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ES8607300A1 - Acidos 1,7-diamino-1,4-dihidro-4-oxo-3-(aza) quinolincarbo- xilicos - Google Patents

Acidos 1,7-diamino-1,4-dihidro-4-oxo-3-(aza) quinolincarbo- xilicos

Info

Publication number
ES8607300A1
ES8607300A1 ES541192A ES541192A ES8607300A1 ES 8607300 A1 ES8607300 A1 ES 8607300A1 ES 541192 A ES541192 A ES 541192A ES 541192 A ES541192 A ES 541192A ES 8607300 A1 ES8607300 A1 ES 8607300A1
Authority
ES
Spain
Prior art keywords
carbon atoms
group
alkyl
radical
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541192A
Other languages
English (en)
Other versions
ES541192A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8607300A1 publication Critical patent/ES8607300A1/es
Publication of ES541192A0 publication Critical patent/ES541192A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 1,7-DIAMINO-1,4-DIHIDRO-4-OXO-3-(AZA)-QUINOLINCARBOXILICOS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, X, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES; Y R5 Y R6 REPRESENTAN HIDROGENO O ALQUILO C1-4. CONSISTE EN LA REACCION DE SUSTITUCION DE UN ACIDO 1-AMINOQUINOLONCARBOXILICO, DE FORMULA (II), CON UNA AMINA DE FORMULA R2NHR3, EN LAS QUE Y REPRESENTA CLORO O FLUOR Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DILUYENTE, EN PRESENCIA DE UN ACEPTADO DE ACIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 200JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES BACTERIANAS.
ES541192A 1984-03-17 1985-03-12 Acidos 1,7-diamino-1,4-dihidro-4-oxo-3-(aza) quinolincarbo- xilicos Expired ES8607300A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843409922 DE3409922A1 (de) 1984-03-17 1984-03-17 1,7-diamino-1,4-dihydro-4-oxo-3-(aza)chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung bakterieller erkrankungen

Publications (2)

Publication Number Publication Date
ES8607300A1 true ES8607300A1 (es) 1986-05-16
ES541192A0 ES541192A0 (es) 1986-05-16

Family

ID=6230867

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541192A Expired ES8607300A1 (es) 1984-03-17 1985-03-12 Acidos 1,7-diamino-1,4-dihidro-4-oxo-3-(aza) quinolincarbo- xilicos

Country Status (7)

Country Link
US (2) US4666920A (es)
EP (1) EP0155587B1 (es)
JP (1) JPH064590B2 (es)
KR (1) KR910006635B1 (es)
AT (1) ATE34985T1 (es)
DE (2) DE3409922A1 (es)
ES (1) ES8607300A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3683922D1 (de) * 1985-09-24 1992-03-26 Hoffmann La Roche Chinolinderivate.
JPS62228063A (ja) * 1985-12-27 1987-10-06 Sankyo Co Ltd キノリンカルボン酸誘導体
EP0259804B1 (de) * 1986-09-12 1993-11-18 F. Hoffmann-La Roche Ag Pyrido [3,2,1-ij]-1,3,4-benzoxadiazinderivate, Verfahren zu deren Herstellung, entsprechende pharmazeutische Präparate und im Verfahren verwendbare Zwischenprodukte
US4864023A (en) * 1986-09-12 1989-09-05 Hoffmann-La Roche Inc. Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives
US4889857A (en) * 1987-10-12 1989-12-26 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compounds and pharmaceutical use thereof
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
CS273349B2 (en) * 1988-03-31 1991-03-12 Hoffmann La Roche Method of cephalosporin's new derivatives production
US5336768A (en) * 1988-05-24 1994-08-09 Hoffmann-La Roche Inc. Antibacterial cephalosporin compounds
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
DE3918544A1 (de) * 1989-06-07 1990-12-13 Bayer Ag Verfahren zur herstellung von 7-(3-amino- sowie 3-amino-methyl-1-pyrrolidinyl)-3-chinolon- carbonsaeuren sowie -naphthyridoncarbonsaeuren
US5162523A (en) * 1989-07-21 1992-11-10 Hoffmann-La Roche Inc. Cephalosporin antibacterial compounds
US5159077A (en) * 1989-07-21 1992-10-27 Hoffmann-La Roche Inc. Penam antibacterial compounds
US4992449A (en) * 1990-02-01 1991-02-12 American Cyanamid Company 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
DK0680482T3 (da) * 1993-01-23 1997-05-05 Pfizer Fremgangsmåde til fremstilling af en tricyclisk forbindelse
JPH072783A (ja) * 1993-11-26 1995-01-06 Sankyo Co Ltd キノリンカルボン酸誘導体の製造中間体
JPH08208617A (ja) * 1995-11-02 1996-08-13 Sankyo Co Ltd キノリンカルボン酸誘導体の製造中間体
EP2332916A3 (en) 2009-11-19 2011-08-03 Krka Tovarna Zdravil, D.D., Novo Mesto A process for a preparation of marbofloxacin and intermediate thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS5540656A (en) * 1978-09-19 1980-03-22 Kyorin Pharmaceut Co Ltd Substituted quinoline-carboxylic acid derivative
JPS5649382A (en) * 1979-09-28 1981-05-02 Dainippon Pharmaceut Co Ltd 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
JPS57145862A (en) * 1981-03-06 1982-09-09 Kyorin Pharmaceut Co Ltd Quinolinecarboxylic acid derivative
US4499091A (en) * 1982-03-31 1985-02-12 Sterling Drug Inc. 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents
EP0090424B1 (en) * 1982-03-31 1986-05-28 Sterling Drug Inc. New quinolone compounds and preparation thereof
JPS59128383A (ja) * 1982-12-29 1984-07-24 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Also Published As

Publication number Publication date
DE3409922A1 (de) 1985-09-26
EP0155587A1 (de) 1985-09-25
DE3563210D1 (en) 1988-07-14
JPH064590B2 (ja) 1994-01-19
EP0155587B1 (de) 1988-06-08
JPS60204765A (ja) 1985-10-16
US4666920A (en) 1987-05-19
US4753925A (en) 1988-06-28
ATE34985T1 (de) 1988-06-15
KR910006635B1 (ko) 1991-08-29
KR850006400A (ko) 1985-10-05
ES541192A0 (es) 1986-05-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060220