985 A ES544985 A ES 544985A ES 544985 A ES544985 A ES 544985A ES 8608534 A1 ES8608534 A1 ES 8608534A1
- Authority
- ES
- Spain
- Prior art keywords
- etoposide
- new
- haloacetyl
- ester
- haloacetyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960005420 etoposide Drugs 0.000 title abstract 2
- -1 etoposide haloacetyl ester Chemical class 0.000 title 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE ETOPOSIDOS CON BAJO CONTENIDO DE IMPUREZAS. SE PREPARAN ETOPOSIDOS DE FORMULA (I), HACIENDO REACCIONAR UN 4K-HALOGENOACETIL-4K-DESMETIL-EPIPODOFILOTOXIN-B-D-2,3-DI-0-HALOGENOACETIL-4,6-0-ETILIDESGLUCOSIDO DE FORMULA GENERAL (II), EN LA QUE R1 Y R2, QUE PUEDEN SER IGUALES O DIFERENTES, REPRESENTAN CADA UNO DE ELLOS -COCHX2 O -COCX3, SIENDO X2 Y X3 ATOMOS DE HALOGENO, CON UN ALCOHOL, UNA AMINA Y/O AMONIACO, PARA ELIMINAR R1 Y R2 SIMULTANEAMENTE Y OBTENER EL ETOPOSIDO EN UNA FORMA FACILMENTE PURIFICABLE Y CON UN BUEN RENDIMIENTO. LA REACCION TERMINA EN POCO TIEMPO A LA TEMPERATURA AMBIENTE Y EL ETOPOSIDO SE RECUPERA POR SIMPLE CONCENTRACION DE LA SOLUCION DE REACCION, LO QUE SUPONE LA POSIBILIDAD DE UTILIZACION INDUSTRIAL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES544985A ES8608534A1 (es) | 1985-07-09 | 1985-07-09 | Procedimiento para la fabricacion de etoposido. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES544985A ES8608534A1 (es) | 1985-07-09 | 1985-07-09 | Procedimiento para la fabricacion de etoposido. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8608534A1 true ES8608534A1 (es) | 1986-07-16 |
| ES544985A0 ES544985A0 (es) | 1986-07-16 |
Family
ID=8489488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544985A Expired ES8608534A1 (es) | 1985-07-09 | 1985-07-09 | Procedimiento para la fabricacion de etoposido. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8608534A1 (es) |
-
1985
- 1985-07-09 ES ES544985A patent/ES8608534A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES544985A0 (es) | 1986-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20060411 |