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ES8604213A1 - Procedimiento para la preparacion de derivados de acridanona - Google Patents

Procedimiento para la preparacion de derivados de acridanona

Info

Publication number
ES8604213A1
ES8604213A1 ES534337A ES534337A ES8604213A1 ES 8604213 A1 ES8604213 A1 ES 8604213A1 ES 534337 A ES534337 A ES 534337A ES 534337 A ES534337 A ES 534337A ES 8604213 A1 ES8604213 A1 ES 8604213A1
Authority
ES
Spain
Prior art keywords
group
acridanone
amino
rent
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534337A
Other languages
English (en)
Other versions
ES534337A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8604213A1 publication Critical patent/ES8604213A1/es
Publication of ES534337A0 publication Critical patent/ES534337A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K19/00—Liquid crystal materials
    • C09K19/04—Liquid crystal materials characterised by the chemical structure of the liquid crystal components, e.g. by a specific unit
    • C09K19/06—Non-steroidal liquid crystal compounds
    • C09K19/08—Non-steroidal liquid crystal compounds containing at least two non-condensed rings
    • C09K19/10—Non-steroidal liquid crystal compounds containing at least two non-condensed rings containing at least two benzene rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ACRIDANONA. CONSISTE EN DISOCIAR EL GRUPO N-PROTECTOR, DEL COMPUESTO DE FORMULA (XII), POR HIDROLISIS ACIDA, PARA OBTENER DERIVADOS DE ACRIDANONA, DE FORMULA GENERAL (I). SIENDO: LA LINEA DE TRAZOS, ENLACE OPCIONAL; A, ALQUILENO INFERIOR; R1, H, HAL, O NITRO; R2, H, O ALQUILO INFERIOR; R3 Y R4, ALQUILO INFERIOR O H, Y JUNTO CON R, UN ENLACE ADICIONAL; R5, AMINO O EL GRUPO DE FORMULA (III) B, -CO-, -COO-, O SO2; N, 0 O 1; A1, ALQUILENO INFERIOR; R6 AMINO, ALQUILAMINO INFERIOR Y OTROS; R7, HIDROGENO; Y R8, UN GRUPO R5 QUE CONTIENE UN GRUPO AMINO BASICO PRIMARIO O SECUNDARIO BLOQUEADO POR UN GRUPO N-PROTECTOR. LA HIDROLISI SE REALIZA CON BRH Y ACIDO ACETICO GLACIAL, EN UN DISOLVENTE COMO DICLOROMETANO. SE USA EN FARMACOLOGIA PARA EL CONTROL O PREVENCION DE ESQUISTOSOMIASIS.
ES534337A 1982-11-26 1984-07-16 Procedimiento para la preparacion de derivados de acridanona Expired ES8604213A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH689682 1982-11-26

Publications (2)

Publication Number Publication Date
ES8604213A1 true ES8604213A1 (es) 1986-01-16
ES534337A0 ES534337A0 (es) 1986-01-16

Family

ID=4316762

Family Applications (3)

Application Number Title Priority Date Filing Date
ES527552A Granted ES527552A0 (es) 1982-11-26 1983-11-25 Procedimiento para la preparacion de acridanona
ES534337A Expired ES8604213A1 (es) 1982-11-26 1984-07-16 Procedimiento para la preparacion de derivados de acridanona
ES534338A Expired ES8505367A1 (es) 1982-11-26 1984-07-16 Procedimiento para la preparacion de derivados de acridanona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES527552A Granted ES527552A0 (es) 1982-11-26 1983-11-25 Procedimiento para la preparacion de acridanona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES534338A Expired ES8505367A1 (es) 1982-11-26 1984-07-16 Procedimiento para la preparacion de derivados de acridanona

Country Status (24)

Country Link
EP (1) EP0110298B1 (es)
JP (1) JPS59108783A (es)
KR (1) KR840006653A (es)
AR (1) AR240934A1 (es)
AT (1) ATE34749T1 (es)
AU (1) AU565078B2 (es)
BR (1) BR8306513A (es)
CA (1) CA1258854A (es)
CS (1) CS235991B2 (es)
DE (1) DE3376832D1 (es)
DK (1) DK542383D0 (es)
DO (1) DOP1983004180A (es)
ES (3) ES527552A0 (es)
FI (1) FI79847C (es)
HU (1) HU192829B (es)
IE (1) IE56311B1 (es)
IL (1) IL70273A (es)
MC (1) MC1556A1 (es)
NO (1) NO160139C (es)
NZ (1) NZ206317A (es)
PH (1) PH19364A (es)
PT (1) PT77730B (es)
ZA (1) ZA838639B (es)
ZW (1) ZW23783A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2036198C1 (ru) * 1993-04-01 1995-05-27 Товарищество с ограниченной ответственностью "Полисан" N-МЕТИЛ-N-( α,D -ГЛЮКОПИРАНОЗИЛ) АММОНИЯ-2-(АКРИДОН-9-ОН-10-ИЛ)АЦЕТАТ(ЦИКЛОФЕРОН), ОБЛАДАЮЩИЙ ИНТЕРФЕРОНОГЕННОЙ, ПРОТИВОВИРУСНОЙ, В ТОМ ЧИСЛЕ АНТИВИЧ, АНТИПАРАЗИТАРНОЙ, АНТИПРОМОТОРНОЙ И РАДИОПРОТЕКТИВНОЙ АКТИВНОСТЬЮ
US7829578B1 (en) 2005-12-12 2010-11-09 Oregon Health & Science University Aromatic ketones and uses thereof
US8592447B2 (en) 2006-11-13 2013-11-26 Oregon Health & Science University Acridone compounds
US8598354B2 (en) 2008-12-05 2013-12-03 University Of South Florida Compounds having antiparasitic or anti-infectious activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1068595A (en) * 1964-06-08 1967-05-10 Gevaert Photo Prod Nv Colour photographic process
DE1811409A1 (de) * 1968-11-28 1970-06-18 Bayer Ag Mittel zur Bekaempfung von Insekten,Milben,Hasenartigen und Nagetieren

Also Published As

Publication number Publication date
AU2148883A (en) 1984-05-31
IE832770L (en) 1984-05-26
KR840006653A (ko) 1984-12-01
DE3376832D1 (de) 1988-07-07
ES8504184A1 (es) 1985-04-16
MC1556A1 (fr) 1984-08-31
AR240934A1 (es) 1991-03-27
JPS59108783A (ja) 1984-06-23
IL70273A0 (en) 1984-02-29
ES534338A0 (es) 1985-06-01
CA1258854A (en) 1989-08-29
ZA838639B (en) 1984-07-25
AU565078B2 (en) 1987-09-03
FI79847B (fi) 1989-11-30
EP0110298B1 (de) 1988-06-01
ATE34749T1 (de) 1988-06-15
PH19364A (en) 1986-04-02
DK542383D0 (da) 1983-11-25
IE56311B1 (en) 1991-06-19
IL70273A (en) 1987-01-30
NZ206317A (en) 1987-06-30
EP0110298A1 (de) 1984-06-13
NO834344L (no) 1984-05-28
CS235991B2 (en) 1985-05-15
ZW23783A1 (en) 1985-05-22
FI79847C (fi) 1990-03-12
FI834321A7 (fi) 1984-05-27
BR8306513A (pt) 1984-07-03
PT77730A (en) 1983-12-01
FI834321A0 (fi) 1983-11-24
ES8505367A1 (es) 1985-06-01
HU192829B (en) 1987-07-28
ES534337A0 (es) 1986-01-16
NO160139B (no) 1988-12-05
DOP1983004180A (es) 1988-12-19
PT77730B (en) 1986-05-12
ES527552A0 (es) 1985-04-16
AR240934A2 (es) 1991-03-27
NO160139C (no) 1989-03-15

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